Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1.

abstract：:The retinoblastoma protein (pRB) negatively regulates the progression from G1 to S phase of the cell cycle, in part, by repressing E2F-dependent transcription. pRB also possesses E2F-independent functions that contribute to cell-cycle control--for example, during pRB-mediated cell-cycle arrest pRB associates with Skp2...

journal_title：Nature cell biology

authors： Binné UK,Classon MK,Dick FA,Wei W,Rape M,Kaelin WG Jr,Näär AM,Dyson NJ

更新日期：2007-02-01 00:00:00

abstract：:Once considered to be contained, infectious diseases of bacterial origin are now making a comeback. A lack of innovative therapies and the appearance of drug-resistant pathogens are becoming increasingly serious problems. A better understanding of pathogen-host interactions at the cellular and molecular levels is nece...

journal_title：Nature cell biology

authors： Méresse S,Steele-Mortimer O,Moreno E,Desjardins M,Finlay B,Gorvel JP

更新日期：1999-11-01 00:00:00

abstract：:The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find ...

journal_title：Nature cell biology

authors： Hanssen LLP,Kassouf MT,Oudelaar AM,Biggs D,Preece C,Downes DJ,Gosden M,Sharpe JA,Sloane-Stanley JA,Hughes JR,Davies B,Higgs DR

更新日期：2017-08-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) are generated via the expression of the transcription factors OCT4 (also known as POU5F1), SOX2, KLF4 and cMYC (OSKM) in somatic cells. In contrast to murine naive iPSCs, conventional human iPSCs are in a more developmentally advanced state called primed pluripotency. Here, we re...

journal_title：Nature cell biology

authors： Giulitti S,Pellegrini M,Zorzan I,Martini P,Gagliano O,Mutarelli M,Ziller MJ,Cacchiarelli D,Romualdi C,Elvassore N,Martello G

更新日期：2019-02-01 00:00:00

abstract：:The tumour-suppressor gene ATM, mutations in which cause the human genetic disease ataxia telangiectasia (A-T), encodes a key protein kinase that controls the cellular response to DNA double-strand breaks (DSBs). DNA DSBs caused by ionizing radiation or chemicals result in rapid ATM autophosphorylation, leading to che...

journal_title：Nature cell biology

authors： You Z,Bailis JM,Johnson SA,Dilworth SM,Hunter T

更新日期：2007-11-01 00:00:00

abstract：:Secretory proteins are transported to the Golgi complex in vesicles that bud from the endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for cargo sorting and vesicle morphogenesis. COPII was first described in Saccharomyces cerevisiae, but its basic function is conserved throughout ...

journal_title：Nature cell biology

authors： Zanetti G,Pahuja KB,Studer S,Shim S,Schekman R

更新日期：2011-12-22 00:00:00

abstract：:Rad23 is a nucleotide-excision repair protein with a previously unknown biochemical function. We determined that yeast and human Rad23 inhibited multi-ubiquitin (Ub) chain formation and the degradation of proteolytic substrates. Significantly, Rad23 could be co-precipitated with a substrate that contained a short mult...

journal_title：Nature cell biology

authors： Ortolan TG,Tongaonkar P,Lambertson D,Chen L,Schauber C,Madura K

更新日期：2000-09-01 00:00:00

abstract：:Chaperone proteins are thought to promote the correct folding and assembly of newly synthesized proteins and to facilitate restoration of the folded state under environmental conditions that favour protein denaturation. They are among the most ubiquitous and highly conserved of all proteins. The eukaryotic endoplasmic...

journal_title：Nature cell biology

authors： Randow F,Seed B

更新日期：2001-10-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) may provide a potential source of haematopoietic stem/progenitor cells (HSPCs) for transplantation; however, unknown molecular barriers prevent the self-renewal of PSC-HSPCs. Using two-step differentiation, human embryonic stem cells (hESCs) differentiated in vitro into multipotent haemat...

journal_title：Nature cell biology

authors： Dou DR,Calvanese V,Sierra MI,Nguyen AT,Minasian A,Saarikoski P,Sasidharan R,Ramirez CM,Zack JA,Crooks GM,Galic Z,Mikkola HK

更新日期：2016-06-01 00:00:00

abstract：:Dozens of proteins capture, polymerize and reshape the clathrin lattice during clathrin-mediated endocytosis (CME). How or if this ensemble of proteins is organized in relation to the clathrin coat is unknown. Here, we map key molecules involved in CME at the nanoscale using correlative super-resolution light and tran...

journal_title：Nature cell biology

authors： Sochacki KA,Dickey AM,Strub MP,Taraska JW

更新日期：2017-04-01 00:00:00

abstract：:The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to the state of attachment of the kinetochore to spindle microtubules. SAC signalling is activated by unattached kinetochores, and it is silenced after these kinetochores form end-on microtubule attachments. Although the biochemical c...

