Abstract：
:Chaperone proteins are thought to promote the correct folding and assembly of newly synthesized proteins and to facilitate restoration of the folded state under environmental conditions that favour protein denaturation. They are among the most ubiquitous and highly conserved of all proteins. The eukaryotic endoplasmic reticulum (ER) chaperone gp96 in particular has long been thought to be indispensable for cell survival. Here we report that a screen for genes required for the immune response to bacterial endotoxins has identified a B-cell line deficient in gp96. Absence of gp96 is compatible with cellular survival even under stress conditions and causes a defect in the formation of only a small subset of cell surface receptors. Toll-like receptors are retained intracellularly in the absence of gp96, explaining the unresponsiveness of the mutant to microbial stimuli.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Randow F,Seed Bdoi
10.1038/ncb1001-891keywords:
subject
Has Abstractpub_date
2001-10-01 00:00:00pages
891-6issue
10eissn
1465-7392issn
1476-4679pii
ncb1001-891journal_volume
3pub_type
杂志文章abstract：:The planar cell polarity (PCP) signalling pathway is essential for embryonic development because it governs diverse cellular behaviours, and 'core PCP' proteins, such as Dishevelled and Frizzled, have been extensively characterized. By contrast, the 'PCP effector' proteins, such as Intu and Fuz, remain largely unstudi...
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更新日期：2004-03-01 00:00:00
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更新日期：2012-11-01 00:00:00
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更新日期：2003-08-01 00:00:00
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更新日期：2000-07-01 00:00:00
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pub_type： 评论,新闻
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abstract：: ...
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pub_type： 评论,杂志文章
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更新日期：2018-12-01 00:00:00
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doi：10.1038/ncb1447
更新日期：2006-08-01 00:00:00
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更新日期：2004-06-01 00:00:00
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更新日期：2003-04-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
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更新日期：2009-03-01 00:00:00
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更新日期：2008-06-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
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更新日期：2003-08-01 00:00:00
