Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.

abstract：:Individual neurons form specific elaborate dendritic structures that receive presynaptic information. The pattern of dendritic branching is regulated by the microtubule-associated motor protein dynein, which is responsible for the transport of essential endosomes and other organelles into the dendrites. ...

journal_title：Nature cell biology

authors： Tear G

更新日期：2008-10-01 00:00:00

abstract：:Mammalian telomeres consist of non-coding TTAGGG repeats that are bound by the multi-protein complex 'shelterin', thus protecting chromosome ends from DNA repair mechanisms and degradation. Mammalian telomeric chromatin is enriched for the constitutive heterochromatin marks H3K9me3, H4K20me3 and HP1 (refs 2, 3, 4, 5, ...

journal_title：Nature cell biology

authors： Schoeftner S,Blasco MA

更新日期：2008-02-01 00:00:00

abstract：:To generate the various tissues and organs that build up the adult body, plants and animals require organized formative cell divisions and correct cell specification. In plants, these processes are controlled mainly by phytohormones and transcriptional networks. Recently, ligand-receptor-like kinase signalling pathway...

journal_title：Nature cell biology

authors： De Smet I,Voss U,Jürgens G,Beeckman T

更新日期：2009-10-01 00:00:00

abstract：:The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to the state of attachment of the kinetochore to spindle microtubules. SAC signalling is activated by unattached kinetochores, and it is silenced after these kinetochores form end-on microtubule attachments. Although the biochemical c...

journal_title：Nature cell biology

authors： Aravamudhan P,Goldfarb AA,Joglekar AP

更新日期：2015-07-01 00:00:00

abstract：:Proteins essential for vesicle formation by the Coat Protein I (COPI) complex are being identified, but less is known about the role of specific lipids. Brefeldin-A ADP-ribosylated substrate (BARS) functions in the fission step of COPI vesicle formation. Here, we show that BARS induces membrane curvature in cooperatio...

journal_title：Nature cell biology

authors： Yang JS,Gad H,Lee SY,Mironov A,Zhang L,Beznoussenko GV,Valente C,Turacchio G,Bonsra AN,Du G,Baldanzi G,Graziani A,Bourgoin S,Frohman MA,Luini A,Hsu VW

更新日期：2008-10-01 00:00:00

abstract：:The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and...

journal_title：Nature cell biology

authors： Varga J,Greten FR

更新日期：2017-10-01 00:00:00

abstract：:The self-perpetuating amyloid isoform, or prion, of the yeast translation termination factor eRF3 modulates programmed translational frameshifting that controls a regulatory circuit determining the polyamine levels in a yeast cell. But it is still unclear whether this effect is adaptive or pathological. ...

journal_title：Nature cell biology

authors： Chernoff YO

更新日期：2008-09-01 00:00:00

abstract：:Clathrin-coated vesicles mediate endocytosis and transport between the trans-Golgi network (TGN) and endosomes in eukaryotic cells. Clathrin adaptors play central roles in coat assembly, interacting with clathrin, cargo and membranes. Two main types of clathrin adaptor act in TGN-endosome traffic: GGA proteins and the...

journal_title：Nature cell biology

authors： Daboussi L,Costaguta G,Payne GS

更新日期：2012-02-19 00:00:00

abstract：:Many classical biologists working in Antarctica have 'gone molecular' to study the physiological basis for life on or below the ice. Investigating the remarkable adaptations of specific cells, organelles and molecules to this extreme environment can provide new perspectives on the processes studied in conventional exp...

journal_title：Nature cell biology

authors： Römisch K,Matheson T

更新日期：2003-01-01 00:00:00

abstract：:Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed microtubule seeds or from γ-tubulin recruited to the side of a pre-existing microtubule. Here, we found that microtubules c...

journal_title：Nature cell biology

authors： Basnet N,Nedozralova H,Crevenna AH,Bodakuntla S,Schlichthaerle T,Taschner M,Cardone G,Janke C,Jungmann R,Magiera MM,Biertümpfel C,Mizuno N

更新日期：2018-10-01 00:00:00

abstract：:Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2 5-phosphatase. Here we unveil a lysosomal response to the arrival of autophagosomal cargo i...

