Prion: disease or relief?

abstract：:During mammalian development, neuroepithelial cells function as mitotic progenitors, which self-renew and generate neurons. Although spindle orientation is important for such polarized cells to undergo symmetric or asymmetric divisions, its role in mammalian neurogenesis remains unclear. Here we show that control of s...

journal_title：Nature cell biology

authors： Konno D,Shioi G,Shitamukai A,Mori A,Kiyonari H,Miyata T,Matsuzaki F

更新日期：2008-01-01 00:00:00

abstract：:The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-pr...

journal_title：Nature cell biology

authors： Hariharan IK

更新日期：2015-04-01 00:00:00

abstract：:LATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. LATS1 inhibits both the phosphorylation of cofilin by LIMK...

journal_title：Nature cell biology

authors： Yang X,Yu K,Hao Y,Li DM,Stewart R,Insogna KL,Xu T

更新日期：2004-07-01 00:00:00

abstract：:When brassinosteroid levels are low, the GSK3-like kinase BIN2 phosphorylates and inactivates the BZR1 transcription factor to inhibit growth in plants. Brassinosteroid promotes growth by inducing dephosphorylation of BZR1, but the phosphatase that dephosphorylates BZR1 has remained unknown. Here, using tandem affinit...

journal_title：Nature cell biology

authors： Tang W,Yuan M,Wang R,Yang Y,Wang C,Oses-Prieto JA,Kim TW,Zhou HW,Deng Z,Gampala SS,Gendron JM,Jonassen EM,Lillo C,DeLong A,Burlingame AL,Sun Y,Wang ZY

更新日期：2011-02-01 00:00:00

abstract：:The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributo...

journal_title：Nature cell biology

authors： Delaunay S,Frye M

更新日期：2019-05-01 00:00:00

abstract：:The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for force generation coupled to plus-end polymerization and depolymerization. Spc24/Spc25 at one end of the Ndc80 complex binds the kinetochore. The N-terminal ...

journal_title：Nature cell biology

authors： Suzuki A,Badger BL,Haase J,Ohashi T,Erickson HP,Salmon ED,Bloom K

更新日期：2016-04-01 00:00:00

abstract：:Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling cascade, but how ubiqu...

journal_title：Nature cell biology

authors： Meerang M,Ritz D,Paliwal S,Garajova Z,Bosshard M,Mailand N,Janscak P,Hübscher U,Meyer H,Ramadan K

更新日期：2011-10-23 00:00:00

abstract：:Re-establishment of nuclear structure and chromatin organization after cell division is integral for genome regulation or development and is frequently altered during cancer progression. The mechanisms underlying chromatin expansion in daughter cells remain largely unclear. Here, we describe the transient formation of...

journal_title：Nature cell biology

authors： Baarlink C,Plessner M,Sherrard A,Morita K,Misu S,Virant D,Kleinschnitz EM,Harniman R,Alibhai D,Baumeister S,Miyamoto K,Endesfelder U,Kaidi A,Grosse R

更新日期：2017-12-01 00:00:00

abstract：:Formation of a bipolar spindle is essential for faithful chromosome segregation at mitosis. Because centrosomes define spindle poles, defects in centrosome number and structural organization can lead to a loss of bipolarity. In addition, microtubule-mediated pulling and pushing forces acting on centrosomes and chromos...

journal_title：Nature cell biology

authors： Oshimori N,Ohsugi M,Yamamoto T

更新日期：2006-10-01 00:00:00

abstract：:Metazoan internal organs are assembled from polarized tubular epithelia that must set aside an apical membrane domain as a lumenal surface. In a global Caenorhabditis elegans tubulogenesis screen, interference with several distinct fatty-acid-biosynthetic enzymes transformed a contiguous central intestinal lumen into ...

journal_title：Nature cell biology

authors： Zhang H,Abraham N,Khan LA,Hall DH,Fleming JT,Göbel V

更新日期：2011-09-18 00:00:00

abstract：:Chromatin structure is thought to play a critical role in gene expression. Using the lac operator/repressor system and two colour variants of green fluorescent protein (GFP), we developed a system to visualize a gene and its protein product directly in living cells, allowing us to examine the spatial organization and ...

