Topoisomerase IIalpha controls the decatenation checkpoint.

abstract：:Hypoxia and acidosis occur in a wide variety of physiological and pathological settings that include muscle stress, tumour development and ischaemic disorders. A central element in the adaptive response to cellular hypoxia is HIF (hypoxia-inducible factor), a transcription factor that activates an array of genes impli...

journal_title：Nature cell biology

authors： Mekhail K,Gunaratnam L,Bonicalzi ME,Lee S

更新日期：2004-07-01 00:00:00

abstract：:Aberrant microRNA (miRNA) expression is a defining feature of human malignancy. Specific miRNAs have been identified as promoters or suppressors of metastatic progression. miRNAs control metastasis through divergent or convergent regulation of metastatic gene pathways. Some miRNA regulatory networks govern cell-autono...

journal_title：Nature cell biology

authors： Pencheva N,Tavazoie SF

更新日期：2013-06-01 00:00:00

abstract：:Metaphase spindles are microtubule-based structures that use a multitude of proteins to modulate their morphology and function. Today, we understand many details of microtubule assembly, the role of microtubule-associated proteins, and the action of molecular motors. Ultimately, the challenge remains to understand how...

journal_title：Nature cell biology

authors： Reber SB,Baumgart J,Widlund PO,Pozniakovsky A,Howard J,Hyman AA,Jülicher F

更新日期：2013-09-01 00:00:00

abstract：:The spindle checkpoint ensures accurate chromosome segregation by delaying cell-cycle progression until all sister kinetochores capture microtubules from opposite poles and come under tension (for reviews, see refs 1, 2). Although the checkpoint is activated by either the lack of kinetochore-microtubule attachments or...

journal_title：Nature cell biology

authors： Pinsky BA,Kung C,Shokat KM,Biggins S

更新日期：2006-01-01 00:00:00

abstract：:Canonical Wnt signalling has been implicated in mouse and human embryonic stem cell (ESC) maintenance; however, its requirement is controversial. β-catenin is the key component in this highly conserved Wnt pathway, acting as a transcriptional transactivator. However, β-catenin has additional roles at the plasma membra...

journal_title：Nature cell biology

authors： Lyashenko N,Winter M,Migliorini D,Biechele T,Moon RT,Hartmann C

更新日期：2011-06-19 00:00:00

abstract：:The promyelocytic leukaemia (PML) tumour-suppressor protein potentiates p53 function by regulating post-translational modifications, such as CBP-dependent acetylation and Chk2-dependent phosphorylation, in the PML-Nuclear Body (NB). PML was recently shown to interact with the p53 ubiquitin-ligase Mdm2 (refs 4-6); howe...

journal_title：Nature cell biology

authors： Bernardi R,Scaglioni PP,Bergmann S,Horn HF,Vousden KH,Pandolfi PP

更新日期：2004-07-01 00:00:00

abstract：:p53 mutations occur very frequently in human cancer. Besides abrogating the tumour suppressive functions of wild-type p53, many of those mutations also acquire oncogenic gain-of-function activities. Augmentation of proteasome activity is now reported as a common gain-of-function mechanism shared by different p53 mutan...

journal_title：Nature cell biology

authors： Oren M,Kotler E

更新日期：2016-07-27 00:00:00

abstract：:MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endo...

journal_title：Nature cell biology

authors： Kotlyarov A,Neininger A,Schubert C,Eckert R,Birchmeier C,Volk HD,Gaestel M

更新日期：1999-06-01 00:00:00

abstract：:The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to the state of attachment of the kinetochore to spindle microtubules. SAC signalling is activated by unattached kinetochores, and it is silenced after these kinetochores form end-on microtubule attachments. Although the biochemical c...

journal_title：Nature cell biology

authors： Aravamudhan P,Goldfarb AA,Joglekar AP

更新日期：2015-07-01 00:00:00

abstract：:ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardio...

journal_title：Nature cell biology

authors： David R,Brenner C,Stieber J,Schwarz F,Brunner S,Vollmer M,Mentele E,Müller-Höcker J,Kitajima S,Lickert H,Rupp R,Franz WM

更新日期：2008-03-01 00:00:00

abstract：:It has long-been accepted that normal somatic cells have intrinsic mechanisms that limit their proliferative lifespan. Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential. ...

