Abstract:
:Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degenerative conditions. Current progress in this rapidly expanding field was the subject of an EMBO workshop, Maintenance of Genomic Integrity, that took place in June 2004 in Galway, Ireland. Top
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Shiloh Y,Lehmann ARdoi
10.1038/ncb1004-923keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
923-8issue
10eissn
1465-7392issn
1476-4679pii
ncb1004-923journal_volume
6pub_type
abstract::Spatial and temporal coordination of polo-like kinase 1 (Plk1) activity is necessary for mitosis and cytokinesis, and this is achieved through binding to phosphorylated docking proteins with distinct subcellular localizations. Although cyclin-dependent kinase 1 (Cdk1) creates these phosphorylated docking sites in meta...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1557
更新日期:2007-04-01 00:00:00
abstract::The tumour vascular microenvironment supports tumorigenesis not only by supplying oxygen and diffusible nutrients but also by secreting soluble factors that promote tumorigenesis. Here we identify a feedforward mechanism in which endothelial cells (ECs), in response to tumour-derived mediators, release angiocrines dri...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2954
更新日期:2014-05-01 00:00:00
abstract::During mammalian development, neuroepithelial cells function as mitotic progenitors, which self-renew and generate neurons. Although spindle orientation is important for such polarized cells to undergo symmetric or asymmetric divisions, its role in mammalian neurogenesis remains unclear. Here we show that control of s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1673
更新日期:2008-01-01 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cancers. Here, we generate quadruple TIMP knockout (TIMPless) fibroblasts ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3021
更新日期:2014-09-01 00:00:00
abstract::Nutrient availability is central for T-cell functions and immune responses. Here we report that CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non-essential amino acid Asn. Increased Asn levels enhance CD8+ T-cell activation and effector functions against tumour cells in vitro and in ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-020-00615-4
更新日期:2021-01-01 00:00:00
abstract::Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates embryonic development and tissue homeostasis; however, aberrations of its activity occur in cancer. TGF-beta signals through its Type II and Type I receptors (TbetaRII and TbetaRI) causing phosphorylation of Smad proteins. TGF-beta...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1780
更新日期:2008-10-01 00:00:00
abstract::BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to neurodegeneration. The voltage-gated sodium channel (Na(v)1) beta2-subunit (beta2), a type I membrane protein that covalently binds to Na(v)1 alpha-subunits, is a substrate for BACE1 and gamma-secretase...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1602
更新日期:2007-07-01 00:00:00
abstract::Activation of mitosis-promoting factor (MPF) drives mitotic commitment. In human cells active MPF appears first on centrosomes. We show that local activation of MPF on the equivalent organelle of fission yeast, the spindle pole body (SPB), promotes Polo kinase activity at the SPBs long before global MPF activation dri...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2633
更新日期:2013-01-01 00:00:00
abstract::Glioblastoma multiforme (GBMs) are recurrent lethal brain tumours. Recurrent GBMs often exhibit mesenchymal, stem-like phenotypes that could explain their resistance to therapy. Analyses revealed that recurrent GBMs have increased tension and express high levels of glycoproteins that increase the bulkiness of the glyc...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0183-3
更新日期:2018-10-01 00:00:00
abstract::Here we investigate the role of the control of apoptosis in normal cell division. We show that interference with the expression or function of the apoptosis inhibitor survivin causes caspase-dependent cell death in the G2/M phase of the cell cycle, and a cell-division defect characterized by centrosome dysregulation, ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/70242
更新日期:1999-12-01 00:00:00
abstract::The SNF2h (sucrose non-fermenting protein 2 homologue)-containing chromatin-remodelling complex NoRC silences a fraction of ribosomal RNA genes (rDNA) by establishing a heterochromatic structure at the rDNA promoter. Here we show that the acetyltransferase MOF (males absent on the first) acetylates TIP5, the largest s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1914
更新日期:2009-08-01 00:00:00
abstract::Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process,...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3458
更新日期:2016-12-23 00:00:00
abstract::mTOR (mammalian target of rapamycin) signalling and macroautophagy (henceforth autophagy) regulate numerous pathological and physiological processes, including cellular responses to altered nutrient levels. However, the mechanisms regulating mTOR and autophagy remain incompletely understood. Lysosomes are dynamic intr...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2204
更新日期:2011-04-01 00:00:00
abstract::In the version of this article originally published, parts of Figure 5 were misaligned because of a shift during production. In a, one data point was outside of the graph border. In b, axes lines were not connected, and graph lines did not reach the data points. In c and d, the axes lines were not connected. In e and ...
journal_title:Nature cell biology
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41556-019-0326-1
更新日期:2019-06-01 00:00:00
abstract::The vertebrate neural crest arises at the border of the neural plate during early stages of nervous system development; however, little is known about the molecular mechanisms underlying neural crest formation. Here we identify a secreted protein, Noelin-1, which has the ability to prolong neural crest production. Noe...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35008643
更新日期:2000-04-01 00:00:00
abstract::Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3' untranslated region of p27 mRNA. This conformational change is required for efficient microRNA-mediated repression of this cell-cycle regulator in rapidly proliferating cells. ...
