当前位置： SCI文献检索 > NATURE CELL BIOLOGY期刊下所有文献 > Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis.

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis.

Abstract：

:Autophagy is an evolutionarily conserved 'self-eating' process. Although the genes essential for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how Atg proteins control autophagosome formation in mammalian cells remains to be elucidated. Here, we demonstrate that Bif-1 (also known as Endophilin B1) interacts with Beclin 1 through ultraviolet irradiation resistance-associated gene (UVRAG) and functions as a positive mediator of the class III PI(3) kinase (PI(3)KC3). In response to nutrient deprivation, Bif-1 localizes to autophagosomes where it colocalizes with Atg5, as well as microtubule-associated protein light chain 3 (LC3). Furthermore, loss of Bif-1 suppresses autophagosome formation. Although the SH3 domain of Bif-1 is sufficient for binding to UVRAG, both the BAR and SH3 domains are required for Bif-1 to activate PI(3)KC3 and induce autophagosome formation. We also observed that Bif-1 ablation prolongs cell survival under starvation conditions. Moreover, knockout of Bif-1 significantly enhances the development of spontaneous tumours in mice. These findings suggest that Bif-1 joins the UVRAG-Beclin 1 complex as a potential activator of autophagy and tumour suppressor.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Takahashi Y,Coppola D,Matsushita N,Cualing HD,Sun M,Sato Y,Liang C,Jung JU,Cheng JQ,Mulé JJ,Pledger WJ,Wang HG

doi

10.1038/ncb1634

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

1142-51

issue

10

eissn

1465-7392

issn

1476-4679

pii

ncb1634

journal_volume

9

pub_type

杂志文章

相关文献

NATURE CELL BIOLOGY文献大全
  • PML regulates p53 stability by sequestering Mdm2 to the nucleolus.

    abstract：:The promyelocytic leukaemia (PML) tumour-suppressor protein potentiates p53 function by regulating post-translational modifications, such as CBP-dependent acetylation and Chk2-dependent phosphorylation, in the PML-Nuclear Body (NB). PML was recently shown to interact with the p53 ubiquitin-ligase Mdm2 (refs 4-6); howe...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1147

    authors： Bernardi R,Scaglioni PP,Bergmann S,Horn HF,Vousden KH,Pandolfi PP

    更新日期：2004-07-01 00:00:00

  • BACE1 regulates voltage-gated sodium channels and neuronal activity.

    abstract：:BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to neurodegeneration. The voltage-gated sodium channel (Na(v)1) beta2-subunit (beta2), a type I membrane protein that covalently binds to Na(v)1 alpha-subunits, is a substrate for BACE1 and gamma-secretase...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1602

    authors： Kim DY,Carey BW,Wang H,Ingano LA,Binshtok AM,Wertz MH,Pettingell WH,He P,Lee VM,Woolf CJ,Kovacs DM

    更新日期：2007-07-01 00:00:00

  • Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.

    abstract：:Collective cell migration occurs in a range of contexts: cancer cells frequently invade in cohorts while retaining cell-cell junctions. Here we show that collective invasion by cancer cells depends on decreasing actomyosin contractility at sites of cell-cell contact. When actomyosin is not downregulated at cell-cell c...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2133

    authors： Hidalgo-Carcedo C,Hooper S,Chaudhry SI,Williamson P,Harrington K,Leitinger B,Sahai E

    更新日期：2011-01-01 00:00:00

  • Ankyrin repeat-containing N-Ank proteins shape cellular membranes.

    abstract：:Cells of multicellular organisms need to adopt specific morphologies. However, the molecular mechanisms bringing about membrane topology changes are far from understood-mainly because knowledge of membrane-shaping proteins that can promote local membrane curvatures is still limited. Our analyses unveiled that several ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-019-0381-7

    authors： Wolf D,Hofbrucker-MacKenzie SA,Izadi M,Seemann E,Steiniger F,Schwintzer L,Koch D,Kessels MM,Qualmann B

    更新日期：2019-10-01 00:00:00

  • PI-loting membrane traffic.

