解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The molecular requirements and morphology of migrating cells can vary depending on matrix geometry; therefore, predicting the optimal migration strategy or the effect of experimental perturbation is difficult. We present a model of cell motility that encompasses actin-polymerization-based protrusions, actomyosin contr...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2775
更新日期:2013-07-01 00:00:00
abstract::To learn more about cancer-associated fibroblasts (CAFs), we have isolated fibroblasts from different stages of breast cancer progression and analysed their function and gene expression. These analyses reveal that activation of the YAP transcription factor is a signature feature of CAFs. YAP function is required for C...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2756
更新日期:2013-06-01 00:00:00
abstract::The most dangerous insults to the genome's integrity are those that break both strands of the DNA. Double-strand breaks can be repaired by homologous recombination; in this conserved mechanism, a global genomic homology search finds sequences similar to those near the break, and uses them as a template for DNA synthes...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2745
更新日期:2013-06-01 00:00:00
abstract::Aberrant microRNA (miRNA) expression is a defining feature of human malignancy. Specific miRNAs have been identified as promoters or suppressors of metastatic progression. miRNAs control metastasis through divergent or convergent regulation of metastatic gene pathways. Some miRNA regulatory networks govern cell-autono...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2769
更新日期:2013-06-01 00:00:00
abstract::Lingual keratinized epithelial cells, which constitute the filiform papillae of the tongue, have one of the most rapid tissue turnover rates in the mammalian body and are thought to be the source of squamous cell carcinoma of the tongue. However, the mechanism of tissue maintenance and regeneration is largely unknown ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2719
更新日期:2013-05-01 00:00:00
abstract::Although it is well recognized that haematopoietic stem cells (HSCs) develop from a specialized population of endothelial cells known as haemogenic endothelium, the regulatory pathways that control this transition are not well defined. Here we identify Sox17 as a key regulator of haemogenic endothelial development. An...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2724
更新日期:2013-05-01 00:00:00
abstract::The tumour stroma is an active participant during cancer progression. Stromal cells promote tumour progression and metastasis through multiple mechanisms including enhancing tumour invasiveness and angiogenesis, and suppressing immune surveillance. We report here that miR-126/miR-126(*), a microRNA pair derived from a...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2690
更新日期:2013-03-01 00:00:00
abstract::We have identified Rab10 as an ER-specific Rab GTPase that regulates ER structure and dynamics. We show that Rab10 localizes to the ER and to dynamic ER-associated structures that track along microtubules and mark the position of new ER tubule growth. Rab10 depletion or expression of a Rab10 GDP-locked mutant alters E...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2647
更新日期:2013-02-01 00:00:00
abstract::Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncoge...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2657
更新日期:2013-02-01 00:00:00
abstract::Primordial germ cell (PGC) development in the human fetus remains relatively uncharted. A new study suggests that epigenetic reprogramming and sex differentiation in human PGCs occur asynchronously over an extended time period. This finding raises questions and implications for in vitro PGC differentiation. ...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb2665
更新日期:2013-01-01 00:00:00
abstract::Activation of mitosis-promoting factor (MPF) drives mitotic commitment. In human cells active MPF appears first on centrosomes. We show that local activation of MPF on the equivalent organelle of fission yeast, the spindle pole body (SPB), promotes Polo kinase activity at the SPBs long before global MPF activation dri...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2633
更新日期:2013-01-01 00:00:00
abstract::Pyruvate kinase M2 (PKM2) is upregulated in multiple cancer types and contributes to the Warburg effect by unclear mechanisms. Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1. Phosphor...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2629
更新日期:2012-12-01 00:00:00
abstract::The pericentriolar material (PCM), the microtubule-organizing component of the centrosome, contains a multitude of proteins and is commonly described as an amorphous cloud surrounding the centrioles. However, the days of the PCM as an unstructured matrix are numbered. Using super-resolution microscopy, several reports...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2617
更新日期:2012-11-01 00:00:00
abstract::A number of key regulators of mouse embryonic stem (ES) cell identity, including the transcription factor Nanog, show strong expression fluctuations at the single-cell level. The molecular basis for these fluctuations is unknown. Here we used a genetic complementation strategy to investigate expression changes during ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2603
更新日期:2012-11-01 00:00:00
abstract::Given the important role of the hypothalamus in regulating feeding and metabolism, there has been considerable interest in a possible function for hypothalamic stem cells in modulating body weight in health and disease. Mice given a high-fat diet develop inflammation in the hypothalamus and lose key types of neurons. ...
