Abstract：
:Here we show that segregation of homologous chromosomes and that of sister chromatids are differentially regulated in Xenopus and possibly in other higher eukaryotes. Upon hormonal stimulation, Xenopus oocytes microinjected with antibodies against the anaphase-promoting complex (APC) activator Fizzy or the APC core subunit Cdc27, or with the checkpoint protein Mad2, a destruction-box peptide or methylated ubiquitin, readily progress through the first meiotic cell cycle and arrest at second meiotic metaphase. However, they fail to segregate sister chromatids and remain arrested at second meiotic metaphase when electrically stimulated or when treated with ionophore A34187, two treatments that mimic fertilization and readily induce chromatid segregation in control oocytes. Thus, APC is required for second meiotic anaphase but not for first meiotic anaphase.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Peter M,Castro A,Lorca T,Le Peuch C,Magnaghi-Jaulin L,Dorée M,Labbé JCdoi
10.1038/35050607keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
83-7issue
1eissn
1465-7392issn
1476-4679journal_volume
3pub_type
杂志文章abstract：:The AP-1 transcription factor c-Jun is essential for cellular proliferation in many cell types, but the molecular link between growth factors and c-Jun activation has been enigmatic. In this study we identify a previously uncharacterized RING-domain-containing protein, RACO-1 (RING domain AP-1 co-activator-1), as a c-...
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abstract：:A number of key regulators of mouse embryonic stem (ES) cell identity, including the transcription factor Nanog, show strong expression fluctuations at the single-cell level. The molecular basis for these fluctuations is unknown. Here we used a genetic complementation strategy to investigate expression changes during ...
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abstract：:Guard cells, which form stomata in leaf epidermes, sense a multitude of environmental signals and integrate this information to regulate stomatal movements. Compared with the advanced understanding of light and water stress responses in guard cells, the molecular mechanisms that underlie stomatal CO(2) signalling have...
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pub_type： 杂志文章
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更新日期：2006-04-01 00:00:00
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pub_type： 杂志文章,评审
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abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
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abstract：:Here we investigate the role of the control of apoptosis in normal cell division. We show that interference with the expression or function of the apoptosis inhibitor survivin causes caspase-dependent cell death in the G2/M phase of the cell cycle, and a cell-division defect characterized by centrosome dysregulation, ...
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更新日期：1999-07-01 00:00:00
abstract：:As obligatory intracellular parasites, viruses rely on host-cell functions for most aspects of their replication cycle. This is born out during entry, when most viruses that infect vertebrate and insect cells exploit the endocytic activities of the host cell to move into the cytoplasm. Viruses belonging to vaccinia, a...
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更新日期：2006-05-01 00:00:00
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更新日期：2011-06-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb990
更新日期：2003-06-01 00:00:00
abstract：:Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions. ...
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pub_type： 杂志文章
doi：10.1038/ncb3645
更新日期：2017-11-29 00:00:00
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doi：10.1038/s41556-018-0271-4
更新日期：2019-02-01 00:00:00
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doi：10.1038/ncb3488
更新日期：2017-04-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/71323
更新日期：2000-01-01 00:00:00
abstract：:Whereas total loss of Lis1 is lethal, disruption of one allele of the Lis1 gene results in brain abnormalities, indicating that developing neurons are particularly sensitive to a reduction in Lis1 dosage. Here we show that Lis1 is enriched in neurons relative to levels in other cell types, and that Lis1 interacts with...
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pub_type： 评论,杂志文章
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更新日期：2000-11-01 00:00:00
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更新日期：2003-10-01 00:00:00
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journal_title：Nature cell biology
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更新日期：2011-06-19 00:00:00
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abstract：: ...
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更新日期：2014-10-01 00:00:00
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更新日期：2013-09-01 00:00:00
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更新日期：2018-07-01 00:00:00
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更新日期：2016-05-27 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1685
更新日期：2008-02-01 00:00:00
abstract：:To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt - a major kinase that coordinates diverse signalling pathways - phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphoryla...
journal_title：Nature cell biology
pub_type： 评论,新闻
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更新日期：2009-04-01 00:00:00
abstract：:Epithelial-mesenchymal transition (EMT) is essential for organogenesis and is triggered during carcinoma progression to an invasive state. Transforming growth factor-beta (TGF-beta) cooperates with signalling pathways, such as Ras and Wnt, to induce EMT, but the molecular mechanisms are not clear. Here, we report that...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1905
更新日期：2009-08-01 00:00:00
