A new view of mRNA export: separating the wheat from the chaff.

abstract：:Lysosomes respond to environmental cues by controlling their own biogenesis, but the underlying mechanisms are poorly understood. Here we describe a protein kinase C (PKC)-dependent and mTORC1-independent mechanism for regulating lysosome biogenesis, which provides insights into previously reported effects of PKC on l...

journal_title：Nature cell biology

authors： Li Y,Xu M,Ding X,Yan C,Song Z,Chen L,Huang X,Wang X,Jian Y,Tang G,Tang C,Di Y,Mu S,Liu X,Liu K,Li T,Wang Y,Miao L,Guo W,Hao X,Yang C

更新日期：2016-10-01 00:00:00

abstract：:Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11-Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11-Rab8 cascade, ...

journal_title：Nature cell biology

authors： Lu Q,Insinna C,Ott C,Stauffer J,Pintado PA,Rahajeng J,Baxa U,Walia V,Cuenca A,Hwang YS,Daar IO,Lopes S,Lippincott-Schwartz J,Jackson PK,Caplan S,Westlake CJ

更新日期：2015-03-01 00:00:00

abstract：:Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now been shed on the molecular requirements of LAP, establishing a central role for the protein Rubic...

journal_title：Nature cell biology

authors： Boyle KB,Randow F

更新日期：2015-07-01 00:00:00

abstract：:The GTPase dynamin plays an essential part in endocytosis by catalysing the fission of nascent clathrin-coated vesicles from the plasma membrane. Using preformed phosphatidylinositol-4,5-bisphosphate-containing lipid nanotubes as a membrane template for dynamin self-assembly, we investigate the conformational changes ...

journal_title：Nature cell biology

authors： Stowell MH,Marks B,Wigge P,McMahon HT

更新日期：1999-05-01 00:00:00

abstract：:In Huntington disease, polyglutamine expansion of the protein huntingtin (Htt) leads to selective neurodegenerative loss of medium spiny neurons throughout the striatum by an unknown apoptotic mechanism. Binding of Hip-1, a protein normally associated with Htt, is reduced by polyglutamine expansion. Free Hip-1 binds t...

journal_title：Nature cell biology

authors： Gervais FG,Singaraja R,Xanthoudakis S,Gutekunst CA,Leavitt BR,Metzler M,Hackam AS,Tam J,Vaillancourt JP,Houtzager V,Rasper DM,Roy S,Hayden MR,Nicholson DW

更新日期：2002-02-01 00:00:00

abstract：:Given the important role of the hypothalamus in regulating feeding and metabolism, there has been considerable interest in a possible function for hypothalamic stem cells in modulating body weight in health and disease. Mice given a high-fat diet develop inflammation in the hypothalamus and lose key types of neurons. ...

journal_title：Nature cell biology

authors： Livesey FJ

更新日期：2012-10-01 00:00:00

abstract：:Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to divide during a new hair cycle. The quiescence of HFSCs is known to be regulated by a number of intrinsic and extrinsic mechanisms. Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism a...

journal_title：Nature cell biology

authors： Flores A,Schell J,Krall AS,Jelinek D,Miranda M,Grigorian M,Braas D,White AC,Zhou JL,Graham NA,Graeber T,Seth P,Evseenko D,Coller HA,Rutter J,Christofk HR,Lowry WE

更新日期：2017-09-01 00:00:00

abstract：:Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed microtubule seeds or from γ-tubulin recruited to the side of a pre-existing microtubule. Here, we found that microtubules c...

journal_title：Nature cell biology

authors： Basnet N,Nedozralova H,Crevenna AH,Bodakuntla S,Schlichthaerle T,Taschner M,Cardone G,Janke C,Jungmann R,Magiera MM,Biertümpfel C,Mizuno N

更新日期：2018-10-01 00:00:00

abstract：:In the version of this Article originally published, ref. 52 was incorrectly only attributed to its corresponding author, Fre, S., and an older title was used. The correct citation should have been: Lilja, A. M. et al. Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain...

journal_title：Nature cell biology

authors： Wuidart A,Sifrim A,Fioramonti M,Matsumura S,Brisebarre A,Brown D,Centonze A,Dannau A,Dubois C,Van Keymeulen A,Voet T,Blanpain C

更新日期：2018-09-01 00:00:00

abstract：:Haematopoietic stem cells (HSCs) arise in the developing aorta during embryogenesis. The number of HSC clones born has been estimated through transplantation, but experimental approaches to assess the absolute number of forming HSCs in a native setting have remained challenging. Here, we applied single-cell and clonal...

journal_title：Nature cell biology

authors： Henninger J,Santoso B,Hans S,Durand E,Moore J,Mosimann C,Brand M,Traver D,Zon L