journal_title:Nature cell biology
pub_type: 新闻
doi:10.1038/ncb2599
更新日期:2012-10-01 00:00:00
abstract::Autophagy is a lysosome-based degradation pathway. During autophagy, lysosomes fuse with autophagosomes to form autolysosomes. Following starvation-induced autophagy, nascent lysosomes are formed from autolysosomal membranes through an evolutionarily conserved cellular process, autophagic lysosome reformation (ALR), w...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2557
更新日期:2012-09-01 00:00:00
abstract::Most invasive solid tumours display predominantly collective invasion, in which groups of cells invade the peritumoral stroma while maintaining cell-cell contacts. As the concepts and experimental models for functional analysis of collective cancer cell invasion are rapidly developing, we propose a framework for addre...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2548
更新日期:2012-08-01 00:00:00
abstract::The stability and membrane localization of the transforming growth factor-β (TGF-β) type I receptor (TβRI) determines the levels of TGF-β signalling. TβRI is targeted for ubiquitylation-mediated degradation by the SMAD7-SMURF2 complex. Here we performed a genome-wide gain-of-function screen and identified ubiquitin-sp...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2522
更新日期:2012-06-17 00:00:00
abstract::Cellular senescence is a stable proliferation arrest induced by triggers such as short telomeres, activated oncogenes and genotoxic stress. Two studies show that cellular senescence induced by genotoxic stress depends on chronic DNA-damage signalling from irreparable damage to telomeres. Hence, dysfunctional or damage...
journal_title:Nature cell biology
pub_type: 评论,新闻
doi:10.1038/ncb2476
更新日期:2012-04-02 00:00:00
abstract::Humans suffer from high rates of fetal aneuploidy, often arising from the absence of meiotic crossover recombination between homologous chromosomes. Meiotic recombination is initiated by double-strand breaks (DSBs) generated by the SPO11 transesterase. In yeast and worms, at least one buffering mechanism, crossover ho...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2451
更新日期:2012-03-04 00:00:00
abstract::Clathrin-coated vesicles mediate endocytosis and transport between the trans-Golgi network (TGN) and endosomes in eukaryotic cells. Clathrin adaptors play central roles in coat assembly, interacting with clathrin, cargo and membranes. Two main types of clathrin adaptor act in TGN-endosome traffic: GGA proteins and the...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2427
更新日期:2012-02-19 00:00:00
abstract::Loss of spindle-pole integrity during mitosis leads to multipolarity independent of centrosome amplification. Multipolar-spindle conformation favours incorrect kinetochore-microtubule attachments, compromising faithful chromosome segregation and daughter-cell viability. Spindle-pole organization influences and is infl...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2423
更新日期:2012-02-05 00:00:00
abstract::The anaphase-promoting complex or cyclosome (APC/C) initiates mitotic exit by ubiquitylating cell-cycle regulators such as cyclin B1 and securin. Lys 48-linked ubiquitin chains represent the canonical signal targeting proteins for degradation by the proteasome, but they are not required for the degradation of cyclin B...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2425
更新日期:2012-01-29 00:00:00
abstract::Secretory proteins are transported to the Golgi complex in vesicles that bud from the endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for cargo sorting and vesicle morphogenesis. COPII was first described in Saccharomyces cerevisiae, but its basic function is conserved throughout ...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2390
更新日期:2011-12-22 00:00:00
abstract::Actin and myosin are major components of the cell cytoskeleton, with structural and regulatory functions that affect many essential cellular processes. Although they were traditionally thought to function only in the cytoplasm, it is now well accepted that actin and multiple myosins are found in the nucleus. Increasin...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2364
更新日期:2011-11-02 00:00:00
abstract::Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling cascade, but how ubiqu...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2367
更新日期:2011-10-23 00:00:00
abstract::Cohesin confers both intrachromatid and interchromatid cohesion through formation of a tripartite ring within which DNA is thought to be entrapped. Here, I discuss what is known about the four stages of the cohesin ring cycle using the ring model as an intellectual framework. I postulate that cohesin loading onto chro...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2349
更新日期:2011-10-03 00:00:00
abstract::Regulated activation of integrins is critical for cell adhesion, motility and tissue homeostasis. Talin and kindlins activate β1-integrins, but the counteracting inhibiting mechanisms are poorly defined. We identified SHARPIN as an important inactivator of β1-integrins in an RNAi screen. SHARPIN inhibited β1-integrin ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2340
