Abstract：
:Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia1, yet the physiological state of tau molecules within cells remains unclear. Using single-molecule imaging, we directly observe that the microtubule lattice regulates reversible tau self-association, leading to localized, dynamic condensation of tau molecules on the microtubule surface. Tau condensates form selectively permissible barriers, spatially regulating the activity of microtubule-severing enzymes and the movement of molecular motors through their boundaries. We propose that reversible self-association of tau molecules, gated by the microtubule lattice, is an important mechanism of the biological functions of tau, and that oligomerization of tau is a common property shared between the physiological and disease-associated forms of the molecule.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Tan R,Lam AJ,Tan T,Han J,Nowakowski DW,Vershinin M,Simó S,Ori-McKenney KM,McKenney RJdoi
10.1038/s41556-019-0375-5subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1078-1085issue
9eissn
1465-7392issn
1476-4679pii
10.1038/s41556-019-0375-5journal_volume
21pub_type
杂志文章abstract：:Ciliates and flagellates temporarily swim backwards on collision by generating a mechanoreceptor potential. Although this potential has been shown to be associated with cilia in Paramecium, the molecular entity of the mechanoreceptor has remained unknown. Here we show that Chlamydomonas cells express TRP11, a member o...
journal_title：Nature cell biology
pub_type： 杂志文章
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abstract：:The mitogen-activated protein kinase (MAPK) network is a conserved signalling module that regulates cell fate by transducing a myriad of growth-factor signals. The ability of this network to coordinate and process a variety of inputs from different growth-factor receptors into specific biological responses is, however...
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pub_type： 评论,新闻
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pub_type： 杂志文章,已发布勘误
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更新日期：2006-02-01 00:00:00
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journal_title：Nature cell biology
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