Abstract:
:
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Serebrenik YV,Shalem Odoi
10.1038/s41556-018-0224-ysubject
pub_date
2018-11-01 00:00:00pages
1235-1237issue
11eissn
1465-7392issn
1476-4679pii
10.1038/s41556-018-0224-yjournal_volume
20pub_type
评论,杂志文章abstract::The actin filament (F-actin) cytoskeleton associates dynamically with the plasma membrane and is thus ideally positioned to participate in endocytosis. Indeed, a wealth of genetic and biochemical evidence has confirmed that actin interacts with components of the endocytic machinery, although its precise function in en...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1025
更新日期:2003-08-01 00:00:00
abstract::During cell division, many animal cells transform into a spherical shape and assemble a contractile ring composed of actin filaments and myosin motors at the equator to separate the cell body into two. Although actomyosin regulatory proteins are spatio-temporally controlled during cytokinesis, the direct contribution ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3142
更新日期:2015-04-01 00:00:00
abstract::Formation of a stable lamellipodium at the front of migrating cells requires localization of Rac activation to the leading edge. Restriction of alpha4 integrin phosphorylation to the leading edge limits the interaction of alpha4 with paxillin to the sides and rear of a migrating cell. The alpha4-paxillin complex inhib...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1234
更新日期:2005-04-01 00:00:00
abstract::Lamina-associated polypeptide (LAP) 2alpha is a chromatin-associated protein that binds A-type lamins. Mutations in both LAP2alpha and A-type lamins are linked to human diseases called laminopathies, but the molecular mechanisms are poorly understood. The A-type lamin-LAP2alpha complex interacts with and regulates ret...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1793
更新日期:2008-11-01 00:00:00
abstract::Extracellular signal-regulated kinase (ERK) controls fundamental cellular functions, including cell fate decisions. In PC12, cells shifting ERK activation from transient to sustained induces neuronal differentiation. As ERK associates with both regulators and effectors, we hypothesized that the mechanisms underlying t...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1994
更新日期:2009-12-01 00:00:00
abstract::The target of rapamycin complex 2 (TORC2) plays a key role in maintaining the homeostasis of plasma membrane (PM) tension. TORC2 activation following increased PM tension involves redistribution of the Slm1 and 2 paralogues from PM invaginations known as eisosomes into membrane compartments containing TORC2. How Slm1/...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0150-z
更新日期:2018-09-01 00:00:00
abstract::The store-operated calcium channel (SOC) located in the plasma membrane (PM) mediates capacitative entry of extracellular calcium after depletion of intracellular calcium stores in the endoplasmic or sarcoplasmic reticulum (ER/SR). An intimate interaction between the PM and the ER/SR is essential for the operation of ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb788
更新日期:2002-05-01 00:00:00
abstract::Genomic integrity is maintained by checkpoints that guard against undesired replication after DNA damage. Here, we show that CDT1, a licensing factor of the pre-replication complex (preRC), is rapidly proteolysed after UV- or gamma-irradiation. The preRC assembles on replication origins at the end of mitosis and durin...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1061
更新日期:2003-11-01 00:00:00
abstract::Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a fam...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-020-0488-x
更新日期:2020-04-01 00:00:00
abstract::The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication stress response protein in two proteomic screens. ETAA1-deficient c...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3415
更新日期:2016-11-01 00:00:00
abstract::Formins have been implicated in the regulation of cytoskeletal structure in animals and fungi. Here we show that the formins Bni1 and Bnr1 of budding yeast stimulate the assembly of actin filaments that function as precursors to tropomyosin-stabilized cables that direct polarized cell growth. With loss of formin funct...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb718
更新日期:2002-01-01 00:00:00
abstract::To maintain genome function and stability, DNA sequence and its organization into chromatin must be duplicated during cell division. Understanding how entire chromosomes are copied remains a major challenge. Here, we use nascent chromatin capture (NCC) to profile chromatin proteome dynamics during replication in human...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2918
更新日期:2014-03-01 00:00:00
abstract::Transforming growth factor-beta (TGF-beta) induces epithelial-mesenchymal transdifferentiation (EMT) accompanied by cellular differentiation and migration. Despite extensive transcriptomic profiling, the identification of TGF-beta-inducible, EMT-specific genes has met with limited success. Here we identify a post-tran...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2029
更新日期:2010-03-01 00:00:00
abstract::The mitochondrial inner membrane is the central energy-converting membrane of eukaryotic cells. The electrochemical proton gradient generated by the respiratory chain drives the ATP synthase. To maintain this proton-motive force, the inner membrane forms a tight barrier and strictly controls the translocation of ions....
