Biologistes sans frontières.

abstract：:It has long-been accepted that normal somatic cells have intrinsic mechanisms that limit their proliferative lifespan. Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential. ...

journal_title：Nature cell biology

authors： Lloyd AC

更新日期：2002-02-01 00:00:00

abstract：:Gastrulation leads to three germ layers--ectoderm, mesoderm and endoderm--that are separated by two basement membranes. In the mouse embryo, the emergent gut endoderm results from the widespread intercalation of cells of two distinct origins: pluripotent epiblast-derived definitive endoderm (DE) and extra-embryonic vi...

journal_title：Nature cell biology

authors： Viotti M,Nowotschin S,Hadjantonakis AK

更新日期：2014-12-01 00:00:00

abstract：:Here we investigate the role of the control of apoptosis in normal cell division. We show that interference with the expression or function of the apoptosis inhibitor survivin causes caspase-dependent cell death in the G2/M phase of the cell cycle, and a cell-division defect characterized by centrosome dysregulation, ...

journal_title：Nature cell biology

authors： Li F,Ackermann EJ,Bennett CF,Rothermel AL,Plescia J,Tognin S,Villa A,Marchisio PC,Altieri DC

更新日期：1999-12-01 00:00:00

abstract：:Starvation of animals or cells triggers autophagic degradation of cell contents to retrieve nutrients, but, paradoxically, mitochondria enlarge. This is now shown to result from inhibition of mitochondrial fission through PKA-mediated phosphorylation of the GTPase DRP1. Elongation of mitochondria optimizes ATP product...

journal_title：Nature cell biology

authors： Blackstone C,Chang CR

更新日期：2011-05-01 00:00:00

abstract：:Autophagy is characterized by the sequestration of bulk cytoplasm, including damaged proteins and organelles, and delivery of the cargo to lysosomes for degradation. Although the autophagic pathway is also linked to tumour suppression activity, the mechanism is not yet clear. Here we report that cytosolic FoxO1, a for...

journal_title：Nature cell biology

authors： Zhao Y,Yang J,Liao W,Liu X,Zhang H,Wang S,Wang D,Feng J,Yu L,Zhu WG

更新日期：2010-07-01 00:00:00

abstract：:The actin cytoskeleton has been implicated in restricting diffusion of plasma membrane components. Here, simultaneous observations of quantum dot-labelled FcepsilonRI motion and GFP-tagged actin dynamics provide direct evidence that actin filament bundles define micron-sized domains that confine mobile receptors. Dyna...

journal_title：Nature cell biology

authors： Andrews NL,Lidke KA,Pfeiffer JR,Burns AR,Wilson BS,Oliver JM,Lidke DS

更新日期：2008-08-01 00:00:00

abstract：:Primary cilia are required for vertebrate cells to respond to specific intercellular signals. Here we define when and where primary cilia appear in the mouse embryo using a transgenic line that expresses ARL13B-mCherry in cilia and Centrin 2-GFP in centrosomes. Primary cilia first appear on cells of the epiblast at E6...

journal_title：Nature cell biology

authors： Bangs FK,Schrode N,Hadjantonakis AK,Anderson KV

更新日期：2015-02-01 00:00:00

abstract：:Here we show that human Zeste White 10 (Zw10) and Rough deal (Rod) are new components of the mitotic checkpoint, as cells lacking these proteins at kinetochores fail to arrest in mitosis when exposed to microtubule inhibitors. Checkpoint failure and premature mitotic exit may explain why cells defective for hZw10 and ...

journal_title：Nature cell biology

authors： Chan GK,Jablonski SA,Starr DA,Goldberg ML,Yen TJ

更新日期：2000-12-01 00:00:00

abstract：:As obligatory intracellular parasites, viruses rely on host-cell functions for most aspects of their replication cycle. This is born out during entry, when most viruses that infect vertebrate and insect cells exploit the endocytic activities of the host cell to move into the cytoplasm. Viruses belonging to vaccinia, a...

journal_title：Nature cell biology

authors： Mercer J,Helenius A

更新日期：2009-05-01 00:00:00

abstract：:Cancer-induced immune responses affect tumour progression and therapeutic response. In multiple murine models and clinical datasets, we identified large variations of neutrophils and macrophages that define 'immune subtypes' of triple-negative breast cancer (TNBC), including neutrophil-enriched (NES) and macrophage-en...

journal_title：Nature cell biology

authors： Kim IS,Gao Y,Welte T,Wang H,Liu J,Janghorban M,Sheng K,Niu Y,Goldstein A,Zhao N,Bado I,Lo HC,Toneff MJ,Nguyen T,Bu W,Jiang W,Arnold J,Gu F,He J,Jebakumar D,Walker K,Li Y,Mo Q,Westbrook TF,Zong C,Rao A,

