听力与言语-语言病理学

行为科学

医学伦理学

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  • Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses.

    abstract::Nutrient availability is central for T-cell functions and immune responses. Here we report that CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non-essential amino acid Asn. Increased Asn levels enhance CD8+ T-cell activation and effector functions against tumour cells in vitro and in ...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-020-00615-4

    authors: Wu J,Li G,Li L,Li D,Dong Z,Jiang P

    更新日期:2021-01-01 00:00:00

  • ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells.

    abstract::Tumour growth and invasiveness require extracellular matrix (ECM) degradation and are stimulated by the GALA pathway, which induces protein O-glycosylation in the endoplasmic reticulum (ER). ECM degradation requires metalloproteases, but whether other enzymes are required is unclear. Here, we show that GALA induces th...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-020-00590-w

    authors: Ros M,Nguyen AT,Chia J,Le Tran S,Le Guezennec X,McDowall R,Vakhrushev S,Clausen H,Humphries MJ,Saltel F,Bard FA

    更新日期:2020-11-01 00:00:00

  • LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.

    abstract::Sensing and clearance of dysfunctional lysosomes is critical for cellular homeostasis. Here we show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated during the lysosomal damage response, and its activation is dependent on the function of the ATG ...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-020-00583-9

    authors: Nakamura S,Shigeyama S,Minami S,Shima T,Akayama S,Matsuda T,Esposito A,Napolitano G,Kuma A,Namba-Hamano T,Nakamura J,Yamamoto K,Sasai M,Tokumura A,Miyamoto M,Oe Y,Fujita T,Terawaki S,Takahashi A,Hamasaki M,Yamamot

    更新日期:2020-10-01 00:00:00

  • LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

    abstract::Breast cancer brain metastasis (BCBM) is a devastating disease. Radiation therapy remains the mainstay for treatment of this disease. Unfortunately, its efficacy is limited by the dose that can be safely applied. One promising approach to overcoming this limitation is to sensitize BCBMs to radiation by inhibiting thei...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-020-00586-6

    authors: Chen Y,Jiang T,Zhang H,Gou X,Han C,Wang J,Chen AT,Ma J,Liu J,Chen Z,Jing X,Lei H,Wang Z,Bao Y,Baqri M,Zhu Y,Bindra RS,Hansen JE,Dou J,Huang C,Zhou J

    更新日期:2020-10-01 00:00:00

  • The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells.

    abstract::Organs and cells must adapt to shear stress induced by biological fluids, but how fluid flow contributes to the execution of specific cell programs is poorly understood. Here we show that shear stress favours mitochondrial biogenesis and metabolic reprogramming to ensure energy production and cellular adaptation in ki...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-020-0566-0

    authors: Miceli C,Roccio F,Penalva-Mousset L,Burtin M,Leroy C,Nemazanyy I,Kuperwasser N,Pontoglio M,Friedlander G,Morel E,Terzi F,Codogno P,Dupont N

    更新日期:2020-09-01 00:00:00

  • Extracellular serine controls epidermal stem cell fate and tumour initiation.

    abstract::Tissue stem cells are the cell of origin for many malignancies. Metabolites regulate the balance between self-renewal and differentiation, but whether endogenous metabolic pathways or nutrient availability predispose stem cells towards transformation remains unknown. Here, we address this question in epidermal stem ce...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-020-0525-9

    authors: Baksh SC,Todorova PK,Gur-Cohen S,Hurwitz B,Ge Y,Novak JSS,Tierney MT,Dela Cruz-Racelis J,Fuchs E,Finley LWS

    更新日期:2020-07-01 00:00:00

  • Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling.

    abstract::Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland function, their diversity has not been fully addressed. By exploiting high-resolution three-dimensional imaging and flow cytometry, we identified a unique population of tissue-resident ductal mac...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-020-0505-0

    authors: Dawson CA,Pal B,Vaillant F,Gandolfo LC,Liu Z,Bleriot C,Ginhoux F,Smyth GK,Lindeman GJ,Mueller SN,Rios AC,Visvader JE

    更新日期:2020-05-01 00:00:00

  • Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.

