Hippo signalling directs intestinal fate.

abstract：:Rad23 is a nucleotide-excision repair protein with a previously unknown biochemical function. We determined that yeast and human Rad23 inhibited multi-ubiquitin (Ub) chain formation and the degradation of proteolytic substrates. Significantly, Rad23 could be co-precipitated with a substrate that contained a short mult...

journal_title：Nature cell biology

authors： Ortolan TG,Tongaonkar P,Lambertson D,Chen L,Schauber C,Madura K

更新日期：2000-09-01 00:00:00

abstract：:Primary cilia are required for vertebrate cells to respond to specific intercellular signals. Here we define when and where primary cilia appear in the mouse embryo using a transgenic line that expresses ARL13B-mCherry in cilia and Centrin 2-GFP in centrosomes. Primary cilia first appear on cells of the epiblast at E6...

journal_title：Nature cell biology

authors： Bangs FK,Schrode N,Hadjantonakis AK,Anderson KV

更新日期：2015-02-01 00:00:00

abstract：:Metaphase spindles are microtubule-based structures that use a multitude of proteins to modulate their morphology and function. Today, we understand many details of microtubule assembly, the role of microtubule-associated proteins, and the action of molecular motors. Ultimately, the challenge remains to understand how...

journal_title：Nature cell biology

authors： Reber SB,Baumgart J,Widlund PO,Pozniakovsky A,Howard J,Hyman AA,Jülicher F

更新日期：2013-09-01 00:00:00

abstract：:The presence of actin in the nucleus has been well established, and several studies have implicated nuclear actin in transcriptional regulation. Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is a member of the WASP family of proteins; these proteins function in the cytoplasm as key regulators of cortical actin fi...

journal_title：Nature cell biology

authors： Wu X,Yoo Y,Okuhama NN,Tucker PW,Liu G,Guan JL

更新日期：2006-07-01 00:00:00

abstract：:Parallel quantification of large numbers of messenger RNA transcripts using microarray technology promises to provide detailed insight into cellular processes involved in the regulation of gene expression. This should allow new understanding of signalling networks that operate in the cell and of the molecular basis an...

journal_title：Nature cell biology

authors： Schulze A,Downward J

更新日期：2001-08-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cancers. Here, we generate quadruple TIMP knockout (TIMPless) fibroblasts ...

journal_title：Nature cell biology

authors： Shimoda M,Principe S,Jackson HW,Luga V,Fang H,Molyneux SD,Shao YW,Aiken A,Waterhouse PD,Karamboulas C,Hess FM,Ohtsuka T,Okada Y,Ailles L,Ludwig A,Wrana JL,Kislinger T,Khokha R

更新日期：2014-09-01 00:00:00

abstract：:Extracellular signal-regulated kinase (ERK) controls fundamental cellular functions, including cell fate decisions. In PC12, cells shifting ERK activation from transient to sustained induces neuronal differentiation. As ERK associates with both regulators and effectors, we hypothesized that the mechanisms underlying t...

journal_title：Nature cell biology

authors： von Kriegsheim A,Baiocchi D,Birtwistle M,Sumpton D,Bienvenut W,Morrice N,Yamada K,Lamond A,Kalna G,Orton R,Gilbert D,Kolch W

更新日期：2009-12-01 00:00:00

abstract：:The planar cell polarity (PCP) signalling pathway is essential for embryonic development because it governs diverse cellular behaviours, and 'core PCP' proteins, such as Dishevelled and Frizzled, have been extensively characterized. By contrast, the 'PCP effector' proteins, such as Intu and Fuz, remain largely unstudi...

journal_title：Nature cell biology

authors： Gray RS,Abitua PB,Wlodarczyk BJ,Szabo-Rogers HL,Blanchard O,Lee I,Weiss GS,Liu KJ,Marcotte EM,Wallingford JB,Finnell RH

更新日期：2009-10-01 00:00:00

abstract：:Nutrient availability is central for T-cell functions and immune responses. Here we report that CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non-essential amino acid Asn. Increased Asn levels enhance CD8+ T-cell activation and effector functions against tumour cells in vitro and in ...

journal_title：Nature cell biology

authors： Wu J,Li G,Li L,Li D,Dong Z,Jiang P

更新日期：2021-01-01 00:00:00

abstract：:Cancer-induced immune responses affect tumour progression and therapeutic response. In multiple murine models and clinical datasets, we identified large variations of neutrophils and macrophages that define 'immune subtypes' of triple-negative breast cancer (TNBC), including neutrophil-enriched (NES) and macrophage-en...

