Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.

abstract：:Wnt/β-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO-LGR4/5-ZNF3/RNF43 is now shown to direct Wnt/β-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanis...

journal_title：Nature cell biology

authors： Birchmeier W

更新日期：2016-04-27 00:00:00

abstract：:Actin dynamics is a tightly regulated process involved in various cellular events including biogenesis of clathrin-coated, AP-1 (adaptor protein 1)-coated transport carriers connecting the trans-Golgi network (TGN) and the endocytic pathway. However, the mechanisms coordinating coat assembly, membrane and actin remode...

journal_title：Nature cell biology

authors： Anitei M,Stange C,Parshina I,Baust T,Schenck A,Raposo G,Kirchhausen T,Hoflack B

更新日期：2010-04-01 00:00:00

abstract：:The AP-1 transcription factor c-Jun is essential for cellular proliferation in many cell types, but the molecular link between growth factors and c-Jun activation has been enigmatic. In this study we identify a previously uncharacterized RING-domain-containing protein, RACO-1 (RING domain AP-1 co-activator-1), as a c-...

journal_title：Nature cell biology

authors： Davies CC,Chakraborty A,Cipriani F,Haigh K,Haigh JJ,Behrens A

更新日期：2010-10-01 00:00:00

abstract：:During cell division, many animal cells transform into a spherical shape and assemble a contractile ring composed of actin filaments and myosin motors at the equator to separate the cell body into two. Although actomyosin regulatory proteins are spatio-temporally controlled during cytokinesis, the direct contribution ...

journal_title：Nature cell biology

authors： Miyazaki M,Chiba M,Eguchi H,Ohki T,Ishiwata S

更新日期：2015-04-01 00:00:00

abstract：:Wiskott-Aldrich syndrome protein (WASP) and N-WASP have emerged as key proteins connecting signalling cascades to actin polymerization. Here we show that the amino-terminal WH1 domain, and not the polyproline-rich region, of N-WASP is responsible for its recruitment to sites of actin polymerization during Cdc42-indepe...

journal_title：Nature cell biology

authors： Moreau V,Frischknecht F,Reckmann I,Vincentelli R,Rabut G,Stewart D,Way M

更新日期：2000-07-01 00:00:00

abstract：:Autophagy is characterized by the sequestration of bulk cytoplasm, including damaged proteins and organelles, and delivery of the cargo to lysosomes for degradation. Although the autophagic pathway is also linked to tumour suppression activity, the mechanism is not yet clear. Here we report that cytosolic FoxO1, a for...

journal_title：Nature cell biology

authors： Zhao Y,Yang J,Liao W,Liu X,Zhang H,Wang S,Wang D,Feng J,Yu L,Zhu WG

更新日期：2010-07-01 00:00:00

abstract：:Mitochondria drive apoptosis by releasing pro-apoptotic proteins that promote caspase activation in the cytosol. The rhomboid protease PARL, an intramembrane cleaving peptidase in the inner membrane, regulates mitophagy and plays an ill-defined role in apoptosis. Here, we employed PARL-based proteomics to define its s...

journal_title：Nature cell biology

authors： Saita S,Nolte H,Fiedler KU,Kashkar H,Venne AS,Zahedi RP,Krüger M,Langer T

更新日期：2017-04-01 00:00:00

abstract：:Previous analyses of labelled clones of cells within the developing nervous system of the mouse have indicated that descendants are initially dispersed rostrocaudally followed by more local proliferation, which is consistent with the progressing node's contributing descendants from a resident population of progenitor ...

journal_title：Nature cell biology

authors： Mathis L,Kulesa PM,Fraser SE

更新日期：2001-06-01 00:00:00

abstract：:The molecular requirements and morphology of migrating cells can vary depending on matrix geometry; therefore, predicting the optimal migration strategy or the effect of experimental perturbation is difficult. We present a model of cell motility that encompasses actin-polymerization-based protrusions, actomyosin contr...

journal_title：Nature cell biology

authors： Tozluoğlu M,Tournier AL,Jenkins RP,Hooper S,Bates PA,Sahai E

更新日期：2013-07-01 00:00:00

abstract：:Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recen...

journal_title：Nature cell biology

authors： Heinrich C,Spagnoli FM,Berninger B

更新日期：2015-03-01 00:00:00

abstract：:LATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. LATS1 inhibits both the phosphorylation of cofilin by LIMK...