journal_title：Nature cell biology

authors： Tsukamoto T,Hashiguchi N,Janicki SM,Tumbar T,Belmont AS,Spector DL

更新日期：2000-12-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitor p27(Kip1) is degraded at the G0-G1 transition of the cell cycle by the ubiquitin-proteasome pathway. Although the nuclear ubiquitin ligase (E3) SCF(Skp2) is implicated in p27(Kip1) degradation, proteolysis of p27(Kip1) at the G0-G1 transition proceeds normally in Skp2(-/-) cells. ...

journal_title：Nature cell biology

authors： Kamura T,Hara T,Matsumoto M,Ishida N,Okumura F,Hatakeyama S,Yoshida M,Nakayama K,Nakayama KI

更新日期：2004-12-01 00:00:00

abstract：:When replication forks collapse, Rad3 phosphorylates the checkpoint-clamp protein Rad9 in a manner that depends on Thr 225, a residue within the PCNA-like domain. The physiological function of Thr 225-dependent Rad9 phosphorylation, however, remains elusive. Here, we show that Thr 225-dependent Rad9 phosphorylation by...

journal_title：Nature cell biology

authors： Kai M,Furuya K,Paderi F,Carr AM,Wang TS

更新日期：2007-06-01 00:00:00

abstract：:Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncoge...

journal_title：Nature cell biology

authors： Blanpain C

更新日期：2013-02-01 00:00:00

abstract：:Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia1, yet the physiological state of tau molecules within cells remains unclear. Using single-molecule imaging, we directly observe that the microtubule latt...

journal_title：Nature cell biology

authors： Tan R,Lam AJ,Tan T,Han J,Nowakowski DW,Vershinin M,Simó S,Ori-McKenney KM,McKenney RJ

更新日期：2019-09-01 00:00:00

abstract：:Bcl-2 stimulates mutagenesis after the exposure of cells to DNA-damaging agents. However, the biological mechanisms of Bcl-2-mediated mutagenesis have remained largely obscure. Here we demonstrate that the Bcl-2-mediated suppression of hMSH2 expression results in a reduced cellular capacity to repair mismatches. The p...

journal_title：Nature cell biology

authors： Youn CK,Cho HJ,Kim SH,Kim HB,Kim MH,Chang IY,Lee JS,Chung MH,Hahm KS,You HJ

更新日期：2005-02-01 00:00:00

abstract：:Historically, the late arrival of optical microscopy is something of a puzzle, although it may be a testament to the fact that the development of new technology is driven by the desire for scientific knowledge, and not the other way around. The explorations that began in the 17th century are by no means complete, but ...

journal_title：Nature cell biology

authors： Amos B

更新日期：2000-08-01 00:00:00

abstract：:Haematopoietic stem cells (HSCs) arise in the developing aorta during embryogenesis. The number of HSC clones born has been estimated through transplantation, but experimental approaches to assess the absolute number of forming HSCs in a native setting have remained challenging. Here, we applied single-cell and clonal...

journal_title：Nature cell biology

authors： Henninger J,Santoso B,Hans S,Durand E,Moore J,Mosimann C,Brand M,Traver D,Zon L

更新日期：2017-01-01 00:00:00

abstract：:During apoptosis, dying cells are swiftly removed by phagocytes. It is not fully understood how apoptotic cells are recognized by phagocytes. Here we report the identification and characterization of the Caenorhabditis elegans ttr-52 gene, which encodes a transthyretin-like protein and is required for efficient cell c...

journal_title：Nature cell biology

authors： Wang X,Li W,Zhao D,Liu B,Shi Y,Chen B,Yang H,Guo P,Geng X,Shang Z,Peden E,Kage-Nakadai E,Mitani S,Xue D

更新日期：2010-07-01 00:00:00

abstract：:Mammalian and most fungal infectious proteins (also known as prions) are self-propagating amyloid, a filamentous beta-sheet structure. A prion domain determines the infectious properties of a protein by forming the core of the amyloid. We compare the properties of known prion domains and their interactions with the re...

journal_title：Nature cell biology

authors： Ross ED,Minton A,Wickner RB

更新日期：2005-11-01 00:00:00

abstract：:Lamellipodia/ruffles and filopodia are protruding organelles containing short and highly branched or long and unbranched actin filaments, respectively. The microscopic morphology, dynamic development and protein signature of both lamellipodia/ruffles and filopodia have been investigated; however, little is known about...

