Author Correction: Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.

abstract：:Recent theoretical analysis of a model lattice of interacting transmembrane receptor proteins has indicated that such clustering in the membrane could provide a novel mechanism for regulating receptor signalling in cells. It has been calculated that cooperative interactions between receptors organized into a cluster, ...

journal_title：Nature cell biology

authors： Yin CC,Lai FA

更新日期：2000-09-01 00:00:00

abstract：:Dyneins are large microtubule motor proteins required for mitosis, intracellular transport and ciliary and flagellar motility. They generate force through a power-stroke mechanism, which is an ATP-consuming cycle of pre- and post-power-stroke conformational changes that cause relative motion between different dynein d...

journal_title：Nature cell biology

authors： Lin J,Okada K,Raytchev M,Smith MC,Nicastro D

更新日期：2014-05-01 00:00:00

abstract：:Rad23 is a nucleotide-excision repair protein with a previously unknown biochemical function. We determined that yeast and human Rad23 inhibited multi-ubiquitin (Ub) chain formation and the degradation of proteolytic substrates. Significantly, Rad23 could be co-precipitated with a substrate that contained a short mult...

journal_title：Nature cell biology

authors： Ortolan TG,Tongaonkar P,Lambertson D,Chen L,Schauber C,Madura K

更新日期：2000-09-01 00:00:00

abstract：:Current models for the export of messenger RNA share the notion that the highly abundant class of nuclear RNA-binding proteins--the hnRNP proteins--have a key role in exporting RNA. But recent studies have led to a new understanding of several non-hnRNP proteins, including SR proteins and the conserved mRNA export fac...

journal_title：Nature cell biology

authors： Reed R,Magni K

更新日期：2001-09-01 00:00:00

abstract：:Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating bot...

journal_title：Nature cell biology

authors： Le Bouteiller M,Jensen KB

更新日期：2015-01-01 00:00:00

abstract：:Lamellipodia/ruffles and filopodia are protruding organelles containing short and highly branched or long and unbranched actin filaments, respectively. The microscopic morphology, dynamic development and protein signature of both lamellipodia/ruffles and filopodia have been investigated; however, little is known about...

journal_title：Nature cell biology

authors： Beli P,Mascheroni D,Xu D,Innocenti M

更新日期：2008-07-01 00:00:00

abstract：:In three-dimensional matrices cancer cells move with a rounded, amoeboid morphology that is controlled by ROCK-dependent contraction of acto-myosin. In this study, we show that PDK1 is required for phosphorylation of myosin light chain and cell motility, both on deformable gels and in vivo. Depletion of PDK1 alters th...

journal_title：Nature cell biology

authors： Pinner S,Sahai E

更新日期：2008-02-01 00:00:00

abstract：:Endoplasmic reticulum (ER)-associated protein degradation by the ubiquitin-proteasome system requires the dislocation of substrates from the ER into the cytosol. It has been speculated that a functional ubiquitin proteasome pathway is not only essential for proteolysis, but also for the preceding export step. Here, we...

journal_title：Nature cell biology

authors： Jarosch E,Taxis C,Volkwein C,Bordallo J,Finley D,Wolf DH,Sommer T

更新日期：2002-02-01 00:00:00

abstract：:Cell division is fundamental for all organisms. Here we report a genome-scale RNA-mediated interference screen in HeLa cells designed to identify human genes that are important for cell division. We have used a library of endoribonuclease-prepared short interfering RNAs for gene silencing and have used DNA content ana...

journal_title：Nature cell biology

authors： Kittler R,Pelletier L,Heninger AK,Slabicki M,Theis M,Miroslaw L,Poser I,Lawo S,Grabner H,Kozak K,Wagner J,Surendranath V,Richter C,Bowen W,Jackson AL,Habermann B,Hyman AA,Buchholz F

更新日期：2007-12-01 00:00:00

abstract：:The double fertilization process in angiosperms is based on the delivery of a pair of sperm cells by the pollen tube (the male gametophyte), which elongates towards an embryo sac (the female gametophyte) enclosing an egg and a central cell. Several studies have described the mechanisms of gametophyte interaction, and ...

journal_title：Nature cell biology

authors： Mori T,Kuroiwa H,Higashiyama T,Kuroiwa T

更新日期：2006-01-01 00:00:00

abstract：:The SNF2h (sucrose non-fermenting protein 2 homologue)-containing chromatin-remodelling complex NoRC silences a fraction of ribosomal RNA genes (rDNA) by establishing a heterochromatic structure at the rDNA promoter. Here we show that the acetyltransferase MOF (males absent on the first) acetylates TIP5, the largest s...

