Author Correction: Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.


:An amendment to this paper has been published and can be accessed via a link at the top of the paper.


Nat Cell Biol


Nature cell biology


Bagci H,Sriskandarajah N,Robert A,Boulais J,Elkholi IE,Tran V,Lin ZY,Thibault MP,Dubé N,Faubert D,Hipfner DR,Gingras AC,Côté JF




Has Abstract


2020-03-01 00:00:00














  • Discrete interactions in cell adhesion measured by single-molecule force spectroscopy.

    abstract::Cell-cell adhesion mediated by specific cell-surface molecules is essential for multicellular development. Here we quantify de-adhesion forces at the resolution of individual cell-adhesion molecules, by controlling the interactions between single cells and combining single-molecule force spectroscopy with genetic mani...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Benoit M,Gabriel D,Gerisch G,Gaub HE

    更新日期:2000-06-01 00:00:00

  • Linking HSCs to their youth.

    abstract::Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated t...

    journal_title:Nature cell biology

    pub_type: 评论,新闻


    authors: Pietras EM,Passegué E

    更新日期:2013-08-01 00:00:00

  • Actin restricts FcepsilonRI diffusion and facilitates antigen-induced receptor immobilization.

    abstract::The actin cytoskeleton has been implicated in restricting diffusion of plasma membrane components. Here, simultaneous observations of quantum dot-labelled FcepsilonRI motion and GFP-tagged actin dynamics provide direct evidence that actin filament bundles define micron-sized domains that confine mobile receptors. Dyna...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Andrews NL,Lidke KA,Pfeiffer JR,Burns AR,Wilson BS,Oliver JM,Lidke DS

    更新日期:2008-08-01 00:00:00

  • Metastatic niche functions and therapeutic opportunities.

    abstract::Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external...

    journal_title:Nature cell biology

    pub_type: 杂志文章,评审


    authors: Celià-Terrassa T,Kang Y

    更新日期:2018-08-01 00:00:00

  • The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.

    abstract::Cellular transformation and cancer progression is accompanied by changes in the metabolic landscape. Master co-regulators of metabolism orchestrate the modulation of multiple metabolic pathways through transcriptional programs, and hence constitute a probabilistically parsimonious mechanism for general metabolic rewir...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Torrano V,Valcarcel-Jimenez L,Cortazar AR,Liu X,Urosevic J,Castillo-Martin M,Fernández-Ruiz S,Morciano G,Caro-Maldonado A,Guiu M,Zúñiga-García P,Graupera M,Bellmunt A,Pandya P,Lorente M,Martín-Martín N,Sutherland JD,San

    更新日期:2016-06-01 00:00:00

  • Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.

    abstract::Mammalian telomeres consist of non-coding TTAGGG repeats that are bound by the multi-protein complex 'shelterin', thus protecting chromosome ends from DNA repair mechanisms and degradation. Mammalian telomeric chromatin is enriched for the constitutive heterochromatin marks H3K9me3, H4K20me3 and HP1 (refs 2, 3, 4, 5, ...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Schoeftner S,Blasco MA

    更新日期:2008-02-01 00:00:00

  • GTP-dependent segregation of H-ras from lipid rafts is required for biological activity.

    abstract::Different sites of plasma membrane attachment may underlie functional differences between isoforms of Ras. Here we show that palmitoylation and farnesylation targets H-ras to lipid rafts and caveolae, but that the interaction of H-ras with these membrane subdomains is dynamic. GTP-loading redistributes H-ras from raft...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Prior IA,Harding A,Yan J,Sluimer J,Parton RG,Hancock JF

    更新日期:2001-04-01 00:00:00

  • Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells.

    abstract::Lingual keratinized epithelial cells, which constitute the filiform papillae of the tongue, have one of the most rapid tissue turnover rates in the mammalian body and are thought to be the source of squamous cell carcinoma of the tongue. However, the mechanism of tissue maintenance and regeneration is largely unknown ...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Tanaka T,Komai Y,Tokuyama Y,Yanai H,Ohe S,Okazaki K,Ueno H

    更新日期:2013-05-01 00:00:00

  • PML regulates p53 stability by sequestering Mdm2 to the nucleolus.

    abstract::The promyelocytic leukaemia (PML) tumour-suppressor protein potentiates p53 function by regulating post-translational modifications, such as CBP-dependent acetylation and Chk2-dependent phosphorylation, in the PML-Nuclear Body (NB). PML was recently shown to interact with the p53 ubiquitin-ligase Mdm2 (refs 4-6); howe...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Bernardi R,Scaglioni PP,Bergmann S,Horn HF,Vousden KH,Pandolfi PP

    更新日期:2004-07-01 00:00:00

  • The base of the proteasome regulatory particle exhibits chaperone-like activity.

