Author Correction: Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.


:An amendment to this paper has been published and can be accessed via a link at the top of the paper.


Nat Cell Biol


Nature cell biology


Bagci H,Sriskandarajah N,Robert A,Boulais J,Elkholi IE,Tran V,Lin ZY,Thibault MP,Dubé N,Faubert D,Hipfner DR,Gingras AC,Côté JF




Has Abstract


2020-03-01 00:00:00














  • To be or not to be in the nucleolus.

    abstract::Compartmentalization has long been known to have a key role in regulation of cellular processes. By keeping enzymes and regulatory complexes in compartments where the delivery of substrate or exit of product is controlled, competing reactions can occur simultaneously in different parts of the cell. Moreover, spatial c...

    journal_title:Nature cell biology

    pub_type: 杂志文章,评审


    authors: Carmo-Fonseca M,Mendes-Soares L,Campos I

    更新日期:2000-06-01 00:00:00

  • Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining.

    abstract::Chromosome missegregation into a micronucleus can cause complex and localized genomic rearrangements known as chromothripsis, but the underlying mechanisms remain unresolved. Here we developed an inducible Y centromere-selective inactivation strategy by exploiting a CENP-A/histone H3 chimaera to directly examine the f...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Ly P,Teitz LS,Kim DH,Shoshani O,Skaletsky H,Fachinetti D,Page DC,Cleveland DW

    更新日期:2017-01-01 00:00:00

  • MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis.

    abstract::MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endo...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Kotlyarov A,Neininger A,Schubert C,Eckert R,Birchmeier C,Volk HD,Gaestel M

    更新日期:1999-06-01 00:00:00

  • Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events.

    abstract::The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucle...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Selva EM,Hong K,Baeg GH,Beverley SM,Turco SJ,Perrimon N,Häcker U

    更新日期:2001-09-01 00:00:00

  • Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres.

    abstract::The motion of a chromosome during mitosis is mediated by a bundle of microtubules, termed a kinetochore fibre (K-fibre), which connects the kinetochore of the chromosome to a spindle pole. Once formed, mature K-fibres maintain a steady state length because the continuous addition of microtubule subunits onto microtubu...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Maiato H,Khodjakov A,Rieder CL

    更新日期:2005-01-01 00:00:00

  • Differentiation plasticity regulated by TGF-beta family proteins in development and disease.

    abstract::During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes that specify lineage and differentiation status. Among these factors, the transforming growth factor (TGF)-beta family is imp...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Derynck R,Akhurst RJ

    更新日期:2007-09-01 00:00:00

  • Y chromothripsis?

    abstract::Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process,...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Hatch EM

    更新日期:2016-12-23 00:00:00

  • The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila.

    abstract::Many extracellular signals are transmitted to the interior of the cell by receptors with seven membrane-spanning helices that trigger their effects by means of heterotrimeric guanine-nucleotide-binding regulatory proteins (G proteins). These G-protein-coupled receptors (GPCRs) control various physiological functions i...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Cvejic S,Zhu Z,Felice SJ,Berman Y,Huang XY

    更新日期:2004-06-01 00:00:00

  • Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.

    abstract::Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal, we have developed cell culture conditions to closely mimic events occurring during pancreatic islet organogenesis and β...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Nair GG,Liu JS,Russ HA,Tran S,Saxton MS,Chen R,Juang C,Li ML,Nguyen VQ,Giacometti S,Puri S,Xing Y,Wang Y,Szot GL,Oberholzer J,Bhushan A,Hebrok M

    更新日期:2019-02-01 00:00:00

  • Single-cell technologies sharpen up mammalian stem cell research.

    abstract::Analysis of the mechanisms underlying cell fates requires the molecular quantification of cellular features. Classical techniques use population average readouts at single time points. However, these approaches mask cellular heterogeneity and dynamics and are limited for studying rare and heterogeneous cell population...

    journal_title:Nature cell biology

    pub_type: 杂志文章,评审


    authors: Hoppe PS,Coutu DL,Schroeder T

    更新日期:2014-10-01 00:00:00

  • Lysosomal positioning coordinates cellular nutrient responses.

    abstract::mTOR (mammalian target of rapamycin) signalling and macroautophagy (henceforth autophagy) regulate numerous pathological and physiological processes, including cellular responses to altered nutrient levels. However, the mechanisms regulating mTOR and autophagy remain incompletely understood. Lysosomes are dynamic intr...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Korolchuk VI,Saiki S,Lichtenberg M,Siddiqi FH,Roberts EA,Imarisio S,Jahreiss L,Sarkar S,Futter M,Menzies FM,O'Kane CJ,Deretic V,Rubinsztein DC

