Abstract:
:In the version of this article originally published, parts of Figure 5 were misaligned because of a shift during production. In a, one data point was outside of the graph border. In b, axes lines were not connected, and graph lines did not reach the data points. In c and d, the axes lines were not connected. In e and g, the axes lines were not connected, and error bars and columns were not aligned. Shown below are the original and corrected versions of Figure 5. The errors have been corrected in the PDF and HTML versions of the paper.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Boos F,Krämer L,Groh C,Jung F,Haberkant P,Stein F,Wollweber F,Gackstatter A,Zöller E,van der Laan M,Savitski MM,Benes V,Herrmann JMdoi
10.1038/s41556-019-0326-1subject
Has Abstractpub_date
2019-06-01 00:00:00pages
793-794issue
6eissn
1465-7392issn
1476-4679pii
10.1038/s41556-019-0326-1journal_volume
21pub_type
杂志文章,已发布勘误abstract::Whereas total loss of Lis1 is lethal, disruption of one allele of the Lis1 gene results in brain abnormalities, indicating that developing neurons are particularly sensitive to a reduction in Lis1 dosage. Here we show that Lis1 is enriched in neurons relative to levels in other cell types, and that Lis1 interacts with...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/35041000
更新日期:2000-11-01 00:00:00
abstract::Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated chloride channel expressed in a wide variety of epithelial cells, mutations of which are responsible for the hallmark defective chloride secretion observed in cystic fibrosis (CF). Although CFTR has been implicated in bicarbonate secretion,...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1047
更新日期:2003-10-01 00:00:00
abstract::The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in r...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3619
更新日期:2017-09-29 00:00:00
abstract::Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a fam...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-020-0488-x
更新日期:2020-04-01 00:00:00
abstract::When co-translationally inserted into endoplasmic reticulum (ER) membranes, newly synthesized proteins encounter the lumenal environment of the ER, which contains chaperone proteins that facilitate the folding reactions necessary for protein oligomerization, maturation and export from the ER. Here we show, using a tem...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35010558
更新日期:2000-05-01 00:00:00
abstract::Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11-Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11-Rab8 cascade, ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3109
更新日期:2015-03-01 00:00:00
abstract::Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2 5-phosphatase. Here we unveil a lysosomal response to the arrival of autophagosomal cargo i...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3386
更新日期:2016-08-01 00:00:00
abstract::RNA interference has become an indispensable tool for loss-of-function studies across eukaryotes. By enabling stable and reversible gene silencing, shRNAs provide a means to study long-term phenotypes, perform pool-based forward genetic screens and examine the consequences of temporary target inhibition in vivo. Howev...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2895
更新日期:2014-01-01 00:00:00
abstract::The Semliki Forest virus capsid protein contains a chymotrypsin-like protease domain that must fold before it can autocatalytically cleave the protein from a larger polyprotein precursor. Here we analyse this cleavage in living mammalian and prokaryotic cells, and find that it occurs immediately after the emergence of...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/14032
更新日期:1999-10-01 00:00:00
abstract::We have identified Rab10 as an ER-specific Rab GTPase that regulates ER structure and dynamics. We show that Rab10 localizes to the ER and to dynamic ER-associated structures that track along microtubules and mark the position of new ER tubule growth. Rab10 depletion or expression of a Rab10 GDP-locked mutant alters E...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2647
更新日期:2013-02-01 00:00:00
abstract::Aberrant activation of beta-catenin promotes cell proliferation and initiates colorectal tumorigenesis. However, the expansion of tumours and the inadequacy of their local vasculature results in areas of hypoxia where cell growth is typically constrained. Here, we report a novel diversion in beta-catenin signalling tr...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1534
更新日期:2007-02-01 00:00:00
abstract::Autophagy is a lysosome-based degradation pathway. During autophagy, lysosomes fuse with autophagosomes to form autolysosomes. Following starvation-induced autophagy, nascent lysosomes are formed from autolysosomal membranes through an evolutionarily conserved cellular process, autophagic lysosome reformation (ALR), w...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2557
更新日期:2012-09-01 00:00:00
abstract::The GTPase dynamin plays an essential part in endocytosis by catalysing the fission of nascent clathrin-coated vesicles from the plasma membrane. Using preformed phosphatidylinositol-4,5-bisphosphate-containing lipid nanotubes as a membrane template for dynamin self-assembly, we investigate the conformational changes ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/8997
更新日期:1999-05-01 00:00:00
abstract::KLF4 (GKLF/EZF) encodes a transcription factor that is associated with both tumour suppression and oncogenesis. We describe the identification of KLF4 in a functional genomic screen for genes that bypass RAS(V12)-induced senescence. However, in untransformed cells, KLF4 acts as a potent inhibitor of proliferation. KLF...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1314
更新日期:2005-11-01 00:00:00
abstract::Bcl-2 stimulates mutagenesis after the exposure of cells to DNA-damaging agents. However, the biological mechanisms of Bcl-2-mediated mutagenesis have remained largely obscure. Here we demonstrate that the Bcl-2-mediated suppression of hMSH2 expression results in a reduced cellular capacity to repair mismatches. The p...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1215
更新日期:2005-02-01 00:00:00
abstract:: ...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/s41556-018-0246-5
更新日期:2018-12-01 00:00:00
abstract::p53 mutations occur very frequently in human cancer. Besides abrogating the tumour suppressive functions of wild-type p53, many of those mutations also acquire oncogenic gain-of-function activities. Augmentation of proteasome activity is now reported as a common gain-of-function mechanism shared by different p53 mutan...