    abstract::SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival. Here we show that this comes at a significant cost for cancer cells with high levels of SLC7A11. Actively importing cystine is potentially toxic due to its low solubility, forcing cancer cells with high levels of SLC7A11 (SLC7...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-020-0496-x

    authors: Liu X,Olszewski K,Zhang Y,Lim EW,Shi J,Zhang X,Zhang J,Lee H,Koppula P,Lei G,Zhuang L,You MJ,Fang B,Li W,Metallo CM,Poyurovsky MV,Gan B

    更新日期:2020-04-01 00:00:00

  • Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

    abstract::Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a fam...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-020-0488-x

    authors: Müller PM,Rademacher J,Bagshaw RD,Wortmann C,Barth C,van Unen J,Alp KM,Giudice G,Eccles RL,Heinrich LE,Pascual-Vargas P,Sanchez-Castro M,Brandenburg L,Mbamalu G,Tucholska M,Spatt L,Czajkowski MT,Welke RW,Zhang S,Ngu

    更新日期:2020-04-01 00:00:00

  • Author Correction: Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature cell biology

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41556-020-0479-y

    authors: Bagci H,Sriskandarajah N,Robert A,Boulais J,Elkholi IE,Tran V,Lin ZY,Thibault MP,Dubé N,Faubert D,Hipfner DR,Gingras AC,Côté JF

    更新日期:2020-03-01 00:00:00

  • Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T-cell memory development.

    abstract::Glycogen has long been considered to have a function in energy metabolism. However, our recent study indicated that glycogen metabolism, directed by cytosolic phosphoenolpyruvate carboxykinase Pck1, controls the formation and maintenance of CD8+ memory T (Tmem) cells by regulating redox homeostasis1. This unusual meta...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-019-0440-0

    authors: Zhang H,Tang K,Ma J,Zhou L,Liu J,Zeng L,Zhu L,Xu P,Chen J,Wei K,Liang X,Lv J,Xie J,Liu Y,Wan Y,Huang B

    更新日期:2020-01-01 00:00:00

  • Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair.

    abstract::Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies-labelling cells expressing Cx3cr1, Csf1r or Flt3-to identify the precursors of osteoclasts in mice. We identified an erythromyeloid progenitor (EMP)-derived osteoclast precursor population. ...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-019-0437-8

    authors: Yahara Y,Barrientos T,Tang YJ,Puviindran V,Nadesan P,Zhang H,Gibson JR,Gregory SG,Diao Y,Xiang Y,Qadri YJ,Souma T,Shinohara ML,Alman BA

    更新日期:2020-01-01 00:00:00

  • Early chromatin shaping predetermines multipotent vagal neural crest into neural, neuronal and mesenchymal lineages.

    abstract::The enteric nervous system (ENS) predominantly originates from vagal neural crest (VNC) cells that emerge from the caudal hindbrain, invade the foregut and populate the gastrointestinal tract. However, the gene regulatory network (GRN) orchestrating the early specification of VNC remains unknown. Using an EdnrB enhanc...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-019-0428-9

    authors: Ling ITC,Sauka-Spengler T

    更新日期:2019-12-01 00:00:00

  • Differential scaling between G1 protein production and cell size dynamics promotes commitment to the cell division cycle in budding yeast.

    abstract::In the unicellular eukaryote Saccharomyces cerevisiae, Cln3-cyclin-dependent kinase activity enables Start, the irreversible commitment to the cell division cycle. However, the concentration of Cln3 has been paradoxically considered to remain constant during G1, due to the presumed scaling of its production rate with ...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-019-0413-3

    authors: Litsios A,Huberts DHEW,Terpstra HM,Guerra P,Schmidt A,Buczak K,Papagiannakis A,Rovetta M,Hekelaar J,Hubmann G,Exterkate M,Milias-Argeitis A,Heinemann M

    更新日期:2019-11-01 00:00:00

  • The NSL complex maintains nuclear architecture stability via lamin A/C acetylation.

    abstract::While nuclear lamina abnormalities are hallmarks of human diseases, their interplay with epigenetic regulators and precise epigenetic landscape remain poorly understood. Here, we show that loss of the lysine acetyltransferase MOF or its associated NSL-complex members KANSL2 or KANSL3 leads to a stochastic accumulation...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-019-0397-z

    authors: Karoutas A,Szymanski W,Rausch T,Guhathakurta S,Rog-Zielinska EA,Peyronnet R,Seyfferth J,Chen HR,de Leeuw R,Herquel B,Kimura H,Mittler G,Kohl P,Medalia O,Korbel JO,Akhtar A

