Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.

abstract：:MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased cell motility and invasiveness. miR-9-mediated E-cadherin downregula...

journal_title：Nature cell biology

authors： Ma L,Young J,Prabhala H,Pan E,Mestdagh P,Muth D,Teruya-Feldstein J,Reinhardt F,Onder TT,Valastyan S,Westermann F,Speleman F,Vandesompele J,Weinberg RA

更新日期：2010-03-01 00:00:00

abstract：:The promyelocytic leukaemia (PML) tumour-suppressor protein potentiates p53 function by regulating post-translational modifications, such as CBP-dependent acetylation and Chk2-dependent phosphorylation, in the PML-Nuclear Body (NB). PML was recently shown to interact with the p53 ubiquitin-ligase Mdm2 (refs 4-6); howe...

journal_title：Nature cell biology

authors： Bernardi R,Scaglioni PP,Bergmann S,Horn HF,Vousden KH,Pandolfi PP

更新日期：2004-07-01 00:00:00

abstract：:Mammalian and most fungal infectious proteins (also known as prions) are self-propagating amyloid, a filamentous beta-sheet structure. A prion domain determines the infectious properties of a protein by forming the core of the amyloid. We compare the properties of known prion domains and their interactions with the re...

journal_title：Nature cell biology

authors： Ross ED,Minton A,Wickner RB

更新日期：2005-11-01 00:00:00

abstract：:The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in r...

journal_title：Nature cell biology

authors： Oberst A

更新日期：2017-09-29 00:00:00

abstract：:The tumour-suppressor gene ATM, mutations in which cause the human genetic disease ataxia telangiectasia (A-T), encodes a key protein kinase that controls the cellular response to DNA double-strand breaks (DSBs). DNA DSBs caused by ionizing radiation or chemicals result in rapid ATM autophosphorylation, leading to che...

journal_title：Nature cell biology

authors： You Z,Bailis JM,Johnson SA,Dilworth SM,Hunter T

更新日期：2007-11-01 00:00:00

abstract：:Mitochondria drive apoptosis by releasing pro-apoptotic proteins that promote caspase activation in the cytosol. The rhomboid protease PARL, an intramembrane cleaving peptidase in the inner membrane, regulates mitophagy and plays an ill-defined role in apoptosis. Here, we employed PARL-based proteomics to define its s...

journal_title：Nature cell biology

authors： Saita S,Nolte H,Fiedler KU,Kashkar H,Venne AS,Zahedi RP,Krüger M,Langer T

更新日期：2017-04-01 00:00:00

abstract：:Structural maintenance of chromosomes (SMC) protein complexes are key determinants of chromosome conformation. Using Hi-C and polymer modelling, we study how cohesin and condensin, two deeply conserved SMC complexes, organize chromosomes in the budding yeast Saccharomyces cerevisiae. The canonical role of cohesin is t...

journal_title：Nature cell biology

authors： Schalbetter SA,Goloborodko A,Fudenberg G,Belton JM,Miles C,Yu M,Dekker J,Mirny L,Baxter J

更新日期：2017-09-01 00:00:00

abstract：:Lysosomes respond to environmental cues by controlling their own biogenesis, but the underlying mechanisms are poorly understood. Here we describe a protein kinase C (PKC)-dependent and mTORC1-independent mechanism for regulating lysosome biogenesis, which provides insights into previously reported effects of PKC on l...

journal_title：Nature cell biology

authors： Li Y,Xu M,Ding X,Yan C,Song Z,Chen L,Huang X,Wang X,Jian Y,Tang G,Tang C,Di Y,Mu S,Liu X,Liu K,Li T,Wang Y,Miao L,Guo W,Hao X,Yang C

更新日期：2016-10-01 00:00:00

abstract：:To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt - a major kinase that coordinates diverse signalling pathways - phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphoryla...

journal_title：Nature cell biology

authors： Ecker K,Hengst L

更新日期：2009-04-01 00:00:00

abstract：:Cell division is fundamental for all organisms. Here we report a genome-scale RNA-mediated interference screen in HeLa cells designed to identify human genes that are important for cell division. We have used a library of endoribonuclease-prepared short interfering RNAs for gene silencing and have used DNA content ana...

journal_title：Nature cell biology

authors： Kittler R,Pelletier L,Heninger AK,Slabicki M,Theis M,Miroslaw L,Poser I,Lawo S,Grabner H,Kozak K,Wagner J,Surendranath V,Richter C,Bowen W,Jackson AL,Habermann B,Hyman AA,Buchholz F

更新日期：2007-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature cell biology

authors： Huang Y,Zucker B,Zhang S,Elias S,Zhu Y,Chen H,Ding T,Li Y,Sun Y,Lou J,Kozlov MM,Yu L

