当前位置： SCI文献检索 > NATURE CELL BIOLOGY期刊下所有文献 > COPII and the regulation of protein sorting in mammals.

COPII and the regulation of protein sorting in mammals.

Abstract：

:Secretory proteins are transported to the Golgi complex in vesicles that bud from the endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for cargo sorting and vesicle morphogenesis. COPII was first described in Saccharomyces cerevisiae, but its basic function is conserved throughout all eukaryotes. Nevertheless, the COPII coat has adapted to the higher complexity of mammalian physiology, achieving more sophisticated levels of secretory regulation. In this review we cover aspects of mammalian COPII-mediated regulation of secretion, in particular related to the function of COPII paralogues, the spatial organization of cargo export and the role of accessory proteins.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Zanetti G,Pahuja KB,Studer S,Shim S,Schekman R

doi

10.1038/ncb2390

subject

Has Abstract

pub_date

2011-12-22 00:00:00

pages

20-8

issue

1

eissn

1465-7392

issn

1476-4679

pii

ncb2390

journal_volume

14

pub_type

杂志文章,评审

相关文献

NATURE CELL BIOLOGY文献大全
  • Arabidopsis cortical microtubules position cellulose synthase delivery to the plasma membrane and interact with cellulose synthase trafficking compartments.

    abstract：:Plant cell morphogenesis relies on the organization and function of two polymer arrays separated by the plasma membrane: the cortical microtubule cytoskeleton and cellulose microfibrils in the cell wall. Studies using in vivo markers confirmed that one function of the cortical microtubule array is to drive organizatio...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1886

    authors： Gutierrez R,Lindeboom JJ,Paredez AR,Emons AM,Ehrhardt DW

    更新日期：2009-07-01 00:00:00

  • VHL takes HIF's breath away.

    abstract：:Inactivation of the von Hippel-Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel-Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dep...

    journal_title：Nature cell biology

    pub_type： 评论,新闻

    doi：10.1038/35017129

    authors： Krek W

    更新日期：2000-07-01 00:00:00

  • The extracellular matrix guides the orientation of the cell division axis.

    abstract：:The cell division axis determines the future positions of daughter cells and is therefore critical for cell fate. The positioning of the division axis has been mostly studied in systems such as embryos or yeasts, in which cell shape is well defined. In these cases, cell shape anisotropy and cell polarity affect spindl...

    journal_title：Nature cell biology

    pub_type： 信件

    doi：10.1038/ncb1307

    authors： Théry M,Racine V,Pépin A,Piel M,Chen Y,Sibarita JB,Bornens M

    更新日期：2005-10-01 00:00:00

  • Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development.

    abstract：:Haematopoietic stem cells (HSCs) arise in the developing aorta during embryogenesis. The number of HSC clones born has been estimated through transplantation, but experimental approaches to assess the absolute number of forming HSCs in a native setting have remained challenging. Here, we applied single-cell and clonal...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3444

    authors： Henninger J,Santoso B,Hans S,Durand E,Moore J,Mosimann C,Brand M,Traver D,Zon L

    更新日期：2017-01-01 00:00:00

  • Why do worms need cholesterol?

    abstract：:Cholesterol is a structural component of animal membranes that influences fluidity, permeability and formation of lipid microdomains. It is also a precursor to signalling molecules, including mammalian steroid hormones and insect ecdysones. The nematode Caenorhabditis elegans requires too little cholesterol for it to ...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb0803-684

    authors： Kurzchalia TV,Ward S

    更新日期：2003-08-01 00:00:00

  • Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.

    abstract：:Actin dynamics is a tightly regulated process involved in various cellular events including biogenesis of clathrin-coated, AP-1 (adaptor protein 1)-coated transport carriers connecting the trans-Golgi network (TGN) and the endocytic pathway. However, the mechanisms coordinating coat assembly, membrane and actin remode...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2034

    authors： Anitei M,Stange C,Parshina I,Baust T,Schenck A,Raposo G,Kirchhausen T,Hoflack B

