PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.

abstract：:Clathrin-coated vesicles (CCVs) are a central component of endocytosis and traffic between the trans-Golgi network (TGN) and endosomes. Although endocytic CCV formation is well characterized, much less is known about CCV formation at internal membranes. Here we describe two epsin amino-terminal homology (ENTH) domain-...

journal_title：Nature cell biology

authors： Duncan MC,Costaguta G,Payne GS

更新日期：2003-01-01 00:00:00

abstract：:The pericentriolar material (PCM), the microtubule-organizing component of the centrosome, contains a multitude of proteins and is commonly described as an amorphous cloud surrounding the centrioles. However, the days of the PCM as an unstructured matrix are numbered. Using super-resolution microscopy, several reports...

journal_title：Nature cell biology

authors： Lüders J

更新日期：2012-11-01 00:00:00

abstract：:The remarkable stability of gene expression in somatic cells is exemplified by the way memory of an active gene state is retained when an endoderm cell nucleus is transplanted to an enucleated egg. Here we analyse the mechanism of a similar example of epigenetic memory. We find that memory can persist through 24 cell ...

journal_title：Nature cell biology

authors： Ng RK,Gurdon JB

更新日期：2008-01-01 00:00:00

abstract：:The Semliki Forest virus capsid protein contains a chymotrypsin-like protease domain that must fold before it can autocatalytically cleave the protein from a larger polyprotein precursor. Here we analyse this cleavage in living mammalian and prokaryotic cells, and find that it occurs immediately after the emergence of...

journal_title：Nature cell biology

authors： Nicola AV,Chen W,Helenius A

更新日期：1999-10-01 00:00:00

abstract：:Collective cell migration occurs in a range of contexts: cancer cells frequently invade in cohorts while retaining cell-cell junctions. Here we show that collective invasion by cancer cells depends on decreasing actomyosin contractility at sites of cell-cell contact. When actomyosin is not downregulated at cell-cell c...

journal_title：Nature cell biology

authors： Hidalgo-Carcedo C,Hooper S,Chaudhry SI,Williamson P,Harrington K,Leitinger B,Sahai E

更新日期：2011-01-01 00:00:00

abstract：:Here we investigate the role of the control of apoptosis in normal cell division. We show that interference with the expression or function of the apoptosis inhibitor survivin causes caspase-dependent cell death in the G2/M phase of the cell cycle, and a cell-division defect characterized by centrosome dysregulation, ...

journal_title：Nature cell biology

authors： Li F,Ackermann EJ,Bennett CF,Rothermel AL,Plescia J,Tognin S,Villa A,Marchisio PC,Altieri DC

更新日期：1999-12-01 00:00:00

abstract：:Cellular transformation and cancer progression is accompanied by changes in the metabolic landscape. Master co-regulators of metabolism orchestrate the modulation of multiple metabolic pathways through transcriptional programs, and hence constitute a probabilistically parsimonious mechanism for general metabolic rewir...

journal_title：Nature cell biology

authors： Torrano V,Valcarcel-Jimenez L,Cortazar AR,Liu X,Urosevic J,Castillo-Martin M,Fernández-Ruiz S,Morciano G,Caro-Maldonado A,Guiu M,Zúñiga-García P,Graupera M,Bellmunt A,Pandya P,Lorente M,Martín-Martín N,Sutherland JD,San

更新日期：2016-06-01 00:00:00

abstract：:The contribution of autophagy to cancer development remains controversial, largely owing to the fact that autophagy can be tumour suppressive or oncogenic in different biological contexts. Here, we show that in non-small-cell lung cancer (NSCLC), casein kinase 1 alpha 1 (CK1α) suppresses tumour growth by functioning a...

journal_title：Nature cell biology

authors： Cai J,Li R,Xu X,Zhang L,Lian R,Fang L,Huang Y,Feng X,Liu X,Li X,Zhu X,Zhang H,Wu J,Zeng M,Song E,He Y,Yin Y,Li J,Li M

更新日期：2018-04-01 00:00:00

abstract：:Here we show that segregation of homologous chromosomes and that of sister chromatids are differentially regulated in Xenopus and possibly in other higher eukaryotes. Upon hormonal stimulation, Xenopus oocytes microinjected with antibodies against the anaphase-promoting complex (APC) activator Fizzy or the APC core su...