更新日期：2019-10-01 00:00:00

abstract：:The motion of a chromosome during mitosis is mediated by a bundle of microtubules, termed a kinetochore fibre (K-fibre), which connects the kinetochore of the chromosome to a spindle pole. Once formed, mature K-fibres maintain a steady state length because the continuous addition of microtubule subunits onto microtubu...

journal_title：Nature cell biology

authors： Maiato H,Khodjakov A,Rieder CL

更新日期：2005-01-01 00:00:00

abstract：:During interphase, centrosomes are held together by a proteinaceous linker that connects the proximal ends of the mother and daughter centriole. This linker is disassembled at the onset of mitosis in a process known as centrosome disjunction, thereby facilitating centrosome separation and bipolar spindle formation. Th...

journal_title：Nature cell biology

authors： Mardin BR,Lange C,Baxter JE,Hardy T,Scholz SR,Fry AM,Schiebel E

更新日期：2010-12-01 00:00:00

abstract：:Cellular transformation and cancer progression is accompanied by changes in the metabolic landscape. Master co-regulators of metabolism orchestrate the modulation of multiple metabolic pathways through transcriptional programs, and hence constitute a probabilistically parsimonious mechanism for general metabolic rewir...

journal_title：Nature cell biology

authors： Torrano V,Valcarcel-Jimenez L,Cortazar AR,Liu X,Urosevic J,Castillo-Martin M,Fernández-Ruiz S,Morciano G,Caro-Maldonado A,Guiu M,Zúñiga-García P,Graupera M,Bellmunt A,Pandya P,Lorente M,Martín-Martín N,Sutherland JD,San

更新日期：2016-06-01 00:00:00

abstract：:Organs and cells must adapt to shear stress induced by biological fluids, but how fluid flow contributes to the execution of specific cell programs is poorly understood. Here we show that shear stress favours mitochondrial biogenesis and metabolic reprogramming to ensure energy production and cellular adaptation in ki...

journal_title：Nature cell biology

authors： Miceli C,Roccio F,Penalva-Mousset L,Burtin M,Leroy C,Nemazanyy I,Kuperwasser N,Pontoglio M,Friedlander G,Morel E,Terzi F,Codogno P,Dupont N

更新日期：2020-09-01 00:00:00

abstract：:Lamina-associated polypeptide (LAP) 2alpha is a chromatin-associated protein that binds A-type lamins. Mutations in both LAP2alpha and A-type lamins are linked to human diseases called laminopathies, but the molecular mechanisms are poorly understood. The A-type lamin-LAP2alpha complex interacts with and regulates ret...

journal_title：Nature cell biology

authors： Naetar N,Korbei B,Kozlov S,Kerenyi MA,Dorner D,Kral R,Gotic I,Fuchs P,Cohen TV,Bittner R,Stewart CL,Foisner R

更新日期：2008-11-01 00:00:00

abstract：:Chromosome loss or gain is associated with a large number of solid cancers, providing genomic plasticity and thus adaptability to cancer cells. Numerical centrosome abnormalities arising from centrosome over-duplication or failed cytokinesis are a recognized cause of aneuploidy. In higher eukaryotic cells, the centros...

journal_title：Nature cell biology

authors： Cuomo ME,Knebel A,Morrice N,Paterson H,Cohen P,Mittnacht S

更新日期：2008-06-01 00:00:00

abstract：:Analysis of the mechanisms underlying cell fates requires the molecular quantification of cellular features. Classical techniques use population average readouts at single time points. However, these approaches mask cellular heterogeneity and dynamics and are limited for studying rare and heterogeneous cell population...

journal_title：Nature cell biology

authors： Hoppe PS,Coutu DL,Schroeder T

更新日期：2014-10-01 00:00:00

abstract：:NF-kappa B/Rel transcription factors control apoptosis, also known as programmed cell death. This control is crucial for oncogenesis, cancer chemo-resistance and for antagonizing tumour necrosis factor alpha (TNFalpha)-induced killing. With regard to TNFalpha, the anti-apoptotic activity of NF-kappa B involves suppres...

journal_title：Nature cell biology

authors： Papa S,Zazzeroni F,Bubici C,Jayawardena S,Alvarez K,Matsuda S,Nguyen DU,Pham CG,Nelsbach AH,Melis T,De Smaele E,Tang WJ,D'Adamio L,Franzoso G

更新日期：2004-02-01 00:00:00

abstract：:The stability and membrane localization of the transforming growth factor-β (TGF-β) type I receptor (TβRI) determines the levels of TGF-β signalling. TβRI is targeted for ubiquitylation-mediated degradation by the SMAD7-SMURF2 complex. Here we performed a genome-wide gain-of-function screen and identified ubiquitin-sp...

