Abstract:
:The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-protective activity.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Hariharan IKdoi
10.1038/ncb3141subject
Has Abstractpub_date
2015-04-01 00:00:00pages
362-3issue
4eissn
1465-7392issn
1476-4679pii
ncb3141journal_volume
17pub_type
杂志文章abstract::Current models for the export of messenger RNA share the notion that the highly abundant class of nuclear RNA-binding proteins--the hnRNP proteins--have a key role in exporting RNA. But recent studies have led to a new understanding of several non-hnRNP proteins, including SR proteins and the conserved mRNA export fac...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb0901-e201
更新日期:2001-09-01 00:00:00
abstract::The small GTPase ADP-ribosylation factor (ARF) regulates the structure and function of the Golgi complex through mechanisms that are understood only in part, and which include an ability to control the assembly of coat complexes and phospholipase D (PLD). Here we describe a new property of ARF, the ability to recruit ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/12993
更新日期:1999-09-01 00:00:00
abstract::Glycogen has long been considered to have a function in energy metabolism. However, our recent study indicated that glycogen metabolism, directed by cytosolic phosphoenolpyruvate carboxykinase Pck1, controls the formation and maintenance of CD8+ memory T (Tmem) cells by regulating redox homeostasis1. This unusual meta...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-019-0440-0
更新日期:2020-01-01 00:00:00
abstract::Many pro-apoptotic signals activate caspase-9, an initiator protease that activates caspase-3 and downstream caspases to initiate cellular destruction. However, survival signals can impinge on this pathway and suppress apoptosis. Activation of the Ras-Raf-MEK-ERK mitogen-activated protein kinase (MAPK) pathway is asso...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1005
更新日期:2003-07-01 00:00:00
abstract::Altered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes a limit on the proliferative potential of normal cells that all cancer cells must bypass. Here we show by whole-genome single-nucleotide bi...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2879
更新日期:2013-12-01 00:00:00
abstract::Structural maintenance of chromosomes (SMC) protein complexes are key determinants of chromosome conformation. Using Hi-C and polymer modelling, we study how cohesin and condensin, two deeply conserved SMC complexes, organize chromosomes in the budding yeast Saccharomyces cerevisiae. The canonical role of cohesin is t...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3594
更新日期:2017-09-01 00:00:00
abstract::Loss of spindle-pole integrity during mitosis leads to multipolarity independent of centrosome amplification. Multipolar-spindle conformation favours incorrect kinetochore-microtubule attachments, compromising faithful chromosome segregation and daughter-cell viability. Spindle-pole organization influences and is infl...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2423
更新日期:2012-02-05 00:00:00
abstract::Although myosin II filaments are known to exist in non-muscle cells, their dynamics and organization are incompletely understood. Here, we combined structured illumination microscopy with pharmacological and genetic perturbations, to study the process of actomyosin cytoskeleton self-organization into arcs and stress f...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3466
更新日期:2017-02-01 00:00:00
abstract::During mammalian development, neuroepithelial cells function as mitotic progenitors, which self-renew and generate neurons. Although spindle orientation is important for such polarized cells to undergo symmetric or asymmetric divisions, its role in mammalian neurogenesis remains unclear. Here we show that control of s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1673
更新日期:2008-01-01 00:00:00
abstract::Metaphase spindles are microtubule-based structures that use a multitude of proteins to modulate their morphology and function. Today, we understand many details of microtubule assembly, the role of microtubule-associated proteins, and the action of molecular motors. Ultimately, the challenge remains to understand how...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2834
更新日期:2013-09-01 00:00:00
abstract::The physical characteristics of tumours are intricately linked to the tumour phenotype and difficulties during treatment. Many factors contribute to the increased stiffness of tumours; from increased matrix deposition, matrix remodelling by forces from cancer cells and stromal fibroblasts, matrix crosslinking, increas...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/s41556-018-0131-2
更新日期:2018-07-01 00:00:00
abstract::RNA interference has become an indispensable tool for loss-of-function studies across eukaryotes. By enabling stable and reversible gene silencing, shRNAs provide a means to study long-term phenotypes, perform pool-based forward genetic screens and examine the consequences of temporary target inhibition in vivo. Howev...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2895
更新日期:2014-01-01 00:00:00
abstract::Formins have been implicated in the regulation of cytoskeletal structure in animals and fungi. Here we show that the formins Bni1 and Bnr1 of budding yeast stimulate the assembly of actin filaments that function as precursors to tropomyosin-stabilized cables that direct polarized cell growth. With loss of formin funct...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb718
更新日期:2002-01-01 00:00:00
abstract::The cyclin-dependent kinase inhibitor p27(Kip1) is degraded at the G0-G1 transition of the cell cycle by the ubiquitin-proteasome pathway. Although the nuclear ubiquitin ligase (E3) SCF(Skp2) is implicated in p27(Kip1) degradation, proteolysis of p27(Kip1) at the G0-G1 transition proceeds normally in Skp2(-/-) cells. ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1194
更新日期:2004-12-01 00:00:00
abstract::The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributo...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/s41556-019-0319-0