更新日期：2017-01-01 00:00:00

abstract：:The mechanistic target of rapamycin (mTOR) functions as a critical regulator of cellular growth and metabolism by forming multi-component, yet functionally distinct complexes mTORC1 and mTORC2. Although mTORC2 has been implicated in mTORC1 activation, little is known about how mTORC2 is regulated. Here we report that ...

journal_title：Nature cell biology

authors： Liu P,Gan W,Inuzuka H,Lazorchak AS,Gao D,Arojo O,Liu D,Wan L,Zhai B,Yu Y,Yuan M,Kim BM,Shaik S,Menon S,Gygi SP,Lee TH,Asara JM,Manning BD,Blenis J,Su B,Wei W

更新日期：2013-11-01 00:00:00

abstract：:Etk/BMX, a member of the Btk family of tyrosine kinases, is highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines. Here, we present evidence that Etk is involved in integrin signalling and promotes cell migration. The activation of Etk by extracellula...

journal_title：Nature cell biology

authors： Chen R,Kim O,Li M,Xiong X,Guan JL,Kung HJ,Chen H,Shimizu Y,Qiu Y

更新日期：2001-05-01 00:00:00

abstract：:Junior researchers are encouraged to gain experience abroad, and for senior scientists, sabbaticals remain popular. France has taken the next step in fostering international exchange, by supporting long-term collaborations with foreign laboratories and by creating research units abroad. ...

journal_title：Nature cell biology

authors：

更新日期：2007-06-01 00:00:00

abstract：:Rad23 is a nucleotide-excision repair protein with a previously unknown biochemical function. We determined that yeast and human Rad23 inhibited multi-ubiquitin (Ub) chain formation and the degradation of proteolytic substrates. Significantly, Rad23 could be co-precipitated with a substrate that contained a short mult...

journal_title：Nature cell biology

authors： Ortolan TG,Tongaonkar P,Lambertson D,Chen L,Schauber C,Madura K

更新日期：2000-09-01 00:00:00

abstract：:Coordination of microtubules and the actin cytoskeleton is important in several types of cell movement. mDia1 is a member of the formin-homology family of proteins and an effector of the small GTPase Rho. It contains the Rho-binding domain in its amino terminus and two distinct regions of formin homology, FH1 in the m...

journal_title：Nature cell biology

authors： Ishizaki T,Morishima Y,Okamoto M,Furuyashiki T,Kato T,Narumiya S

更新日期：2001-01-01 00:00:00

abstract：:Canonical Wnt signalling has been implicated in mouse and human embryonic stem cell (ESC) maintenance; however, its requirement is controversial. β-catenin is the key component in this highly conserved Wnt pathway, acting as a transcriptional transactivator. However, β-catenin has additional roles at the plasma membra...

journal_title：Nature cell biology

authors： Lyashenko N,Winter M,Migliorini D,Biechele T,Moon RT,Hartmann C

更新日期：2011-06-19 00:00:00

abstract：:The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from other extracellular vesicles in terms of their biogenesis and functions remains ...

journal_title：Nature cell biology

authors： Mathieu M,Martin-Jaular L,Lavieu G,Théry C

更新日期：2019-01-01 00:00:00

abstract：:Pyruvate kinase M2 (PKM2) is upregulated in multiple cancer types and contributes to the Warburg effect by unclear mechanisms. Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1. Phosphor...

journal_title：Nature cell biology

authors： Yang W,Zheng Y,Xia Y,Ji H,Chen X,Guo F,Lyssiotis CA,Aldape K,Cantley LC,Lu Z

更新日期：2012-12-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) induces epithelial-mesenchymal transdifferentiation (EMT) accompanied by cellular differentiation and migration. Despite extensive transcriptomic profiling, the identification of TGF-beta-inducible, EMT-specific genes has met with limited success. Here we identify a post-tran...

journal_title：Nature cell biology

authors： Chaudhury A,Hussey GS,Ray PS,Jin G,Fox PL,Howe PH

更新日期：2010-03-01 00:00:00

abstract：:Autophagy is characterized by the sequestration of bulk cytoplasm, including damaged proteins and organelles, and delivery of the cargo to lysosomes for degradation. Although the autophagic pathway is also linked to tumour suppression activity, the mechanism is not yet clear. Here we report that cytosolic FoxO1, a for...

journal_title：Nature cell biology

authors： Zhao Y,Yang J,Liao W,Liu X,Zhang H,Wang S,Wang D,Feng J,Yu L,Zhu WG

更新日期：2010-07-01 00:00:00

abstract：:Primary cilia are required for vertebrate cells to respond to specific intercellular signals. Here we define when and where primary cilia appear in the mouse embryo using a transgenic line that expresses ARL13B-mCherry in cilia and Centrin 2-GFP in centrosomes. Primary cilia first appear on cells of the epiblast at E6...