journal_title：Nature cell biology

authors： Lloyd AC

更新日期：2002-02-01 00:00:00

abstract：:A key step in nutrient sensing is activation of the master growth regulator, mTORC1 kinase, on the lysosomal membrane. Nutrients enable mTORC1 scaffolding by a complex composed of the Rag GTPases (Rags) and Ragulator, but the underlying mechanism of mTORC1 capture is poorly understood. Combining dynamic imaging in cel...

journal_title：Nature cell biology

authors： Lawrence RE,Cho KF,Rappold R,Thrun A,Tofaute M,Kim DJ,Moldavski O,Hurley JH,Zoncu R

更新日期：2018-09-01 00:00:00

abstract：:Etk/BMX, a member of the Btk family of tyrosine kinases, is highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines. Here, we present evidence that Etk is involved in integrin signalling and promotes cell migration. The activation of Etk by extracellula...

journal_title：Nature cell biology

authors： Chen R,Kim O,Li M,Xiong X,Guan JL,Kung HJ,Chen H,Shimizu Y,Qiu Y

更新日期：2001-05-01 00:00:00

abstract：:Rad23 is a nucleotide-excision repair protein with a previously unknown biochemical function. We determined that yeast and human Rad23 inhibited multi-ubiquitin (Ub) chain formation and the degradation of proteolytic substrates. Significantly, Rad23 could be co-precipitated with a substrate that contained a short mult...

journal_title：Nature cell biology

authors： Ortolan TG,Tongaonkar P,Lambertson D,Chen L,Schauber C,Madura K

更新日期：2000-09-01 00:00:00

abstract：:The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find ...

journal_title：Nature cell biology

authors： Hanssen LLP,Kassouf MT,Oudelaar AM,Biggs D,Preece C,Downes DJ,Gosden M,Sharpe JA,Sloane-Stanley JA,Hughes JR,Davies B,Higgs DR

更新日期：2017-08-01 00:00:00

abstract：:Coordination of microtubules and the actin cytoskeleton is important in several types of cell movement. mDia1 is a member of the formin-homology family of proteins and an effector of the small GTPase Rho. It contains the Rho-binding domain in its amino terminus and two distinct regions of formin homology, FH1 in the m...

journal_title：Nature cell biology

authors： Ishizaki T,Morishima Y,Okamoto M,Furuyashiki T,Kato T,Narumiya S

更新日期：2001-01-01 00:00:00

abstract：:Cancer-induced immune responses affect tumour progression and therapeutic response. In multiple murine models and clinical datasets, we identified large variations of neutrophils and macrophages that define 'immune subtypes' of triple-negative breast cancer (TNBC), including neutrophil-enriched (NES) and macrophage-en...

journal_title：Nature cell biology

authors： Kim IS,Gao Y,Welte T,Wang H,Liu J,Janghorban M,Sheng K,Niu Y,Goldstein A,Zhao N,Bado I,Lo HC,Toneff MJ,Nguyen T,Bu W,Jiang W,Arnold J,Gu F,He J,Jebakumar D,Walker K,Li Y,Mo Q,Westbrook TF,Zong C,Rao A,

更新日期：2019-09-01 00:00:00

abstract：:Organization of chromatin by epigenetic mechanisms is essential for establishing and maintaining cellular identity in developing and adult organisms. A key question that remains unresolved about this process is how epigenetic marks are transmitted to the next cell generation during cell division. Here we provide a mod...

journal_title：Nature cell biology

authors： Hansen KH,Bracken AP,Pasini D,Dietrich N,Gehani SS,Monrad A,Rappsilber J,Lerdrup M,Helin K

更新日期：2008-11-01 00:00:00

abstract：:Extracellular signal regulated kinases (ERKs) represent a signalling hub in many physiological responses and have pivotal functions in cell proliferation, differentiation, development and death, as well as in synaptic plasticity. Mitogen-activated protein kinase phosphatases (MKPs) selectively inactivate ERKs by depho...

journal_title：Nature cell biology

authors： Kang TH,Kim KT

更新日期：2006-08-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) induces epithelial-mesenchymal transdifferentiation (EMT) accompanied by cellular differentiation and migration. Despite extensive transcriptomic profiling, the identification of TGF-beta-inducible, EMT-specific genes has met with limited success. Here we identify a post-tran...

