Abstract：
:In some organs, adult stem cells are uniquely poised to serve as cancer cells of origin. It is unclear, however, whether tumorigenesis is influenced by the activation state of the adult stem cell. Hair follicle stem cells (HFSCs) act as cancer cells of origin for cutaneous squamous cell carcinoma and undergo defined cycles of quiescence and activation. The data presented here show that HFSCs are unable to initiate tumours during the quiescent phase of the hair cycle, indicating that the mechanisms that keep HFSCs dormant are dominant over the gain of oncogenes (such as Ras) or the loss of tumour suppressors (such as p53). Furthermore, Pten activity is necessary for quiescence-based tumour suppression, as its deletion alleviates tumour suppression without affecting proliferation. These data demonstrate that stem cell quiescence is a form of tumour suppression in HFSCs, and that Pten plays a role in maintaining quiescence in the presence of tumorigenic stimuli.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
White AC,Khuu JK,Dang CY,Hu J,Tran KV,Liu A,Gomez S,Zhang Z,Yi R,Scumpia P,Grigorian M,Lowry WEdoi
10.1038/ncb2889subject
Has Abstractpub_date
2014-01-01 00:00:00pages
99-107issue
1eissn
1465-7392issn
1476-4679pii
ncb2889journal_volume
16pub_type
杂志文章abstract：:Canonical Wnt signalling has been implicated in mouse and human embryonic stem cell (ESC) maintenance; however, its requirement is controversial. β-catenin is the key component in this highly conserved Wnt pathway, acting as a transcriptional transactivator. However, β-catenin has additional roles at the plasma membra...
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abstract：:The importance of herpes simplex viruses (HSV) as human pathogens and the emerging prospect of using mutant derivatives of HSV-1 as potential anti-cancer therapeutics have necessitated a thorough investigation into the molecular basis of host-cell permissiveness to HSV. Here we show that NIH-3T3 cells transformed with...
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更新日期：2010-10-01 00:00:00
abstract：:Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalie...
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pub_type： 杂志文章
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journal_title：Nature cell biology
pub_type：
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更新日期：2004-10-01 00:00:00
abstract：:Different sites of plasma membrane attachment may underlie functional differences between isoforms of Ras. Here we show that palmitoylation and farnesylation targets H-ras to lipid rafts and caveolae, but that the interaction of H-ras with these membrane subdomains is dynamic. GTP-loading redistributes H-ras from raft...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35070050
更新日期：2001-04-01 00:00:00
abstract：:In the unicellular eukaryote Saccharomyces cerevisiae, Cln3-cyclin-dependent kinase activity enables Start, the irreversible commitment to the cell division cycle. However, the concentration of Cln3 has been paradoxically considered to remain constant during G1, due to the presumed scaling of its production rate with ...
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pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3369
更新日期：2016-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb2264
更新日期：2011-06-05 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1147
更新日期：2004-07-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3142
更新日期：2015-04-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1038/15620
更新日期：1999-11-01 00:00:00
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journal_title：Nature cell biology
pub_type： 评论,新闻
doi：10.1038/35017129
更新日期：2000-07-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3357
更新日期：2016-06-01 00:00:00
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pub_type： 评论,新闻
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更新日期：2013-08-01 00:00:00
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更新日期：2020-04-01 00:00:00
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更新日期：2017-12-01 00:00:00
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更新日期：2017-02-01 00:00:00
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更新日期：2004-07-01 00:00:00
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更新日期：2011-10-03 00:00:00
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更新日期：2000-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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更新日期：2004-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-12-01 00:00:00
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journal_title：Nature cell biology
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更新日期：2010-04-01 00:00:00
