Abstract:
:The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particular during replication stress.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Tognetti S,Speck Cdoi
10.1038/ncb3367subject
Has Abstractpub_date
2016-05-27 00:00:00pages
593-4issue
6eissn
1465-7392issn
1476-4679pii
ncb3367journal_volume
18pub_type
评论,杂志文章abstract::For accurate segregation of chromosomes during cell division, microtubule fibres must attach sister kinetochores to opposite poles of the mitotic spindle (bi-orientation). Aurora kinases are linked to oncogenesis and have been implicated in the regulation of chromosome-microtubule attachments. Although loss of Aurora ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1102
更新日期:2004-03-01 00:00:00
abstract::The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3573
更新日期:2017-08-01 00:00:00
abstract::Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that tumour-secreted DKK1 is a serological marker of breast cancer metastasis organotropism and inhibits lung metastasis. DKK1 suppresses PTGS2-induced macrophage and ne...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3613
更新日期:2017-10-01 00:00:00
abstract::Physiological oxidants that are generated by activated phagocytes comprise the main source of oxidative stress during inflammation. Oxidants such as taurine chloramine (TnCl) and hydrogen peroxide (H(2)O(2)) can damage proteins and induce apoptosis, but the role of specific protein oxidation in this process has not be...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1968
更新日期:2009-10-01 00:00:00
abstract::Cell-cell adhesion mediated by specific cell-surface molecules is essential for multicellular development. Here we quantify de-adhesion forces at the resolution of individual cell-adhesion molecules, by controlling the interactions between single cells and combining single-molecule force spectroscopy with genetic mani...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35014000
更新日期:2000-06-01 00:00:00
abstract::Actomyosin contractility is a mechanism by which cells exert locomotory force against their environment. Signalling downstream of the small GTPase Rho increases contractility through Rho-kinase (ROCK)-mediated regulation of myosin-II light chain (MLC2) phosphorylation. Cdc42 signalling has been shown to control cell p...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1230
更新日期:2005-03-01 00:00:00
abstract::Current models for the export of messenger RNA share the notion that the highly abundant class of nuclear RNA-binding proteins--the hnRNP proteins--have a key role in exporting RNA. But recent studies have led to a new understanding of several non-hnRNP proteins, including SR proteins and the conserved mRNA export fac...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb0901-e201
更新日期:2001-09-01 00:00:00
abstract::Reference datasets should be accessible independently of scientific papers in a citable form, allowing attribution. ...
journal_title:Nature cell biology
pub_type: 社论
doi:10.1038/ncb1109-1273a
更新日期:2009-11-01 00:00:00
abstract::The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory proteins and delivery of functional solutes throughout the cell1,2. Molecular mobility through the ER network enables these functionalities, but diffusion alone is not sufficient to explain...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0192-2
更新日期:2018-10-01 00:00:00
abstract::The initial differential treatment of the two X chromosomes during X-chromosome inactivation is controlled by the X-inactivation centre (Xic). This locus determines how many X chromosomes are present in a cell ('counting') and which X chromosome will be inactivated in female cells ('choice'). Critical control sequence...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1365
更新日期:2006-03-01 00:00:00
abstract::The most dangerous insults to the genome's integrity are those that break both strands of the DNA. Double-strand breaks can be repaired by homologous recombination; in this conserved mechanism, a global genomic homology search finds sequences similar to those near the break, and uses them as a template for DNA synthes...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2745
更新日期:2013-06-01 00:00:00
abstract::Spatial and temporal coordination of polo-like kinase 1 (Plk1) activity is necessary for mitosis and cytokinesis, and this is achieved through binding to phosphorylated docking proteins with distinct subcellular localizations. Although cyclin-dependent kinase 1 (Cdk1) creates these phosphorylated docking sites in meta...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1557
更新日期:2007-04-01 00:00:00
abstract::Tissue stem cells are the cell of origin for many malignancies. Metabolites regulate the balance between self-renewal and differentiation, but whether endogenous metabolic pathways or nutrient availability predispose stem cells towards transformation remains unknown. Here, we address this question in epidermal stem ce...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-020-0525-9
更新日期:2020-07-01 00:00:00
abstract::The tumour vascular microenvironment supports tumorigenesis not only by supplying oxygen and diffusible nutrients but also by secreting soluble factors that promote tumorigenesis. Here we identify a feedforward mechanism in which endothelial cells (ECs), in response to tumour-derived mediators, release angiocrines dri...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2954
更新日期:2014-05-01 00:00:00
abstract::The formation of branched epithelial networks is fundamental to the development of many organs, such as the lung, the kidney or the vasculature. Little is known about the mechanisms that control cell rearrangements during tubulogenesis and regulate the size of individual tubes. Recent studies indicate that whereas the...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1049
