当前位置： SCI文献检索 > NATURE CELL BIOLOGY期刊下所有文献 > NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.

NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.

Abstract：

:Somatic cell reprogramming by exogenous factors requires cooperation with transcriptional co-activators and co-repressors to effectively remodel the epigenetic environment. How this interplay is regulated remains poorly understood. Here, we demonstrate that NCoR/SMRT co-repressors bind to pluripotency loci to create a barrier to reprogramming with the four Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC), and consequently, suppressing NCoR/SMRT significantly enhances reprogramming efficiency and kinetics. The core epigenetic subunit of the NCoR/SMRT complex, histone deacetylase 3 (HDAC3), contributes to the effects of NCoR/SMRT by inducing histone deacetylation at pluripotency loci. Among the Yamanaka factors, recruitment of NCoR/SMRT-HDAC3 to genomic loci is mostly facilitated by c-MYC. Hence, we describe how c-MYC is beneficial for the early phase of reprogramming but deleterious later. Overall, we uncover a role for NCoR/SMRT co-repressors in reprogramming and propose a dual function for c-MYC in this process.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Zhuang Q,Li W,Benda C,Huang Z,Ahmed T,Liu P,Guo X,Ibañez DP,Luo Z,Zhang M,Abdul MM,Yang Z,Yang J,Huang Y,Zhang H,Huang D,Zhou J,Zhong X,Zhu X,Fu X,Fan W,Liu Y,Xu Y,Ward C,Khan MJ,Kanwal S,Mirza B,Tor

doi

10.1038/s41556-018-0047-x

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

400-412

issue

4

eissn

1465-7392

issn

1476-4679

pii

10.1038/s41556-018-0047-x

journal_volume

20

pub_type

杂志文章

相关文献

NATURE CELL BIOLOGY文献大全
  • Sharing data.

    abstract：:Reference datasets should be accessible independently of scientific papers in a citable form, allowing attribution. ...

    journal_title：Nature cell biology

    pub_type： 社论

    doi：10.1038/ncb1109-1273a

    authors：

    更新日期：2009-11-01 00:00:00

  • A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance.

    abstract：:Proteins essential for vesicle formation by the Coat Protein I (COPI) complex are being identified, but less is known about the role of specific lipids. Brefeldin-A ADP-ribosylated substrate (BARS) functions in the fission step of COPI vesicle formation. Here, we show that BARS induces membrane curvature in cooperatio...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1774

    authors： Yang JS,Gad H,Lee SY,Mironov A,Zhang L,Beznoussenko GV,Valente C,Turacchio G,Bonsra AN,Du G,Baldanzi G,Graziani A,Bourgoin S,Frohman MA,Luini A,Hsu VW

    更新日期：2008-10-01 00:00:00

  • Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells.

    abstract：:Lingual keratinized epithelial cells, which constitute the filiform papillae of the tongue, have one of the most rapid tissue turnover rates in the mammalian body and are thought to be the source of squamous cell carcinoma of the tongue. However, the mechanism of tissue maintenance and regeneration is largely unknown ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2719

    authors： Tanaka T,Komai Y,Tokuyama Y,Yanai H,Ohe S,Okazaki K,Ueno H

    更新日期：2013-05-01 00:00:00

  • Rubicon swaps autophagy for LAP.

    abstract：:Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now been shed on the molecular requirements of LAP, establishing a central role for the protein Rubic...

    journal_title：Nature cell biology

    pub_type： 评论,杂志文章

    doi：10.1038/ncb3197

    authors： Boyle KB,Randow F

    更新日期：2015-07-01 00:00:00

  • STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle.

    abstract：:It is now well established that stromal interaction molecule 1 (STIM1) is the calcium sensor of endoplasmic reticulum stores required to activate store-operated calcium entry (SOC) channels at the surface of non-excitable cells. However, little is known about STIM1 in excitable cells, such as striated muscle, where th...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1731

    authors： Stiber J,Hawkins A,Zhang ZS,Wang S,Burch J,Graham V,Ward CC,Seth M,Finch E,Malouf N,Williams RS,Eu JP,Rosenberg P

    更新日期：2008-06-01 00:00:00

  • ETAA1 acts at stalled replication forks to maintain genome integrity.

    abstract：:The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication stress response protein in two proteomic screens. ETAA1-deficient c...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3415

    authors： Bass TE,Luzwick JW,Kavanaugh G,Carroll C,Dungrawala H,Glick GG,Feldkamp MD,Putney R,Chazin WJ,Cortez D

    更新日期：2016-11-01 00:00:00

  • Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.

    abstract：:YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3111

    authors： Mo JS,Meng Z,Kim YC,Park HW,Hansen CG,Kim S,Lim DS,Guan KL

    更新日期：2015-04-01 00:00:00

  • A-type lamins: guardians of the soma?

    abstract：:The gene LMNA encodes the proteins lamins A and C and is implicated in nine different laminopathies - inherited diseases that are linked to premature ageing. Recent evidence has demonstrated that lamins A and C have essential functions in protecting cells from physical damage, as well as in maintaining the function of...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb1104-1062

    authors： Hutchison CJ,Worman HJ

    更新日期：2004-11-01 00:00:00

  • Orchestrating Wnt signalling for metabolic liver zonation.