    abstract：:Phosphoinositides (PIs) undergo phosphorylation/dephosphorylation cycles through organelle-specific PI kinases and PI phosphatases that lead to distinct subcellular distributions of the individual PI species. Specific PIs control the correct timing and location of many trafficking events. Their ultimate mode of action...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb0604-487

    authors： De Matteis MA,Godi A

    更新日期：2004-06-01 00:00:00

  • Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation.

    abstract：:Canonical Wnt signalling has been implicated in mouse and human embryonic stem cell (ESC) maintenance; however, its requirement is controversial. β-catenin is the key component in this highly conserved Wnt pathway, acting as a transcriptional transactivator. However, β-catenin has additional roles at the plasma membra...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2260

    authors： Lyashenko N,Winter M,Migliorini D,Biechele T,Moon RT,Hartmann C

    更新日期：2011-06-19 00:00:00

  • White-to-brown metabolic conversion of human adipocytes by JAK inhibition.

    abstract：:The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of new therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been shown to prevent diet-i...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3075

    authors： Moisan A,Lee YK,Zhang JD,Hudak CS,Meyer CA,Prummer M,Zoffmann S,Truong HH,Ebeling M,Kiialainen A,Gérard R,Xia F,Schinzel RT,Amrein KE,Cowan CA

    更新日期：2015-01-01 00:00:00

  • RNA takes over control of DNA break repair.

    abstract：:Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions. ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3645

    authors： Storici F,Tichon AE

    更新日期：2017-11-29 00:00:00

  • Homologue recognition during meiosis is associated with a change in chromatin conformation.

    abstract：:During meiosis, homologous chromosomes are sorted into pairs and are then intimately aligned, or synapsed, along their lengths while a proteinaceous structure, the synaptonemal complex, is assembled between them. However, little is known about how chromosomes first recognise each other. Here we show, by comparing the ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1168

    authors： Prieto P,Shaw P,Moore G

    更新日期：2004-09-01 00:00:00

  • The Ets transcription factor GABP is required for cell-cycle progression.

    abstract：:The transition from cellular quiescence (G0) into S phase is regulated by the mitogenic-activation of D-type cyclins and cyclin-dependent kinases (Cdks), the sequestration of the Cdk inhibitors (CDKIs), p21 and p27, and the hyperphosphorylation of Rb with release of E2F transcription factors. However, fibroblasts that...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1548

    authors： Yang ZF,Mott S,Rosmarin AG

    更新日期：2007-03-01 00:00:00

  • Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.

    abstract：:Etk/BMX, a member of the Btk family of tyrosine kinases, is highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines. Here, we present evidence that Etk is involved in integrin signalling and promotes cell migration. The activation of Etk by extracellula...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/35074500

    authors： Chen R,Kim O,Li M,Xiong X,Guan JL,Kung HJ,Chen H,Shimizu Y,Qiu Y

    更新日期：2001-05-01 00:00:00

  • Control of metastatic progression by microRNA regulatory networks.

    abstract：:Aberrant microRNA (miRNA) expression is a defining feature of human malignancy. Specific miRNAs have been identified as promoters or suppressors of metastatic progression. miRNAs control metastasis through divergent or convergent regulation of metastatic gene pathways. Some miRNA regulatory networks govern cell-autono...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb2769

    authors： Pencheva N,Tavazoie SF

    更新日期：2013-06-01 00:00:00

  • Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein.

    abstract：:The formation of branched epithelial networks is fundamental to the development of many organs, such as the lung, the kidney or the vasculature. Little is known about the mechanisms that control cell rearrangements during tubulogenesis and regulate the size of individual tubes. Recent studies indicate that whereas the...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1049

    authors： Jaźwińska A,Ribeiro C,Affolter M

    更新日期：2003-10-01 00:00:00

  • Arabidopsis cortical microtubules position cellulose synthase delivery to the plasma membrane and interact with cellulose synthase trafficking compartments.

