Targeting BAF-perturbed cancers.

abstract：:MicroRNAs (miRs) are a class of single-stranded, non-coding RNAs of about 22 nucleotides in length. Increasing evidence implicates miRs in myocardial disease processes. Here we show that miR-199b is a direct calcineurin/NFAT target gene that increases in expression in mouse and human heart failure, and targets the nuc...

journal_title：Nature cell biology

authors： da Costa Martins PA,Salic K,Gladka MM,Armand AS,Leptidis S,el Azzouzi H,Hansen A,Coenen-de Roo CJ,Bierhuizen MF,van der Nagel R,van Kuik J,de Weger R,de Bruin A,Condorelli G,Arbones ML,Eschenhagen T,De Windt LJ

更新日期：2010-12-01 00:00:00

abstract：:Growing microtubule end regions recruit a variety of proteins collectively termed +TIPs, which confer local functions to the microtubule cytoskeleton. +TIPs form dynamic interaction networks whose behaviour depends on a number of potentially competitive and hierarchical interaction modes. The rules that determine whic...

journal_title：Nature cell biology

authors： Duellberg C,Trokter M,Jha R,Sen I,Steinmetz MO,Surrey T

更新日期：2014-08-01 00:00:00

abstract：:TP53 (tumour protein 53) is one of the most frequently mutated genes in human cancer and its role during cellular transformation has been studied extensively. However, the homeostatic functions of p53 are less well understood. Here, we explore the molecular dependency network of TP53 through an RNAi-mediated synthetic...

journal_title：Nature cell biology

authors： Krastev DB,Slabicki M,Paszkowski-Rogacz M,Hubner NC,Junqueira M,Shevchenko A,Mann M,Neugebauer KM,Buchholz F

更新日期：2011-06-05 00:00:00

abstract：:Understanding the factors that direct tissue organization during development is one of the most fundamental goals in developmental biology. Various hypotheses explain cell sorting and tissue organization on the basis of the adhesive and mechanical properties of the constituent cells. However, validating these hypothes...

journal_title：Nature cell biology

authors： Krieg M,Arboleda-Estudillo Y,Puech PH,Käfer J,Graner F,Müller DJ,Heisenberg CP

更新日期：2008-04-01 00:00:00

abstract：:The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for force generation coupled to plus-end polymerization and depolymerization. Spc24/Spc25 at one end of the Ndc80 complex binds the kinetochore. The N-terminal ...

journal_title：Nature cell biology

authors： Suzuki A,Badger BL,Haase J,Ohashi T,Erickson HP,Salmon ED,Bloom K

更新日期：2016-04-01 00:00:00

abstract：:The molecular requirements and morphology of migrating cells can vary depending on matrix geometry; therefore, predicting the optimal migration strategy or the effect of experimental perturbation is difficult. We present a model of cell motility that encompasses actin-polymerization-based protrusions, actomyosin contr...

journal_title：Nature cell biology

authors： Tozluoğlu M,Tournier AL,Jenkins RP,Hooper S,Bates PA,Sahai E

更新日期：2013-07-01 00:00:00

abstract：:Many of the factors required for chromosomal DNA replication have been identified in unicellular eukaryotes. However, DNA replication is poorly understood in multicellular organisms. Here, we report the identification of GEMC1 (geminin coiled-coil containing protein 1), a novel vertebrate protein required for chromoso...

journal_title：Nature cell biology

authors： Balestrini A,Cosentino C,Errico A,Garner E,Costanzo V

更新日期：2010-05-01 00:00:00

abstract：:Actin and myosin are major components of the cell cytoskeleton, with structural and regulatory functions that affect many essential cellular processes. Although they were traditionally thought to function only in the cytoplasm, it is now well accepted that actin and multiple myosins are found in the nucleus. Increasin...

journal_title：Nature cell biology

authors： de Lanerolle P,Serebryannyy L

更新日期：2011-11-02 00:00:00

abstract：:The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication stress response protein in two proteomic screens. ETAA1-deficient c...

journal_title：Nature cell biology

authors： Bass TE,Luzwick JW,Kavanaugh G,Carroll C,Dungrawala H,Glick GG,Feldkamp MD,Putney R,Chazin WJ,Cortez D

更新日期：2016-11-01 00:00:00

abstract：:Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but requires actin polymerization in others. We show that membrane tension determines the actin dependence of clathrin-coat assembly. As found previously, clathrin assembly supports formation of mature coated pits in the absence of ac...