    更新日期：2010-04-01 00:00:00

  • Multiscale force sensing in development.

    abstract：:The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion,...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb3524

    authors： Petridou NI,Spiró Z,Heisenberg CP

    更新日期：2017-05-31 00:00:00

  • Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.

    abstract：:The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3573

    authors： Hanssen LLP,Kassouf MT,Oudelaar AM,Biggs D,Preece C,Downes DJ,Gosden M,Sharpe JA,Sloane-Stanley JA,Hughes JR,Davies B,Higgs DR

    更新日期：2017-08-01 00:00:00

  • Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.

    abstract：:To learn more about cancer-associated fibroblasts (CAFs), we have isolated fibroblasts from different stages of breast cancer progression and analysed their function and gene expression. These analyses reveal that activation of the YAP transcription factor is a signature feature of CAFs. YAP function is required for C...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2756

    authors： Calvo F,Ege N,Grande-Garcia A,Hooper S,Jenkins RP,Chaudhry SI,Harrington K,Williamson P,Moeendarbary E,Charras G,Sahai E

    更新日期：2013-06-01 00:00:00

  • Publisher Correction: Single-cell multi-omics sequencing of human early embryos.

    abstract：:In the version of this Resource originally published, owing to a technical error an incorrect file was used for Supplementary Table 2; this has now been replaced with the correct file. ...

    journal_title：Nature cell biology

    pub_type： 已发布勘误

    doi：10.1038/s41556-018-0166-4

    authors： Li L,Guo F,Gao Y,Ren Y,Yuan P,Yan L,Li R,Lian Y,Li J,Hu B,Gao J,Wen L,Tang F,Qiao J

    更新日期：2018-10-01 00:00:00

  • Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy.

    abstract：:The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor metastasis-free survival of patients with breast cancer with localized disease. DTCs persist in distant tissues despite systemic administration of adjuvant chemotherapy. Many assume that this is because the majority of DTCs are quies...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-018-0267-0

    authors： Carlson P,Dasgupta A,Grzelak CA,Kim J,Barrett A,Coleman IM,Shor RE,Goddard ET,Dai J,Schweitzer EM,Lim AR,Crist SB,Cheresh DA,Nelson PS,Hansen KC,Ghajar CM

    更新日期：2019-02-01 00:00:00

  • Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1.

    abstract：:Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that tumour-secreted DKK1 is a serological marker of breast cancer metastasis organotropism and inhibits lung metastasis. DKK1 suppresses PTGS2-induced macrophage and ne...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3613

    authors： Zhuang X,Zhang H,Li X,Li X,Cong M,Peng F,Yu J,Zhang X,Yang Q,Hu G

    更新日期：2017-10-01 00:00:00

  • Classifying collective cancer cell invasion.

    abstract：:Most invasive solid tumours display predominantly collective invasion, in which groups of cells invade the peritumoral stroma while maintaining cell-cell contacts. As the concepts and experimental models for functional analysis of collective cancer cell invasion are rapidly developing, we propose a framework for addre...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb2548

    authors： Friedl P,Locker J,Sahai E,Segall JE

    更新日期：2012-08-01 00:00:00

  • EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.

    abstract：:The Notch1 gene has an important role in mammalian cell-fate decision and tumorigenesis. Upstream control mechanisms for transcription of this gene are still poorly understood. In a chemical genetics screen for small molecule activators of Notch signalling, we identified epidermal growth factor receptor (EGFR) as a ke...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1750

    authors： Kolev V,Mandinova A,Guinea-Viniegra J,Hu B,Lefort K,Lambertini C,Neel V,Dummer R,Wagner EF,Dotto GP

    更新日期：2008-08-01 00:00:00

  • How the kinetochore couples microtubule force and centromere stretch to move chromosomes.

    abstract：:The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for force generation coupled to plus-end polymerization and depolymerization. Spc24/Spc25 at one end of the Ndc80 complex binds the kinetochore. The N-terminal ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3323

    authors： Suzuki A,Badger BL,Haase J,Ohashi T,Erickson HP,Salmon ED,Bloom K

    更新日期：2016-04-01 00:00:00

  • PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.

