Abstract:
:The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion, proliferation and differentiation. In this Review, we will discuss how the interplay and feedback between mechanical and biochemical signals control tissue morphogenesis and cell fate specification in embryonic development.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Petridou NI,Spiró Z,Heisenberg CPdoi
10.1038/ncb3524subject
Has Abstractpub_date
2017-05-31 00:00:00pages
581-588issue
6eissn
1465-7392issn
1476-4679pii
ncb3524journal_volume
19pub_type
杂志文章,评审abstract::While nuclear lamina abnormalities are hallmarks of human diseases, their interplay with epigenetic regulators and precise epigenetic landscape remain poorly understood. Here, we show that loss of the lysine acetyltransferase MOF or its associated NSL-complex members KANSL2 or KANSL3 leads to a stochastic accumulation...
journal_title:Nature cell biology
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abstract::Primordial germ cell (PGC) development in the human fetus remains relatively uncharted. A new study suggests that epigenetic reprogramming and sex differentiation in human PGCs occur asynchronously over an extended time period. This finding raises questions and implications for in vitro PGC differentiation. ...
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pub_type: 评论,杂志文章
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更新日期:2013-01-01 00:00:00
abstract::Programmed cell death (apoptosis) is used by multicellular organisms during development and to maintain homeostasis within mature tissues. One of the first genes shown to regulate apoptosis was bcl-2. Subsequently, a number of Bcl-2-related proteins have been identified. Despite overwhelming evidence that Bcl-2 protei...
journal_title:Nature cell biology
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abstract::Topoisomerase II (Topo II) is required to separate intertwined sister chromatids before chromosome segregation can occur in mitosis. However, it remains to be resolved whether Topo II has any role in checkpoint control. Here we report that when phosphorylated, Ser 1524 of Topo IIalpha acts as a binding site for the BR...
journal_title:Nature cell biology
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journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35014000
更新日期:2000-06-01 00:00:00
abstract::MicroRNAs (miRNAs) have emerged as novel cancer genes. In particular, the miR-17-92 cluster, containing six individual miRNAs, is highly expressed in haematopoietic cancers and promotes lymphomagenesis in vivo. Clinical use of these findings hinges on isolating the oncogenic activity within the 17-92 cluster and defin...
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abstract::Although nuclear envelope (NE) assembly is known to require the GTPase Ran, the membrane fusion machinery involved is uncharacterized. NE assembly involves formation of a reticular network on chromatin, fusion of this network into a closed NE and subsequent expansion. Here we show that p97, an AAA-ATPase previously im...
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更新日期:2002-10-01 00:00:00
abstract::N-WASP is a major cytoskeletal regulator that stimulates Arp2/3-mediated actin nucleation. Here, we identify a nucleation-independent pathway by which N-WASP regulates the cytoskeleton and junctional integrity at the epithelial zonula adherens. N-WASP is a junctional protein whose depletion decreased junctional F-acti...
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pub_type: 杂志文章,已发布勘误
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更新日期:2020-03-01 00:00:00
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journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3111
更新日期:2015-04-01 00:00:00
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journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2029
更新日期:2010-03-01 00:00:00
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journal_title:Nature cell biology
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doi:10.1038/ncb1774
更新日期:2008-10-01 00:00:00
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journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1635
更新日期:2007-10-01 00:00:00
abstract::In plants, cell shape is defined by the cell wall, and changes in cell shape and size are dictated by modification of existing cell walls and deposition of newly synthesized cell-wall material. In root hairs, expansion occurs by a process called tip growth, which is shared by root hairs, pollen tubes and fungal hyphae...
journal_title:Nature cell biology
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abstract::Mouse embryos with a loss-of-function mutation in the gene encoding the receptor tyrosine kinase ErbB4 exhibit misprojections of cranial sensory ganglion afferent axons. Here we analyse ErbB4-deficient mice, and find that morphological differences between wild-type and mutant cranial ganglia correlate with aberrant mi...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35000058
更新日期:2000-02-01 00:00:00
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更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Nature cell biology
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pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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