A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold.

abstract：:Actomyosin contractility is a mechanism by which cells exert locomotory force against their environment. Signalling downstream of the small GTPase Rho increases contractility through Rho-kinase (ROCK)-mediated regulation of myosin-II light chain (MLC2) phosphorylation. Cdc42 signalling has been shown to control cell p...

journal_title：Nature cell biology

authors： Wilkinson S,Paterson HF,Marshall CJ

更新日期：2005-03-01 00:00:00

abstract：:MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endo...

journal_title：Nature cell biology

authors： Kotlyarov A,Neininger A,Schubert C,Eckert R,Birchmeier C,Volk HD,Gaestel M

更新日期：1999-06-01 00:00:00

abstract：:Endocytosis of cell surface receptors is an important regulatory event in signal transduction. The transforming growth factor beta (TGF-beta) superfamily signals to the Smad pathway through heteromeric Ser-Thr kinase receptors that are rapidly internalized and then downregulated in a ubiquitin-dependent manner. Here w...

journal_title：Nature cell biology

authors： Di Guglielmo GM,Le Roy C,Goodfellow AF,Wrana JL

更新日期：2003-05-01 00:00:00

abstract：:The actin filament (F-actin) cytoskeleton associates dynamically with the plasma membrane and is thus ideally positioned to participate in endocytosis. Indeed, a wealth of genetic and biochemical evidence has confirmed that actin interacts with components of the endocytic machinery, although its precise function in en...

journal_title：Nature cell biology

authors： Sokac AM,Co C,Taunton J,Bement W

更新日期：2003-08-01 00:00:00

abstract：:Protein ubiquitination regulates many cellular processes, including protein degradation, signal transduction, DNA repair and cell division. In the classical model, a uniform polyubiquitin chain that is linked through Lys 48 is required for recognition and degradation by the 26S proteasome. Here, we used a reconstitute...

journal_title：Nature cell biology

authors： Kirkpatrick DS,Hathaway NA,Hanna J,Elsasser S,Rush J,Finley D,King RW,Gygi SP

更新日期：2006-07-01 00:00:00

abstract：:Gastrulation leads to three germ layers--ectoderm, mesoderm and endoderm--that are separated by two basement membranes. In the mouse embryo, the emergent gut endoderm results from the widespread intercalation of cells of two distinct origins: pluripotent epiblast-derived definitive endoderm (DE) and extra-embryonic vi...

journal_title：Nature cell biology

authors： Viotti M,Nowotschin S,Hadjantonakis AK

更新日期：2014-12-01 00:00:00

abstract：:The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of new therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been shown to prevent diet-i...

journal_title：Nature cell biology

authors： Moisan A,Lee YK,Zhang JD,Hudak CS,Meyer CA,Prummer M,Zoffmann S,Truong HH,Ebeling M,Kiialainen A,Gérard R,Xia F,Schinzel RT,Amrein KE,Cowan CA

更新日期：2015-01-01 00:00:00

abstract：:A number of key regulators of mouse embryonic stem (ES) cell identity, including the transcription factor Nanog, show strong expression fluctuations at the single-cell level. The molecular basis for these fluctuations is unknown. Here we used a genetic complementation strategy to investigate expression changes during ...

journal_title：Nature cell biology

authors： MacArthur BD,Sevilla A,Lenz M,Müller FJ,Schuldt BM,Schuppert AA,Ridden SJ,Stumpf PS,Fidalgo M,Ma'ayan A,Wang J,Lemischka IR

更新日期：2012-11-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature cell biology

authors： Huang Y,Zucker B,Zhang S,Elias S,Zhu Y,Chen H,Ding T,Li Y,Sun Y,Lou J,Kozlov MM,Yu L

更新日期：2019-10-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitor p27(Kip1) is degraded at the G0-G1 transition of the cell cycle by the ubiquitin-proteasome pathway. Although the nuclear ubiquitin ligase (E3) SCF(Skp2) is implicated in p27(Kip1) degradation, proteolysis of p27(Kip1) at the G0-G1 transition proceeds normally in Skp2(-/-) cells. ...

journal_title：Nature cell biology

authors： Kamura T,Hara T,Matsumoto M,Ishida N,Okumura F,Hatakeyama S,Yoshida M,Nakayama K,Nakayama KI

更新日期：2004-12-01 00:00:00

abstract：:The mechanistic target of rapamycin (mTOR) functions as a critical regulator of cellular growth and metabolism by forming multi-component, yet functionally distinct complexes mTORC1 and mTORC2. Although mTORC2 has been implicated in mTORC1 activation, little is known about how mTORC2 is regulated. Here we report that ...