journal_title：Nature cell biology

authors： Zhou Y,Schmitz KM,Mayer C,Yuan X,Akhtar A,Grummt I

更新日期：2009-08-01 00:00:00

abstract：:The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in r...

journal_title：Nature cell biology

authors： Oberst A

更新日期：2017-09-29 00:00:00

abstract：:ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardio...

journal_title：Nature cell biology

authors： David R,Brenner C,Stieber J,Schwarz F,Brunner S,Vollmer M,Mentele E,Müller-Höcker J,Kitajima S,Lickert H,Rupp R,Franz WM

更新日期：2008-03-01 00:00:00

abstract：:During the development of multicellular organisms, concerted actions of molecular signalling networks determine whether cells undergo proliferation, differentiation, death or ageing. Here we show that genetic inactivation of the stress signalling kinase, MKK7, a direct activator of JNKs in mice, results in embryonic l...

journal_title：Nature cell biology

authors： Wada T,Joza N,Cheng HY,Sasaki T,Kozieradzki I,Bachmaier K,Katada T,Schreiber M,Wagner EF,Nishina H,Penninger JM

更新日期：2004-03-01 00:00:00

abstract：:Genomic integrity is maintained by checkpoints that guard against undesired replication after DNA damage. Here, we show that CDT1, a licensing factor of the pre-replication complex (preRC), is rapidly proteolysed after UV- or gamma-irradiation. The preRC assembles on replication origins at the end of mitosis and durin...

journal_title：Nature cell biology

authors： Higa LA,Mihaylov IS,Banks DP,Zheng J,Zhang H

更新日期：2003-11-01 00:00:00

abstract：:During cell division, many animal cells transform into a spherical shape and assemble a contractile ring composed of actin filaments and myosin motors at the equator to separate the cell body into two. Although actomyosin regulatory proteins are spatio-temporally controlled during cytokinesis, the direct contribution ...

journal_title：Nature cell biology

authors： Miyazaki M,Chiba M,Eguchi H,Ohki T,Ishiwata S

更新日期：2015-04-01 00:00:00

abstract：:The resolution of joint molecules that link recombining sister chromatids is essential for chromosome segregation. Here, we determine the fate of unresolved recombination intermediates arising in cells lacking two nucleases required for resolution (GEN1 -/- knockout cells depleted of MUS81). We find that intermediates...

journal_title：Nature cell biology

authors： Chan YW,Fugger K,West SC

更新日期：2018-01-01 00:00:00

abstract：:Actin dynamics is a tightly regulated process involved in various cellular events including biogenesis of clathrin-coated, AP-1 (adaptor protein 1)-coated transport carriers connecting the trans-Golgi network (TGN) and the endocytic pathway. However, the mechanisms coordinating coat assembly, membrane and actin remode...

journal_title：Nature cell biology

authors： Anitei M,Stange C,Parshina I,Baust T,Schenck A,Raposo G,Kirchhausen T,Hoflack B

更新日期：2010-04-01 00:00:00

abstract：:Treatment of cultured vertebrate neurons with nitric oxide leads to growth-cone collapse, axon retraction and the reconfiguration of axonal microtubules. We show that the light chain of microtubule-associated protein (MAP) 1B is a substrate for S-nitrosylation in vivo, in cultured cells and in vitro. S-nitrosylation o...

journal_title：Nature cell biology

authors： Stroissnigg H,Trancíková A,Descovich L,Fuhrmann J,Kutschera W,Kostan J,Meixner A,Nothias F,Propst F

更新日期：2007-09-01 00:00:00

abstract：:The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find ...

journal_title：Nature cell biology

authors： Hanssen LLP,Kassouf MT,Oudelaar AM,Biggs D,Preece C,Downes DJ,Gosden M,Sharpe JA,Sloane-Stanley JA,Hughes JR,Davies B,Higgs DR

更新日期：2017-08-01 00:00:00

abstract：:Glioblastoma multiforme (GBMs) are recurrent lethal brain tumours. Recurrent GBMs often exhibit mesenchymal, stem-like phenotypes that could explain their resistance to therapy. Analyses revealed that recurrent GBMs have increased tension and express high levels of glycoproteins that increase the bulkiness of the glyc...

journal_title：Nature cell biology

authors： Barnes JM,Kaushik S,Bainer RO,Sa JK,Woods EC,Kai F,Przybyla L,Lee M,Lee HW,Tung JC,Maller O,Barrett AS,Lu KV,Lakins JN,Hansen KC,Obernier K,Alvarez-Buylla A,Bergers G,Phillips JJ,Nam DH,Bertozzi CR,Weaver VM