journal_title：Nature cell biology

authors： Peter M,Castro A,Lorca T,Le Peuch C,Magnaghi-Jaulin L,Dorée M,Labbé JC

更新日期：2001-01-01 00:00:00

abstract：:The planar cell polarity (PCP) signalling pathway is essential for embryonic development because it governs diverse cellular behaviours, and 'core PCP' proteins, such as Dishevelled and Frizzled, have been extensively characterized. By contrast, the 'PCP effector' proteins, such as Intu and Fuz, remain largely unstudi...

journal_title：Nature cell biology

authors： Gray RS,Abitua PB,Wlodarczyk BJ,Szabo-Rogers HL,Blanchard O,Lee I,Weiss GS,Liu KJ,Marcotte EM,Wallingford JB,Finnell RH

更新日期：2009-10-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations cause inherited diseases and are implicated in the pathogenesis of common late-onset disorders, but how they arise is not clear1,2. Here we show that mtDNA mutations are present in primordial germ cells (PGCs) within healthy female human embryos. Isolated PGCs have a profound reduct...

journal_title：Nature cell biology

authors： Floros VI,Pyle A,Dietmann S,Wei W,Tang WCW,Irie N,Payne B,Capalbo A,Noli L,Coxhead J,Hudson G,Crosier M,Strahl H,Khalaf Y,Saitou M,Ilic D,Surani MA,Chinnery PF

更新日期：2018-02-01 00:00:00

abstract：:Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degene...

journal_title：Nature cell biology

authors： Shiloh Y,Lehmann AR

更新日期：2004-10-01 00:00:00

abstract：:Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalie...

journal_title：Nature cell biology

authors： Jin Y,Muhl L,Burmakin M,Wang Y,Duchez AC,Betsholtz C,Arthur HM,Jakobsson L

更新日期：2017-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased cell motility and invasiveness. miR-9-mediated E-cadherin downregula...

journal_title：Nature cell biology

authors： Ma L,Young J,Prabhala H,Pan E,Mestdagh P,Muth D,Teruya-Feldstein J,Reinhardt F,Onder TT,Valastyan S,Westermann F,Speleman F,Vandesompele J,Weinberg RA

更新日期：2010-03-01 00:00:00

abstract：:Mouse embryos with a loss-of-function mutation in the gene encoding the receptor tyrosine kinase ErbB4 exhibit misprojections of cranial sensory ganglion afferent axons. Here we analyse ErbB4-deficient mice, and find that morphological differences between wild-type and mutant cranial ganglia correlate with aberrant mi...

journal_title：Nature cell biology

authors： Golding JP,Trainor P,Krumlauf R,Gassmann M

更新日期：2000-02-01 00:00:00

abstract：:Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncoge...

journal_title：Nature cell biology

authors： Blanpain C

更新日期：2013-02-01 00:00:00

abstract：:The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to the state of attachment of the kinetochore to spindle microtubules. SAC signalling is activated by unattached kinetochores, and it is silenced after these kinetochores form end-on microtubule attachments. Although the biochemical c...

journal_title：Nature cell biology

authors： Aravamudhan P,Goldfarb AA,Joglekar AP

更新日期：2015-07-01 00:00:00

abstract：:The enteric nervous system (ENS) predominantly originates from vagal neural crest (VNC) cells that emerge from the caudal hindbrain, invade the foregut and populate the gastrointestinal tract. However, the gene regulatory network (GRN) orchestrating the early specification of VNC remains unknown. Using an EdnrB enhanc...

journal_title：Nature cell biology

authors： Ling ITC,Sauka-Spengler T

更新日期：2019-12-01 00:00:00

abstract：:Treatment of cultured vertebrate neurons with nitric oxide leads to growth-cone collapse, axon retraction and the reconfiguration of axonal microtubules. We show that the light chain of microtubule-associated protein (MAP) 1B is a substrate for S-nitrosylation in vivo, in cultured cells and in vitro. S-nitrosylation o...

journal_title：Nature cell biology

authors： Stroissnigg H,Trancíková A,Descovich L,Fuhrmann J,Kutschera W,Kostan J,Meixner A,Nothias F,Propst F

