Abstract:
:Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3' untranslated region of p27 mRNA. This conformational change is required for efficient microRNA-mediated repression of this cell-cycle regulator in rapidly proliferating cells.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Triboulet R,Gregory RIdoi
10.1038/ncb1010-928subject
Has Abstractpub_date
2010-10-01 00:00:00pages
928-9issue
10eissn
1465-7392issn
1476-4679pii
ncb1010-928journal_volume
12pub_type
评论,新闻abstract::The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion,...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb3524
更新日期:2017-05-31 00:00:00
abstract::In the version of this Article originally published, the author had misnumbered the reference citations in the Methods, using numbers 1-14 instead of 46-59. These errors have now been corrected in all online versions of the Article. ...
journal_title:Nature cell biology
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41556-018-0053-z
更新日期:2018-08-01 00:00:00
abstract::Several subunits of the class III phosphatidylinositol-3-OH kinase (PI(3)K-III) complex are known as tumour suppressors. Here we uncover a function for this complex and its catalytic product phosphatidylinositol-3-phosphate (PtdIns(3)P) in cytokinesis. We show that PtdIns(3)P localizes to the midbody during cytokinesi...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2036
更新日期:2010-04-01 00:00:00
abstract::Induced pluripotent stem cells (iPSCs) are generated via the expression of the transcription factors OCT4 (also known as POU5F1), SOX2, KLF4 and cMYC (OSKM) in somatic cells. In contrast to murine naive iPSCs, conventional human iPSCs are in a more developmentally advanced state called primed pluripotency. Here, we re...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0254-5
更新日期:2019-02-01 00:00:00
abstract::Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now been shed on the molecular requirements of LAP, establishing a central role for the protein Rubic...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb3197
更新日期:2015-07-01 00:00:00
abstract::The directional movement of cells in a gradient of external stimulus is termed chemotaxis and is important in many aspects of development and differentiated cell function. Phophoinositide 3-kinases (PI(3)Ks) are thought to have critical roles within the gradient-sensing machinery of a variety of highly motile cells, s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1517
更新日期:2007-01-01 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables their collective invasion. Force transmission is mediated by a heterophilic adhesion involving N-cadherin at the CAF membrane and E-cadherin at the cancer cell membrane. Th...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3478
更新日期:2017-03-01 00:00:00
abstract::The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-pr...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3141
更新日期:2015-04-01 00:00:00
abstract::Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates embryonic development and tissue homeostasis; however, aberrations of its activity occur in cancer. TGF-beta signals through its Type II and Type I receptors (TbetaRII and TbetaRI) causing phosphorylation of Smad proteins. TGF-beta...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1780
更新日期:2008-10-01 00:00:00
abstract::Metaphase spindles are microtubule-based structures that use a multitude of proteins to modulate their morphology and function. Today, we understand many details of microtubule assembly, the role of microtubule-associated proteins, and the action of molecular motors. Ultimately, the challenge remains to understand how...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2834
更新日期:2013-09-01 00:00:00
abstract::NF-kappa B/Rel transcription factors control apoptosis, also known as programmed cell death. This control is crucial for oncogenesis, cancer chemo-resistance and for antagonizing tumour necrosis factor alpha (TNFalpha)-induced killing. With regard to TNFalpha, the anti-apoptotic activity of NF-kappa B involves suppres...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1093
更新日期:2004-02-01 00:00:00
abstract::Extracellular signal-regulated kinase (ERK) controls fundamental cellular functions, including cell fate decisions. In PC12, cells shifting ERK activation from transient to sustained induces neuronal differentiation. As ERK associates with both regulators and effectors, we hypothesized that the mechanisms underlying t...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1994
更新日期:2009-12-01 00:00:00
abstract::Cell-cell adhesion mediated by specific cell-surface molecules is essential for multicellular development. Here we quantify de-adhesion forces at the resolution of individual cell-adhesion molecules, by controlling the interactions between single cells and combining single-molecule force spectroscopy with genetic mani...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35014000
更新日期:2000-06-01 00:00:00
abstract::As obligatory intracellular parasites, viruses rely on host-cell functions for most aspects of their replication cycle. This is born out during entry, when most viruses that infect vertebrate and insect cells exploit the endocytic activities of the host cell to move into the cytoplasm. Viruses belonging to vaccinia, a...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb0509-510
更新日期:2009-05-01 00:00:00
abstract::Blocking mitotic progression has been proposed as an attractive therapeutic strategy to impair proliferation of tumour cells. However, how cells survive during prolonged mitotic arrest is not well understood. We show here that survival during mitotic arrest is affected by the special energetic requirements of mitotic ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3231
更新日期:2015-10-01 00:00:00