    abstract：:In three-dimensional matrices cancer cells move with a rounded, amoeboid morphology that is controlled by ROCK-dependent contraction of acto-myosin. In this study, we show that PDK1 is required for phosphorylation of myosin light chain and cell motility, both on deformable gels and in vivo. Depletion of PDK1 alters th...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1675

    authors： Pinner S,Sahai E

    更新日期：2008-02-01 00:00:00

  • Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation.

    abstract：:The tumour vascular microenvironment supports tumorigenesis not only by supplying oxygen and diffusible nutrients but also by secreting soluble factors that promote tumorigenesis. Here we identify a feedforward mechanism in which endothelial cells (ECs), in response to tumour-derived mediators, release angiocrines dri...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2954

    authors： Fan Y,Potdar AA,Gong Y,Eswarappa SM,Donnola S,Lathia JD,Hambardzumyan D,Rich JN,Fox PL

    更新日期：2014-05-01 00:00:00

  • Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells.

    abstract：:Changes in phosphorylation of the carboxy-terminal domain (CTD) of RNA polymerase II (RNAP) are associated with transcription initiation, elongation and termination. Sites of active transcription are generally characterized by hyperphosphorylated RNAP, particularly at Ser 2 residues, whereas inactive or poised genes m...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1663

    authors： Stock JK,Giadrossi S,Casanova M,Brookes E,Vidal M,Koseki H,Brockdorff N,Fisher AG,Pombo A

    更新日期：2007-12-01 00:00:00

  • FGF receptor signalling is required to maintain neural progenitors during Hensen's node progression.

    abstract：:Previous analyses of labelled clones of cells within the developing nervous system of the mouse have indicated that descendants are initially dispersed rostrocaudally followed by more local proliferation, which is consistent with the progressing node's contributing descendants from a resident population of progenitor ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/35078535

    authors： Mathis L,Kulesa PM,Fraser SE

    更新日期：2001-06-01 00:00:00

  • Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system.

    abstract：:The asymmetric segregation of cell-fate determinants and the generation of daughter cells of different sizes rely on the correct orientation and position of the mitotic spindle. In the Drosophila embryo, the determinant Prospero is localized basally and is segregated equally to daughters of similar cell size during ep...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/71323

    authors： Kaltschmidt JA,Davidson CM,Brown NH,Brand AH

    更新日期：2000-01-01 00:00:00

  • Direct induction of microtubule branching by microtubule nucleation factor SSNA1.

    abstract：:Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed microtubule seeds or from γ-tubulin recruited to the side of a pre-existing microtubule. Here, we found that microtubules c...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-018-0199-8

    authors： Basnet N,Nedozralova H,Crevenna AH,Bodakuntla S,Schlichthaerle T,Taschner M,Cardone G,Janke C,Jungmann R,Magiera MM,Biertümpfel C,Mizuno N

    更新日期：2018-10-01 00:00:00

  • Cdk1 coordinates cell-surface growth with the cell cycle.

    abstract：:The mechanisms that control cell growth during the cell cycle are poorly understood. In budding yeast, cyclin dependent kinase 1 (Cdk1) triggers polarization of the actin cytoskeleton and bud emergence in late G1 through activation of the Cdc42 GTPase. However, Cdk1 is not thought to be required for subsequent growth ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1568

    authors： McCusker D,Denison C,Anderson S,Egelhofer TA,Yates JR 3rd,Gygi SP,Kellogg DR

    更新日期：2007-05-01 00:00:00

  • Motor-free mitochondrial presequence translocase drives membrane integration of preproteins.

    abstract：:The mitochondrial inner membrane is the central energy-converting membrane of eukaryotic cells. The electrochemical proton gradient generated by the respiratory chain drives the ATP synthase. To maintain this proton-motive force, the inner membrane forms a tight barrier and strictly controls the translocation of ions....