    更新日期:2019-10-01 00:00:00

  • Ankyrin repeat-containing N-Ank proteins shape cellular membranes.

    abstract::Cells of multicellular organisms need to adopt specific morphologies. However, the molecular mechanisms bringing about membrane topology changes are far from understood-mainly because knowledge of membrane-shaping proteins that can promote local membrane curvatures is still limited. Our analyses unveiled that several ...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-019-0381-7

    authors: Wolf D,Hofbrucker-MacKenzie SA,Izadi M,Seemann E,Steiniger F,Schwintzer L,Koch D,Kessels MM,Qualmann B

    更新日期:2019-10-01 00:00:00

  • Publisher Correction: Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature cell biology

    pub_type: 已发布勘误

    doi:10.1038/s41556-019-0389-z

    authors: Huang Y,Zucker B,Zhang S,Elias S,Zhu Y,Chen H,Ding T,Li Y,Sun Y,Lou J,Kozlov MM,Yu L

    更新日期:2019-10-01 00:00:00

  • Microtubules gate tau condensation to spatially regulate microtubule functions.

    abstract::Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia1, yet the physiological state of tau molecules within cells remains unclear. Using single-molecule imaging, we directly observe that the microtubule latt...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-019-0375-5

    authors: Tan R,Lam AJ,Tan T,Han J,Nowakowski DW,Vershinin M,Simó S,Ori-McKenney KM,McKenney RJ

    更新日期:2019-09-01 00:00:00

  • Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms.

    abstract::Cancer-induced immune responses affect tumour progression and therapeutic response. In multiple murine models and clinical datasets, we identified large variations of neutrophils and macrophages that define 'immune subtypes' of triple-negative breast cancer (TNBC), including neutrophil-enriched (NES) and macrophage-en...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-019-0373-7

    authors: Kim IS,Gao Y,Welte T,Wang H,Liu J,Janghorban M,Sheng K,Niu Y,Goldstein A,Zhao N,Bado I,Lo HC,Toneff MJ,Nguyen T,Bu W,Jiang W,Arnold J,Gu F,He J,Jebakumar D,Walker K,Li Y,Mo Q,Westbrook TF,Zong C,Rao A,

    更新日期:2019-09-01 00:00:00

  • Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities.

    abstract::Phosphorylation networks intimately regulate mechanisms of response to therapies. Mapping the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-throughput system to measure the enzymatic activity of kinases using biological peptide targets as phospho-sens...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-019-0328-z

    authors: Coppé JP,Mori M,Pan B,Yau C,Wolf DM,Ruiz-Saenz A,Brunen D,Prahallad A,Cornelissen-Steijger P,Kemper K,Posch C,Wang C,Dreyer CA,Krijgsman O,Lee PRE,Chen Z,Peeper DS,Moasser MM,Bernards R,van 't Veer LJ

    更新日期:2019-06-01 00:00:00

  • Publisher Correction: Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme.

    abstract::In the version of this article originally published, parts of Figure 5 were misaligned because of a shift during production. In a, one data point was outside of the graph border. In b, axes lines were not connected, and graph lines did not reach the data points. In c and d, the axes lines were not connected. In e and ...

    journal_title:Nature cell biology

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41556-019-0326-1

    authors: Boos F,Krämer L,Groh C,Jung F,Haberkant P,Stein F,Wollweber F,Gackstatter A,Zöller E,van der Laan M,Savitski MM,Benes V,Herrmann JM

    更新日期:2019-06-01 00:00:00

  • RNA modifications regulating cell fate in cancer.

    abstract::The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributo...

    journal_title:Nature cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/s41556-019-0319-0

    authors: Delaunay S,Frye M

    更新日期:2019-05-01 00:00:00

  • Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells.

    abstract::Over their lifetime, long-term haematopoietic stem cells (HSC) are exposed to a variety of stress conditions that they must endure. Many stresses, such as infection/inflammation, reactive oxygen species, nutritional deprivation and hypoxia, activate unfolded protein response signalling, which induces either adaptive c...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-019-0285-6

    authors: Liu L,Zhao M,Jin X,Ney G,Yang KB,Peng F,Cao J,Iwawaki T,Del Valle J,Chen X,Li Q

