Author Correction: Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.

abstract：:Compartmentalization has long been known to have a key role in regulation of cellular processes. By keeping enzymes and regulatory complexes in compartments where the delivery of substrate or exit of product is controlled, competing reactions can occur simultaneously in different parts of the cell. Moreover, spatial c...

journal_title：Nature cell biology

authors： Carmo-Fonseca M,Mendes-Soares L,Campos I

更新日期：2000-06-01 00:00:00

abstract：:Chromosome missegregation into a micronucleus can cause complex and localized genomic rearrangements known as chromothripsis, but the underlying mechanisms remain unresolved. Here we developed an inducible Y centromere-selective inactivation strategy by exploiting a CENP-A/histone H3 chimaera to directly examine the f...

journal_title：Nature cell biology

authors： Ly P,Teitz LS,Kim DH,Shoshani O,Skaletsky H,Fachinetti D,Page DC,Cleveland DW

更新日期：2017-01-01 00:00:00

abstract：:MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endo...

journal_title：Nature cell biology

authors： Kotlyarov A,Neininger A,Schubert C,Eckert R,Birchmeier C,Volk HD,Gaestel M

更新日期：1999-06-01 00:00:00

abstract：:The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucle...

journal_title：Nature cell biology

authors： Selva EM,Hong K,Baeg GH,Beverley SM,Turco SJ,Perrimon N,Häcker U

更新日期：2001-09-01 00:00:00

abstract：:The motion of a chromosome during mitosis is mediated by a bundle of microtubules, termed a kinetochore fibre (K-fibre), which connects the kinetochore of the chromosome to a spindle pole. Once formed, mature K-fibres maintain a steady state length because the continuous addition of microtubule subunits onto microtubu...

journal_title：Nature cell biology

authors： Maiato H,Khodjakov A,Rieder CL

更新日期：2005-01-01 00:00:00

abstract：:During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes that specify lineage and differentiation status. Among these factors, the transforming growth factor (TGF)-beta family is imp...

journal_title：Nature cell biology

authors： Derynck R,Akhurst RJ

更新日期：2007-09-01 00:00:00

abstract：:Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process,...

journal_title：Nature cell biology

authors： Hatch EM

更新日期：2016-12-23 00:00:00

abstract：:Many extracellular signals are transmitted to the interior of the cell by receptors with seven membrane-spanning helices that trigger their effects by means of heterotrimeric guanine-nucleotide-binding regulatory proteins (G proteins). These G-protein-coupled receptors (GPCRs) control various physiological functions i...

journal_title：Nature cell biology

authors： Cvejic S,Zhu Z,Felice SJ,Berman Y,Huang XY

更新日期：2004-06-01 00:00:00

abstract：:Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal, we have developed cell culture conditions to closely mimic events occurring during pancreatic islet organogenesis and β...

journal_title：Nature cell biology

authors： Nair GG,Liu JS,Russ HA,Tran S,Saxton MS,Chen R,Juang C,Li ML,Nguyen VQ,Giacometti S,Puri S,Xing Y,Wang Y,Szot GL,Oberholzer J,Bhushan A,Hebrok M

更新日期：2019-02-01 00:00:00

abstract：:Analysis of the mechanisms underlying cell fates requires the molecular quantification of cellular features. Classical techniques use population average readouts at single time points. However, these approaches mask cellular heterogeneity and dynamics and are limited for studying rare and heterogeneous cell population...

journal_title：Nature cell biology

authors： Hoppe PS,Coutu DL,Schroeder T

更新日期：2014-10-01 00:00:00

abstract：:mTOR (mammalian target of rapamycin) signalling and macroautophagy (henceforth autophagy) regulate numerous pathological and physiological processes, including cellular responses to altered nutrient levels. However, the mechanisms regulating mTOR and autophagy remain incompletely understood. Lysosomes are dynamic intr...

journal_title：Nature cell biology

authors： Korolchuk VI,Saiki S,Lichtenberg M,Siddiqi FH,Roberts EA,Imarisio S,Jahreiss L,Sarkar S,Futter M,Menzies FM,O'Kane CJ,Deretic V,Rubinsztein DC