journal_title：Nature cell biology

authors： De Leo MG,Staiano L,Vicinanza M,Luciani A,Carissimo A,Mutarelli M,Di Campli A,Polishchuk E,Di Tullio G,Morra V,Levtchenko E,Oltrabella F,Starborg T,Santoro M,Di Bernardo D,Devuyst O,Lowe M,Medina DL,Ballabio A,De Ma

更新日期：2016-08-01 00:00:00

abstract：:Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degene...

journal_title：Nature cell biology

authors： Shiloh Y,Lehmann AR

更新日期：2004-10-01 00:00:00

abstract：:Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints. Histone H2AX, p53 binding-protein 1 (53BP1) and Chk2 are targets of ATM-mediated phosphorylation, but little is known about their roles in sig...

journal_title：Nature cell biology

authors： Fernandez-Capetillo O,Chen HT,Celeste A,Ward I,Romanienko PJ,Morales JC,Naka K,Xia Z,Camerini-Otero RD,Motoyama N,Carpenter PB,Bonner WM,Chen J,Nussenzweig A

更新日期：2002-12-01 00:00:00

abstract：:Proteins containing ubiquitin-binding domains (UBDs) interact with ubiquitinated targets and regulate diverse biological processes, including endocytosis, signal transduction, transcription and DNA repair. Many of the UBD-containing proteins are also themselves monoubiquitinated, but the functional role and the mechan...

journal_title：Nature cell biology

authors： Hoeller D,Crosetto N,Blagoev B,Raiborg C,Tikkanen R,Wagner S,Kowanetz K,Breitling R,Mann M,Stenmark H,Dikic I

更新日期：2006-02-01 00:00:00

abstract：:Endothelial cells and leptin receptor+ (LepR+) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone marrow. After irradiation or chemotherapy, these cells are depleted while adipocytes become abundant. We discovered that bone marrow adipocytes sy...

journal_title：Nature cell biology

authors： Zhou BO,Yu H,Yue R,Zhao Z,Rios JJ,Naveiras O,Morrison SJ

更新日期：2017-08-01 00:00:00

abstract：:Influx of Ca(2+) through store-operated Ca(2+) channels (SOCs) is a central component of receptor-evoked Ca(2+) signals. Orai channels are SOCs that are gated by STIM1, a Ca(2+) sensor located in the ER but how it gates and regulates the Orai channels is unknown. Here, we report the molecular basis for gating of Orais...

journal_title：Nature cell biology

authors： Yuan JP,Zeng W,Dorwart MR,Choi YJ,Worley PF,Muallem S

更新日期：2009-03-01 00:00:00

abstract：:Compartmentalization has long been known to have a key role in regulation of cellular processes. By keeping enzymes and regulatory complexes in compartments where the delivery of substrate or exit of product is controlled, competing reactions can occur simultaneously in different parts of the cell. Moreover, spatial c...

journal_title：Nature cell biology

authors： Carmo-Fonseca M,Mendes-Soares L,Campos I

更新日期：2000-06-01 00:00:00

abstract：:Over their lifetime, long-term haematopoietic stem cells (HSC) are exposed to a variety of stress conditions that they must endure. Many stresses, such as infection/inflammation, reactive oxygen species, nutritional deprivation and hypoxia, activate unfolded protein response signalling, which induces either adaptive c...

journal_title：Nature cell biology

authors： Liu L,Zhao M,Jin X,Ney G,Yang KB,Peng F,Cao J,Iwawaki T,Del Valle J,Chen X,Li Q

更新日期：2019-03-01 00:00:00

abstract：:Broken ends of a budding yeast chromosome exhibit increased mobility, presumably to facilitate repair by recombination. A new study reports that increased mobility reflects the untethering of the broken chromosome, triggered by a DNA damage response that phosphorylates the Cep3 kinetochore protein and weakens the asso...

journal_title：Nature cell biology

authors： Nakajima Y,Haber JE

更新日期：2016-03-01 00:00:00

abstract：:The guanosine tri-phosphatase Ran stimulates assembly of microtubule spindles. However, it is not known what aspects of the microtubule cytoskeleton are subject to regulation by Ran in mitosis. Here we show that Ran-GTP stimulates microtubule assembly by increasing the rescue frequency of microtubules three- to eightf...

journal_title：Nature cell biology

authors： Wilde A,Lizarraga SB,Zhang L,Wiese C,Gliksman NR,Walczak CE,Zheng Y

更新日期：2001-03-01 00:00:00

abstract：:The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particu...

