Abstract：
:In the version of this Article originally published, ref. 52 was incorrectly only attributed to its corresponding author, Fre, S., and an older title was used. The correct citation should have been: Lilja, A. M. et al. Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0108-1 (2018)'. This has now been amended in all online versions of the Article.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Wuidart A,Sifrim A,Fioramonti M,Matsumura S,Brisebarre A,Brown D,Centonze A,Dannau A,Dubois C,Van Keymeulen A,Voet T,Blanpain Cdoi
10.1038/s41556-018-0164-6subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1099issue
9eissn
1465-7392issn
1476-4679pii
10.1038/s41556-018-0164-6journal_volume
20pub_type
已发布勘误abstract：:Cell division is fundamental for all organisms. Here we report a genome-scale RNA-mediated interference screen in HeLa cells designed to identify human genes that are important for cell division. We have used a library of endoribonuclease-prepared short interfering RNAs for gene silencing and have used DNA content ana...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1659
更新日期：2007-12-01 00:00:00
abstract：:Dyneins are large microtubule motor proteins required for mitosis, intracellular transport and ciliary and flagellar motility. They generate force through a power-stroke mechanism, which is an ATP-consuming cycle of pre- and post-power-stroke conformational changes that cause relative motion between different dynein d...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2939
更新日期：2014-05-01 00:00:00
abstract：:Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncoge...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb2657
更新日期：2013-02-01 00:00:00
abstract：:Apoptosis is induced by caspases, which are members of the cysteine protease family. Caspases are synthesized as inactive zymogens and initiator caspases first gain activity by associating with an oligomeric complex of their adaptor proteins, such as the apoptosome. Activated initiator caspases subsequently cleave and...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1803
更新日期：2008-12-01 00:00:00
abstract：:Tie2 belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1 (Ang1). Gene-targeting analyses of either Ang1 or Tie2 in mice reveal a critical role of Ang1-Tie2 signalling in developmental vascular formation. It remains elusive how the Tie2 signalling pathway plays distinct roles i...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1714
更新日期：2008-05-01 00:00:00
abstract：:MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endo...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/10061
更新日期：1999-06-01 00:00:00
abstract：:Analysis of the mechanisms underlying cell fates requires the molecular quantification of cellular features. Classical techniques use population average readouts at single time points. However, these approaches mask cellular heterogeneity and dynamics and are limited for studying rare and heterogeneous cell population...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb3042
更新日期：2014-10-01 00:00:00
abstract：:The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in r...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3619
更新日期：2017-09-29 00:00:00
abstract：:The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory proteins and delivery of functional solutes throughout the cell1,2. Molecular mobility through the ER network enables these functionalities, but diffusion alone is not sufficient to explain...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-018-0192-2
更新日期：2018-10-01 00:00:00
abstract：:Direct reprogramming by forced expression of transcription factors can convert one cell type into another. Thus, desired cell types can be generated bypassing pluripotency. However, direct reprogramming towards renal cells remains an unmet challenge. Here, we identify renal cell fate-inducing factors on the basis of t...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3437
更新日期：2016-12-01 00:00:00
abstract：:Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed microtubule seeds or from γ-tubulin recruited to the side of a pre-existing microtubule. Here, we found that microtubules c...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-018-0199-8
更新日期：2018-10-01 00:00:00
abstract：:The actin cytoskeleton has been implicated in restricting diffusion of plasma membrane components. Here, simultaneous observations of quantum dot-labelled FcepsilonRI motion and GFP-tagged actin dynamics provide direct evidence that actin filament bundles define micron-sized domains that confine mobile receptors. Dyna...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1755
更新日期：2008-08-01 00:00:00
abstract：:Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyses the trimethylation of histone H3 on Lys 27 (H3K27), which represses gene transcription. EZH2 enhances cancer-cell invasiveness and regulates stem cell differentiation. Here, we demonstrate that EZH2 can ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2139
更新日期：2011-01-01 00:00:00
abstract：:The planar cell polarity (PCP) signalling pathway is essential for embryonic development because it governs diverse cellular behaviours, and 'core PCP' proteins, such as Dishevelled and Frizzled, have been extensively characterized. By contrast, the 'PCP effector' proteins, such as Intu and Fuz, remain largely unstudi...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1966
更新日期：2009-10-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature cell biology
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41556-020-0479-y
更新日期：2020-03-01 00:00:00
abstract：:Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling cascade, but how ubiqu...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2367
更新日期：2011-10-23 00:00:00
abstract：:Many classical biologists working in Antarctica have 'gone molecular' to study the physiological basis for life on or below the ice. Investigating the remarkable adaptations of specific cells, organelles and molecules to this extreme environment can provide new perspectives on the processes studied in conventional exp...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb0103-3
更新日期：2003-01-01 00:00:00
abstract：:Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that tumour-secreted DKK1 is a serological marker of breast cancer metastasis organotropism and inhibits lung metastasis. DKK1 suppresses PTGS2-induced macrophage and ne...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3613
更新日期：2017-10-01 00:00:00
abstract：:Inactivation of the von Hippel-Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel-Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dep...