    更新日期:2011-04-01 00:00:00

  • Dynein branches out.

    abstract::Individual neurons form specific elaborate dendritic structures that receive presynaptic information. The pattern of dendritic branching is regulated by the microtubule-associated motor protein dynein, which is responsible for the transport of essential endosomes and other organelles into the dendrites. ...

    journal_title:Nature cell biology

    pub_type: 评论,杂志文章


    authors: Tear G

    更新日期:2008-10-01 00:00:00

  • STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle.

    abstract::It is now well established that stromal interaction molecule 1 (STIM1) is the calcium sensor of endoplasmic reticulum stores required to activate store-operated calcium entry (SOC) channels at the surface of non-excitable cells. However, little is known about STIM1 in excitable cells, such as striated muscle, where th...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Stiber J,Hawkins A,Zhang ZS,Wang S,Burch J,Graham V,Ward CC,Seth M,Finch E,Malouf N,Williams RS,Eu JP,Rosenberg P

    更新日期:2008-06-01 00:00:00

  • CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.

    abstract::Loss of spindle-pole integrity during mitosis leads to multipolarity independent of centrosome amplification. Multipolar-spindle conformation favours incorrect kinetochore-microtubule attachments, compromising faithful chromosome segregation and daughter-cell viability. Spindle-pole organization influences and is infl...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Logarinho E,Maffini S,Barisic M,Marques A,Toso A,Meraldi P,Maiato H

    更新日期:2012-02-05 00:00:00

  • DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.

    abstract::Telomere attrition and other forms of telomere damage can activate the ATM kinase pathway. What generates the DNA damage signal at mammalian chromosome ends or at other double-strand breaks is not known. Telomere dysfunction is often accompanied by disappearance of the 3' telomeric overhang, raising the possibility th...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Celli GB,de Lange T

    更新日期:2005-07-01 00:00:00

  • Adherens junction treadmilling during collective migration.

    abstract::Collective cell migration is essential for both physiological and pathological processes. Adherens junctions (AJs) maintain the integrity of the migrating cell group and promote cell coordination while allowing cellular rearrangements. Here, we show that AJs undergo a continuous treadmilling along the lateral sides of...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Peglion F,Llense F,Etienne-Manneville S

    更新日期:2014-07-01 00:00:00

  • Maintaining integrity.

    abstract::Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degene...

    journal_title:Nature cell biology



    authors: Shiloh Y,Lehmann AR

    更新日期:2004-10-01 00:00:00

  • LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.

    abstract::Sensing and clearance of dysfunctional lysosomes is critical for cellular homeostasis. Here we show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated during the lysosomal damage response, and its activation is dependent on the function of the ATG ...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Nakamura S,Shigeyama S,Minami S,Shima T,Akayama S,Matsuda T,Esposito A,Napolitano G,Kuma A,Namba-Hamano T,Nakamura J,Yamamoto K,Sasai M,Tokumura A,Miyamoto M,Oe Y,Fujita T,Terawaki S,Takahashi A,Hamasaki M,Yamamot

    更新日期:2020-10-01 00:00:00

  • Activator-inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium.

    abstract::Animal cell cytokinesis results from patterned activation of the small GTPase Rho, which directs assembly of actomyosin in the equatorial cortex. Cytokinesis is restricted to a portion of the cell cycle following anaphase onset in which the cortex is responsive to signals from the spindle. We show that shortly after a...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Bement WM,Leda M,Moe AM,Kita AM,Larson ME,Golding AE,Pfeuti C,Su KC,Miller AL,Goryachev AB,von Dassow G

    更新日期:2015-11-01 00:00:00

  • Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover.

    abstract::Endocytosis of cell surface receptors is an important regulatory event in signal transduction. The transforming growth factor beta (TGF-beta) superfamily signals to the Smad pathway through heteromeric Ser-Thr kinase receptors that are rapidly internalized and then downregulated in a ubiquitin-dependent manner. Here w...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Di Guglielmo GM,Le Roy C,Goodfellow AF,Wrana JL

    更新日期:2003-05-01 00:00:00

  • Long-range self-organization of cytoskeletal myosin II filament stacks.