更新日期：2018-10-01 00:00:00

abstract：:Apoptosis is induced by caspases, which are members of the cysteine protease family. Caspases are synthesized as inactive zymogens and initiator caspases first gain activity by associating with an oligomeric complex of their adaptor proteins, such as the apoptosome. Activated initiator caspases subsequently cleave and...

journal_title：Nature cell biology

authors： Shapiro PJ,Hsu HH,Jung H,Robbins ES,Ryoo HD

更新日期：2008-12-01 00:00:00

abstract：:Although nuclear envelope (NE) assembly is known to require the GTPase Ran, the membrane fusion machinery involved is uncharacterized. NE assembly involves formation of a reticular network on chromatin, fusion of this network into a closed NE and subsequent expansion. Here we show that p97, an AAA-ATPase previously im...

journal_title：Nature cell biology

authors： Hetzer M,Meyer HH,Walther TC,Bilbao-Cortes D,Warren G,Mattaj IW

更新日期：2001-12-01 00:00:00

abstract：:The asymmetric segregation of cell-fate determinants and the generation of daughter cells of different sizes rely on the correct orientation and position of the mitotic spindle. In the Drosophila embryo, the determinant Prospero is localized basally and is segregated equally to daughters of similar cell size during ep...

journal_title：Nature cell biology

authors： Kaltschmidt JA,Davidson CM,Brown NH,Brand AH

更新日期：2000-01-01 00:00:00

abstract：:Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2 5-phosphatase. Here we unveil a lysosomal response to the arrival of autophagosomal cargo i...

journal_title：Nature cell biology

authors： De Leo MG,Staiano L,Vicinanza M,Luciani A,Carissimo A,Mutarelli M,Di Campli A,Polishchuk E,Di Tullio G,Morra V,Levtchenko E,Oltrabella F,Starborg T,Santoro M,Di Bernardo D,Devuyst O,Lowe M,Medina DL,Ballabio A,De Ma

更新日期：2016-08-01 00:00:00

abstract：:When replication forks collapse, Rad3 phosphorylates the checkpoint-clamp protein Rad9 in a manner that depends on Thr 225, a residue within the PCNA-like domain. The physiological function of Thr 225-dependent Rad9 phosphorylation, however, remains elusive. Here, we show that Thr 225-dependent Rad9 phosphorylation by...

journal_title：Nature cell biology

authors： Kai M,Furuya K,Paderi F,Carr AM,Wang TS

更新日期：2007-06-01 00:00:00

abstract：:Ciliates and flagellates temporarily swim backwards on collision by generating a mechanoreceptor potential. Although this potential has been shown to be associated with cilia in Paramecium, the molecular entity of the mechanoreceptor has remained unknown. Here we show that Chlamydomonas cells express TRP11, a member o...

journal_title：Nature cell biology

authors： Fujiu K,Nakayama Y,Iida H,Sokabe M,Yoshimura K

更新日期：2011-05-01 00:00:00

abstract：:FoxG1 is an evolutionarily conserved, winged-helix transcriptional repressor that maintains progenitor cells in the vertebrate forebrain. How the activity of FoxG1 is regulated is not known. Here, we report that in the developing Xenopus and mouse forebrain, FoxG1 is nuclear in progenitor cells but cytoplasmic in diff...

journal_title：Nature cell biology

authors： Regad T,Roth M,Bredenkamp N,Illing N,Papalopulu N

更新日期：2007-05-01 00:00:00

abstract：:The AP-1 transcription factor c-Jun is essential for cellular proliferation in many cell types, but the molecular link between growth factors and c-Jun activation has been enigmatic. In this study we identify a previously uncharacterized RING-domain-containing protein, RACO-1 (RING domain AP-1 co-activator-1), as a c-...

journal_title：Nature cell biology

authors： Davies CC,Chakraborty A,Cipriani F,Haigh K,Haigh JJ,Behrens A

更新日期：2010-10-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cancers. Here, we generate quadruple TIMP knockout (TIMPless) fibroblasts ...

journal_title：Nature cell biology

authors： Shimoda M,Principe S,Jackson HW,Luga V,Fang H,Molyneux SD,Shao YW,Aiken A,Waterhouse PD,Karamboulas C,Hess FM,Ohtsuka T,Okada Y,Ailles L,Ludwig A,Wrana JL,Kislinger T,Khokha R

更新日期：2014-09-01 00:00:00