journal_title：Nature cell biology

authors： Beli P,Mascheroni D,Xu D,Innocenti M

更新日期：2008-07-01 00:00:00

abstract：:A surprising functional association between TRPM3, a mysterious member of the family of transient receptor potential (TRP) cation channels, and the sulphated version of pregnenolone, 'mother' of all steroid hormones, has been identified. ...

journal_title：Nature cell biology

authors： Nilius B,Voets T

更新日期：2008-12-01 00:00:00

abstract：:The asymmetric segregation of cell-fate determinants and the generation of daughter cells of different sizes rely on the correct orientation and position of the mitotic spindle. In the Drosophila embryo, the determinant Prospero is localized basally and is segregated equally to daughters of similar cell size during ep...

journal_title：Nature cell biology

authors： Kaltschmidt JA,Davidson CM,Brown NH,Brand AH

更新日期：2000-01-01 00:00:00

abstract：:Coordination of microtubules and the actin cytoskeleton is important in several types of cell movement. mDia1 is a member of the formin-homology family of proteins and an effector of the small GTPase Rho. It contains the Rho-binding domain in its amino terminus and two distinct regions of formin homology, FH1 in the m...

journal_title：Nature cell biology

authors： Ishizaki T,Morishima Y,Okamoto M,Furuyashiki T,Kato T,Narumiya S

更新日期：2001-01-01 00:00:00

abstract：:Mitochondria drive apoptosis by releasing pro-apoptotic proteins that promote caspase activation in the cytosol. The rhomboid protease PARL, an intramembrane cleaving peptidase in the inner membrane, regulates mitophagy and plays an ill-defined role in apoptosis. Here, we employed PARL-based proteomics to define its s...

journal_title：Nature cell biology

authors： Saita S,Nolte H,Fiedler KU,Kashkar H,Venne AS,Zahedi RP,Krüger M,Langer T

更新日期：2017-04-01 00:00:00

abstract：:Many extracellular signals are transmitted to the interior of the cell by receptors with seven membrane-spanning helices that trigger their effects by means of heterotrimeric guanine-nucleotide-binding regulatory proteins (G proteins). These G-protein-coupled receptors (GPCRs) control various physiological functions i...

journal_title：Nature cell biology

authors： Cvejic S,Zhu Z,Felice SJ,Berman Y,Huang XY

更新日期：2004-06-01 00:00:00

abstract：:The spindle checkpoint ensures accurate chromosome segregation by delaying cell-cycle progression until all sister kinetochores capture microtubules from opposite poles and come under tension (for reviews, see refs 1, 2). Although the checkpoint is activated by either the lack of kinetochore-microtubule attachments or...

journal_title：Nature cell biology

authors： Pinsky BA,Kung C,Shokat KM,Biggins S

更新日期：2006-01-01 00:00:00

abstract：:The cell division axis determines the future positions of daughter cells and is therefore critical for cell fate. The positioning of the division axis has been mostly studied in systems such as embryos or yeasts, in which cell shape is well defined. In these cases, cell shape anisotropy and cell polarity affect spindl...

journal_title：Nature cell biology

authors： Théry M,Racine V,Pépin A,Piel M,Chen Y,Sibarita JB,Bornens M

更新日期：2005-10-01 00:00:00

abstract：:Broken ends of a budding yeast chromosome exhibit increased mobility, presumably to facilitate repair by recombination. A new study reports that increased mobility reflects the untethering of the broken chromosome, triggered by a DNA damage response that phosphorylates the Cep3 kinetochore protein and weakens the asso...

journal_title：Nature cell biology

authors： Nakajima Y,Haber JE

更新日期：2016-03-01 00:00:00

abstract：:Aurora A, an integral mitotic kinase, is essential for microtubule dynamics of post-mitotic neurons. PKCzeta activates Aurora A, which in turn phosphorylates NDEL1 to promote neurite extension. This raises the possibility that Aurora A may also be involved in establishing cell polarity and axon/dendrite elaboration in...

journal_title：Nature cell biology

authors： Lefkowitz GK,Gleeson JG

更新日期：2009-09-01 00:00:00