Abstract：
:The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and the epithelial-mesenchymal transition-two distinct, yet closely related, forms of plasticity with fundamental roles in homeostasis and cancer.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Varga J,Greten FRdoi
10.1038/ncb3611subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1133-1141issue
10eissn
1465-7392issn
1476-4679pii
ncb3611journal_volume
19pub_type
杂志文章,评审abstract：:Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to b...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/s41556-018-0196-y
更新日期：2019-01-01 00:00:00
abstract：:The contribution of autophagy to cancer development remains controversial, largely owing to the fact that autophagy can be tumour suppressive or oncogenic in different biological contexts. Here, we show that in non-small-cell lung cancer (NSCLC), casein kinase 1 alpha 1 (CK1α) suppresses tumour growth by functioning a...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-018-0065-8
更新日期：2018-04-01 00:00:00
abstract：:Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cancers. Here, we generate quadruple TIMP knockout (TIMPless) fibroblasts ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3021
更新日期：2014-09-01 00:00:00
abstract：:FoxG1 is an evolutionarily conserved, winged-helix transcriptional repressor that maintains progenitor cells in the vertebrate forebrain. How the activity of FoxG1 is regulated is not known. Here, we report that in the developing Xenopus and mouse forebrain, FoxG1 is nuclear in progenitor cells but cytoplasmic in diff...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1573
更新日期：2007-05-01 00:00:00
abstract：:The transition from cellular quiescence (G0) into S phase is regulated by the mitogenic-activation of D-type cyclins and cyclin-dependent kinases (Cdks), the sequestration of the Cdk inhibitors (CDKIs), p21 and p27, and the hyperphosphorylation of Rb with release of E2F transcription factors. However, fibroblasts that...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1548
更新日期：2007-03-01 00:00:00
abstract：:Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated t...
journal_title：Nature cell biology
pub_type： 评论,新闻
doi：10.1038/ncb2817
更新日期：2013-08-01 00:00:00
abstract：:Inhibitors of apoptosis (IAPs) inhibit caspases, thereby preventing proteolysis of apoptotic substrates. IAPs occlude the active sites of caspases to which they are bound and can function as ubiquitin ligases. IAPs are also reported to ubiquitinate themselves and caspases. Several proteins induce apoptosis, at least i...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb798
更新日期：2002-06-01 00:00:00
abstract：:Although nuclear envelope (NE) assembly is known to require the GTPase Ran, the membrane fusion machinery involved is uncharacterized. NE assembly involves formation of a reticular network on chromatin, fusion of this network into a closed NE and subsequent expansion. Here we show that p97, an AAA-ATPase previously im...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1201-1086
更新日期：2001-12-01 00:00:00
abstract：:Adenomatous polyposis coli protein (APC) is an important tumour suppressor in the human colon epithelium. In a complex with glycogen synthase kinase-3 (GSK-3), APC binds to and destabilizes cytoplasmic ('free') beta-catenin. Here, using a yeast two-hybrid screen for proteins that bind to the Drosophila beta-catenin ho...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/11064
更新日期：1999-07-01 00:00:00
abstract：:Compartmentalization has long been known to have a key role in regulation of cellular processes. By keeping enzymes and regulatory complexes in compartments where the delivery of substrate or exit of product is controlled, competing reactions can occur simultaneously in different parts of the cell. Moreover, spatial c...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/35014078
更新日期：2000-06-01 00:00:00
abstract：:Understanding the factors that direct tissue organization during development is one of the most fundamental goals in developmental biology. Various hypotheses explain cell sorting and tissue organization on the basis of the adhesive and mechanical properties of the constituent cells. However, validating these hypothes...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1705
更新日期：2008-04-01 00:00:00
abstract：:Cohesin confers both intrachromatid and interchromatid cohesion through formation of a tripartite ring within which DNA is thought to be entrapped. Here, I discuss what is known about the four stages of the cohesin ring cycle using the ring model as an intellectual framework. I postulate that cohesin loading onto chro...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb2349
更新日期：2011-10-03 00:00:00
abstract：:The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion,...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb3524
更新日期：2017-05-31 00:00:00
abstract：:Correct placement and orientation of the mitotic spindle is essential for segregation of localized components and positioning of daughter cells. Although these processes are important in many cells, few factors that regulate spindle placement are known. Previous work has shown that GPB-1, the Gbeta subunit of a hetero...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35060092
更新日期：2001-03-01 00:00:00
abstract：:N-WASP is a major cytoskeletal regulator that stimulates Arp2/3-mediated actin nucleation. Here, we identify a nucleation-independent pathway by which N-WASP regulates the cytoskeleton and junctional integrity at the epithelial zonula adherens. N-WASP is a junctional protein whose depletion decreased junctional F-acti...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2290
更新日期：2011-07-24 00:00:00
abstract：:In the version of this Article originally published, the author had misnumbered the reference citations in the Methods, using numbers 1-14 instead of 46-59. These errors have now been corrected in all online versions of the Article. ...