journal_title：Nature cell biology

authors： Aravamudhan P,Goldfarb AA,Joglekar AP

更新日期：2015-07-01 00:00:00

abstract：:Somatic cell reprogramming by exogenous factors requires cooperation with transcriptional co-activators and co-repressors to effectively remodel the epigenetic environment. How this interplay is regulated remains poorly understood. Here, we demonstrate that NCoR/SMRT co-repressors bind to pluripotency loci to create a...

journal_title：Nature cell biology

authors： Zhuang Q,Li W,Benda C,Huang Z,Ahmed T,Liu P,Guo X,Ibañez DP,Luo Z,Zhang M,Abdul MM,Yang Z,Yang J,Huang Y,Zhang H,Huang D,Zhou J,Zhong X,Zhu X,Fu X,Fan W,Liu Y,Xu Y,Ward C,Khan MJ,Kanwal S,Mirza B,Tor

更新日期：2018-04-01 00:00:00

abstract：:The serine/threonine protein kinase Akt is involved in a variety of cellular processes including cell proliferation, survival, metabolism and gene expression. It is essential in vascular endothelial growth factor (VEGF)-mediated angiogenesis; however, it is not known how Akt regulates the migration of endothelial cell...

journal_title：Nature cell biology

authors： Kitamura T,Asai N,Enomoto A,Maeda K,Kato T,Ishida M,Jiang P,Watanabe T,Usukura J,Kondo T,Costantini F,Murohara T,Takahashi M

更新日期：2008-03-01 00:00:00

abstract：:Work over the past two years has led to a breakthrough in our understanding of the molecular basis of the directionality of the kinesin motor proteins. This breakthrough has come first from the reversal of directionality of the kinesin-related motor Ncd, followed closely by the reversal of kinesin's directionality and...

journal_title：Nature cell biology

authors： Endow SA

更新日期：1999-10-01 00:00:00

abstract：:Store-operated Ca(2+) channels (SOCs) are activated in response to Ca(2+) release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca(2+) content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STI...

journal_title：Nature cell biology

authors： Shin DM,Muallem S

更新日期：2008-06-01 00:00:00

abstract：:The self-perpetuating amyloid isoform, or prion, of the yeast translation termination factor eRF3 modulates programmed translational frameshifting that controls a regulatory circuit determining the polyamine levels in a yeast cell. But it is still unclear whether this effect is adaptive or pathological. ...

journal_title：Nature cell biology

authors： Chernoff YO

更新日期：2008-09-01 00:00:00

abstract：:Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degene...

journal_title：Nature cell biology

authors： Shiloh Y,Lehmann AR

更新日期：2004-10-01 00:00:00

abstract：:Extracellular signal regulated kinases (ERKs) represent a signalling hub in many physiological responses and have pivotal functions in cell proliferation, differentiation, development and death, as well as in synaptic plasticity. Mitogen-activated protein kinase phosphatases (MKPs) selectively inactivate ERKs by depho...

journal_title：Nature cell biology

authors： Kang TH,Kim KT

更新日期：2006-08-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates embryonic development and tissue homeostasis; however, aberrations of its activity occur in cancer. TGF-beta signals through its Type II and Type I receptors (TbetaRII and TbetaRI) causing phosphorylation of Smad proteins. TGF-beta...

journal_title：Nature cell biology

authors： Sorrentino A,Thakur N,Grimsby S,Marcusson A,von Bulow V,Schuster N,Zhang S,Heldin CH,Landström M

更新日期：2008-10-01 00:00:00

abstract：:The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor metastasis-free survival of patients with breast cancer with localized disease. DTCs persist in distant tissues despite systemic administration of adjuvant chemotherapy. Many assume that this is because the majority of DTCs are quies...

journal_title：Nature cell biology

authors： Carlson P,Dasgupta A,Grzelak CA,Kim J,Barrett A,Coleman IM,Shor RE,Goddard ET,Dai J,Schweitzer EM,Lim AR,Crist SB,Cheresh DA,Nelson PS,Hansen KC,Ghajar CM

更新日期：2019-02-01 00:00:00

abstract：:Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling cascade, but how ubiqu...

journal_title：Nature cell biology

authors： Meerang M,Ritz D,Paliwal S,Garajova Z,Bosshard M,Mailand N,Janscak P,Hübscher U,Meyer H,Ramadan K

更新日期：2011-10-23 00:00:00

abstract：:Proteins essential for vesicle formation by the Coat Protein I (COPI) complex are being identified, but less is known about the role of specific lipids. Brefeldin-A ADP-ribosylated substrate (BARS) functions in the fission step of COPI vesicle formation. Here, we show that BARS induces membrane curvature in cooperatio...