更新日期：2019-09-01 00:00:00

abstract：:RNA interference has become an indispensable tool for loss-of-function studies across eukaryotes. By enabling stable and reversible gene silencing, shRNAs provide a means to study long-term phenotypes, perform pool-based forward genetic screens and examine the consequences of temporary target inhibition in vivo. Howev...

journal_title：Nature cell biology

authors： Fellmann C,Lowe SW

更新日期：2014-01-01 00:00:00

abstract：:Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated chloride channel expressed in a wide variety of epithelial cells, mutations of which are responsible for the hallmark defective chloride secretion observed in cystic fibrosis (CF). Although CFTR has been implicated in bicarbonate secretion,...

journal_title：Nature cell biology

authors： Wang XF,Zhou CX,Shi QX,Yuan YY,Yu MK,Ajonuma LC,Ho LS,Lo PS,Tsang LL,Liu Y,Lam SY,Chan LN,Zhao WC,Chung YW,Chan HC

更新日期：2003-10-01 00:00:00

abstract：:Historically, the late arrival of optical microscopy is something of a puzzle, although it may be a testament to the fact that the development of new technology is driven by the desire for scientific knowledge, and not the other way around. The explorations that began in the 17th century are by no means complete, but ...

journal_title：Nature cell biology

authors： Amos B

更新日期：2000-08-01 00:00:00

abstract：:Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2 5-phosphatase. Here we unveil a lysosomal response to the arrival of autophagosomal cargo i...

journal_title：Nature cell biology

authors： De Leo MG,Staiano L,Vicinanza M,Luciani A,Carissimo A,Mutarelli M,Di Campli A,Polishchuk E,Di Tullio G,Morra V,Levtchenko E,Oltrabella F,Starborg T,Santoro M,Di Bernardo D,Devuyst O,Lowe M,Medina DL,Ballabio A,De Ma

更新日期：2016-08-01 00:00:00

abstract：:The self-perpetuating amyloid isoform, or prion, of the yeast translation termination factor eRF3 modulates programmed translational frameshifting that controls a regulatory circuit determining the polyamine levels in a yeast cell. But it is still unclear whether this effect is adaptive or pathological. ...

journal_title：Nature cell biology

authors： Chernoff YO

更新日期：2008-09-01 00:00:00

abstract：:In mammals, motile cilia cover many organs, such as fallopian tubes, respiratory tracts and brain ventricles. The development and function of these organs critically depend on efficient directional fluid flow ensured by the alignment of ciliary beating. To identify the mechanisms involved in this process, we analysed ...

journal_title：Nature cell biology

authors： Guirao B,Meunier A,Mortaud S,Aguilar A,Corsi JM,Strehl L,Hirota Y,Desoeuvre A,Boutin C,Han YG,Mirzadeh Z,Cremer H,Montcouquiol M,Sawamoto K,Spassky N

更新日期：2010-04-01 00:00:00

abstract：:Nutrient availability is central for T-cell functions and immune responses. Here we report that CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non-essential amino acid Asn. Increased Asn levels enhance CD8+ T-cell activation and effector functions against tumour cells in vitro and in ...

journal_title：Nature cell biology

authors： Wu J,Li G,Li L,Li D,Dong Z,Jiang P

更新日期：2021-01-01 00:00:00

abstract：:Chromophore-assisted laser inactivation (CALI) is a light-mediated technique used to selectively inactivate proteins within cells. Here, we demonstrate that GFP can be used as a CALI reagent to locally inactivate proteins in living cells. We show that focused laser irradiation of EGFP-alpha-actinin expressed in Swiss ...

journal_title：Nature cell biology

authors： Rajfur Z,Roy P,Otey C,Romer L,Jacobson K

更新日期：2002-04-01 00:00:00

abstract：:In chromaffin cells, exocytosis of single granules and properties of the fusion pore--the first connection between vesicular lumen and extracellular space --can be studied by cell-attached patch amperometry, which couples patch-clamp capacitance measurements with simultaneous amperometric recordings of transmitter rel...

journal_title：Nature cell biology

authors： Dernick G,Alvarez de Toledo G,Lindau M

更新日期：2003-04-01 00:00:00

abstract：:Previous analyses of labelled clones of cells within the developing nervous system of the mouse have indicated that descendants are initially dispersed rostrocaudally followed by more local proliferation, which is consistent with the progressing node's contributing descendants from a resident population of progenitor ...

