Abstract：
:During mammalian development, neuroepithelial cells function as mitotic progenitors, which self-renew and generate neurons. Although spindle orientation is important for such polarized cells to undergo symmetric or asymmetric divisions, its role in mammalian neurogenesis remains unclear. Here we show that control of spindle orientation is essential in maintaining the population of neuroepithelial cells, but dispensable for the decision to either proliferate or differentiate. Knocking out LGN, (the G protein regulator), randomized the orientation of normally planar neuroepithelial divisions. The resultant loss of the apical membrane from daughter cells frequently converted them into abnormally localized progenitors without affecting neuronal production rate. Furthermore, overexpression of Inscuteable to induce vertical neuroepithelial divisions shifted the fate of daughter cells. Our results suggest that planar mitosis ensures the self-renewal of neuroepithelial progenitors by one daughter inheriting both apical and basal compartments during neurogenesis.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Konno D,Shioi G,Shitamukai A,Mori A,Kiyonari H,Miyata T,Matsuzaki Fdoi
10.1038/ncb1673subject
Has Abstractpub_date
2008-01-01 00:00:00pages
93-101issue
1eissn
1465-7392issn
1476-4679pii
ncb1673journal_volume
10pub_type
杂志文章abstract：:Different sites of plasma membrane attachment may underlie functional differences between isoforms of Ras. Here we show that palmitoylation and farnesylation targets H-ras to lipid rafts and caveolae, but that the interaction of H-ras with these membrane subdomains is dynamic. GTP-loading redistributes H-ras from raft...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35070050
更新日期：2001-04-01 00:00:00
abstract：:Autophagy is characterized by the sequestration of bulk cytoplasm, including damaged proteins and organelles, and delivery of the cargo to lysosomes for degradation. Although the autophagic pathway is also linked to tumour suppression activity, the mechanism is not yet clear. Here we report that cytosolic FoxO1, a for...
journal_title：Nature cell biology
pub_type： 杂志文章
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更新日期：2010-07-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2095
更新日期：2010-09-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1319
更新日期：2005-11-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1474
更新日期：2006-10-01 00:00:00
abstract：:Parallel quantification of large numbers of messenger RNA transcripts using microarray technology promises to provide detailed insight into cellular processes involved in the regulation of gene expression. This should allow new understanding of signalling networks that operate in the cell and of the molecular basis an...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 评论,杂志文章
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更新日期：2009-03-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1695
更新日期：2008-03-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2307
更新日期：2011-08-14 00:00:00
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pub_type： 评论,杂志文章
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更新日期：2015-01-01 00:00:00
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pub_type： 杂志文章,已发布勘误
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更新日期：2019-06-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1387
更新日期：2006-04-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1234
更新日期：2005-04-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2999
更新日期：2014-08-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1078
更新日期：2004-01-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3573
更新日期：2017-08-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35041089
更新日期：2000-11-01 00:00:00
abstract：:Programmed cell death (apoptosis) is used by multicellular organisms during development and to maintain homeostasis within mature tissues. One of the first genes shown to regulate apoptosis was bcl-2. Subsequently, a number of Bcl-2-related proteins have been identified. Despite overwhelming evidence that Bcl-2 protei...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/70237
更新日期：1999-12-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-020-00615-4
更新日期：2021-01-01 00:00:00
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journal_title：Nature cell biology
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更新日期：2010-07-01 00:00:00
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doi：10.1038/s41556-018-0040-4
更新日期：2018-03-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2098
更新日期：2010-10-01 00:00:00
abstract：: ...
journal_title：Nature cell biology
pub_type： 评论,杂志文章
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更新日期：2018-11-01 00:00:00
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journal_title：Nature cell biology
pub_type： 已发布勘误
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更新日期：2018-09-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2690
更新日期：2013-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb1069
更新日期：2003-12-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb3042
更新日期：2014-10-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1994
更新日期：2009-12-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/14113
更新日期：1999-10-01 00:00:00