journal_title：Nature cell biology

authors： Boulant S,Kural C,Zeeh JC,Ubelmann F,Kirchhausen T

更新日期：2011-08-14 00:00:00

abstract：:When brassinosteroid levels are low, the GSK3-like kinase BIN2 phosphorylates and inactivates the BZR1 transcription factor to inhibit growth in plants. Brassinosteroid promotes growth by inducing dephosphorylation of BZR1, but the phosphatase that dephosphorylates BZR1 has remained unknown. Here, using tandem affinit...

journal_title：Nature cell biology

authors： Tang W,Yuan M,Wang R,Yang Y,Wang C,Oses-Prieto JA,Kim TW,Zhou HW,Deng Z,Gampala SS,Gendron JM,Jonassen EM,Lillo C,DeLong A,Burlingame AL,Sun Y,Wang ZY

更新日期：2011-02-01 00:00:00

abstract：:In the version of this article originally published, parts of Figure 5 were misaligned because of a shift during production. In a, one data point was outside of the graph border. In b, axes lines were not connected, and graph lines did not reach the data points. In c and d, the axes lines were not connected. In e and ...

journal_title：Nature cell biology

authors： Boos F,Krämer L,Groh C,Jung F,Haberkant P,Stein F,Wollweber F,Gackstatter A,Zöller E,van der Laan M,Savitski MM,Benes V,Herrmann JM

更新日期：2019-06-01 00:00:00

abstract：:Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated chloride channel expressed in a wide variety of epithelial cells, mutations of which are responsible for the hallmark defective chloride secretion observed in cystic fibrosis (CF). Although CFTR has been implicated in bicarbonate secretion,...

journal_title：Nature cell biology

authors： Wang XF,Zhou CX,Shi QX,Yuan YY,Yu MK,Ajonuma LC,Ho LS,Lo PS,Tsang LL,Liu Y,Lam SY,Chan LN,Zhao WC,Chung YW,Chan HC

更新日期：2003-10-01 00:00:00

abstract：:A number of key regulators of mouse embryonic stem (ES) cell identity, including the transcription factor Nanog, show strong expression fluctuations at the single-cell level. The molecular basis for these fluctuations is unknown. Here we used a genetic complementation strategy to investigate expression changes during ...

journal_title：Nature cell biology

authors： MacArthur BD,Sevilla A,Lenz M,Müller FJ,Schuldt BM,Schuppert AA,Ridden SJ,Stumpf PS,Fidalgo M,Ma'ayan A,Wang J,Lemischka IR

更新日期：2012-11-01 00:00:00

abstract：:Autophagy is a lysosome-based degradation pathway. During autophagy, lysosomes fuse with autophagosomes to form autolysosomes. Following starvation-induced autophagy, nascent lysosomes are formed from autolysosomal membranes through an evolutionarily conserved cellular process, autophagic lysosome reformation (ALR), w...

journal_title：Nature cell biology

authors： Rong Y,Liu M,Ma L,Du W,Zhang H,Tian Y,Cao Z,Li Y,Ren H,Zhang C,Li L,Chen S,Xi J,Yu L

更新日期：2012-09-01 00:00:00

abstract：:Obesity occurs when excess energy accumulates in white adipose tissue (WAT), whereas brown adipose tissue (BAT), specialized for energy expenditure through thermogenesis, potently counteracts obesity. Factors that induce brown adipocyte commitment and energy expenditure would be a promising defence against adiposity. ...

journal_title：Nature cell biology

authors： Wang J,Liu R,Wang F,Hong J,Li X,Chen M,Ke Y,Zhang X,Ma Q,Wang R,Shi J,Cui B,Gu W,Zhang Y,Zhang Z,Wang W,Xia X,Liu M,Ning G

更新日期：2013-12-01 00:00:00

abstract：:The accurate spatial and temporal coordination of cell polarization with DNA replication and segregation guarantees the fidelity of genetic transmission. Here we report that in Saccharomyces cerevisiae, a build-up or burst of G1 cyclin-dependent kinase (CDK) activity through activation of the cyclin genes CLN1,2 and P...

journal_title：Nature cell biology

authors： Moffat J,Andrews B

更新日期：2004-01-01 00:00:00

abstract：:Formation of a stable lamellipodium at the front of migrating cells requires localization of Rac activation to the leading edge. Restriction of alpha4 integrin phosphorylation to the leading edge limits the interaction of alpha4 with paxillin to the sides and rear of a migrating cell. The alpha4-paxillin complex inhib...