更新日期:2019-05-01 00:00:00
abstract::Stereocilia are microvilli-derived mechanosensory organelles that are arranged in rows of graded heights on the apical surface of inner-ear hair cells. The 'staircase'-like architecture of stereocilia bundles is necessary to detect sound and head movement, and is achieved through differential elongation of the actin c...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1219
更新日期:2005-02-01 00:00:00
abstract::LATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. LATS1 inhibits both the phosphorylation of cofilin by LIMK...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1140
更新日期:2004-07-01 00:00:00
abstract::Broken ends of a budding yeast chromosome exhibit increased mobility, presumably to facilitate repair by recombination. A new study reports that increased mobility reflects the untethering of the broken chromosome, triggered by a DNA damage response that phosphorylates the Cep3 kinetochore protein and weakens the asso...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb3321
更新日期:2016-03-01 00:00:00
abstract::Cadherin-containing cell-cell junctions respond to intercellular tension by increasing their size, strength and complexity. The mechanical regulation of cadherin adhesions is now shown to involve myosin-dependent tension in the cortical actomyosin cytoskeleton. This reduces actin turnover to decrease the mobility of c...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb2980
更新日期:2014-06-01 00:00:00
abstract::Cells of multicellular organisms need to adopt specific morphologies. However, the molecular mechanisms bringing about membrane topology changes are far from understood-mainly because knowledge of membrane-shaping proteins that can promote local membrane curvatures is still limited. Our analyses unveiled that several ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-019-0381-7
更新日期:2019-10-01 00:00:00
abstract::While nuclear lamina abnormalities are hallmarks of human diseases, their interplay with epigenetic regulators and precise epigenetic landscape remain poorly understood. Here, we show that loss of the lysine acetyltransferase MOF or its associated NSL-complex members KANSL2 or KANSL3 leads to a stochastic accumulation...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-019-0397-z
更新日期:2019-10-01 00:00:00
abstract::The molecular requirements and morphology of migrating cells can vary depending on matrix geometry; therefore, predicting the optimal migration strategy or the effect of experimental perturbation is difficult. We present a model of cell motility that encompasses actin-polymerization-based protrusions, actomyosin contr...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2775
更新日期:2013-07-01 00:00:00
abstract::NF-kappa B/Rel transcription factors control apoptosis, also known as programmed cell death. This control is crucial for oncogenesis, cancer chemo-resistance and for antagonizing tumour necrosis factor alpha (TNFalpha)-induced killing. With regard to TNFalpha, the anti-apoptotic activity of NF-kappa B involves suppres...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1093
更新日期:2004-02-01 00:00:00
abstract::Localization and activation of heterotrimeric G proteins have a crucial role during asymmetric cell division. The asymmetric division of the Drosophila sensory precursor cell (pl) is polarized along the antero-posterior axis by Frizzled signalling and, during this division, activation of Galphai depends on Partner of ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1319
更新日期:2005-11-01 00:00:00
abstract::Glioblastoma multiforme (GBMs) are recurrent lethal brain tumours. Recurrent GBMs often exhibit mesenchymal, stem-like phenotypes that could explain their resistance to therapy. Analyses revealed that recurrent GBMs have increased tension and express high levels of glycoproteins that increase the bulkiness of the glyc...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0183-3
更新日期:2018-10-01 00:00:00
abstract::The GTPase dynamin plays an essential part in endocytosis by catalysing the fission of nascent clathrin-coated vesicles from the plasma membrane. Using preformed phosphatidylinositol-4,5-bisphosphate-containing lipid nanotubes as a membrane template for dynamin self-assembly, we investigate the conformational changes ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/8997
更新日期:1999-05-01 00:00:00
abstract::PX domains are found in a variety of proteins that associate with cell membranes, but their molecular function has remained obscure. We show here that the PX domains in p47phox and p40phox subunits of the phagocyte NADPH oxidase bind to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P(2)) and phosphatidylinositol-3...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35083070
更新日期:2001-07-01 00:00:00
abstract::Genomic integrity is maintained by checkpoints that guard against undesired replication after DNA damage. Here, we show that CDT1, a licensing factor of the pre-replication complex (preRC), is rapidly proteolysed after UV- or gamma-irradiation. The preRC assembles on replication origins at the end of mitosis and durin...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1061
更新日期:2003-11-01 00:00:00
abstract::Haematopoietic stem-progenitor cells (HSPCs) reside in the bone marrow niche, where interactions with osteoblasts provide essential cues for their proliferation and survival. Here, we use live-cell imaging to characterize both the site of contact between osteoblasts and haematopoietic progenitor cells (HPCs) and event...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1838
更新日期:2009-03-01 00:00:00
abstract::Dozens of proteins capture, polymerize and reshape the clathrin lattice during clathrin-mediated endocytosis (CME). How or if this ensemble of proteins is organized in relation to the clathrin coat is unknown. Here, we map key molecules involved in CME at the nanoscale using correlative super-resolution light and tran...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3498
更新日期:2017-04-01 00:00:00