    更新日期:2019-03-01 00:00:00

  • Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics.

    abstract::Induced pluripotent stem cells (iPSCs) are generated via the expression of the transcription factors OCT4 (also known as POU5F1), SOX2, KLF4 and cMYC (OSKM) in somatic cells. In contrast to murine naive iPSCs, conventional human iPSCs are in a more developmentally advanced state called primed pluripotency. Here, we re...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-018-0254-5

    authors: Giulitti S,Pellegrini M,Zorzan I,Martini P,Gagliano O,Mutarelli M,Ziller MJ,Cacchiarelli D,Romualdi C,Elvassore N,Martello G

    更新日期:2019-02-01 00:00:00

  • Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.

    abstract::Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal, we have developed cell culture conditions to closely mimic events occurring during pancreatic islet organogenesis and β...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-018-0271-4

    authors: Nair GG,Liu JS,Russ HA,Tran S,Saxton MS,Chen R,Juang C,Li ML,Nguyen VQ,Giacometti S,Puri S,Xing Y,Wang Y,Szot GL,Oberholzer J,Bhushan A,Hebrok M

    更新日期:2019-02-01 00:00:00

  • Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy.

    abstract::The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor metastasis-free survival of patients with breast cancer with localized disease. DTCs persist in distant tissues despite systemic administration of adjuvant chemotherapy. Many assume that this is because the majority of DTCs are quies...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-018-0267-0

    authors: Carlson P,Dasgupta A,Grzelak CA,Kim J,Barrett A,Coleman IM,Shor RE,Goddard ET,Dai J,Schweitzer EM,Lim AR,Crist SB,Cheresh DA,Nelson PS,Hansen KC,Ghajar CM

    更新日期:2019-02-01 00:00:00

  • Non-redundant functions of EMT transcription factors.

    abstract::Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to b...

    journal_title:Nature cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/s41556-018-0196-y

    authors: Stemmler MP,Eccles RL,Brabletz S,Brabletz T

    更新日期:2019-01-01 00:00:00

  • Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication.

    abstract::The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from other extracellular vesicles in terms of their biogenesis and functions remains ...

    journal_title:Nature cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/s41556-018-0250-9

    authors: Mathieu M,Martin-Jaular L,Lavieu G,Théry C

    更新日期:2019-01-01 00:00:00

  • Targeting BAF-perturbed cancers.

    abstract:: ...

    journal_title:Nature cell biology

    pub_type: 评论,杂志文章

    doi:10.1038/s41556-018-0246-5

    authors: Reddy D,Workman JL

    更新日期:2018-12-01 00:00:00

  • The challenge of the post-truth era.

    abstract::Science denial is not new but, in the digital age, evidence-based conclusions appear to be increasingly threatened by beliefs based on emotion and isolated personal experience. When confronting a post-truth world, scientists must defend the scientific method and increase public engagement. ...

    journal_title:Nature cell biology

    pub_type: 社论

    doi:10.1038/s41556-018-0231-z

    authors:

    更新日期:2018-11-01 00:00:00

  • CRISPR mutagenesis screening of mice.

    abstract:: ...

    journal_title:Nature cell biology

    pub_type: 评论,杂志文章

    doi:10.1038/s41556-018-0224-y

    authors: Serebrenik YV,Shalem O

    更新日期:2018-11-01 00:00:00

  • Publisher Correction: Single-cell multi-omics sequencing of human early embryos.

    abstract::In the version of this Resource originally published, owing to a technical error an incorrect file was used for Supplementary Table 2; this has now been replaced with the correct file. ...

    journal_title:Nature cell biology

    pub_type: 已发布勘误

    doi:10.1038/s41556-018-0166-4

    authors: Li L,Guo F,Gao Y,Ren Y,Yuan P,Yan L,Li R,Lian Y,Li J,Hu B,Gao J,Wen L,Tang F,Qiao J

    更新日期:2018-10-01 00:00:00

  • Direct induction of microtubule branching by microtubule nucleation factor SSNA1.