journal_title：Nature cell biology
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41556-018-0053-z
更新日期：2018-08-01 00:00:00
abstract：:The asymmetric segregation of cell-fate determinants and the generation of daughter cells of different sizes rely on the correct orientation and position of the mitotic spindle. In the Drosophila embryo, the determinant Prospero is localized basally and is segregated equally to daughters of similar cell size during ep...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/71323
更新日期：2000-01-01 00:00:00
abstract：:The polarity protein Scribble (SCRIB) regulates apical-basal polarity, directional migration and tumour suppression in Drosophila and mammals. Here we report that SCRIB is an important regulator of myeloid cell functions including bacterial infection and inflammation. SCRIB interacts directly with the NADPH oxidase (N...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3413
更新日期：2016-11-01 00:00:00
abstract：:Collective cell migration is essential for both physiological and pathological processes. Adherens junctions (AJs) maintain the integrity of the migrating cell group and promote cell coordination while allowing cellular rearrangements. Here, we show that AJs undergo a continuous treadmilling along the lateral sides of...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2985
更新日期：2014-07-01 00:00:00
abstract：:The importance of herpes simplex viruses (HSV) as human pathogens and the emerging prospect of using mutant derivatives of HSV-1 as potential anti-cancer therapeutics have necessitated a thorough investigation into the molecular basis of host-cell permissiveness to HSV. Here we show that NIH-3T3 cells transformed with...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35087061
更新日期：2001-08-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature cell biology
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41556-020-0479-y
更新日期：2020-03-01 00:00:00
abstract：:Plant cell morphogenesis relies on the organization and function of two polymer arrays separated by the plasma membrane: the cortical microtubule cytoskeleton and cellulose microfibrils in the cell wall. Studies using in vivo markers confirmed that one function of the cortical microtubule array is to drive organizatio...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1886
更新日期：2009-07-01 00:00:00
abstract：:The presence of actin in the nucleus has been well established, and several studies have implicated nuclear actin in transcriptional regulation. Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is a member of the WASP family of proteins; these proteins function in the cytoplasm as key regulators of cortical actin fi...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1433
更新日期：2006-07-01 00:00:00
abstract：:The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication stress response protein in two proteomic screens. ETAA1-deficient c...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3415
更新日期：2016-11-01 00:00:00
abstract：:Actomyosin contractility is a mechanism by which cells exert locomotory force against their environment. Signalling downstream of the small GTPase Rho increases contractility through Rho-kinase (ROCK)-mediated regulation of myosin-II light chain (MLC2) phosphorylation. Cdc42 signalling has been shown to control cell p...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1230
更新日期：2005-03-01 00:00:00
abstract：:The migration of border cells during Drosophila melanogaster oogenesis is a simple and powerful system for studying invasive cell migration in vivo. Border cells are somatic cells that delaminate from the follicular epithelium of an egg chamber and invade the germ line cluster. They migrate between the nurse cells to ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb848
更新日期：2002-09-01 00:00:00
abstract：:Formation of a bipolar spindle is essential for faithful chromosome segregation at mitosis. Because centrosomes define spindle poles, defects in centrosome number and structural organization can lead to a loss of bipolarity. In addition, microtubule-mediated pulling and pushing forces acting on centrosomes and chromos...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1474
更新日期：2006-10-01 00:00:00
abstract：:The Drosophila fruitless (fru) gene product Fru has been postulated to be a neural sex-determination factor that directs the development of at least two male-specific characteristics, namely courtship behaviour and formation of the muscle of Lawrence (MOL). The fru gene encodes a putative transcription factor with a B...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35019537
更新日期：2000-08-01 00:00:00
abstract：:Chromatin structure is thought to play a critical role in gene expression. Using the lac operator/repressor system and two colour variants of green fluorescent protein (GFP), we developed a system to visualize a gene and its protein product directly in living cells, allowing us to examine the spatial organization and ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35046510
更新日期：2000-12-01 00:00:00
abstract：:Phosphatase and tensin homologue (Pten) suppresses neoplastic growth by negatively regulating PI(3)K signalling through its phosphatase activity. To gain insight into the actions of non-catalytic Pten domains in normal physiological processes and tumorigenesis, we engineered mice lacking the PDZ-binding domain (PDZ-BD...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3369
更新日期：2016-07-01 00:00:00