journal_title：Nature cell biology

authors： Yang JS,Gad H,Lee SY,Mironov A,Zhang L,Beznoussenko GV,Valente C,Turacchio G,Bonsra AN,Du G,Baldanzi G,Graziani A,Bourgoin S,Frohman MA,Luini A,Hsu VW

更新日期：2008-10-01 00:00:00

abstract：:In Huntington disease, polyglutamine expansion of the protein huntingtin (Htt) leads to selective neurodegenerative loss of medium spiny neurons throughout the striatum by an unknown apoptotic mechanism. Binding of Hip-1, a protein normally associated with Htt, is reduced by polyglutamine expansion. Free Hip-1 binds t...

journal_title：Nature cell biology

authors： Gervais FG,Singaraja R,Xanthoudakis S,Gutekunst CA,Leavitt BR,Metzler M,Hackam AS,Tam J,Vaillancourt JP,Houtzager V,Rasper DM,Roy S,Hayden MR,Nicholson DW

更新日期：2002-02-01 00:00:00

abstract：:Neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE are members of a family of proteins that use the Arp2/3 complex to stimulate actin assembly in actin-based motile processes. By entering into distinct macromolecular complexes, they act as convergent nodes of different signalling pathways. The role of WAVE in g...

journal_title：Nature cell biology

authors： Innocenti M,Gerboth S,Rottner K,Lai FP,Hertzog M,Stradal TE,Frittoli E,Didry D,Polo S,Disanza A,Benesch S,Di Fiore PP,Carlier MF,Scita G

更新日期：2005-10-01 00:00:00

abstract：:Organization of chromatin by epigenetic mechanisms is essential for establishing and maintaining cellular identity in developing and adult organisms. A key question that remains unresolved about this process is how epigenetic marks are transmitted to the next cell generation during cell division. Here we provide a mod...

journal_title：Nature cell biology

authors： Hansen KH,Bracken AP,Pasini D,Dietrich N,Gehani SS,Monrad A,Rappsilber J,Lerdrup M,Helin K

更新日期：2008-11-01 00:00:00

abstract：:The actin cytoskeleton has been implicated in restricting diffusion of plasma membrane components. Here, simultaneous observations of quantum dot-labelled FcepsilonRI motion and GFP-tagged actin dynamics provide direct evidence that actin filament bundles define micron-sized domains that confine mobile receptors. Dyna...

journal_title：Nature cell biology

authors： Andrews NL,Lidke KA,Pfeiffer JR,Burns AR,Wilson BS,Oliver JM,Lidke DS

更新日期：2008-08-01 00:00:00

abstract：:Physiological oxidants that are generated by activated phagocytes comprise the main source of oxidative stress during inflammation. Oxidants such as taurine chloramine (TnCl) and hydrogen peroxide (H(2)O(2)) can damage proteins and induce apoptosis, but the role of specific protein oxidation in this process has not be...

journal_title：Nature cell biology

authors： Klamt F,Zdanov S,Levine RL,Pariser A,Zhang Y,Zhang B,Yu LR,Veenstra TD,Shacter E

更新日期：2009-10-01 00:00:00

abstract：:The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice. We show that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells. Cel...

journal_title：Nature cell biology

authors： Laberge RM,Sun Y,Orjalo AV,Patil CK,Freund A,Zhou L,Curran SC,Davalos AR,Wilson-Edell KA,Liu S,Limbad C,Demaria M,Li P,Hubbard GB,Ikeno Y,Javors M,Desprez PY,Benz CC,Kapahi P,Nelson PS,Campisi J

更新日期：2015-08-01 00:00:00

abstract：:Nitric oxide (NO) is a pleiotropic signalling molecule that binds to cytochrome c oxidase (complex IV) reversibly and in competition with oxygen. This action of NO has both physiological and pathophysiological consequences. Here we report that endogenously generated NO, which disrupts the respiratory chain, may cause ...

journal_title：Nature cell biology

authors： Xu W,Liu L,Charles IG,Moncada S

更新日期：2004-11-01 00:00:00

abstract：:Metazoan internal organs are assembled from polarized tubular epithelia that must set aside an apical membrane domain as a lumenal surface. In a global Caenorhabditis elegans tubulogenesis screen, interference with several distinct fatty-acid-biosynthetic enzymes transformed a contiguous central intestinal lumen into ...

journal_title：Nature cell biology

authors： Zhang H,Abraham N,Khan LA,Hall DH,Fleming JT,Göbel V

更新日期：2011-09-18 00:00:00