    abstract：:Plant cell morphogenesis relies on the organization and function of two polymer arrays separated by the plasma membrane: the cortical microtubule cytoskeleton and cellulose microfibrils in the cell wall. Studies using in vivo markers confirmed that one function of the cortical microtubule array is to drive organizatio...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1886

    authors： Gutierrez R,Lindeboom JJ,Paredez AR,Emons AM,Ehrhardt DW

    更新日期：2009-07-01 00:00:00

  • The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.

    abstract：:PX domains are found in a variety of proteins that associate with cell membranes, but their molecular function has remained obscure. We show here that the PX domains in p47phox and p40phox subunits of the phagocyte NADPH oxidase bind to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P(2)) and phosphatidylinositol-3...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/35083070

    authors： Kanai F,Liu H,Field SJ,Akbary H,Matsuo T,Brown GE,Cantley LC,Yaffe MB

    更新日期：2001-07-01 00:00:00

  • A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance.

    abstract：:Proteins essential for vesicle formation by the Coat Protein I (COPI) complex are being identified, but less is known about the role of specific lipids. Brefeldin-A ADP-ribosylated substrate (BARS) functions in the fission step of COPI vesicle formation. Here, we show that BARS induces membrane curvature in cooperatio...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1774

    authors： Yang JS,Gad H,Lee SY,Mironov A,Zhang L,Beznoussenko GV,Valente C,Turacchio G,Bonsra AN,Du G,Baldanzi G,Graziani A,Bourgoin S,Frohman MA,Luini A,Hsu VW

    更新日期：2008-10-01 00:00:00

  • Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.

    abstract：:Direct reprogramming by forced expression of transcription factors can convert one cell type into another. Thus, desired cell types can be generated bypassing pluripotency. However, direct reprogramming towards renal cells remains an unmet challenge. Here, we identify renal cell fate-inducing factors on the basis of t...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3437

    authors： Kaminski MM,Tosic J,Kresbach C,Engel H,Klockenbusch J,Müller AL,Pichler R,Grahammer F,Kretz O,Huber TB,Walz G,Arnold SJ,Lienkamp SS

    更新日期：2016-12-01 00:00:00

  • GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication.

    abstract：:Many of the factors required for chromosomal DNA replication have been identified in unicellular eukaryotes. However, DNA replication is poorly understood in multicellular organisms. Here, we report the identification of GEMC1 (geminin coiled-coil containing protein 1), a novel vertebrate protein required for chromoso...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2050

    authors： Balestrini A,Cosentino C,Errico A,Garner E,Costanzo V

    更新日期：2010-05-01 00:00:00

  • A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold.

    abstract：:A key step in nutrient sensing is activation of the master growth regulator, mTORC1 kinase, on the lysosomal membrane. Nutrients enable mTORC1 scaffolding by a complex composed of the Rag GTPases (Rags) and Ragulator, but the underlying mechanism of mTORC1 capture is poorly understood. Combining dynamic imaging in cel...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-018-0148-6

    authors： Lawrence RE,Cho KF,Rappold R,Thrun A,Tofaute M,Kim DJ,Moldavski O,Hurley JH,Zoncu R

    更新日期：2018-09-01 00:00:00

  • Author Correction: Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature cell biology

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41556-020-0479-y

    authors： Bagci H,Sriskandarajah N,Robert A,Boulais J,Elkholi IE,Tran V,Lin ZY,Thibault MP,Dubé N,Faubert D,Hipfner DR,Gingras AC,Côté JF

    更新日期：2020-03-01 00:00:00

  • RNA modifications regulating cell fate in cancer.

    abstract：:The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributo...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/s41556-019-0319-0

    authors： Delaunay S,Frye M

    更新日期：2019-05-01 00:00:00

  • Exocytosis of single chromaffin granules in cell-free inside-out membrane patches.

    abstract：:In chromaffin cells, exocytosis of single granules and properties of the fusion pore--the first connection between vesicular lumen and extracellular space --can be studied by cell-attached patch amperometry, which couples patch-clamp capacitance measurements with simultaneous amperometric recordings of transmitter rel...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb956

    authors： Dernick G,Alvarez de Toledo G,Lindau M

    更新日期：2003-04-01 00:00:00

  • Rapid activation of ATM on DNA flanking double-strand breaks.