journal_title：Nature cell biology

authors： Liu P,Gan W,Inuzuka H,Lazorchak AS,Gao D,Arojo O,Liu D,Wan L,Zhai B,Yu Y,Yuan M,Kim BM,Shaik S,Menon S,Gygi SP,Lee TH,Asara JM,Manning BD,Blenis J,Su B,Wei W

更新日期：2013-11-01 00:00:00

abstract：:The contribution of autophagy to cancer development remains controversial, largely owing to the fact that autophagy can be tumour suppressive or oncogenic in different biological contexts. Here, we show that in non-small-cell lung cancer (NSCLC), casein kinase 1 alpha 1 (CK1α) suppresses tumour growth by functioning a...

journal_title：Nature cell biology

authors： Cai J,Li R,Xu X,Zhang L,Lian R,Fang L,Huang Y,Feng X,Liu X,Li X,Zhu X,Zhang H,Wu J,Zeng M,Song E,He Y,Yin Y,Li J,Li M

更新日期：2018-04-01 00:00:00

abstract：:Humans suffer from high rates of fetal aneuploidy, often arising from the absence of meiotic crossover recombination between homologous chromosomes. Meiotic recombination is initiated by double-strand breaks (DSBs) generated by the SPO11 transesterase. In yeast and worms, at least one buffering mechanism, crossover ho...

journal_title：Nature cell biology

authors： Cole F,Kauppi L,Lange J,Roig I,Wang R,Keeney S,Jasin M

更新日期：2012-03-04 00:00:00

abstract：:Lamellipodia/ruffles and filopodia are protruding organelles containing short and highly branched or long and unbranched actin filaments, respectively. The microscopic morphology, dynamic development and protein signature of both lamellipodia/ruffles and filopodia have been investigated; however, little is known about...

journal_title：Nature cell biology

authors： Beli P,Mascheroni D,Xu D,Innocenti M

更新日期：2008-07-01 00:00:00

abstract：:Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence is accompanied by a dynamic fluctuation of NOTCH1 activity, which drives a TGF-β-rich s...

journal_title：Nature cell biology

authors： Hoare M,Ito Y,Kang TW,Weekes MP,Matheson NJ,Patten DA,Shetty S,Parry AJ,Menon S,Salama R,Antrobus R,Tomimatsu K,Howat W,Lehner PJ,Zender L,Narita M

更新日期：2016-09-01 00:00:00

abstract：:The actin cable is a supracellular structure that embryonic epithelia produce to close gaps. However, the action of the cable remains debated. Here, we address the function of the cable using Drosophila dorsal closure, a paradigm to understand wound healing. First, we show that the actin cytoskeleton protein Zasp52 is...

journal_title：Nature cell biology

authors： Ducuing A,Vincent S

更新日期：2016-11-01 00:00:00

abstract：:Rad23 is a nucleotide-excision repair protein with a previously unknown biochemical function. We determined that yeast and human Rad23 inhibited multi-ubiquitin (Ub) chain formation and the degradation of proteolytic substrates. Significantly, Rad23 could be co-precipitated with a substrate that contained a short mult...

journal_title：Nature cell biology

authors： Ortolan TG,Tongaonkar P,Lambertson D,Chen L,Schauber C,Madura K

更新日期：2000-09-01 00:00:00

abstract：:Repulsive guidance molecule (RGM) is a recently identified protein implicated in both axonal guidance and neural tube closure. The avoidance of chick RGM in the posterior optic tectum by growing temporal, but not nasal, retinal ganglion cell axons is thought to contribute to visual map formation. In contrast to ephrin...

journal_title：Nature cell biology

authors： Rajagopalan S,Deitinghoff L,Davis D,Conrad S,Skutella T,Chedotal A,Mueller BK,Strittmatter SM

更新日期：2004-08-01 00:00:00

abstract：:The mitochondrial inner membrane is the central energy-converting membrane of eukaryotic cells. The electrochemical proton gradient generated by the respiratory chain drives the ATP synthase. To maintain this proton-motive force, the inner membrane forms a tight barrier and strictly controls the translocation of ions....

journal_title：Nature cell biology

authors： van der Laan M,Meinecke M,Dudek J,Hutu DP,Lind M,Perschil I,Guiard B,Wagner R,Pfanner N,Rehling P

更新日期：2007-10-01 00:00:00

abstract：:Primary cilia are required for vertebrate cells to respond to specific intercellular signals. Here we define when and where primary cilia appear in the mouse embryo using a transgenic line that expresses ARL13B-mCherry in cilia and Centrin 2-GFP in centrosomes. Primary cilia first appear on cells of the epiblast at E6...