journal_title：Nature cell biology

authors： Mathis L,Kulesa PM,Fraser SE

更新日期：2001-06-01 00:00:00

abstract：:Regulated activation of integrins is critical for cell adhesion, motility and tissue homeostasis. Talin and kindlins activate β1-integrins, but the counteracting inhibiting mechanisms are poorly defined. We identified SHARPIN as an important inactivator of β1-integrins in an RNAi screen. SHARPIN inhibited β1-integrin ...

journal_title：Nature cell biology

authors： Rantala JK,Pouwels J,Pellinen T,Veltel S,Laasola P,Mattila E,Potter CS,Duffy T,Sundberg JP,Kallioniemi O,Askari JA,Humphries MJ,Parsons M,Salmi M,Ivaska J

更新日期：2011-09-25 00:00:00

abstract：:Direct reprogramming by forced expression of transcription factors can convert one cell type into another. Thus, desired cell types can be generated bypassing pluripotency. However, direct reprogramming towards renal cells remains an unmet challenge. Here, we identify renal cell fate-inducing factors on the basis of t...

journal_title：Nature cell biology

authors： Kaminski MM,Tosic J,Kresbach C,Engel H,Klockenbusch J,Müller AL,Pichler R,Grahammer F,Kretz O,Huber TB,Walz G,Arnold SJ,Lienkamp SS

更新日期：2016-12-01 00:00:00

abstract：:The importance of herpes simplex viruses (HSV) as human pathogens and the emerging prospect of using mutant derivatives of HSV-1 as potential anti-cancer therapeutics have necessitated a thorough investigation into the molecular basis of host-cell permissiveness to HSV. Here we show that NIH-3T3 cells transformed with...

journal_title：Nature cell biology

authors： Farassati F,Yang AD,Lee PW

更新日期：2001-08-01 00:00:00

abstract：:Chaperone proteins are thought to promote the correct folding and assembly of newly synthesized proteins and to facilitate restoration of the folded state under environmental conditions that favour protein denaturation. They are among the most ubiquitous and highly conserved of all proteins. The eukaryotic endoplasmic...

journal_title：Nature cell biology

authors： Randow F,Seed B

更新日期：2001-10-01 00:00:00

abstract：:Reference datasets should be accessible independently of scientific papers in a citable form, allowing attribution. ...

journal_title：Nature cell biology

authors：

更新日期：2009-11-01 00:00:00

abstract：:Recent theoretical analysis of a model lattice of interacting transmembrane receptor proteins has indicated that such clustering in the membrane could provide a novel mechanism for regulating receptor signalling in cells. It has been calculated that cooperative interactions between receptors organized into a cluster, ...

journal_title：Nature cell biology

authors： Yin CC,Lai FA

更新日期：2000-09-01 00:00:00

abstract：:Endocytosis of cell surface receptors is an important regulatory event in signal transduction. The transforming growth factor beta (TGF-beta) superfamily signals to the Smad pathway through heteromeric Ser-Thr kinase receptors that are rapidly internalized and then downregulated in a ubiquitin-dependent manner. Here w...

journal_title：Nature cell biology

authors： Di Guglielmo GM,Le Roy C,Goodfellow AF,Wrana JL

更新日期：2003-05-01 00:00:00

abstract：:The enteric nervous system (ENS) predominantly originates from vagal neural crest (VNC) cells that emerge from the caudal hindbrain, invade the foregut and populate the gastrointestinal tract. However, the gene regulatory network (GRN) orchestrating the early specification of VNC remains unknown. Using an EdnrB enhanc...

journal_title：Nature cell biology

authors： Ling ITC,Sauka-Spengler T

更新日期：2019-12-01 00:00:00

abstract：:Haematopoietic stem cells (HSCs) arise in the developing aorta during embryogenesis. The number of HSC clones born has been estimated through transplantation, but experimental approaches to assess the absolute number of forming HSCs in a native setting have remained challenging. Here, we applied single-cell and clonal...

journal_title：Nature cell biology

authors： Henninger J,Santoso B,Hans S,Durand E,Moore J,Mosimann C,Brand M,Traver D,Zon L

更新日期：2017-01-01 00:00:00

abstract：:Telomere attrition and other forms of telomere damage can activate the ATM kinase pathway. What generates the DNA damage signal at mammalian chromosome ends or at other double-strand breaks is not known. Telomere dysfunction is often accompanied by disappearance of the 3' telomeric overhang, raising the possibility th...

journal_title：Nature cell biology

authors： Celli GB,de Lange T

更新日期：2005-07-01 00:00:00