journal_title：Nature cell biology

authors： Kim IS,Gao Y,Welte T,Wang H,Liu J,Janghorban M,Sheng K,Niu Y,Goldstein A,Zhao N,Bado I,Lo HC,Toneff MJ,Nguyen T,Bu W,Jiang W,Arnold J,Gu F,He J,Jebakumar D,Walker K,Li Y,Mo Q,Westbrook TF,Zong C,Rao A,

更新日期：2019-09-01 00:00:00

abstract：:Treatment of cultured vertebrate neurons with nitric oxide leads to growth-cone collapse, axon retraction and the reconfiguration of axonal microtubules. We show that the light chain of microtubule-associated protein (MAP) 1B is a substrate for S-nitrosylation in vivo, in cultured cells and in vitro. S-nitrosylation o...

journal_title：Nature cell biology

authors： Stroissnigg H,Trancíková A,Descovich L,Fuhrmann J,Kutschera W,Kostan J,Meixner A,Nothias F,Propst F

更新日期：2007-09-01 00:00:00

abstract：:The accurate spatial and temporal coordination of cell polarization with DNA replication and segregation guarantees the fidelity of genetic transmission. Here we report that in Saccharomyces cerevisiae, a build-up or burst of G1 cyclin-dependent kinase (CDK) activity through activation of the cyclin genes CLN1,2 and P...

journal_title：Nature cell biology

authors： Moffat J,Andrews B

更新日期：2004-01-01 00:00:00

abstract：: ...

journal_title：Nature cell biology

authors： Reddy D,Workman JL

更新日期：2018-12-01 00:00:00

abstract：:Protein ubiquitination regulates many cellular processes, including protein degradation, signal transduction, DNA repair and cell division. In the classical model, a uniform polyubiquitin chain that is linked through Lys 48 is required for recognition and degradation by the 26S proteasome. Here, we used a reconstitute...

journal_title：Nature cell biology

authors： Kirkpatrick DS,Hathaway NA,Hanna J,Elsasser S,Rush J,Finley D,King RW,Gygi SP

更新日期：2006-07-01 00:00:00

abstract：:Many classical biologists working in Antarctica have 'gone molecular' to study the physiological basis for life on or below the ice. Investigating the remarkable adaptations of specific cells, organelles and molecules to this extreme environment can provide new perspectives on the processes studied in conventional exp...

journal_title：Nature cell biology

authors： Römisch K,Matheson T

更新日期：2003-01-01 00:00:00

abstract：:The asymmetric segregation of cell-fate determinants and the generation of daughter cells of different sizes rely on the correct orientation and position of the mitotic spindle. In the Drosophila embryo, the determinant Prospero is localized basally and is segregated equally to daughters of similar cell size during ep...

journal_title：Nature cell biology

authors： Kaltschmidt JA,Davidson CM,Brown NH,Brand AH

更新日期：2000-01-01 00:00:00

abstract：:Blocking mitotic progression has been proposed as an attractive therapeutic strategy to impair proliferation of tumour cells. However, how cells survive during prolonged mitotic arrest is not well understood. We show here that survival during mitotic arrest is affected by the special energetic requirements of mitotic ...

journal_title：Nature cell biology

authors： Doménech E,Maestre C,Esteban-Martínez L,Partida D,Pascual R,Fernández-Miranda G,Seco E,Campos-Olivas R,Pérez M,Megias D,Allen K,López M,Saha AK,Velasco G,Rial E,Méndez R,Boya P,Salazar-Roa M,Malumbres M

更新日期：2015-10-01 00:00:00

abstract：:Formins have been implicated in the regulation of cytoskeletal structure in animals and fungi. Here we show that the formins Bni1 and Bnr1 of budding yeast stimulate the assembly of actin filaments that function as precursors to tropomyosin-stabilized cables that direct polarized cell growth. With loss of formin funct...

journal_title：Nature cell biology

authors： Evangelista M,Pruyne D,Amberg DC,Boone C,Bretscher A

更新日期：2002-03-01 00:00:00

abstract：:The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to the state of attachment of the kinetochore to spindle microtubules. SAC signalling is activated by unattached kinetochores, and it is silenced after these kinetochores form end-on microtubule attachments. Although the biochemical c...

journal_title：Nature cell biology

authors： Aravamudhan P,Goldfarb AA,Joglekar AP

更新日期：2015-07-01 00:00:00

abstract：:During cell division, many animal cells transform into a spherical shape and assemble a contractile ring composed of actin filaments and myosin motors at the equator to separate the cell body into two. Although actomyosin regulatory proteins are spatio-temporally controlled during cytokinesis, the direct contribution ...