journal_title：Nature cell biology

authors： Nishiya N,Kiosses WB,Han J,Ginsberg MH

更新日期：2005-04-01 00:00:00

abstract：:In the version of this Article originally published, the author had misnumbered the reference citations in the Methods, using numbers 1-14 instead of 46-59. These errors have now been corrected in all online versions of the Article. ...

journal_title：Nature cell biology

authors： Chen J,Xu N,Wang C,Huang P,Huang H,Jin Z,Yu Z,Cai T,Jiao R,Xi R

更新日期：2018-08-01 00:00:00

abstract：:Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions. ...

journal_title：Nature cell biology

authors： Storici F,Tichon AE

更新日期：2017-11-29 00:00:00

abstract：:Connective-tissue growth factor (CTGF) is a secreted protein implicated in multiple cellular events including angiogenesis, skeletogenesis and wound healing. It is a member of the CCN family of secreted proteins, named after CTGF, cysteine-rich 61 (CYR61), and nephroblastoma overexpressed (NOV) proteins. The molecular...

journal_title：Nature cell biology

authors： Abreu JG,Ketpura NI,Reversade B,De Robertis EM

更新日期：2002-08-01 00:00:00

abstract：:Hypoxia and acidosis occur in a wide variety of physiological and pathological settings that include muscle stress, tumour development and ischaemic disorders. A central element in the adaptive response to cellular hypoxia is HIF (hypoxia-inducible factor), a transcription factor that activates an array of genes impli...

journal_title：Nature cell biology

authors： Mekhail K,Gunaratnam L,Bonicalzi ME,Lee S

更新日期：2004-07-01 00:00:00

abstract：:Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalie...

journal_title：Nature cell biology

authors： Jin Y,Muhl L,Burmakin M,Wang Y,Duchez AC,Betsholtz C,Arthur HM,Jakobsson L

更新日期：2017-06-01 00:00:00

abstract：:The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributo...

journal_title：Nature cell biology

authors： Delaunay S,Frye M

更新日期：2019-05-01 00:00:00

abstract：:The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion,...

journal_title：Nature cell biology

authors： Petridou NI,Spiró Z,Heisenberg CP

更新日期：2017-05-31 00:00:00

abstract：:Genomic integrity is maintained by checkpoints that guard against undesired replication after DNA damage. Here, we show that CDT1, a licensing factor of the pre-replication complex (preRC), is rapidly proteolysed after UV- or gamma-irradiation. The preRC assembles on replication origins at the end of mitosis and durin...

journal_title：Nature cell biology

authors： Higa LA,Mihaylov IS,Banks DP,Zheng J,Zhang H

更新日期：2003-11-01 00:00:00

abstract：:The stability and membrane localization of the transforming growth factor-β (TGF-β) type I receptor (TβRI) determines the levels of TGF-β signalling. TβRI is targeted for ubiquitylation-mediated degradation by the SMAD7-SMURF2 complex. Here we performed a genome-wide gain-of-function screen and identified ubiquitin-sp...

journal_title：Nature cell biology

authors： Zhang L,Zhou F,Drabsch Y,Gao R,Snaar-Jagalska BE,Mickanin C,Huang H,Sheppard KA,Porter JA,Lu CX,ten Dijke P

更新日期：2012-06-17 00:00:00

abstract：:It has long-been accepted that normal somatic cells have intrinsic mechanisms that limit their proliferative lifespan. Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential. ...

journal_title：Nature cell biology

authors： Lloyd AC

更新日期：2002-02-01 00:00:00

abstract：:The target of rapamycin complex 2 (TORC2) plays a key role in maintaining the homeostasis of plasma membrane (PM) tension. TORC2 activation following increased PM tension involves redistribution of the Slm1 and 2 paralogues from PM invaginations known as eisosomes into membrane compartments containing TORC2. How Slm1/...

journal_title：Nature cell biology

authors： Riggi M,Niewola-Staszkowska K,Chiaruttini N,Colom A,Kusmider B,Mercier V,Soleimanpour S,Stahl M,Matile S,Roux A,Loewith R

更新日期：2018-09-01 00:00:00

abstract：:It is now well established that stromal interaction molecule 1 (STIM1) is the calcium sensor of endoplasmic reticulum stores required to activate store-operated calcium entry (SOC) channels at the surface of non-excitable cells. However, little is known about STIM1 in excitable cells, such as striated muscle, where th...

journal_title：Nature cell biology

authors： Stiber J,Hawkins A,Zhang ZS,Wang S,Burch J,Graham V,Ward CC,Seth M,Finch E,Malouf N,Williams RS,Eu JP,Rosenberg P

更新日期：2008-06-01 00:00:00