    abstract：:The tumour-suppressor gene ATM, mutations in which cause the human genetic disease ataxia telangiectasia (A-T), encodes a key protein kinase that controls the cellular response to DNA double-strand breaks (DSBs). DNA DSBs caused by ionizing radiation or chemicals result in rapid ATM autophosphorylation, leading to che...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1651

    authors： You Z,Bailis JM,Johnson SA,Dilworth SM,Hunter T

    更新日期：2007-11-01 00:00:00

  • Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.

    abstract：:Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal, we have developed cell culture conditions to closely mimic events occurring during pancreatic islet organogenesis and β...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-018-0271-4

    authors： Nair GG,Liu JS,Russ HA,Tran S,Saxton MS,Chen R,Juang C,Li ML,Nguyen VQ,Giacometti S,Puri S,Xing Y,Wang Y,Szot GL,Oberholzer J,Bhushan A,Hebrok M

    更新日期：2019-02-01 00:00:00

  • Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.

    abstract：:Phosphoinositide 3-kinase (PI(3)K) is a unique enzyme characterized by both lipid and protein kinase activities. Here, we demonstrate a requirement for the protein kinase activity of PI(3)K in agonist-dependent beta-adrenergic receptor (betaAR) internalization. Using PI(3)K mutants with either protein or lipid phospho...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1278

    authors： Naga Prasad SV,Jayatilleke A,Madamanchi A,Rockman HA

    更新日期：2005-08-01 00:00:00

  • Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche.

    abstract：:Haematopoietic stem-progenitor cells (HSPCs) reside in the bone marrow niche, where interactions with osteoblasts provide essential cues for their proliferation and survival. Here, we use live-cell imaging to characterize both the site of contact between osteoblasts and haematopoietic progenitor cells (HPCs) and event...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1838

    authors： Gillette JM,Larochelle A,Dunbar CE,Lippincott-Schwartz J

    更新日期：2009-03-01 00:00:00

  • Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF.

    abstract：:Endothelial cells and leptin receptor+ (LepR+) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone marrow. After irradiation or chemotherapy, these cells are depleted while adipocytes become abundant. We discovered that bone marrow adipocytes sy...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3570

    authors： Zhou BO,Yu H,Yue R,Zhao Z,Rios JJ,Naveiras O,Morrison SJ

    更新日期：2017-08-01 00:00:00

  • MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling.

    abstract：:ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardio...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1696

    authors： David R,Brenner C,Stieber J,Schwarz F,Brunner S,Vollmer M,Mentele E,Müller-Höcker J,Kitajima S,Lickert H,Rupp R,Franz WM

    更新日期：2008-03-01 00:00:00

  • Medial HOXA genes demarcate haematopoietic stem cell fate during human development.

    abstract：:Pluripotent stem cells (PSCs) may provide a potential source of haematopoietic stem/progenitor cells (HSPCs) for transplantation; however, unknown molecular barriers prevent the self-renewal of PSC-HSPCs. Using two-step differentiation, human embryonic stem cells (hESCs) differentiated in vitro into multipotent haemat...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3354

    authors： Dou DR,Calvanese V,Sierra MI,Nguyen AT,Minasian A,Saarikoski P,Sasidharan R,Ramirez CM,Zack JA,Crooks GM,Galic Z,Mikkola HK

    更新日期：2016-06-01 00:00:00

  • Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components.

    abstract：:To maintain genome function and stability, DNA sequence and its organization into chromatin must be duplicated during cell division. Understanding how entire chromosomes are copied remains a major challenge. Here, we use nascent chromatin capture (NCC) to profile chromatin proteome dynamics during replication in human...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2918

    authors： Alabert C,Bukowski-Wills JC,Lee SB,Kustatscher G,Nakamura K,de Lima Alves F,Menard P,Mejlvang J,Rappsilber J,Groth A

    更新日期：2014-03-01 00:00:00