更新日期:2011-09-25 00:00:00
abstract::Metazoan internal organs are assembled from polarized tubular epithelia that must set aside an apical membrane domain as a lumenal surface. In a global Caenorhabditis elegans tubulogenesis screen, interference with several distinct fatty-acid-biosynthetic enzymes transformed a contiguous central intestinal lumen into ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2328
更新日期:2011-09-18 00:00:00
abstract::The position of the mitotic spindle controls the plane of cell cleavage and determines whether polarized cells divide symmetrically or asymmetrically. In animals, an evolutionarily conserved pathway of LIN-5 (homologues: Mud and NuMA), GPR-1/2 (homologues: Pins, LGN, AGS-3) and Gα mediates spindle positioning, and act...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2315
更新日期:2011-08-21 00:00:00
abstract::Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but requires actin polymerization in others. We show that membrane tension determines the actin dependence of clathrin-coat assembly. As found previously, clathrin assembly supports formation of mature coated pits in the absence of ac...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2307
更新日期:2011-08-14 00:00:00
abstract::N-WASP is a major cytoskeletal regulator that stimulates Arp2/3-mediated actin nucleation. Here, we identify a nucleation-independent pathway by which N-WASP regulates the cytoskeleton and junctional integrity at the epithelial zonula adherens. N-WASP is a junctional protein whose depletion decreased junctional F-acti...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2290
更新日期:2011-07-24 00:00:00
abstract::In plants, cell shape is defined by the cell wall, and changes in cell shape and size are dictated by modification of existing cell walls and deposition of newly synthesized cell-wall material. In root hairs, expansion occurs by a process called tip growth, which is shared by root hairs, pollen tubes and fungal hyphae...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2294
更新日期:2011-07-17 00:00:00
abstract::Canonical Wnt signalling has been implicated in mouse and human embryonic stem cell (ESC) maintenance; however, its requirement is controversial. β-catenin is the key component in this highly conserved Wnt pathway, acting as a transcriptional transactivator. However, β-catenin has additional roles at the plasma membra...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2260
更新日期:2011-06-19 00:00:00
abstract::TP53 (tumour protein 53) is one of the most frequently mutated genes in human cancer and its role during cellular transformation has been studied extensively. However, the homeostatic functions of p53 are less well understood. Here, we explore the molecular dependency network of TP53 through an RNAi-mediated synthetic...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2264
更新日期:2011-06-05 00:00:00
abstract::The cyclical protrusion and retraction of the leading edge is a hallmark of many migrating cells involved in processes such as development, inflammation and tumorigenesis. The molecular identity of the signalling mechanisms that control these cycles has remained unknown. Here, we used live-cell imaging of biosensors t...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2231
更新日期:2011-06-01 00:00:00
abstract::Starvation of animals or cells triggers autophagic degradation of cell contents to retrieve nutrients, but, paradoxically, mitochondria enlarge. This is now shown to result from inhibition of mitochondrial fission through PKA-mediated phosphorylation of the GTPase DRP1. Elongation of mitochondria optimizes ATP product...
journal_title:Nature cell biology
pub_type: 评论,新闻
doi:10.1038/ncb0511-521
更新日期:2011-05-01 00:00:00
abstract::Ciliates and flagellates temporarily swim backwards on collision by generating a mechanoreceptor potential. Although this potential has been shown to be associated with cilia in Paramecium, the molecular entity of the mechanoreceptor has remained unknown. Here we show that Chlamydomonas cells express TRP11, a member o...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2214
更新日期:2011-05-01 00:00:00
abstract::mTOR (mammalian target of rapamycin) signalling and macroautophagy (henceforth autophagy) regulate numerous pathological and physiological processes, including cellular responses to altered nutrient levels. However, the mechanisms regulating mTOR and autophagy remain incompletely understood. Lysosomes are dynamic intr...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2204
更新日期:2011-04-01 00:00:00
abstract::Cancer cells consume large quantities of glucose and primarily use glycolysis for ATP production, even in the presence of adequate oxygen. This metabolic signature (aerobic glycolysis or the Warburg effect) enables cancer cells to direct glucose to biosynthesis, supporting their rapid growth and proliferation. However...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2172
更新日期:2011-03-01 00:00:00