journal_title：Nature cell biology

authors： Bangs FK,Schrode N,Hadjantonakis AK,Anderson KV

更新日期：2015-02-01 00:00:00

abstract：:The formation of branched epithelial networks is fundamental to the development of many organs, such as the lung, the kidney or the vasculature. Little is known about the mechanisms that control cell rearrangements during tubulogenesis and regulate the size of individual tubes. Recent studies indicate that whereas the...

journal_title：Nature cell biology

authors： Jaźwińska A,Ribeiro C,Affolter M

更新日期：2003-10-01 00:00:00

abstract：:Dozens of proteins capture, polymerize and reshape the clathrin lattice during clathrin-mediated endocytosis (CME). How or if this ensemble of proteins is organized in relation to the clathrin coat is unknown. Here, we map key molecules involved in CME at the nanoscale using correlative super-resolution light and tran...

journal_title：Nature cell biology

authors： Sochacki KA,Dickey AM,Strub MP,Taraska JW

更新日期：2017-04-01 00:00:00

abstract：:Lysosomes respond to environmental cues by controlling their own biogenesis, but the underlying mechanisms are poorly understood. Here we describe a protein kinase C (PKC)-dependent and mTORC1-independent mechanism for regulating lysosome biogenesis, which provides insights into previously reported effects of PKC on l...

journal_title：Nature cell biology

authors： Li Y,Xu M,Ding X,Yan C,Song Z,Chen L,Huang X,Wang X,Jian Y,Tang G,Tang C,Di Y,Mu S,Liu X,Liu K,Li T,Wang Y,Miao L,Guo W,Hao X,Yang C

更新日期：2016-10-01 00:00:00

abstract：:In some organs, adult stem cells are uniquely poised to serve as cancer cells of origin. It is unclear, however, whether tumorigenesis is influenced by the activation state of the adult stem cell. Hair follicle stem cells (HFSCs) act as cancer cells of origin for cutaneous squamous cell carcinoma and undergo defined c...

journal_title：Nature cell biology

authors： White AC,Khuu JK,Dang CY,Hu J,Tran KV,Liu A,Gomez S,Zhang Z,Yi R,Scumpia P,Grigorian M,Lowry WE

更新日期：2014-01-01 00:00:00

abstract：:Animal cell cytokinesis results from patterned activation of the small GTPase Rho, which directs assembly of actomyosin in the equatorial cortex. Cytokinesis is restricted to a portion of the cell cycle following anaphase onset in which the cortex is responsive to signals from the spindle. We show that shortly after a...

journal_title：Nature cell biology

authors： Bement WM,Leda M,Moe AM,Kita AM,Larson ME,Golding AE,Pfeuti C,Su KC,Miller AL,Goryachev AB,von Dassow G

更新日期：2015-11-01 00:00:00

abstract：:Actin networks drive many essential cellular processes, including cell migration, cytokinesis and tissue morphogenesis. However, how cells organize and regulate dynamic actin networks that consist of long, unbranched actin filaments is only poorly understood. This study in mouse oocytes reveals that cells can use vesi...

journal_title：Nature cell biology

authors： Holubcová Z,Howard G,Schuh M

更新日期：2013-08-01 00:00:00

abstract：:Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that tumour-secreted DKK1 is a serological marker of breast cancer metastasis organotropism and inhibits lung metastasis. DKK1 suppresses PTGS2-induced macrophage and ne...

journal_title：Nature cell biology

authors： Zhuang X,Zhang H,Li X,Li X,Cong M,Peng F,Yu J,Zhang X,Yang Q,Hu G

更新日期：2017-10-01 00:00:00

abstract：:Direct reprogramming by forced expression of transcription factors can convert one cell type into another. Thus, desired cell types can be generated bypassing pluripotency. However, direct reprogramming towards renal cells remains an unmet challenge. Here, we identify renal cell fate-inducing factors on the basis of t...

journal_title：Nature cell biology

authors： Kaminski MM,Tosic J,Kresbach C,Engel H,Klockenbusch J,Müller AL,Pichler R,Grahammer F,Kretz O,Huber TB,Walz G,Arnold SJ,Lienkamp SS

更新日期：2016-12-01 00:00:00

abstract：:Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed microtubule seeds or from γ-tubulin recruited to the side of a pre-existing microtubule. Here, we found that microtubules c...

journal_title：Nature cell biology

authors： Basnet N,Nedozralova H,Crevenna AH,Bodakuntla S,Schlichthaerle T,Taschner M,Cardone G,Janke C,Jungmann R,Magiera MM,Biertümpfel C,Mizuno N

更新日期：2018-10-01 00:00:00

abstract：:Science denial is not new but, in the digital age, evidence-based conclusions appear to be increasingly threatened by beliefs based on emotion and isolated personal experience. When confronting a post-truth world, scientists must defend the scientific method and increase public engagement. ...

journal_title：Nature cell biology

authors：

更新日期：2018-11-01 00:00:00