journal_title：Nature cell biology

authors： Chaudhury A,Hussey GS,Ray PS,Jin G,Fox PL,Howe PH

更新日期：2010-03-01 00:00:00

abstract：:Protein degradation in eukaryotes often requires the ubiquitin-selective chaperone p97 for substrate recruitment and ubiquitin-chain assembly. However, the physiological relevance of p97, and its role in developmental processes, remain unclear. Here, we discover an unanticipated function for CDC-48/p97 in myosin assem...

journal_title：Nature cell biology

authors： Janiesch PC,Kim J,Mouysset J,Barikbin R,Lochmüller H,Cassata G,Krause S,Hoppe T

更新日期：2007-04-01 00:00:00

abstract：:The planar cell polarity (PCP) signalling pathway is essential for embryonic development because it governs diverse cellular behaviours, and 'core PCP' proteins, such as Dishevelled and Frizzled, have been extensively characterized. By contrast, the 'PCP effector' proteins, such as Intu and Fuz, remain largely unstudi...

journal_title：Nature cell biology

authors： Gray RS,Abitua PB,Wlodarczyk BJ,Szabo-Rogers HL,Blanchard O,Lee I,Weiss GS,Liu KJ,Marcotte EM,Wallingford JB,Finnell RH

更新日期：2009-10-01 00:00:00

abstract：:Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recen...

journal_title：Nature cell biology

authors： Heinrich C,Spagnoli FM,Berninger B

更新日期：2015-03-01 00:00:00

abstract：:The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and...

journal_title：Nature cell biology

authors： Varga J,Greten FR

更新日期：2017-10-01 00:00:00

abstract：:Current models for the export of messenger RNA share the notion that the highly abundant class of nuclear RNA-binding proteins--the hnRNP proteins--have a key role in exporting RNA. But recent studies have led to a new understanding of several non-hnRNP proteins, including SR proteins and the conserved mRNA export fac...

journal_title：Nature cell biology

authors： Reed R,Magni K

更新日期：2001-09-01 00:00:00

abstract：:Changes in phosphorylation of the carboxy-terminal domain (CTD) of RNA polymerase II (RNAP) are associated with transcription initiation, elongation and termination. Sites of active transcription are generally characterized by hyperphosphorylated RNAP, particularly at Ser 2 residues, whereas inactive or poised genes m...

journal_title：Nature cell biology

authors： Stock JK,Giadrossi S,Casanova M,Brookes E,Vidal M,Koseki H,Brockdorff N,Fisher AG,Pombo A

更新日期：2007-12-01 00:00:00

abstract：:The motion of a chromosome during mitosis is mediated by a bundle of microtubules, termed a kinetochore fibre (K-fibre), which connects the kinetochore of the chromosome to a spindle pole. Once formed, mature K-fibres maintain a steady state length because the continuous addition of microtubule subunits onto microtubu...

journal_title：Nature cell biology

authors： Maiato H,Khodjakov A,Rieder CL

更新日期：2005-01-01 00:00:00

abstract：:The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from other extracellular vesicles in terms of their biogenesis and functions remains ...

journal_title：Nature cell biology

authors： Mathieu M,Martin-Jaular L,Lavieu G,Théry C

更新日期：2019-01-01 00:00:00

abstract：:LATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. LATS1 inhibits both the phosphorylation of cofilin by LIMK...

journal_title：Nature cell biology

authors： Yang X,Yu K,Hao Y,Li DM,Stewart R,Insogna KL,Xu T

更新日期：2004-07-01 00:00:00

abstract：:Reprogrammed glucose metabolism as a result of increased glycolysis and glucose uptake is a hallmark of cancer. Here we show that cancer cells can suppress glucose uptake by non-tumour cells in the premetastatic niche, by secreting vesicles that carry high levels of the miR-122 microRNA. High miR-122 levels in the cir...

journal_title：Nature cell biology

authors： Fong MY,Zhou W,Liu L,Alontaga AY,Chandra M,Ashby J,Chow A,O'Connor ST,Li S,Chin AR,Somlo G,Palomares M,Li Z,Tremblay JR,Tsuyada A,Sun G,Reid MA,Wu X,Swiderski P,Ren X,Shi Y,Kong M,Zhong W,Chen Y,Wang SE

更新日期：2015-02-01 00:00:00