abstract::Tissue stem cells are the cell of origin for many malignancies. Metabolites regulate the balance between self-renewal and differentiation, but whether endogenous metabolic pathways or nutrient availability predispose stem cells towards transformation remains unknown. Here, we address this question in epidermal stem ce...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-020-0525-9
更新日期:2020-07-01 00:00:00
abstract::In vertebrates, centromeres lack defined sequences and are thought to be propagated by epigenetic mechanisms involving the incorporation of specialized nucleosomes containing the histone H3 variant centromere protein (CENP)-A. However, the precise mechanisms that target CENP-A to centromeres remain poorly understood. ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1396
更新日期:2006-05-01 00:00:00
abstract::The Semliki Forest virus capsid protein contains a chymotrypsin-like protease domain that must fold before it can autocatalytically cleave the protein from a larger polyprotein precursor. Here we analyse this cleavage in living mammalian and prokaryotic cells, and find that it occurs immediately after the emergence of...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/14032
更新日期:1999-10-01 00:00:00
abstract::Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal, we have developed cell culture conditions to closely mimic events occurring during pancreatic islet organogenesis and β...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0271-4
更新日期:2019-02-01 00:00:00
abstract::Stat3 has been shown to regulate lysosome membrane permeabilization and cell death in vivo during post-lactation mammary gland involution. It is now revealed that Stat3 induces lysosome membrane permeabilization by causing phagocytosis of milk fat globules, which destabilize the lysosome membrane leading to leakage of...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb3059
更新日期:2014-11-01 00:00:00
abstract::Gastrulation leads to three germ layers--ectoderm, mesoderm and endoderm--that are separated by two basement membranes. In the mouse embryo, the emergent gut endoderm results from the widespread intercalation of cells of two distinct origins: pluripotent epiblast-derived definitive endoderm (DE) and extra-embryonic vi...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3070
更新日期:2014-12-01 00:00:00
abstract::Protein degradation in eukaryotes often requires the ubiquitin-selective chaperone p97 for substrate recruitment and ubiquitin-chain assembly. However, the physiological relevance of p97, and its role in developmental processes, remain unclear. Here, we discover an unanticipated function for CDC-48/p97 in myosin assem...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1554
更新日期:2007-04-01 00:00:00
abstract::Caenorhabditis elegans chromosomes contain specialized regions called pairing centres, which mediate homologous pairing and synapsis during meiosis. Four related proteins, ZIM-1, 2, 3 and HIM-8, associate with these sites and are required for their essential functions. Here we show that short sequence elements enriche...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1904
更新日期:2009-08-01 00:00:00
abstract::Hypoxia and acidosis occur in a wide variety of physiological and pathological settings that include muscle stress, tumour development and ischaemic disorders. A central element in the adaptive response to cellular hypoxia is HIF (hypoxia-inducible factor), a transcription factor that activates an array of genes impli...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1144
更新日期:2004-07-01 00:00:00
abstract::Etk/BMX, a member of the Btk family of tyrosine kinases, is highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines. Here, we present evidence that Etk is involved in integrin signalling and promotes cell migration. The activation of Etk by extracellula...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35074500
更新日期:2001-05-01 00:00:00
abstract::The SNF2h (sucrose non-fermenting protein 2 homologue)-containing chromatin-remodelling complex NoRC silences a fraction of ribosomal RNA genes (rDNA) by establishing a heterochromatic structure at the rDNA promoter. Here we show that the acetyltransferase MOF (males absent on the first) acetylates TIP5, the largest s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1914
更新日期:2009-08-01 00:00:00
abstract::Filament-forming cytoskeletal proteins are essential for the structure and organization of all cells. Bacterial homologues of the major eukaryotic cytoskeletal families have now been discovered, but studies suggest that yet more remain to be identified. We demonstrate that the metabolic enzyme CTP synthase (CtpS) form...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2087
更新日期:2010-08-01 00:00:00
abstract::To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt - a major kinase that coordinates diverse signalling pathways - phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphoryla...
journal_title:Nature cell biology
pub_type: 评论,新闻
doi:10.1038/ncb0409-377
更新日期:2009-04-01 00:00:00
abstract::Phosphoinositides (PIs) undergo phosphorylation/dephosphorylation cycles through organelle-specific PI kinases and PI phosphatases that lead to distinct subcellular distributions of the individual PI species. Specific PIs control the correct timing and location of many trafficking events. Their ultimate mode of action...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb0604-487
更新日期:2004-06-01 00:00:00
abstract::The pericentriolar material (PCM), the microtubule-organizing component of the centrosome, contains a multitude of proteins and is commonly described as an amorphous cloud surrounding the centrioles. However, the days of the PCM as an unstructured matrix are numbered. Using super-resolution microscopy, several reports...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2617
更新日期:2012-11-01 00:00:00