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1635

    authors： van der Laan M,Meinecke M,Dudek J,Hutu DP,Lind M,Perschil I,Guiard B,Wagner R,Pfanner N,Rehling P

    更新日期：2007-10-01 00:00:00

  • Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components.

    abstract：:To maintain genome function and stability, DNA sequence and its organization into chromatin must be duplicated during cell division. Understanding how entire chromosomes are copied remains a major challenge. Here, we use nascent chromatin capture (NCC) to profile chromatin proteome dynamics during replication in human...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2918

    authors： Alabert C,Bukowski-Wills JC,Lee SB,Kustatscher G,Nakamura K,de Lima Alves F,Menard P,Mejlvang J,Rappsilber J,Groth A

    更新日期：2014-03-01 00:00:00

  • Neogenin mediates the action of repulsive guidance molecule.

    abstract：:Repulsive guidance molecule (RGM) is a recently identified protein implicated in both axonal guidance and neural tube closure. The avoidance of chick RGM in the posterior optic tectum by growing temporal, but not nasal, retinal ganglion cell axons is thought to contribute to visual map formation. In contrast to ephrin...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1156

    authors： Rajagopalan S,Deitinghoff L,Davis D,Conrad S,Skutella T,Chedotal A,Mueller BK,Strittmatter SM

    更新日期：2004-08-01 00:00:00

  • Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.

    abstract：:Robust mechanisms to control cell proliferation have evolved to maintain the integrity of organ architecture. Here, we investigated how two critical proliferative pathways, Myc and E2f, are integrated to control cell cycles in normal and Rb-deficient cells using a murine intestinal model. We show that Myc and E2f1-3 h...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3210

    authors： Liu H,Tang X,Srivastava A,Pécot T,Daniel P,Hemmelgarn B,Reyes S,Fackler N,Bajwa A,Kladney R,Koivisto C,Chen Z,Wang Q,Huang K,Machiraju R,Sáenz-Robles MT,Cantalupo P,Pipas JM,Leone G

    更新日期：2015-08-01 00:00:00

  • Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.

    abstract：:The AP-1 transcription factor c-Jun is essential for cellular proliferation in many cell types, but the molecular link between growth factors and c-Jun activation has been enigmatic. In this study we identify a previously uncharacterized RING-domain-containing protein, RACO-1 (RING domain AP-1 co-activator-1), as a c-...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2098

    authors： Davies CC,Chakraborty A,Cipriani F,Haigh K,Haigh JJ,Behrens A

    更新日期：2010-10-01 00:00:00

  • New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.

    abstract：:Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3. Cells transfected with a seven-transmembrane-domain receptor, OT7T022, specifically ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/35036326

    authors： Hinuma S,Shintani Y,Fukusumi S,Iijima N,Matsumoto Y,Hosoya M,Fujii R,Watanabe T,Kikuchi K,Terao Y,Yano T,Yamamoto T,Kawamata Y,Habata Y,Asada M,Kitada C,Kurokawa T,Onda H,Nishimura O,Tanaka M,Ibata Y,Fujino M

    更新日期：2000-10-01 00:00:00

  • LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.

    abstract：:Sensing and clearance of dysfunctional lysosomes is critical for cellular homeostasis. Here we show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated during the lysosomal damage response, and its activation is dependent on the function of the ATG ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-020-00583-9

    authors： Nakamura S,Shigeyama S,Minami S,Shima T,Akayama S,Matsuda T,Esposito A,Napolitano G,Kuma A,Namba-Hamano T,Nakamura J,Yamamoto K,Sasai M,Tokumura A,Miyamoto M,Oe Y,Fujita T,Terawaki S,Takahashi A,Hamasaki M,Yamamot

    更新日期：2020-10-01 00:00:00

  • Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response.

    abstract：:Nitric oxide (NO) is a pleiotropic signalling molecule that binds to cytochrome c oxidase (complex IV) reversibly and in competition with oxygen. This action of NO has both physiological and pathophysiological consequences. Here we report that endogenously generated NO, which disrupts the respiratory chain, may cause ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1188

    authors： Xu W,Liu L,Charles IG,Moncada S

    更新日期：2004-11-01 00:00:00