Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Bagci H,Sriskandarajah N,Robert A,Boulais J,Elkholi IE,Tran V,Lin ZY,Thibault MP,Dubé N,Faubert D,Hipfner DR,Gingras AC,Côté JFdoi
10.1038/s41556-020-0479-ysubject
Has Abstractpub_date
2020-03-01 00:00:00pages
353issue
3eissn
1465-7392issn
1476-4679pii
10.1038/s41556-020-0479-yjournal_volume
22pub_type
杂志文章,已发布勘误abstract::Compartmentalization has long been known to have a key role in regulation of cellular processes. By keeping enzymes and regulatory complexes in compartments where the delivery of substrate or exit of product is controlled, competing reactions can occur simultaneously in different parts of the cell. Moreover, spatial c...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/35014078
更新日期:2000-06-01 00:00:00
abstract::Chromosome missegregation into a micronucleus can cause complex and localized genomic rearrangements known as chromothripsis, but the underlying mechanisms remain unresolved. Here we developed an inducible Y centromere-selective inactivation strategy by exploiting a CENP-A/histone H3 chimaera to directly examine the f...
journal_title:Nature cell biology
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doi:10.1038/ncb3450
更新日期:2017-01-01 00:00:00
abstract::MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endo...
journal_title:Nature cell biology
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doi:10.1038/10061
更新日期:1999-06-01 00:00:00
abstract::The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucle...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb0901-809
更新日期:2001-09-01 00:00:00
abstract::The motion of a chromosome during mitosis is mediated by a bundle of microtubules, termed a kinetochore fibre (K-fibre), which connects the kinetochore of the chromosome to a spindle pole. Once formed, mature K-fibres maintain a steady state length because the continuous addition of microtubule subunits onto microtubu...
journal_title:Nature cell biology
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doi:10.1038/ncb1207
更新日期:2005-01-01 00:00:00
abstract::During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes that specify lineage and differentiation status. Among these factors, the transforming growth factor (TGF)-beta family is imp...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb434
更新日期:2007-09-01 00:00:00
abstract::Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process,...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3458
更新日期:2016-12-23 00:00:00
abstract::Many extracellular signals are transmitted to the interior of the cell by receptors with seven membrane-spanning helices that trigger their effects by means of heterotrimeric guanine-nucleotide-binding regulatory proteins (G proteins). These G-protein-coupled receptors (GPCRs) control various physiological functions i...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1133
更新日期:2004-06-01 00:00:00
abstract::Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal, we have developed cell culture conditions to closely mimic events occurring during pancreatic islet organogenesis and β...
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pub_type: 杂志文章
doi:10.1038/s41556-018-0271-4
更新日期:2019-02-01 00:00:00
abstract::Analysis of the mechanisms underlying cell fates requires the molecular quantification of cellular features. Classical techniques use population average readouts at single time points. However, these approaches mask cellular heterogeneity and dynamics and are limited for studying rare and heterogeneous cell population...
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doi:10.1038/ncb3042
更新日期:2014-10-01 00:00:00
abstract::mTOR (mammalian target of rapamycin) signalling and macroautophagy (henceforth autophagy) regulate numerous pathological and physiological processes, including cellular responses to altered nutrient levels. However, the mechanisms regulating mTOR and autophagy remain incompletely understood. Lysosomes are dynamic intr...
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doi:10.1038/ncb2204
更新日期:2011-04-01 00:00:00
abstract::Individual neurons form specific elaborate dendritic structures that receive presynaptic information. The pattern of dendritic branching is regulated by the microtubule-associated motor protein dynein, which is responsible for the transport of essential endosomes and other organelles into the dendrites. ...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb1008-1131
更新日期:2008-10-01 00:00:00
abstract::It is now well established that stromal interaction molecule 1 (STIM1) is the calcium sensor of endoplasmic reticulum stores required to activate store-operated calcium entry (SOC) channels at the surface of non-excitable cells. However, little is known about STIM1 in excitable cells, such as striated muscle, where th...
journal_title:Nature cell biology
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doi:10.1038/ncb1731
更新日期:2008-06-01 00:00:00
abstract::Loss of spindle-pole integrity during mitosis leads to multipolarity independent of centrosome amplification. Multipolar-spindle conformation favours incorrect kinetochore-microtubule attachments, compromising faithful chromosome segregation and daughter-cell viability. Spindle-pole organization influences and is infl...
journal_title:Nature cell biology
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doi:10.1038/ncb2423
更新日期:2012-02-05 00:00:00
abstract::Telomere attrition and other forms of telomere damage can activate the ATM kinase pathway. What generates the DNA damage signal at mammalian chromosome ends or at other double-strand breaks is not known. Telomere dysfunction is often accompanied by disappearance of the 3' telomeric overhang, raising the possibility th...
journal_title:Nature cell biology
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doi:10.1038/ncb1275
更新日期:2005-07-01 00:00:00
abstract::Collective cell migration is essential for both physiological and pathological processes. Adherens junctions (AJs) maintain the integrity of the migrating cell group and promote cell coordination while allowing cellular rearrangements. Here, we show that AJs undergo a continuous treadmilling along the lateral sides of...
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更新日期:2014-07-01 00:00:00
abstract::Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degene...
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pub_type:
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更新日期:2004-10-01 00:00:00
abstract::Sensing and clearance of dysfunctional lysosomes is critical for cellular homeostasis. Here we show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated during the lysosomal damage response, and its activation is dependent on the function of the ATG ...
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abstract::Animal cell cytokinesis results from patterned activation of the small GTPase Rho, which directs assembly of actomyosin in the equatorial cortex. Cytokinesis is restricted to a portion of the cell cycle following anaphase onset in which the cortex is responsive to signals from the spindle. We show that shortly after a...
journal_title:Nature cell biology
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doi:10.1038/ncb3251
更新日期:2015-11-01 00:00:00
abstract::Endocytosis of cell surface receptors is an important regulatory event in signal transduction. The transforming growth factor beta (TGF-beta) superfamily signals to the Smad pathway through heteromeric Ser-Thr kinase receptors that are rapidly internalized and then downregulated in a ubiquitin-dependent manner. Here w...
journal_title:Nature cell biology
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abstract::Caenorhabditis elegans chromosomes contain specialized regions called pairing centres, which mediate homologous pairing and synapsis during meiosis. Four related proteins, ZIM-1, 2, 3 and HIM-8, associate with these sites and are required for their essential functions. Here we show that short sequence elements enriche...
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abstract::The polarity protein Scribble (SCRIB) regulates apical-basal polarity, directional migration and tumour suppression in Drosophila and mammals. Here we report that SCRIB is an important regulator of myeloid cell functions including bacterial infection and inflammation. SCRIB interacts directly with the NADPH oxidase (N...
journal_title:Nature cell biology
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doi:10.1038/ncb3413
更新日期:2016-11-01 00:00:00
abstract::The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from other extracellular vesicles in terms of their biogenesis and functions remains ...
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更新日期:2019-01-01 00:00:00
abstract::The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory proteins and delivery of functional solutes throughout the cell1,2. Molecular mobility through the ER network enables these functionalities, but diffusion alone is not sufficient to explain...
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doi:10.1038/s41556-018-0192-2
更新日期:2018-10-01 00:00:00