journal_title：Nature cell biology

authors： Tognetti S,Speck C

更新日期：2016-05-27 00:00:00

abstract：:In plants, cell shape is defined by the cell wall, and changes in cell shape and size are dictated by modification of existing cell walls and deposition of newly synthesized cell-wall material. In root hairs, expansion occurs by a process called tip growth, which is shared by root hairs, pollen tubes and fungal hyphae...

journal_title：Nature cell biology

authors： Park S,Szumlanski AL,Gu F,Guo F,Nielsen E

更新日期：2011-07-17 00:00:00

abstract：:Starvation of animals or cells triggers autophagic degradation of cell contents to retrieve nutrients, but, paradoxically, mitochondria enlarge. This is now shown to result from inhibition of mitochondrial fission through PKA-mediated phosphorylation of the GTPase DRP1. Elongation of mitochondria optimizes ATP product...

journal_title：Nature cell biology

authors： Blackstone C,Chang CR

更新日期：2011-05-01 00:00:00

abstract：:The stability and membrane localization of the transforming growth factor-β (TGF-β) type I receptor (TβRI) determines the levels of TGF-β signalling. TβRI is targeted for ubiquitylation-mediated degradation by the SMAD7-SMURF2 complex. Here we performed a genome-wide gain-of-function screen and identified ubiquitin-sp...

journal_title：Nature cell biology

authors： Zhang L,Zhou F,Drabsch Y,Gao R,Snaar-Jagalska BE,Mickanin C,Huang H,Sheppard KA,Porter JA,Lu CX,ten Dijke P

更新日期：2012-06-17 00:00:00

abstract：:The remarkable stability of gene expression in somatic cells is exemplified by the way memory of an active gene state is retained when an endoderm cell nucleus is transplanted to an enucleated egg. Here we analyse the mechanism of a similar example of epigenetic memory. We find that memory can persist through 24 cell ...

journal_title：Nature cell biology

authors： Ng RK,Gurdon JB

更新日期：2008-01-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cancers. Here, we generate quadruple TIMP knockout (TIMPless) fibroblasts ...

journal_title：Nature cell biology

authors： Shimoda M,Principe S,Jackson HW,Luga V,Fang H,Molyneux SD,Shao YW,Aiken A,Waterhouse PD,Karamboulas C,Hess FM,Ohtsuka T,Okada Y,Ailles L,Ludwig A,Wrana JL,Kislinger T,Khokha R

更新日期：2014-09-01 00:00:00

abstract：:Formins have been implicated in the regulation of cytoskeletal structure in animals and fungi. Here we show that the formins Bni1 and Bnr1 of budding yeast stimulate the assembly of actin filaments that function as precursors to tropomyosin-stabilized cables that direct polarized cell growth. With loss of formin funct...

journal_title：Nature cell biology

authors： Evangelista M,Pruyne D,Amberg DC,Boone C,Bretscher A

更新日期：2002-01-01 00:00:00

abstract：:Actin and myosin are major components of the cell cytoskeleton, with structural and regulatory functions that affect many essential cellular processes. Although they were traditionally thought to function only in the cytoplasm, it is now well accepted that actin and multiple myosins are found in the nucleus. Increasin...

journal_title：Nature cell biology

authors： de Lanerolle P,Serebryannyy L

更新日期：2011-11-02 00:00:00

abstract：:Lysosomes respond to environmental cues by controlling their own biogenesis, but the underlying mechanisms are poorly understood. Here we describe a protein kinase C (PKC)-dependent and mTORC1-independent mechanism for regulating lysosome biogenesis, which provides insights into previously reported effects of PKC on l...

journal_title：Nature cell biology

authors： Li Y,Xu M,Ding X,Yan C,Song Z,Chen L,Huang X,Wang X,Jian Y,Tang G,Tang C,Di Y,Mu S,Liu X,Liu K,Li T,Wang Y,Miao L,Guo W,Hao X,Yang C

更新日期：2016-10-01 00:00:00

abstract：:Given the important role of the hypothalamus in regulating feeding and metabolism, there has been considerable interest in a possible function for hypothalamic stem cells in modulating body weight in health and disease. Mice given a high-fat diet develop inflammation in the hypothalamus and lose key types of neurons. ...

journal_title：Nature cell biology

authors： Livesey FJ

更新日期：2012-10-01 00:00:00