    abstract::Although myosin II filaments are known to exist in non-muscle cells, their dynamics and organization are incompletely understood. Here, we combined structured illumination microscopy with pharmacological and genetic perturbations, to study the process of actomyosin cytoskeleton self-organization into arcs and stress f...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Hu S,Dasbiswas K,Guo Z,Tee YH,Thiagarajan V,Hersen P,Chew TL,Safran SA,Zaidel-Bar R,Bershadsky AD

    更新日期:2017-02-01 00:00:00

  • Mechanoreception in motile flagella of Chlamydomonas.

    abstract::Ciliates and flagellates temporarily swim backwards on collision by generating a mechanoreceptor potential. Although this potential has been shown to be associated with cilia in Paramecium, the molecular entity of the mechanoreceptor has remained unknown. Here we show that Chlamydomonas cells express TRP11, a member o...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Fujiu K,Nakayama Y,Iida H,Sokabe M,Yoshimura K

    更新日期:2011-05-01 00:00:00

  • Actin dynamics counteract membrane tension during clathrin-mediated endocytosis.

    abstract::Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but requires actin polymerization in others. We show that membrane tension determines the actin dependence of clathrin-coat assembly. As found previously, clathrin assembly supports formation of mature coated pits in the absence of ac...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Boulant S,Kural C,Zeeh JC,Ubelmann F,Kirchhausen T

    更新日期:2011-08-14 00:00:00

  • Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.

    abstract::The heterogeneity of exosomal populations has hindered our understanding of their biogenesis, molecular composition, biodistribution and functions. By employing asymmetric flow field-flow fractionation (AF4), we identified two exosome subpopulations (large exosome vesicles, Exo-L, 90-120 nm; small exosome vesicles, Ex...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Zhang H,Freitas D,Kim HS,Fabijanic K,Li Z,Chen H,Mark MT,Molina H,Martin AB,Bojmar L,Fang J,Rampersaud S,Hoshino A,Matei I,Kenific CM,Nakajima M,Mutvei AP,Sansone P,Buehring W,Wang H,Jimenez JP,Cohen-Gould L,P

    更新日期:2018-03-01 00:00:00

  • Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling.

    abstract::Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland function, their diversity has not been fully addressed. By exploiting high-resolution three-dimensional imaging and flow cytometry, we identified a unique population of tissue-resident ductal mac...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Dawson CA,Pal B,Vaillant F,Gandolfo LC,Liu Z,Bleriot C,Ginhoux F,Smyth GK,Lindeman GJ,Mueller SN,Rios AC,Visvader JE

    更新日期:2020-05-01 00:00:00

  • Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegans.

    abstract::Caenorhabditis elegans chromosomes contain specialized regions called pairing centres, which mediate homologous pairing and synapsis during meiosis. Four related proteins, ZIM-1, 2, 3 and HIM-8, associate with these sites and are required for their essential functions. Here we show that short sequence elements enriche...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Phillips CM,Meng X,Zhang L,Chretien JH,Urnov FD,Dernburg AF

    更新日期:2009-08-01 00:00:00

  • The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

    abstract::Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling cascade, but how ubiqu...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Meerang M,Ritz D,Paliwal S,Garajova Z,Bosshard M,Mailand N,Janscak P,Hübscher U,Meyer H,Ramadan K

    更新日期:2011-10-23 00:00:00

  • An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function.

    abstract::The polarity protein Scribble (SCRIB) regulates apical-basal polarity, directional migration and tumour suppression in Drosophila and mammals. Here we report that SCRIB is an important regulator of myeloid cell functions including bacterial infection and inflammation. SCRIB interacts directly with the NADPH oxidase (N...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Zheng W,Umitsu M,Jagan I,Tran CW,Ishiyama N,BeGora M,Araki K,Ohashi PS,Ikura M,Muthuswamy SK

    更新日期:2016-11-01 00:00:00

  • Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication.

    abstract::The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from other extracellular vesicles in terms of their biogenesis and functions remains ...

    journal_title:Nature cell biology

    pub_type: 杂志文章,评审


    authors: Mathieu M,Martin-Jaular L,Lavieu G,Théry C

    更新日期:2019-01-01 00:00:00

  • Single particle trajectories reveal active endoplasmic reticulum luminal flow.

    abstract::The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory proteins and delivery of functional solutes throughout the cell1,2. Molecular mobility through the ER network enables these functionalities, but diffusion alone is not sufficient to explain...

    journal_title:Nature cell biology

    pub_type: 杂志文章


    authors: Holcman D,Parutto P,Chambers JE,Fantham M,Young LJ,Marciniak SJ,Kaminski CF,Ron D,Avezov E

    更新日期:2018-10-01 00:00:00