更新日期：2011-04-01 00:00:00

abstract：:Individual neurons form specific elaborate dendritic structures that receive presynaptic information. The pattern of dendritic branching is regulated by the microtubule-associated motor protein dynein, which is responsible for the transport of essential endosomes and other organelles into the dendrites. ...

journal_title：Nature cell biology

authors： Tear G

更新日期：2008-10-01 00:00:00

abstract：:It is now well established that stromal interaction molecule 1 (STIM1) is the calcium sensor of endoplasmic reticulum stores required to activate store-operated calcium entry (SOC) channels at the surface of non-excitable cells. However, little is known about STIM1 in excitable cells, such as striated muscle, where th...

journal_title：Nature cell biology

authors： Stiber J,Hawkins A,Zhang ZS,Wang S,Burch J,Graham V,Ward CC,Seth M,Finch E,Malouf N,Williams RS,Eu JP,Rosenberg P

更新日期：2008-06-01 00:00:00

abstract：:Loss of spindle-pole integrity during mitosis leads to multipolarity independent of centrosome amplification. Multipolar-spindle conformation favours incorrect kinetochore-microtubule attachments, compromising faithful chromosome segregation and daughter-cell viability. Spindle-pole organization influences and is infl...

journal_title：Nature cell biology

authors： Logarinho E,Maffini S,Barisic M,Marques A,Toso A,Meraldi P,Maiato H

更新日期：2012-02-05 00:00:00

abstract：:Telomere attrition and other forms of telomere damage can activate the ATM kinase pathway. What generates the DNA damage signal at mammalian chromosome ends or at other double-strand breaks is not known. Telomere dysfunction is often accompanied by disappearance of the 3' telomeric overhang, raising the possibility th...

journal_title：Nature cell biology

authors： Celli GB,de Lange T

更新日期：2005-07-01 00:00:00

abstract：:Collective cell migration is essential for both physiological and pathological processes. Adherens junctions (AJs) maintain the integrity of the migrating cell group and promote cell coordination while allowing cellular rearrangements. Here, we show that AJs undergo a continuous treadmilling along the lateral sides of...

journal_title：Nature cell biology

authors： Peglion F,Llense F,Etienne-Manneville S

更新日期：2014-07-01 00:00:00

abstract：:Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degene...

journal_title：Nature cell biology

authors： Shiloh Y,Lehmann AR

更新日期：2004-10-01 00:00:00

abstract：:Sensing and clearance of dysfunctional lysosomes is critical for cellular homeostasis. Here we show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated during the lysosomal damage response, and its activation is dependent on the function of the ATG ...

journal_title：Nature cell biology

authors： Nakamura S,Shigeyama S,Minami S,Shima T,Akayama S,Matsuda T,Esposito A,Napolitano G,Kuma A,Namba-Hamano T,Nakamura J,Yamamoto K,Sasai M,Tokumura A,Miyamoto M,Oe Y,Fujita T,Terawaki S,Takahashi A,Hamasaki M,Yamamot

更新日期：2020-10-01 00:00:00

abstract：:Animal cell cytokinesis results from patterned activation of the small GTPase Rho, which directs assembly of actomyosin in the equatorial cortex. Cytokinesis is restricted to a portion of the cell cycle following anaphase onset in which the cortex is responsive to signals from the spindle. We show that shortly after a...

journal_title：Nature cell biology

authors： Bement WM,Leda M,Moe AM,Kita AM,Larson ME,Golding AE,Pfeuti C,Su KC,Miller AL,Goryachev AB,von Dassow G

更新日期：2015-11-01 00:00:00

abstract：:Endocytosis of cell surface receptors is an important regulatory event in signal transduction. The transforming growth factor beta (TGF-beta) superfamily signals to the Smad pathway through heteromeric Ser-Thr kinase receptors that are rapidly internalized and then downregulated in a ubiquitin-dependent manner. Here w...

journal_title：Nature cell biology

authors： Di Guglielmo GM,Le Roy C,Goodfellow AF,Wrana JL

更新日期：2003-05-01 00:00:00

abstract：:Although myosin II filaments are known to exist in non-muscle cells, their dynamics and organization are incompletely understood. Here, we combined structured illumination microscopy with pharmacological and genetic perturbations, to study the process of actomyosin cytoskeleton self-organization into arcs and stress f...