更新日期:2003-10-01 00:00:00
abstract::Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyses the trimethylation of histone H3 on Lys 27 (H3K27), which represses gene transcription. EZH2 enhances cancer-cell invasiveness and regulates stem cell differentiation. Here, we demonstrate that EZH2 can ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2139
更新日期:2011-01-01 00:00:00
abstract::The intracellular Ca(2+) concentration ([Ca(2+)](i)) in skeletal muscles must be rapidly regulated during the excitation-contraction-relaxation process. However, the signalling components involved in such rapid Ca(2+) movement are not fully understood. Here we report that mice deficient in the newly identified PtdInsP...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1884
更新日期:2009-06-01 00:00:00
abstract::Over their lifetime, long-term haematopoietic stem cells (HSC) are exposed to a variety of stress conditions that they must endure. Many stresses, such as infection/inflammation, reactive oxygen species, nutritional deprivation and hypoxia, activate unfolded protein response signalling, which induces either adaptive c...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-019-0285-6
更新日期:2019-03-01 00:00:00
abstract::Caenorhabditis elegans chromosomes contain specialized regions called pairing centres, which mediate homologous pairing and synapsis during meiosis. Four related proteins, ZIM-1, 2, 3 and HIM-8, associate with these sites and are required for their essential functions. Here we show that short sequence elements enriche...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1904
更新日期:2009-08-01 00:00:00
abstract::Somatic cell reprogramming by exogenous factors requires cooperation with transcriptional co-activators and co-repressors to effectively remodel the epigenetic environment. How this interplay is regulated remains poorly understood. Here, we demonstrate that NCoR/SMRT co-repressors bind to pluripotency loci to create a...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0047-x
更新日期:2018-04-01 00:00:00
abstract::The planar cell polarity (PCP) signalling pathway is essential for embryonic development because it governs diverse cellular behaviours, and 'core PCP' proteins, such as Dishevelled and Frizzled, have been extensively characterized. By contrast, the 'PCP effector' proteins, such as Intu and Fuz, remain largely unstudi...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1966
更新日期:2009-10-01 00:00:00
abstract:: ...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/s41556-018-0224-y
更新日期:2018-11-01 00:00:00
abstract::MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased cell motility and invasiveness. miR-9-mediated E-cadherin downregula...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2024
更新日期:2010-03-01 00:00:00
abstract::Chromatin structure is thought to play a critical role in gene expression. Using the lac operator/repressor system and two colour variants of green fluorescent protein (GFP), we developed a system to visualize a gene and its protein product directly in living cells, allowing us to examine the spatial organization and ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35046510
更新日期:2000-12-01 00:00:00
abstract::BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to neurodegeneration. The voltage-gated sodium channel (Na(v)1) beta2-subunit (beta2), a type I membrane protein that covalently binds to Na(v)1 alpha-subunits, is a substrate for BACE1 and gamma-secretase...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1602
更新日期:2007-07-01 00:00:00
abstract::Protein kinases have central functions in various cellular signal transduction pathways through their substrate phosphorylation. Here we show that a protein kinase, DYRK2, has unexpected role as a scaffold for an E3 ubiquitin ligase complex. DYRK2 associates with an E3 ligase complex containing EDD, DDB1 and VPRBP pro...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1848
更新日期:2009-04-01 00:00:00
abstract::Mitochondrial function degenerates with ageing and in ageing-related neuromuscular degenerative diseases, causing physiological decline of the cell. Factors that can delay the degenerative process are actively sought after. Here, we show that reduced cytosolic protein synthesis is a robust cellular strategy that suppr...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1769
更新日期:2008-09-01 00:00:00
abstract::Phosphatase and tensin homologue (Pten) suppresses neoplastic growth by negatively regulating PI(3)K signalling through its phosphatase activity. To gain insight into the actions of non-catalytic Pten domains in normal physiological processes and tumorigenesis, we engineered mice lacking the PDZ-binding domain (PDZ-BD...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3369
更新日期:2016-07-01 00:00:00
abstract::Secretory proteins are transported to the Golgi complex in vesicles that bud from the endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for cargo sorting and vesicle morphogenesis. COPII was first described in Saccharomyces cerevisiae, but its basic function is conserved throughout ...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2390
更新日期:2011-12-22 00:00:00
abstract::Understanding the factors that direct tissue organization during development is one of the most fundamental goals in developmental biology. Various hypotheses explain cell sorting and tissue organization on the basis of the adhesive and mechanical properties of the constituent cells. However, validating these hypothes...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1705
更新日期:2008-04-01 00:00:00