Abstract:
:Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to be debated. In this Review, we identify and describe specific, non-redundant functions of the different EMT-TFs and discuss the reasons that may underlie disputes about EMT in cancer.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Stemmler MP,Eccles RL,Brabletz S,Brabletz Tdoi
10.1038/s41556-018-0196-ysubject
Has Abstractpub_date
2019-01-01 00:00:00pages
102-112issue
1eissn
1465-7392issn
1476-4679pii
10.1038/s41556-018-0196-yjournal_volume
21pub_type
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