journal_title:Nature cell biology
pub_type: 新闻
doi:10.1038/ncb3392
更新日期:2016-07-27 00:00:00
abstract::In response to DNA damage, eukaryotic cells use a system of checkpoint controls to delay cell-cycle progression. Checkpoint delays provide time for repair of damaged DNA before its replication in S phase and before segregation of chromatids in M phase. The Cds1 (Chk2) tumour-suppressor protein has been implicated in c...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35036406
更新日期:2000-10-01 00:00:00
abstract::Mitochondrial DNA (mtDNA) mutations cause inherited diseases and are implicated in the pathogenesis of common late-onset disorders, but how they arise is not clear1,2. Here we show that mtDNA mutations are present in primordial germ cells (PGCs) within healthy female human embryos. Isolated PGCs have a profound reduct...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-017-0017-8
更新日期:2018-02-01 00:00:00
abstract::The stability and membrane localization of the transforming growth factor-β (TGF-β) type I receptor (TβRI) determines the levels of TGF-β signalling. TβRI is targeted for ubiquitylation-mediated degradation by the SMAD7-SMURF2 complex. Here we performed a genome-wide gain-of-function screen and identified ubiquitin-sp...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2522
更新日期:2012-06-17 00:00:00
abstract::The tumour stroma is an active participant during cancer progression. Stromal cells promote tumour progression and metastasis through multiple mechanisms including enhancing tumour invasiveness and angiogenesis, and suppressing immune surveillance. We report here that miR-126/miR-126(*), a microRNA pair derived from a...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2690
更新日期:2013-03-01 00:00:00
abstract::Autophagy is an evolutionarily conserved 'self-eating' process. Although the genes essential for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how Atg proteins control autophagosome formation in mammalian cells remains to be elucidated. Here, we demonstrate that Bif-1 (also known as E...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1634
更新日期:2007-10-01 00:00:00
abstract::During mammalian development, neuroepithelial cells function as mitotic progenitors, which self-renew and generate neurons. Although spindle orientation is important for such polarized cells to undergo symmetric or asymmetric divisions, its role in mammalian neurogenesis remains unclear. Here we show that control of s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1673
更新日期:2008-01-01 00:00:00
abstract::Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyses the trimethylation of histone H3 on Lys 27 (H3K27), which represses gene transcription. EZH2 enhances cancer-cell invasiveness and regulates stem cell differentiation. Here, we demonstrate that EZH2 can ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2139
更新日期:2011-01-01 00:00:00
abstract::The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributo...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/s41556-019-0319-0
更新日期:2019-05-01 00:00:00
abstract::The target of rapamycin complex 2 (TORC2) plays a key role in maintaining the homeostasis of plasma membrane (PM) tension. TORC2 activation following increased PM tension involves redistribution of the Slm1 and 2 paralogues from PM invaginations known as eisosomes into membrane compartments containing TORC2. How Slm1/...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0150-z
更新日期:2018-09-01 00:00:00
abstract::The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of stalled DNA replication forks is a recently identified PARPi-resistance mechanism that promotes genomic stability in BRCA1/2-deficient cancers. D...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3626
更新日期:2017-11-01 00:00:00
abstract::Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalie...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3534
更新日期:2017-06-01 00:00:00
abstract::Haematopoietic stem-progenitor cells (HSPCs) reside in the bone marrow niche, where interactions with osteoblasts provide essential cues for their proliferation and survival. Here, we use live-cell imaging to characterize both the site of contact between osteoblasts and haematopoietic progenitor cells (HPCs) and event...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1838
更新日期:2009-03-01 00:00:00
abstract::Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling cascade, but how ubiqu...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2367
更新日期:2011-10-23 00:00:00