    abstract::Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed microtubule seeds or from γ-tubulin recruited to the side of a pre-existing microtubule. Here, we found that microtubules c...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-018-0199-8

    authors: Basnet N,Nedozralova H,Crevenna AH,Bodakuntla S,Schlichthaerle T,Taschner M,Cardone G,Janke C,Jungmann R,Magiera MM,Biertümpfel C,Mizuno N

    更新日期:2018-10-01 00:00:00

  • Single particle trajectories reveal active endoplasmic reticulum luminal flow.

    abstract::The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory proteins and delivery of functional solutes throughout the cell1,2. Molecular mobility through the ER network enables these functionalities, but diffusion alone is not sufficient to explain...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-018-0192-2

    authors: Holcman D,Parutto P,Chambers JE,Fantham M,Young LJ,Marciniak SJ,Kaminski CF,Ron D,Avezov E

    更新日期:2018-10-01 00:00:00

  • A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.

    abstract::Glioblastoma multiforme (GBMs) are recurrent lethal brain tumours. Recurrent GBMs often exhibit mesenchymal, stem-like phenotypes that could explain their resistance to therapy. Analyses revealed that recurrent GBMs have increased tension and express high levels of glycoproteins that increase the bulkiness of the glyc...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-018-0183-3

    authors: Barnes JM,Kaushik S,Bainer RO,Sa JK,Woods EC,Kai F,Przybyla L,Lee M,Lee HW,Tung JC,Maller O,Barrett AS,Lu KV,Lakins JN,Hansen KC,Obernier K,Alvarez-Buylla A,Bergers G,Phillips JJ,Nam DH,Bertozzi CR,Weaver VM

    更新日期:2018-10-01 00:00:00

  • A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold.

    abstract::A key step in nutrient sensing is activation of the master growth regulator, mTORC1 kinase, on the lysosomal membrane. Nutrients enable mTORC1 scaffolding by a complex composed of the Rag GTPases (Rags) and Ragulator, but the underlying mechanism of mTORC1 capture is poorly understood. Combining dynamic imaging in cel...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-018-0148-6

    authors: Lawrence RE,Cho KF,Rappold R,Thrun A,Tofaute M,Kim DJ,Moldavski O,Hurley JH,Zoncu R

    更新日期:2018-09-01 00:00:00

  • Publisher Correction: Early lineage segregation of multipotent embryonic mammary gland progenitors.

    abstract::In the version of this Article originally published, ref. 52 was incorrectly only attributed to its corresponding author, Fre, S., and an older title was used. The correct citation should have been: Lilja, A. M. et al. Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain...

    journal_title:Nature cell biology

    pub_type: 已发布勘误

    doi:10.1038/s41556-018-0164-6

    authors: Wuidart A,Sifrim A,Fioramonti M,Matsumura S,Brisebarre A,Brown D,Centonze A,Dannau A,Dubois C,Van Keymeulen A,Voet T,Blanpain C

    更新日期:2018-09-01 00:00:00

  • Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.

    abstract::The target of rapamycin complex 2 (TORC2) plays a key role in maintaining the homeostasis of plasma membrane (PM) tension. TORC2 activation following increased PM tension involves redistribution of the Slm1 and 2 paralogues from PM invaginations known as eisosomes into membrane compartments containing TORC2. How Slm1/...

    journal_title:Nature cell biology

    pub_type: 杂志文章

    doi:10.1038/s41556-018-0150-z

    authors: Riggi M,Niewola-Staszkowska K,Chiaruttini N,Colom A,Kusmider B,Mercier V,Soleimanpour S,Stahl M,Matile S,Roux A,Loewith R

    更新日期:2018-09-01 00:00:00

  • Metastatic niche functions and therapeutic opportunities.

    abstract::Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external...

    journal_title:Nature cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/s41556-018-0145-9

    authors: Celià-Terrassa T,Kang Y

    更新日期:2018-08-01 00:00:00

  • Author Correction: Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.

    abstract::In the version of this Article originally published, the author had misnumbered the reference citations in the Methods, using numbers 1-14 instead of 46-59. These errors have now been corrected in all online versions of the Article. ...

    journal_title:Nature cell biology

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41556-018-0053-z

    authors: Chen J,Xu N,Wang C,Huang P,Huang H,Jin Z,Yu Z,Cai T,Jiao R,Xi R

    更新日期:2018-08-01 00:00:00

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