journal_title：Nature cell biology
pub_type： 评论,新闻
doi：10.1038/35017129
更新日期：2000-07-01 00:00:00
abstract：:Two forms of genetic instability have been described in colorectal cancer: microsatellite instability and chromosomal instability. Microsatellite instability results from mutations in mismatch repair genes; chromosomal instability is the hallmark of many colorectal cancers, although it is not completely understood at ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35070129
更新日期：2001-04-01 00:00:00
abstract：:Lamellipodia/ruffles and filopodia are protruding organelles containing short and highly branched or long and unbranched actin filaments, respectively. The microscopic morphology, dynamic development and protein signature of both lamellipodia/ruffles and filopodia have been investigated; however, little is known about...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1745
更新日期：2008-07-01 00:00:00
abstract：:Localization and activation of heterotrimeric G proteins have a crucial role during asymmetric cell division. The asymmetric division of the Drosophila sensory precursor cell (pl) is polarized along the antero-posterior axis by Frizzled signalling and, during this division, activation of Galphai depends on Partner of ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1319
更新日期：2005-11-01 00:00:00
abstract：:Bcl-2 stimulates mutagenesis after the exposure of cells to DNA-damaging agents. However, the biological mechanisms of Bcl-2-mediated mutagenesis have remained largely obscure. Here we demonstrate that the Bcl-2-mediated suppression of hMSH2 expression results in a reduced cellular capacity to repair mismatches. The p...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1215
更新日期：2005-02-01 00:00:00
abstract：:During meiosis, homologous chromosomes are sorted into pairs and are then intimately aligned, or synapsed, along their lengths while a proteinaceous structure, the synaptonemal complex, is assembled between them. However, little is known about how chromosomes first recognise each other. Here we show, by comparing the ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1168
更新日期：2004-09-01 00:00:00
abstract：:The pericentriolar material (PCM), the microtubule-organizing component of the centrosome, contains a multitude of proteins and is commonly described as an amorphous cloud surrounding the centrioles. However, the days of the PCM as an unstructured matrix are numbered. Using super-resolution microscopy, several reports...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2617
更新日期：2012-11-01 00:00:00
abstract：:LATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. LATS1 inhibits both the phosphorylation of cofilin by LIMK...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1140
更新日期：2004-07-01 00:00:00
abstract：:Although it is well recognized that haematopoietic stem cells (HSCs) develop from a specialized population of endothelial cells known as haemogenic endothelium, the regulatory pathways that control this transition are not well defined. Here we identify Sox17 as a key regulator of haemogenic endothelial development. An...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2724
更新日期：2013-05-01 00:00:00
abstract：:Cancer cells consume large quantities of glucose and primarily use glycolysis for ATP production, even in the presence of adequate oxygen. This metabolic signature (aerobic glycolysis or the Warburg effect) enables cancer cells to direct glucose to biosynthesis, supporting their rapid growth and proliferation. However...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2172
更新日期：2011-03-01 00:00:00
abstract：:Current models for the export of messenger RNA share the notion that the highly abundant class of nuclear RNA-binding proteins--the hnRNP proteins--have a key role in exporting RNA. But recent studies have led to a new understanding of several non-hnRNP proteins, including SR proteins and the conserved mRNA export fac...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb0901-e201
更新日期：2001-09-01 00:00:00
abstract：:Cellular senescence is a stable proliferation arrest induced by triggers such as short telomeres, activated oncogenes and genotoxic stress. Two studies show that cellular senescence induced by genotoxic stress depends on chronic DNA-damage signalling from irreparable damage to telomeres. Hence, dysfunctional or damage...
journal_title：Nature cell biology
pub_type： 评论,新闻
doi：10.1038/ncb2476
更新日期：2012-04-02 00:00:00