journal_title:Nature cell biology
pub_type: 评论,新闻
doi:10.1038/ncb1010-928
更新日期:2010-10-01 00:00:00
abstract::The directional movement of cells in a gradient of external stimulus is termed chemotaxis and is important in many aspects of development and differentiated cell function. Phophoinositide 3-kinases (PI(3)Ks) are thought to have critical roles within the gradient-sensing machinery of a variety of highly motile cells, s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1517
更新日期:2007-01-01 00:00:00
abstract::Physiological oxidants that are generated by activated phagocytes comprise the main source of oxidative stress during inflammation. Oxidants such as taurine chloramine (TnCl) and hydrogen peroxide (H(2)O(2)) can damage proteins and induce apoptosis, but the role of specific protein oxidation in this process has not be...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1968
更新日期:2009-10-01 00:00:00
abstract::The store-operated calcium channel (SOC) located in the plasma membrane (PM) mediates capacitative entry of extracellular calcium after depletion of intracellular calcium stores in the endoplasmic or sarcoplasmic reticulum (ER/SR). An intimate interaction between the PM and the ER/SR is essential for the operation of ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb788
更新日期:2002-05-01 00:00:00
abstract::Although nuclear envelope (NE) assembly is known to require the GTPase Ran, the membrane fusion machinery involved is uncharacterized. NE assembly involves formation of a reticular network on chromatin, fusion of this network into a closed NE and subsequent expansion. Here we show that p97, an AAA-ATPase previously im...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1201-1086
更新日期:2001-12-01 00:00:00
abstract::NMDA (N-methyl-D-aspartate) receptors (NMDARs) are targeted to dendrites and anchored at the post-synaptic density (PSD) through interactions with PDZ proteins. However, little is known about how these receptors are sorted from the endoplasmic reticulum and Golgi apparatus to the synapse. Here, we find that synapse-as...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb990
更新日期:2003-06-01 00:00:00
abstract::When co-translationally inserted into endoplasmic reticulum (ER) membranes, newly synthesized proteins encounter the lumenal environment of the ER, which contains chaperone proteins that facilitate the folding reactions necessary for protein oligomerization, maturation and export from the ER. Here we show, using a tem...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35010558
更新日期:2000-05-01 00:00:00
abstract::Organization of chromatin by epigenetic mechanisms is essential for establishing and maintaining cellular identity in developing and adult organisms. A key question that remains unresolved about this process is how epigenetic marks are transmitted to the next cell generation during cell division. Here we provide a mod...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1787
更新日期:2008-11-01 00:00:00
abstract::The metazoan nuclear pore complex (NPC) disassembles during mitosis, and many of its constituents distribute onto spindles and kinetochores, including the Nup107-160 sub-complex. We have found that Nup107-160 interacts with the gamma-tubulin ring complex (gamma-TuRC), an essential and conserved microtubule nucleator, ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2016
更新日期:2010-02-01 00:00:00
abstract::The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice. We show that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells. Cel...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3195
更新日期:2015-08-01 00:00:00
abstract::Chromatin structure is thought to play a critical role in gene expression. Using the lac operator/repressor system and two colour variants of green fluorescent protein (GFP), we developed a system to visualize a gene and its protein product directly in living cells, allowing us to examine the spatial organization and ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35046510
更新日期:2000-12-01 00:00:00
abstract::Centromeres are specialized chromosomal domains that direct kinetochore assembly during mitosis. CENP-A (centromere protein A), a histone H3-variant present exclusively in centromeric nucleosomes, is thought to function as an epigenetic mark that specifies centromere identity. Here we identify the essential centromere...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1899
更新日期:2009-07-01 00:00:00
abstract::The Semliki Forest virus capsid protein contains a chymotrypsin-like protease domain that must fold before it can autocatalytically cleave the protein from a larger polyprotein precursor. Here we analyse this cleavage in living mammalian and prokaryotic cells, and find that it occurs immediately after the emergence of...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/14032
更新日期:1999-10-01 00:00:00
abstract::The cyclical protrusion and retraction of the leading edge is a hallmark of many migrating cells involved in processes such as development, inflammation and tumorigenesis. The molecular identity of the signalling mechanisms that control these cycles has remained unknown. Here, we used live-cell imaging of biosensors t...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2231
更新日期:2011-06-01 00:00:00
abstract::Induced pluripotent stem cells (iPSCs) are generated via the expression of the transcription factors OCT4 (also known as POU5F1), SOX2, KLF4 and cMYC (OSKM) in somatic cells. In contrast to murine naive iPSCs, conventional human iPSCs are in a more developmentally advanced state called primed pluripotency. Here, we re...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0254-5
更新日期:2019-02-01 00:00:00