    abstract::Protein substrates of the proteasome must apparently be unfolded and translocated through a narrow channel to gain access to the proteolytic active sites of the enzyme. Protein folding in vivo is mediated by molecular chaperones. Here, to test for chaperone activity of the proteasome, we assay the reactivation of dena...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Braun BC,Glickman M,Kraft R,Dahlmann B,Kloetzel PM,Finley D,Schmidt M

    更新日期:1999-08-01 00:00:00

  • The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells.

    abstract::Organs and cells must adapt to shear stress induced by biological fluids, but how fluid flow contributes to the execution of specific cell programs is poorly understood. Here we show that shear stress favours mitochondrial biogenesis and metabolic reprogramming to ensure energy production and cellular adaptation in ki...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Miceli C,Roccio F,Penalva-Mousset L,Burtin M,Leroy C,Nemazanyy I,Kuperwasser N,Pontoglio M,Friedlander G,Morel E,Terzi F,Codogno P,Dupont N

    更新日期:2020-09-01 00:00:00

  • p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.

    abstract::Cancer cells use aerobic glycolysis preferentially for energy provision and this metabolic change is important for tumour growth. Here, we have found a link between the tumour suppressor p53, the transcription factor NF-kappaB and glycolysis. In p53-deficient primary cultured cells, kinase activities of IKKalpha and I...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Kawauchi K,Araki K,Tobiume K,Tanaka N

    更新日期:2008-05-01 00:00:00

  • Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation.

    abstract::Lamina-associated polypeptide (LAP) 2alpha is a chromatin-associated protein that binds A-type lamins. Mutations in both LAP2alpha and A-type lamins are linked to human diseases called laminopathies, but the molecular mechanisms are poorly understood. The A-type lamin-LAP2alpha complex interacts with and regulates ret...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Naetar N,Korbei B,Kozlov S,Kerenyi MA,Dorner D,Kral R,Gotic I,Fuchs P,Cohen TV,Bittner R,Stewart CL,Foisner R

    更新日期:2008-11-01 00:00:00

  • RNA takes over control of DNA break repair.

    abstract::Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions. ...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Storici F,Tichon AE

    更新日期:2017-11-29 00:00:00

  • Homeostatic control of recombination is implemented progressively in mouse meiosis.

    abstract::Humans suffer from high rates of fetal aneuploidy, often arising from the absence of meiotic crossover recombination between homologous chromosomes. Meiotic recombination is initiated by double-strand breaks (DSBs) generated by the SPO11 transesterase. In yeast and worms, at least one buffering mechanism, crossover ho...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Cole F,Kauppi L,Lange J,Roig I,Wang R,Keeney S,Jasin M

    更新日期:2012-03-04 00:00:00

  • Navigating gene expression using microarrays--a technology review.

    abstract::Parallel quantification of large numbers of messenger RNA transcripts using microarray technology promises to provide detailed insight into cellular processes involved in the regulation of gene expression. This should allow new understanding of signalling networks that operate in the cell and of the molecular basis an...

    journal_title:Nature cell biology

    pub_type: 杂志文章,评审


    authors: Schulze A,Downward J

    更新日期:2001-08-01 00:00:00

  • MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis.

    abstract::MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endo...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Kotlyarov A,Neininger A,Schubert C,Eckert R,Birchmeier C,Volk HD,Gaestel M

    更新日期:1999-06-01 00:00:00

  • SHARPIN is an endogenous inhibitor of β1-integrin activation.

    abstract::Regulated activation of integrins is critical for cell adhesion, motility and tissue homeostasis. Talin and kindlins activate β1-integrins, but the counteracting inhibiting mechanisms are poorly defined. We identified SHARPIN as an important inactivator of β1-integrins in an RNAi screen. SHARPIN inhibited β1-integrin ...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Rantala JK,Pouwels J,Pellinen T,Veltel S,Laasola P,Mattila E,Potter CS,Duffy T,Sundberg JP,Kallioniemi O,Askari JA,Humphries MJ,Parsons M,Salmi M,Ivaska J

    更新日期:2011-09-25 00:00:00

  • Hippo signalling directs intestinal fate.

    abstract::Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating bot...

    journal_title:Nature cell biology

    pub_type: 评论,杂志文章


    authors: Le Bouteiller M,Jensen KB

    更新日期:2015-01-01 00:00:00

  • Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency.

    abstract::Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) involves a marked reorganization of chromatin. To identify post-translational histone modifications that change in global abundance during this process, we have applied a quantitative mass-spectrometry-based approach. We found that iPSCs, compa...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Sridharan R,Gonzales-Cope M,Chronis C,Bonora G,McKee R,Huang C,Patel S,Lopez D,Mishra N,Pellegrini M,Carey M,Garcia BA,Plath K

    更新日期:2013-07-01 00:00:00

  • Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate.