    abstract：:Wnt/β-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO-LGR4/5-ZNF3/RNF43 is now shown to direct Wnt/β-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanis...

    journal_title：Nature cell biology

    pub_type： 评论,杂志文章

    doi：10.1038/ncb3349

    authors： Birchmeier W

    更新日期：2016-04-27 00:00:00

  • Kinesin-dependent movement on microtubules precedes actin-based motility of vaccinia virus.

    abstract：:Vaccinia virus, a close relative of the causative agent of smallpox, exploits actin polymerization to enhance its cell-to-cell spread. We show that actin-based motility of vaccinia is initiated only at the plasma membrane and remains associated with it. There must therefore be another form of cytoplasmic viral transpo...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1101-992

    authors： Rietdorf J,Ploubidou A,Reckmann I,Holmström A,Frischknecht F,Zettl M,Zimmermann T,Way M

    更新日期：2001-11-01 00:00:00

  • The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells.

    abstract：:Organs and cells must adapt to shear stress induced by biological fluids, but how fluid flow contributes to the execution of specific cell programs is poorly understood. Here we show that shear stress favours mitochondrial biogenesis and metabolic reprogramming to ensure energy production and cellular adaptation in ki...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-020-0566-0

    authors： Miceli C,Roccio F,Penalva-Mousset L,Burtin M,Leroy C,Nemazanyy I,Kuperwasser N,Pontoglio M,Friedlander G,Morel E,Terzi F,Codogno P,Dupont N

    更新日期：2020-09-01 00:00:00

  • Lactate dehydrogenase activity drives hair follicle stem cell activation.

    abstract：:Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to divide during a new hair cycle. The quiescence of HFSCs is known to be regulated by a number of intrinsic and extrinsic mechanisms. Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism a...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3575

    authors： Flores A,Schell J,Krall AS,Jelinek D,Miranda M,Grigorian M,Braas D,White AC,Zhou JL,Graham NA,Graeber T,Seth P,Evseenko D,Coller HA,Rutter J,Christofk HR,Lowry WE

    更新日期：2017-09-01 00:00:00

  • Limits to lifespan.

    abstract：:It has long-been accepted that normal somatic cells have intrinsic mechanisms that limit their proliferative lifespan. Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential. ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb0202-e25

    authors： Lloyd AC

    更新日期：2002-02-01 00:00:00

  • Mechanisms and impact of altered tumour mechanics.

    abstract：:The physical characteristics of tumours are intricately linked to the tumour phenotype and difficulties during treatment. Many factors contribute to the increased stiffness of tumours; from increased matrix deposition, matrix remodelling by forces from cancer cells and stromal fibroblasts, matrix crosslinking, increas...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/s41556-018-0131-2

    authors： Mohammadi H,Sahai E

    更新日期：2018-07-01 00:00:00

  • Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.

    abstract：:Mitochondrial DNA (mtDNA) mutations cause inherited diseases and are implicated in the pathogenesis of common late-onset disorders, but how they arise is not clear1,2. Here we show that mtDNA mutations are present in primordial germ cells (PGCs) within healthy female human embryos. Isolated PGCs have a profound reduct...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-017-0017-8

    authors： Floros VI,Pyle A,Dietmann S,Wei W,Tang WCW,Irie N,Payne B,Capalbo A,Noli L,Coxhead J,Hudson G,Crosier M,Strahl H,Khalaf Y,Saitou M,Ilic D,Surani MA,Chinnery PF

    更新日期：2018-02-01 00:00:00

  • MK2 balances inflammation and cell death.

    abstract：:The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in r...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3619

    authors： Oberst A

    更新日期：2017-09-29 00:00:00

  • Integrin endosomal signalling suppresses anoikis.

    abstract：:Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic traffic, the potential impact of endocytic traffic on integrin-induced signals is unknown. Here, we demonstr...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3250

    authors： Alanko J,Mai A,Jacquemet G,Schauer K,Kaukonen R,Saari M,Goud B,Ivaska J

    更新日期：2015-11-01 00:00:00

  • Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.

    abstract：:During interphase, centrosomes are held together by a proteinaceous linker that connects the proximal ends of the mother and daughter centriole. This linker is disassembled at the onset of mitosis in a process known as centrosome disjunction, thereby facilitating centrosome separation and bipolar spindle formation. Th...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2120

    authors： Mardin BR,Lange C,Baxter JE,Hardy T,Scholz SR,Fry AM,Schiebel E

    更新日期：2010-12-01 00:00:00

  • Publisher Correction: Single-cell multi-omics sequencing of human early embryos.

    abstract：:In the version of this Resource originally published, owing to a technical error an incorrect file was used for Supplementary Table 2; this has now been replaced with the correct file. ...

    journal_title：Nature cell biology

    pub_type： 已发布勘误

    doi：10.1038/s41556-018-0166-4

    authors： Li L,Guo F,Gao Y,Ren Y,Yuan P,Yan L,Li R,Lian Y,Li J,Hu B,Gao J,Wen L,Tang F,Qiao J