journal_title：Nature cell biology

authors： Zhang L,Zhou F,Drabsch Y,Gao R,Snaar-Jagalska BE,Mickanin C,Huang H,Sheppard KA,Porter JA,Lu CX,ten Dijke P

更新日期：2012-06-17 00:00:00

abstract：:The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributo...

journal_title：Nature cell biology

authors： Delaunay S,Frye M

更新日期：2019-05-01 00:00:00

abstract：:Here we evaluate the idea that the Golgi is in dynamic equilibrium with the endoplasmic reticulum (ER). In cytoplasts that lack the Golgi apparatus, no regrowth of the Golgi is observed, nor is any transport from the ER to the cell surface detected. However, introduction of the smallest measurable amount of Golgi (equ...

journal_title：Nature cell biology

authors： Pelletier L,Jokitalo E,Warren G

更新日期：2000-11-01 00:00:00

abstract：:Given the important role of the hypothalamus in regulating feeding and metabolism, there has been considerable interest in a possible function for hypothalamic stem cells in modulating body weight in health and disease. Mice given a high-fat diet develop inflammation in the hypothalamus and lose key types of neurons. ...

journal_title：Nature cell biology

authors： Livesey FJ

更新日期：2012-10-01 00:00:00

abstract：:In the version of this Article originally published, ref. 52 was incorrectly only attributed to its corresponding author, Fre, S., and an older title was used. The correct citation should have been: Lilja, A. M. et al. Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain...

journal_title：Nature cell biology

authors： Wuidart A,Sifrim A,Fioramonti M,Matsumura S,Brisebarre A,Brown D,Centonze A,Dannau A,Dubois C,Van Keymeulen A,Voet T,Blanpain C

更新日期：2018-09-01 00:00:00

abstract：:Cells of multicellular organisms need to adopt specific morphologies. However, the molecular mechanisms bringing about membrane topology changes are far from understood-mainly because knowledge of membrane-shaping proteins that can promote local membrane curvatures is still limited. Our analyses unveiled that several ...

journal_title：Nature cell biology

authors： Wolf D,Hofbrucker-MacKenzie SA,Izadi M,Seemann E,Steiniger F,Schwintzer L,Koch D,Kessels MM,Qualmann B

更新日期：2019-10-01 00:00:00

abstract：:Here we show that segregation of homologous chromosomes and that of sister chromatids are differentially regulated in Xenopus and possibly in other higher eukaryotes. Upon hormonal stimulation, Xenopus oocytes microinjected with antibodies against the anaphase-promoting complex (APC) activator Fizzy or the APC core su...

journal_title：Nature cell biology

authors： Peter M,Castro A,Lorca T,Le Peuch C,Magnaghi-Jaulin L,Dorée M,Labbé JC

更新日期：2001-01-01 00:00:00

abstract：:Stat3 has been shown to regulate lysosome membrane permeabilization and cell death in vivo during post-lactation mammary gland involution. It is now revealed that Stat3 induces lysosome membrane permeabilization by causing phagocytosis of milk fat globules, which destabilize the lysosome membrane leading to leakage of...

journal_title：Nature cell biology

authors： Krishna S,Overholtzer M

更新日期：2014-11-01 00:00:00

abstract：:Somatic cell reprogramming by exogenous factors requires cooperation with transcriptional co-activators and co-repressors to effectively remodel the epigenetic environment. How this interplay is regulated remains poorly understood. Here, we demonstrate that NCoR/SMRT co-repressors bind to pluripotency loci to create a...

journal_title：Nature cell biology

authors： Zhuang Q,Li W,Benda C,Huang Z,Ahmed T,Liu P,Guo X,Ibañez DP,Luo Z,Zhang M,Abdul MM,Yang Z,Yang J,Huang Y,Zhang H,Huang D,Zhou J,Zhong X,Zhu X,Fu X,Fan W,Liu Y,Xu Y,Ward C,Khan MJ,Kanwal S,Mirza B,Tor

更新日期：2018-04-01 00:00:00

abstract：:Dynamic regulation of adhesion complexes is required for cell migration and has therefore emerged as a key issue in the study of cell motility. Recent progress has been made in defining some of the molecular mechanisms by which adhesion disassembly is regulated, including the contributions of adhesion adaptor proteins...

journal_title：Nature cell biology

authors： Franco SJ,Rodgers MA,Perrin BJ,Han J,Bennin DA,Critchley DR,Huttenlocher A

更新日期：2004-10-01 00:00:00

abstract：:The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find ...

journal_title：Nature cell biology

authors： Hanssen LLP,Kassouf MT,Oudelaar AM,Biggs D,Preece C,Downes DJ,Gosden M,Sharpe JA,Sloane-Stanley JA,Hughes JR,Davies B,Higgs DR

更新日期：2017-08-01 00:00:00