更新日期：2007-09-01 00:00:00

abstract：:The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-pr...

journal_title：Nature cell biology

authors： Hariharan IK

更新日期：2015-04-01 00:00:00

abstract：:BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to neurodegeneration. The voltage-gated sodium channel (Na(v)1) beta2-subunit (beta2), a type I membrane protein that covalently binds to Na(v)1 alpha-subunits, is a substrate for BACE1 and gamma-secretase...

journal_title：Nature cell biology

authors： Kim DY,Carey BW,Wang H,Ingano LA,Binshtok AM,Wertz MH,Pettingell WH,He P,Lee VM,Woolf CJ,Kovacs DM

更新日期：2007-07-01 00:00:00

abstract：:Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recen...

journal_title：Nature cell biology

authors： Heinrich C,Spagnoli FM,Berninger B

更新日期：2015-03-01 00:00:00

abstract：:RNA interference has become an indispensable tool for loss-of-function studies across eukaryotes. By enabling stable and reversible gene silencing, shRNAs provide a means to study long-term phenotypes, perform pool-based forward genetic screens and examine the consequences of temporary target inhibition in vivo. Howev...

journal_title：Nature cell biology

authors： Fellmann C,Lowe SW

更新日期：2014-01-01 00:00:00

abstract：:Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia1, yet the physiological state of tau molecules within cells remains unclear. Using single-molecule imaging, we directly observe that the microtubule latt...

journal_title：Nature cell biology

authors： Tan R,Lam AJ,Tan T,Han J,Nowakowski DW,Vershinin M,Simó S,Ori-McKenney KM,McKenney RJ

更新日期：2019-09-01 00:00:00

abstract：:Protein kinases have central functions in various cellular signal transduction pathways through their substrate phosphorylation. Here we show that a protein kinase, DYRK2, has unexpected role as a scaffold for an E3 ubiquitin ligase complex. DYRK2 associates with an E3 ligase complex containing EDD, DDB1 and VPRBP pro...

journal_title：Nature cell biology

authors： Maddika S,Chen J

更新日期：2009-04-01 00:00:00

abstract：:Tie2 belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1 (Ang1). Gene-targeting analyses of either Ang1 or Tie2 in mice reveal a critical role of Ang1-Tie2 signalling in developmental vascular formation. It remains elusive how the Tie2 signalling pathway plays distinct roles i...

journal_title：Nature cell biology

authors： Fukuhara S,Sako K,Minami T,Noda K,Kim HZ,Kodama T,Shibuya M,Takakura N,Koh GY,Mochizuki N

更新日期：2008-05-01 00:00:00

abstract：:Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3. Cells transfected with a seven-transmembrane-domain receptor, OT7T022, specifically ...

journal_title：Nature cell biology

authors： Hinuma S,Shintani Y,Fukusumi S,Iijima N,Matsumoto Y,Hosoya M,Fujii R,Watanabe T,Kikuchi K,Terao Y,Yano T,Yamamoto T,Kawamata Y,Habata Y,Asada M,Kitada C,Kurokawa T,Onda H,Nishimura O,Tanaka M,Ibata Y,Fujino M

更新日期：2000-10-01 00:00:00

abstract：:The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucle...

journal_title：Nature cell biology

authors： Selva EM,Hong K,Baeg GH,Beverley SM,Turco SJ,Perrimon N,Häcker U

更新日期：2001-09-01 00:00:00

abstract：:Cancer cells use aerobic glycolysis preferentially for energy provision and this metabolic change is important for tumour growth. Here, we have found a link between the tumour suppressor p53, the transcription factor NF-kappaB and glycolysis. In p53-deficient primary cultured cells, kinase activities of IKKalpha and I...

journal_title：Nature cell biology

authors： Kawauchi K,Araki K,Tobiume K,Tanaka N

更新日期：2008-05-01 00:00:00

abstract：:Accurate chromosome segregation during cell division in metazoans relies on proper chromosome congression at the equator. Chromosome congression is achieved after bi-orientation to both spindle poles shortly after nuclear envelope breakdown, or by the coordinated action of motor proteins that slide misaligned chromoso...

journal_title：Nature cell biology

authors： Barisic M,Aguiar P,Geley S,Maiato H

更新日期：2014-12-01 00:00:00