Abstract:
:Gastrulation leads to three germ layers--ectoderm, mesoderm and endoderm--that are separated by two basement membranes. In the mouse embryo, the emergent gut endoderm results from the widespread intercalation of cells of two distinct origins: pluripotent epiblast-derived definitive endoderm (DE) and extra-embryonic visceral endoderm (VE). Here we image the trajectory of prospective DE cells before intercalating into the VE epithelium. We show that the transcription factor SOX17, which is activated in prospective DE cells before intercalation, is necessary for gut endoderm morphogenesis and the assembly of the basement membrane that separates gut endoderm from mesoderm. Our results mechanistically link gut endoderm morphogenesis and germ layer segregation, two central and conserved features of gastrulation.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Viotti M,Nowotschin S,Hadjantonakis AKdoi
10.1038/ncb3070subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1146-56issue
12eissn
1465-7392issn
1476-4679pii
ncb3070journal_volume
16pub_type
杂志文章abstract::Proteins containing ubiquitin-binding domains (UBDs) interact with ubiquitinated targets and regulate diverse biological processes, including endocytosis, signal transduction, transcription and DNA repair. Many of the UBD-containing proteins are also themselves monoubiquitinated, but the functional role and the mechan...
journal_title:Nature cell biology
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pub_type: 评论,新闻
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pub_type: 更正并重新发布的文章,杂志文章
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更新日期:2002-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/ncb1750
更新日期:2008-08-01 00:00:00
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abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
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pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
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