journal_title：Nature cell biology

authors： Hu S,Dasbiswas K,Guo Z,Tee YH,Thiagarajan V,Hersen P,Chew TL,Safran SA,Zaidel-Bar R,Bershadsky AD

更新日期：2017-02-01 00:00:00

abstract：:Ciliates and flagellates temporarily swim backwards on collision by generating a mechanoreceptor potential. Although this potential has been shown to be associated with cilia in Paramecium, the molecular entity of the mechanoreceptor has remained unknown. Here we show that Chlamydomonas cells express TRP11, a member o...

journal_title：Nature cell biology

authors： Fujiu K,Nakayama Y,Iida H,Sokabe M,Yoshimura K

更新日期：2011-05-01 00:00:00

abstract：:Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but requires actin polymerization in others. We show that membrane tension determines the actin dependence of clathrin-coat assembly. As found previously, clathrin assembly supports formation of mature coated pits in the absence of ac...

journal_title：Nature cell biology

authors： Boulant S,Kural C,Zeeh JC,Ubelmann F,Kirchhausen T

更新日期：2011-08-14 00:00:00

abstract：:The heterogeneity of exosomal populations has hindered our understanding of their biogenesis, molecular composition, biodistribution and functions. By employing asymmetric flow field-flow fractionation (AF4), we identified two exosome subpopulations (large exosome vesicles, Exo-L, 90-120 nm; small exosome vesicles, Ex...

journal_title：Nature cell biology

authors： Zhang H,Freitas D,Kim HS,Fabijanic K,Li Z,Chen H,Mark MT,Molina H,Martin AB,Bojmar L,Fang J,Rampersaud S,Hoshino A,Matei I,Kenific CM,Nakajima M,Mutvei AP,Sansone P,Buehring W,Wang H,Jimenez JP,Cohen-Gould L,P

更新日期：2018-03-01 00:00:00

abstract：:Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland function, their diversity has not been fully addressed. By exploiting high-resolution three-dimensional imaging and flow cytometry, we identified a unique population of tissue-resident ductal mac...

journal_title：Nature cell biology

authors： Dawson CA,Pal B,Vaillant F,Gandolfo LC,Liu Z,Bleriot C,Ginhoux F,Smyth GK,Lindeman GJ,Mueller SN,Rios AC,Visvader JE

更新日期：2020-05-01 00:00:00

abstract：:Caenorhabditis elegans chromosomes contain specialized regions called pairing centres, which mediate homologous pairing and synapsis during meiosis. Four related proteins, ZIM-1, 2, 3 and HIM-8, associate with these sites and are required for their essential functions. Here we show that short sequence elements enriche...

journal_title：Nature cell biology

authors： Phillips CM,Meng X,Zhang L,Chretien JH,Urnov FD,Dernburg AF

更新日期：2009-08-01 00:00:00

abstract：:Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling cascade, but how ubiqu...

journal_title：Nature cell biology

authors： Meerang M,Ritz D,Paliwal S,Garajova Z,Bosshard M,Mailand N,Janscak P,Hübscher U,Meyer H,Ramadan K

更新日期：2011-10-23 00:00:00

abstract：:The polarity protein Scribble (SCRIB) regulates apical-basal polarity, directional migration and tumour suppression in Drosophila and mammals. Here we report that SCRIB is an important regulator of myeloid cell functions including bacterial infection and inflammation. SCRIB interacts directly with the NADPH oxidase (N...

journal_title：Nature cell biology

authors： Zheng W,Umitsu M,Jagan I,Tran CW,Ishiyama N,BeGora M,Araki K,Ohashi PS,Ikura M,Muthuswamy SK

更新日期：2016-11-01 00:00:00

abstract：:The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from other extracellular vesicles in terms of their biogenesis and functions remains ...

journal_title：Nature cell biology

authors： Mathieu M,Martin-Jaular L,Lavieu G,Théry C

更新日期：2019-01-01 00:00:00

abstract：:The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory proteins and delivery of functional solutes throughout the cell1,2. Molecular mobility through the ER network enables these functionalities, but diffusion alone is not sufficient to explain...

journal_title：Nature cell biology

authors： Holcman D,Parutto P,Chambers JE,Fantham M,Young LJ,Marciniak SJ,Kaminski CF,Ron D,Avezov E

更新日期：2018-10-01 00:00:00