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1635
更新日期:2007-10-01 00:00:00
abstract::RNA interference has become an indispensable tool for loss-of-function studies across eukaryotes. By enabling stable and reversible gene silencing, shRNAs provide a means to study long-term phenotypes, perform pool-based forward genetic screens and examine the consequences of temporary target inhibition in vivo. Howev...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2895
更新日期:2014-01-01 00:00:00
abstract::Dyneins are large microtubule motor proteins required for mitosis, intracellular transport and ciliary and flagellar motility. They generate force through a power-stroke mechanism, which is an ATP-consuming cycle of pre- and post-power-stroke conformational changes that cause relative motion between different dynein d...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2939
更新日期:2014-05-01 00:00:00
abstract::FoxG1 is an evolutionarily conserved, winged-helix transcriptional repressor that maintains progenitor cells in the vertebrate forebrain. How the activity of FoxG1 is regulated is not known. Here, we report that in the developing Xenopus and mouse forebrain, FoxG1 is nuclear in progenitor cells but cytoplasmic in diff...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1573
更新日期:2007-05-01 00:00:00
abstract::Symmetrical cell division requires duplication of DNA and protein content to generate two daughter cells. Centrosomes also duplicate during cell division, but the mechanism controlling this process is incompletely understood. We describe an alternative splice form of SadB encoding a short SADB Ser/Thr kinase whose act...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1921
更新日期:2009-09-01 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cancers. Here, we generate quadruple TIMP knockout (TIMPless) fibroblasts ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3021
更新日期:2014-09-01 00:00:00
abstract::YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3111
更新日期:2015-04-01 00:00:00
abstract::Once considered to be contained, infectious diseases of bacterial origin are now making a comeback. A lack of innovative therapies and the appearance of drug-resistant pathogens are becoming increasingly serious problems. A better understanding of pathogen-host interactions at the cellular and molecular levels is nece...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/15620
更新日期:1999-11-01 00:00:00
abstract::Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but requires actin polymerization in others. We show that membrane tension determines the actin dependence of clathrin-coat assembly. As found previously, clathrin assembly supports formation of mature coated pits in the absence of ac...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2307
更新日期:2011-08-14 00:00:00
abstract::In plants, cell shape is defined by the cell wall, and changes in cell shape and size are dictated by modification of existing cell walls and deposition of newly synthesized cell-wall material. In root hairs, expansion occurs by a process called tip growth, which is shared by root hairs, pollen tubes and fungal hyphae...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2294
更新日期:2011-07-17 00:00:00
abstract::The planar cell polarity (PCP) signalling pathway is essential for embryonic development because it governs diverse cellular behaviours, and 'core PCP' proteins, such as Dishevelled and Frizzled, have been extensively characterized. By contrast, the 'PCP effector' proteins, such as Intu and Fuz, remain largely unstudi...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1966
更新日期:2009-10-01 00:00:00
abstract::Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) involves a marked reorganization of chromatin. To identify post-translational histone modifications that change in global abundance during this process, we have applied a quantitative mass-spectrometry-based approach. We found that iPSCs, compa...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2768
更新日期:2013-07-01 00:00:00
abstract::Understanding the factors that direct tissue organization during development is one of the most fundamental goals in developmental biology. Various hypotheses explain cell sorting and tissue organization on the basis of the adhesive and mechanical properties of the constituent cells. However, validating these hypothes...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1705
更新日期:2008-04-01 00:00:00
abstract::Topoisomerase II (Topo II) is required to separate intertwined sister chromatids before chromosome segregation can occur in mitosis. However, it remains to be resolved whether Topo II has any role in checkpoint control. Here we report that when phosphorylated, Ser 1524 of Topo IIalpha acts as a binding site for the BR...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1828
更新日期:2009-02-01 00:00:00
abstract::In some organs, adult stem cells are uniquely poised to serve as cancer cells of origin. It is unclear, however, whether tumorigenesis is influenced by the activation state of the adult stem cell. Hair follicle stem cells (HFSCs) act as cancer cells of origin for cutaneous squamous cell carcinoma and undergo defined c...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2889
更新日期:2014-01-01 00:00:00
abstract::A key step in nutrient sensing is activation of the master growth regulator, mTORC1 kinase, on the lysosomal membrane. Nutrients enable mTORC1 scaffolding by a complex composed of the Rag GTPases (Rags) and Ragulator, but the underlying mechanism of mTORC1 capture is poorly understood. Combining dynamic imaging in cel...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0148-6
更新日期:2018-09-01 00:00:00
abstract::Vaccinia virus, a close relative of the causative agent of smallpox, exploits actin polymerization to enhance its cell-to-cell spread. We show that actin-based motility of vaccinia is initiated only at the plasma membrane and remains associated with it. There must therefore be another form of cytoplasmic viral transpo...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1101-992
更新日期:2001-11-01 00:00:00