journal_title：Nature cell biology

authors： Bangs FK,Schrode N,Hadjantonakis AK,Anderson KV

更新日期：2015-02-01 00:00:00

abstract：:When brassinosteroid levels are low, the GSK3-like kinase BIN2 phosphorylates and inactivates the BZR1 transcription factor to inhibit growth in plants. Brassinosteroid promotes growth by inducing dephosphorylation of BZR1, but the phosphatase that dephosphorylates BZR1 has remained unknown. Here, using tandem affinit...

journal_title：Nature cell biology

authors： Tang W,Yuan M,Wang R,Yang Y,Wang C,Oses-Prieto JA,Kim TW,Zhou HW,Deng Z,Gampala SS,Gendron JM,Jonassen EM,Lillo C,DeLong A,Burlingame AL,Sun Y,Wang ZY

更新日期：2011-02-01 00:00:00

abstract：:The actin cable is a supracellular structure that embryonic epithelia produce to close gaps. However, the action of the cable remains debated. Here, we address the function of the cable using Drosophila dorsal closure, a paradigm to understand wound healing. First, we show that the actin cytoskeleton protein Zasp52 is...

journal_title：Nature cell biology

authors： Ducuing A,Vincent S

更新日期：2016-11-01 00:00:00

abstract：:Cohesin confers both intrachromatid and interchromatid cohesion through formation of a tripartite ring within which DNA is thought to be entrapped. Here, I discuss what is known about the four stages of the cohesin ring cycle using the ring model as an intellectual framework. I postulate that cohesin loading onto chro...

journal_title：Nature cell biology

authors： Nasmyth K

更新日期：2011-10-03 00:00:00

abstract：:During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes that specify lineage and differentiation status. Among these factors, the transforming growth factor (TGF)-beta family is imp...

journal_title：Nature cell biology

authors： Derynck R,Akhurst RJ

更新日期：2007-09-01 00:00:00

abstract：:When cells enter mitosis with DNA that is unfit to be segregated, the consequences appear to be loss of centrosome function, abnormal spindles and a failure to segregate chromosomes. These defects may result from the workings of a surveillance mechanism that acts to cull irreparable nuclei. ...

journal_title：Nature cell biology

authors： Su TT,Vidwans SJ

更新日期：2000-02-01 00:00:00

abstract：:Clathrin-coated vesicles mediate endocytosis and transport between the trans-Golgi network (TGN) and endosomes in eukaryotic cells. Clathrin adaptors play central roles in coat assembly, interacting with clathrin, cargo and membranes. Two main types of clathrin adaptor act in TGN-endosome traffic: GGA proteins and the...

journal_title：Nature cell biology

authors： Daboussi L,Costaguta G,Payne GS

更新日期：2012-02-19 00:00:00

abstract：:Several subunits of the class III phosphatidylinositol-3-OH kinase (PI(3)K-III) complex are known as tumour suppressors. Here we uncover a function for this complex and its catalytic product phosphatidylinositol-3-phosphate (PtdIns(3)P) in cytokinesis. We show that PtdIns(3)P localizes to the midbody during cytokinesi...

journal_title：Nature cell biology

authors： Sagona AP,Nezis IP,Pedersen NM,Liestøl K,Poulton J,Rusten TE,Skotheim RI,Raiborg C,Stenmark H

更新日期：2010-04-01 00:00:00

abstract：:Somatic cell reprogramming by exogenous factors requires cooperation with transcriptional co-activators and co-repressors to effectively remodel the epigenetic environment. How this interplay is regulated remains poorly understood. Here, we demonstrate that NCoR/SMRT co-repressors bind to pluripotency loci to create a...

journal_title：Nature cell biology

authors： Zhuang Q,Li W,Benda C,Huang Z,Ahmed T,Liu P,Guo X,Ibañez DP,Luo Z,Zhang M,Abdul MM,Yang Z,Yang J,Huang Y,Zhang H,Huang D,Zhou J,Zhong X,Zhu X,Fu X,Fan W,Liu Y,Xu Y,Ward C,Khan MJ,Kanwal S,Mirza B,Tor

更新日期：2018-04-01 00:00:00

abstract：:Plant cell morphogenesis relies on the organization and function of two polymer arrays separated by the plasma membrane: the cortical microtubule cytoskeleton and cellulose microfibrils in the cell wall. Studies using in vivo markers confirmed that one function of the cortical microtubule array is to drive organizatio...

journal_title：Nature cell biology

authors： Gutierrez R,Lindeboom JJ,Paredez AR,Emons AM,Ehrhardt DW

更新日期：2009-07-01 00:00:00