    更新日期：2018-10-01 00:00:00

  • Microtubules gate tau condensation to spatially regulate microtubule functions.

    abstract：:Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia1, yet the physiological state of tau molecules within cells remains unclear. Using single-molecule imaging, we directly observe that the microtubule latt...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-019-0375-5

    authors： Tan R,Lam AJ,Tan T,Han J,Nowakowski DW,Vershinin M,Simó S,Ori-McKenney KM,McKenney RJ

    更新日期：2019-09-01 00:00:00

  • Tensile forces govern germ-layer organization in zebrafish.

    abstract：:Understanding the factors that direct tissue organization during development is one of the most fundamental goals in developmental biology. Various hypotheses explain cell sorting and tissue organization on the basis of the adhesive and mechanical properties of the constituent cells. However, validating these hypothes...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1705

    authors： Krieg M,Arboleda-Estudillo Y,Puech PH,Käfer J,Graner F,Müller DJ,Heisenberg CP

    更新日期：2008-04-01 00:00:00

  • Author Correction: Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.

    abstract：:In the version of this Article originally published, the author had misnumbered the reference citations in the Methods, using numbers 1-14 instead of 46-59. These errors have now been corrected in all online versions of the Article. ...

    journal_title：Nature cell biology

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41556-018-0053-z

    authors： Chen J,Xu N,Wang C,Huang P,Huang H,Jin Z,Yu Z,Cai T,Jiao R,Xi R

    更新日期：2018-08-01 00:00:00

  • Y chromothripsis?

    abstract：:Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process,...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3458

    authors： Hatch EM

    更新日期：2016-12-23 00:00:00

  • Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1.

    abstract：:The importance of herpes simplex viruses (HSV) as human pathogens and the emerging prospect of using mutant derivatives of HSV-1 as potential anti-cancer therapeutics have necessitated a thorough investigation into the molecular basis of host-cell permissiveness to HSV. Here we show that NIH-3T3 cells transformed with...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/35087061

    authors： Farassati F,Yang AD,Lee PW

    更新日期：2001-08-01 00:00:00

  • Dysfunction of store-operated calcium channel in muscle cells lacking mg29.

    abstract：:The store-operated calcium channel (SOC) located in the plasma membrane (PM) mediates capacitative entry of extracellular calcium after depletion of intracellular calcium stores in the endoplasmic or sarcoplasmic reticulum (ER/SR). An intimate interaction between the PM and the ER/SR is essential for the operation of ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb788

    authors： Pan Z,Yang D,Nagaraj RY,Nosek TA,Nishi M,Takeshima H,Cheng H,Ma J

    更新日期：2002-05-01 00:00:00

  • Receptor-like kinases shape the plant.

    abstract：:To generate the various tissues and organs that build up the adult body, plants and animals require organized formative cell divisions and correct cell specification. In plants, these processes are controlled mainly by phytohormones and transcriptional networks. Recently, ligand-receptor-like kinase signalling pathway...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb1009-1166

    authors： De Smet I,Voss U,Jürgens G,Beeckman T

    更新日期：2009-10-01 00:00:00

  • p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase.

    abstract：:Cancer cells consume large quantities of glucose and primarily use glycolysis for ATP production, even in the presence of adequate oxygen. This metabolic signature (aerobic glycolysis or the Warburg effect) enables cancer cells to direct glucose to biosynthesis, supporting their rapid growth and proliferation. However...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2172

    authors： Jiang P,Du W,Wang X,Mancuso A,Gao X,Wu M,Yang X

    更新日期：2011-03-01 00:00:00

  • Determinants of molecular motor directionality.

    abstract：:Work over the past two years has led to a breakthrough in our understanding of the molecular basis of the directionality of the kinesin motor proteins. This breakthrough has come first from the reversal of directionality of the kinesin-related motor Ncd, followed closely by the reversal of kinesin's directionality and...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/14113

    authors： Endow SA

    更新日期：1999-10-01 00:00:00

  • The APC is dispensable for first meiotic anaphase in Xenopus oocytes.

    abstract：:Here we show that segregation of homologous chromosomes and that of sister chromatids are differentially regulated in Xenopus and possibly in other higher eukaryotes. Upon hormonal stimulation, Xenopus oocytes microinjected with antibodies against the anaphase-promoting complex (APC) activator Fizzy or the APC core su...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/35050607

    authors： Peter M,Castro A,Lorca T,Le Peuch C,Magnaghi-Jaulin L,Dorée M,Labbé JC

    更新日期：2001-01-01 00:00:00

  • Homeostatic control of recombination is implemented progressively in mouse meiosis.

    abstract：:Humans suffer from high rates of fetal aneuploidy, often arising from the absence of meiotic crossover recombination between homologous chromosomes. Meiotic recombination is initiated by double-strand breaks (DSBs) generated by the SPO11 transesterase. In yeast and worms, at least one buffering mechanism, crossover ho...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2451

    authors： Cole F,Kauppi L,Lange J,Roig I,Wang R,Keeney S,Jasin M

    更新日期：2012-03-04 00:00:00