    abstract::The mitogen-activated protein kinase (MAPK) network is a conserved signalling module that regulates cell fate by transducing a myriad of growth-factor signals. The ability of this network to coordinate and process a variety of inputs from different growth-factor receptors into specific biological responses is, however...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Santos SD,Verveer PJ,Bastiaens PI

    更新日期:2007-03-01 00:00:00

  • Invasive cell migration is initiated by guided growth of long cellular extensions.

    abstract::The migration of border cells during Drosophila melanogaster oogenesis is a simple and powerful system for studying invasive cell migration in vivo. Border cells are somatic cells that delaminate from the follicular epithelium of an egg chamber and invade the germ line cluster. They migrate between the nurse cells to ...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Fulga TA,Rørth P

    更新日期:2002-09-01 00:00:00

  • DNA defects target the centrosome.

    abstract::When cells enter mitosis with DNA that is unfit to be segregated, the consequences appear to be loss of centrosome function, abnormal spindles and a failure to segregate chromosomes. These defects may result from the workings of a surveillance mechanism that acts to cull irreparable nuclei. ...

    journal_title:Nature cell biology

    pub_type: 评论,新闻


    authors: Su TT,Vidwans SJ

    更新日期:2000-02-01 00:00:00

  • Structural mechanism of the dynein power stroke.

    abstract::Dyneins are large microtubule motor proteins required for mitosis, intracellular transport and ciliary and flagellar motility. They generate force through a power-stroke mechanism, which is an ATP-consuming cycle of pre- and post-power-stroke conformational changes that cause relative motion between different dynein d...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Lin J,Okada K,Raytchev M,Smith MC,Nicastro D

    更新日期:2014-05-01 00:00:00

  • Controlling the maturation of pathogen-containing vacuoles: a matter of life and death.

    abstract::Once considered to be contained, infectious diseases of bacterial origin are now making a comeback. A lack of innovative therapies and the appearance of drug-resistant pathogens are becoming increasingly serious problems. A better understanding of pathogen-host interactions at the cellular and molecular levels is nece...

    journal_title:Nature cell biology

    pub_type: 杂志文章,评审


    authors: Méresse S,Steele-Mortimer O,Moreno E,Desjardins M,Finlay B,Gorvel JP

    更新日期:1999-11-01 00:00:00

  • How the kinetochore couples microtubule force and centromere stretch to move chromosomes.

    abstract::The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for force generation coupled to plus-end polymerization and depolymerization. Spc24/Spc25 at one end of the Ndc80 complex binds the kinetochore. The N-terminal ...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Suzuki A,Badger BL,Haase J,Ohashi T,Erickson HP,Salmon ED,Bloom K

    更新日期:2016-04-01 00:00:00

  • Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.

    abstract::Obesity occurs when excess energy accumulates in white adipose tissue (WAT), whereas brown adipose tissue (BAT), specialized for energy expenditure through thermogenesis, potently counteracts obesity. Factors that induce brown adipocyte commitment and energy expenditure would be a promising defence against adiposity. ...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Wang J,Liu R,Wang F,Hong J,Li X,Chen M,Ke Y,Zhang X,Ma Q,Wang R,Shi J,Cui B,Gu W,Zhang Y,Zhang Z,Wang W,Xia X,Liu M,Ning G

    更新日期:2013-12-01 00:00:00

  • Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response.

    abstract::Nitric oxide (NO) is a pleiotropic signalling molecule that binds to cytochrome c oxidase (complex IV) reversibly and in competition with oxygen. This action of NO has both physiological and pathophysiological consequences. Here we report that endogenously generated NO, which disrupts the respiratory chain, may cause ...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Xu W,Liu L,Charles IG,Moncada S

    更新日期:2004-11-01 00:00:00

  • Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair.

    abstract::Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies-labelling cells expressing Cx3cr1, Csf1r or Flt3-to identify the precursors of osteoclasts in mice. We identified an erythromyeloid progenitor (EMP)-derived osteoclast precursor population. ...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Yahara Y,Barrientos T,Tang YJ,Puviindran V,Nadesan P,Zhang H,Gibson JR,Gregory SG,Diao Y,Xiang Y,Qadri YJ,Souma T,Shinohara ML,Alman BA

    更新日期:2020-01-01 00:00:00

  • Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1.

    abstract::Tie2 belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1 (Ang1). Gene-targeting analyses of either Ang1 or Tie2 in mice reveal a critical role of Ang1-Tie2 signalling in developmental vascular formation. It remains elusive how the Tie2 signalling pathway plays distinct roles i...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Fukuhara S,Sako K,Minami T,Noda K,Kim HZ,Kodama T,Shibuya M,Takakura N,Koh GY,Mochizuki N

    更新日期:2008-05-01 00:00:00