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Mechanisms and impact of altered tumour mechanics.

Abstract：

:The physical characteristics of tumours are intricately linked to the tumour phenotype and difficulties during treatment. Many factors contribute to the increased stiffness of tumours; from increased matrix deposition, matrix remodelling by forces from cancer cells and stromal fibroblasts, matrix crosslinking, increased cellularity, and the build-up of both solid and interstitial pressure. Increased stiffness then feeds back to increase tumour invasiveness and reduce therapy efficacy. Increased understanding of this interplay is offering new therapeutic avenues.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Mohammadi H,Sahai E

doi

10.1038/s41556-018-0131-2

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

766-774

issue

7

eissn

1465-7392

issn

1476-4679

pii

10.1038/s41556-018-0131-2

journal_volume

20

pub_type

杂志文章,评审

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