journal_title：Nature cell biology

authors： Yang X,Yu K,Hao Y,Li DM,Stewart R,Insogna KL,Xu T

更新日期：2004-07-01 00:00:00

abstract：:Centromeres are specialized chromosomal domains that direct kinetochore assembly during mitosis. CENP-A (centromere protein A), a histone H3-variant present exclusively in centromeric nucleosomes, is thought to function as an epigenetic mark that specifies centromere identity. Here we identify the essential centromere...

journal_title：Nature cell biology

authors： Carroll CW,Silva MC,Godek KM,Jansen LE,Straight AF

更新日期：2009-07-01 00:00:00

abstract：:Phosphorylation networks intimately regulate mechanisms of response to therapies. Mapping the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-throughput system to measure the enzymatic activity of kinases using biological peptide targets as phospho-sens...

journal_title：Nature cell biology

authors： Coppé JP,Mori M,Pan B,Yau C,Wolf DM,Ruiz-Saenz A,Brunen D,Prahallad A,Cornelissen-Steijger P,Kemper K,Posch C,Wang C,Dreyer CA,Krijgsman O,Lee PRE,Chen Z,Peeper DS,Moasser MM,Bernards R,van 't Veer LJ

更新日期：2019-06-01 00:00:00

abstract：:Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now been shed on the molecular requirements of LAP, establishing a central role for the protein Rubic...

journal_title：Nature cell biology

authors： Boyle KB,Randow F

更新日期：2015-07-01 00:00:00

abstract：:ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardio...

journal_title：Nature cell biology

authors： David R,Brenner C,Stieber J,Schwarz F,Brunner S,Vollmer M,Mentele E,Müller-Höcker J,Kitajima S,Lickert H,Rupp R,Franz WM

更新日期：2008-03-01 00:00:00

abstract：:Tissue stem cells are the cell of origin for many malignancies. Metabolites regulate the balance between self-renewal and differentiation, but whether endogenous metabolic pathways or nutrient availability predispose stem cells towards transformation remains unknown. Here, we address this question in epidermal stem ce...

journal_title：Nature cell biology

authors： Baksh SC,Todorova PK,Gur-Cohen S,Hurwitz B,Ge Y,Novak JSS,Tierney MT,Dela Cruz-Racelis J,Fuchs E,Finley LWS

更新日期：2020-07-01 00:00:00

abstract：:Whereas total loss of Lis1 is lethal, disruption of one allele of the Lis1 gene results in brain abnormalities, indicating that developing neurons are particularly sensitive to a reduction in Lis1 dosage. Here we show that Lis1 is enriched in neurons relative to levels in other cell types, and that Lis1 interacts with...

journal_title：Nature cell biology

authors： Smith DS,Niethammer M,Ayala R,Zhou Y,Gambello MJ,Wynshaw-Boris A,Tsai LH

更新日期：2000-11-01 00:00:00

abstract：:Recent theoretical analysis of a model lattice of interacting transmembrane receptor proteins has indicated that such clustering in the membrane could provide a novel mechanism for regulating receptor signalling in cells. It has been calculated that cooperative interactions between receptors organized into a cluster, ...

journal_title：Nature cell biology

authors： Yin CC,Lai FA

更新日期：2000-09-01 00:00:00

abstract：:Telomere attrition and other forms of telomere damage can activate the ATM kinase pathway. What generates the DNA damage signal at mammalian chromosome ends or at other double-strand breaks is not known. Telomere dysfunction is often accompanied by disappearance of the 3' telomeric overhang, raising the possibility th...

journal_title：Nature cell biology

authors： Celli GB,de Lange T

更新日期：2005-07-01 00:00:00

abstract：:Cancer-induced immune responses affect tumour progression and therapeutic response. In multiple murine models and clinical datasets, we identified large variations of neutrophils and macrophages that define 'immune subtypes' of triple-negative breast cancer (TNBC), including neutrophil-enriched (NES) and macrophage-en...

journal_title：Nature cell biology

authors： Kim IS,Gao Y,Welte T,Wang H,Liu J,Janghorban M,Sheng K,Niu Y,Goldstein A,Zhao N,Bado I,Lo HC,Toneff MJ,Nguyen T,Bu W,Jiang W,Arnold J,Gu F,He J,Jebakumar D,Walker K,Li Y,Mo Q,Westbrook TF,Zong C,Rao A,

更新日期：2019-09-01 00:00:00

abstract：:Despite the presence of mutations in APC or beta-catenin, which are believed to activate the Wnt signalling cascade constitutively, most colorectal cancers show cellular heterogeneity when beta-catenin localization is analysed, indicating a more complex regulation of Wnt signalling. We explored this heterogeneity with...