journal_title：Nature cell biology

authors： Miyazaki M,Chiba M,Eguchi H,Ohki T,Ishiwata S

更新日期：2015-04-01 00:00:00

abstract：:Actin networks drive many essential cellular processes, including cell migration, cytokinesis and tissue morphogenesis. However, how cells organize and regulate dynamic actin networks that consist of long, unbranched actin filaments is only poorly understood. This study in mouse oocytes reveals that cells can use vesi...

journal_title：Nature cell biology

authors： Holubcová Z,Howard G,Schuh M

更新日期：2013-08-01 00:00:00

abstract：:BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to neurodegeneration. The voltage-gated sodium channel (Na(v)1) beta2-subunit (beta2), a type I membrane protein that covalently binds to Na(v)1 alpha-subunits, is a substrate for BACE1 and gamma-secretase...

journal_title：Nature cell biology

authors： Kim DY,Carey BW,Wang H,Ingano LA,Binshtok AM,Wertz MH,Pettingell WH,He P,Lee VM,Woolf CJ,Kovacs DM

更新日期：2007-07-01 00:00:00

abstract：:Cancer cells use aerobic glycolysis preferentially for energy provision and this metabolic change is important for tumour growth. Here, we have found a link between the tumour suppressor p53, the transcription factor NF-kappaB and glycolysis. In p53-deficient primary cultured cells, kinase activities of IKKalpha and I...

journal_title：Nature cell biology

authors： Kawauchi K,Araki K,Tobiume K,Tanaka N

更新日期：2008-05-01 00:00:00

abstract：:The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and...

journal_title：Nature cell biology

authors： Varga J,Greten FR

更新日期：2017-10-01 00:00:00

abstract：:Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyses the trimethylation of histone H3 on Lys 27 (H3K27), which represses gene transcription. EZH2 enhances cancer-cell invasiveness and regulates stem cell differentiation. Here, we demonstrate that EZH2 can ...

journal_title：Nature cell biology

authors： Wei Y,Chen YH,Li LY,Lang J,Yeh SP,Shi B,Yang CC,Yang JY,Lin CY,Lai CC,Hung MC

更新日期：2011-01-01 00:00:00

abstract：:In the version of this Resource originally published, owing to a technical error an incorrect file was used for Supplementary Table 2; this has now been replaced with the correct file. ...

journal_title：Nature cell biology

authors： Li L,Guo F,Gao Y,Ren Y,Yuan P,Yan L,Li R,Lian Y,Li J,Hu B,Gao J,Wen L,Tang F,Qiao J

更新日期：2018-10-01 00:00:00

abstract：:To learn more about cancer-associated fibroblasts (CAFs), we have isolated fibroblasts from different stages of breast cancer progression and analysed their function and gene expression. These analyses reveal that activation of the YAP transcription factor is a signature feature of CAFs. YAP function is required for C...

journal_title：Nature cell biology

authors： Calvo F,Ege N,Grande-Garcia A,Hooper S,Jenkins RP,Chaudhry SI,Harrington K,Williamson P,Moeendarbary E,Charras G,Sahai E

更新日期：2013-06-01 00:00:00

abstract：:The target of rapamycin complex 2 (TORC2) plays a key role in maintaining the homeostasis of plasma membrane (PM) tension. TORC2 activation following increased PM tension involves redistribution of the Slm1 and 2 paralogues from PM invaginations known as eisosomes into membrane compartments containing TORC2. How Slm1/...

journal_title：Nature cell biology

authors： Riggi M,Niewola-Staszkowska K,Chiaruttini N,Colom A,Kusmider B,Mercier V,Soleimanpour S,Stahl M,Matile S,Roux A,Loewith R

更新日期：2018-09-01 00:00:00

abstract：:Proteins essential for vesicle formation by the Coat Protein I (COPI) complex are being identified, but less is known about the role of specific lipids. Brefeldin-A ADP-ribosylated substrate (BARS) functions in the fission step of COPI vesicle formation. Here, we show that BARS induces membrane curvature in cooperatio...

journal_title：Nature cell biology

authors： Yang JS,Gad H,Lee SY,Mironov A,Zhang L,Beznoussenko GV,Valente C,Turacchio G,Bonsra AN,Du G,Baldanzi G,Graziani A,Bourgoin S,Frohman MA,Luini A,Hsu VW

更新日期：2008-10-01 00:00:00

abstract：:Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11-Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11-Rab8 cascade, ...

journal_title：Nature cell biology

authors： Lu Q,Insinna C,Ott C,Stauffer J,Pintado PA,Rahajeng J,Baxa U,Walia V,Cuenca A,Hwang YS,Daar IO,Lopes S,Lippincott-Schwartz J,Jackson PK,Caplan S,Westlake CJ

更新日期：2015-03-01 00:00:00