journal_title：Nature cell biology

authors： Vermeulen L,De Sousa E Melo F,van der Heijden M,Cameron K,de Jong JH,Borovski T,Tuynman JB,Todaro M,Merz C,Rodermond H,Sprick MR,Kemper K,Richel DJ,Stassi G,Medema JP

更新日期：2010-05-01 00:00:00

abstract：:Metaphase spindles are microtubule-based structures that use a multitude of proteins to modulate their morphology and function. Today, we understand many details of microtubule assembly, the role of microtubule-associated proteins, and the action of molecular motors. Ultimately, the challenge remains to understand how...

journal_title：Nature cell biology

authors： Reber SB,Baumgart J,Widlund PO,Pozniakovsky A,Howard J,Hyman AA,Jülicher F

更新日期：2013-09-01 00:00:00

abstract：:Growing microtubule end regions recruit a variety of proteins collectively termed +TIPs, which confer local functions to the microtubule cytoskeleton. +TIPs form dynamic interaction networks whose behaviour depends on a number of potentially competitive and hierarchical interaction modes. The rules that determine whic...

journal_title：Nature cell biology

authors： Duellberg C,Trokter M,Jha R,Sen I,Steinmetz MO,Surrey T

更新日期：2014-08-01 00:00:00

abstract：:Nutrient availability is central for T-cell functions and immune responses. Here we report that CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non-essential amino acid Asn. Increased Asn levels enhance CD8+ T-cell activation and effector functions against tumour cells in vitro and in ...

journal_title：Nature cell biology

authors： Wu J,Li G,Li L,Li D,Dong Z,Jiang P

更新日期：2021-01-01 00:00:00

abstract：:Dyneins are large microtubule motor proteins required for mitosis, intracellular transport and ciliary and flagellar motility. They generate force through a power-stroke mechanism, which is an ATP-consuming cycle of pre- and post-power-stroke conformational changes that cause relative motion between different dynein d...

journal_title：Nature cell biology

authors： Lin J,Okada K,Raytchev M,Smith MC,Nicastro D

更新日期：2014-05-01 00:00:00

abstract：:Different sites of plasma membrane attachment may underlie functional differences between isoforms of Ras. Here we show that palmitoylation and farnesylation targets H-ras to lipid rafts and caveolae, but that the interaction of H-ras with these membrane subdomains is dynamic. GTP-loading redistributes H-ras from raft...

journal_title：Nature cell biology

authors： Prior IA,Harding A,Yan J,Sluimer J,Parton RG,Hancock JF

更新日期：2001-04-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables their collective invasion. Force transmission is mediated by a heterophilic adhesion involving N-cadherin at the CAF membrane and E-cadherin at the cancer cell membrane. Th...

journal_title：Nature cell biology

authors： Labernadie A,Kato T,Brugués A,Serra-Picamal X,Derzsi S,Arwert E,Weston A,González-Tarragó V,Elosegui-Artola A,Albertazzi L,Alcaraz J,Roca-Cusachs P,Sahai E,Trepat X

更新日期：2017-03-01 00:00:00

abstract：:Lysosomes respond to environmental cues by controlling their own biogenesis, but the underlying mechanisms are poorly understood. Here we describe a protein kinase C (PKC)-dependent and mTORC1-independent mechanism for regulating lysosome biogenesis, which provides insights into previously reported effects of PKC on l...

journal_title：Nature cell biology

authors： Li Y,Xu M,Ding X,Yan C,Song Z,Chen L,Huang X,Wang X,Jian Y,Tang G,Tang C,Di Y,Mu S,Liu X,Liu K,Li T,Wang Y,Miao L,Guo W,Hao X,Yang C

更新日期：2016-10-01 00:00:00

abstract：:The promyelocytic leukaemia (PML) tumour-suppressor protein potentiates p53 function by regulating post-translational modifications, such as CBP-dependent acetylation and Chk2-dependent phosphorylation, in the PML-Nuclear Body (NB). PML was recently shown to interact with the p53 ubiquitin-ligase Mdm2 (refs 4-6); howe...

journal_title：Nature cell biology

authors： Bernardi R,Scaglioni PP,Bergmann S,Horn HF,Vousden KH,Pandolfi PP

更新日期：2004-07-01 00:00:00

abstract：:During mammalian development, neuroepithelial cells function as mitotic progenitors, which self-renew and generate neurons. Although spindle orientation is important for such polarized cells to undergo symmetric or asymmetric divisions, its role in mammalian neurogenesis remains unclear. Here we show that control of s...

journal_title：Nature cell biology

authors： Konno D,Shioi G,Shitamukai A,Mori A,Kiyonari H,Miyata T,Matsuzaki F

更新日期：2008-01-01 00:00:00