Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response.

abstract：:The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of stalled DNA replication forks is a recently identified PARPi-resistance mechanism that promotes genomic stability in BRCA1/2-deficient cancers. D...

journal_title：Nature cell biology

authors： Rondinelli B,Gogola E,Yücel H,Duarte AA,van de Ven M,van der Sluijs R,Konstantinopoulos PA,Jonkers J,Ceccaldi R,Rottenberg S,D'Andrea AD

更新日期：2017-11-01 00:00:00

abstract：:Cancer cells use aerobic glycolysis preferentially for energy provision and this metabolic change is important for tumour growth. Here, we have found a link between the tumour suppressor p53, the transcription factor NF-kappaB and glycolysis. In p53-deficient primary cultured cells, kinase activities of IKKalpha and I...

journal_title：Nature cell biology

authors： Kawauchi K,Araki K,Tobiume K,Tanaka N

更新日期：2008-05-01 00:00:00

abstract：:Sensing and clearance of dysfunctional lysosomes is critical for cellular homeostasis. Here we show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated during the lysosomal damage response, and its activation is dependent on the function of the ATG ...

journal_title：Nature cell biology

authors： Nakamura S,Shigeyama S,Minami S,Shima T,Akayama S,Matsuda T,Esposito A,Napolitano G,Kuma A,Namba-Hamano T,Nakamura J,Yamamoto K,Sasai M,Tokumura A,Miyamoto M,Oe Y,Fujita T,Terawaki S,Takahashi A,Hamasaki M,Yamamot

更新日期：2020-10-01 00:00:00

abstract：:ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardio...

journal_title：Nature cell biology

authors： David R,Brenner C,Stieber J,Schwarz F,Brunner S,Vollmer M,Mentele E,Müller-Höcker J,Kitajima S,Lickert H,Rupp R,Franz WM

更新日期：2008-03-01 00:00:00

abstract：:Clathrin-coated vesicles mediate endocytosis and transport between the trans-Golgi network (TGN) and endosomes in eukaryotic cells. Clathrin adaptors play central roles in coat assembly, interacting with clathrin, cargo and membranes. Two main types of clathrin adaptor act in TGN-endosome traffic: GGA proteins and the...

journal_title：Nature cell biology

authors： Daboussi L,Costaguta G,Payne GS

更新日期：2012-02-19 00:00:00

abstract：:Here we show that segregation of homologous chromosomes and that of sister chromatids are differentially regulated in Xenopus and possibly in other higher eukaryotes. Upon hormonal stimulation, Xenopus oocytes microinjected with antibodies against the anaphase-promoting complex (APC) activator Fizzy or the APC core su...

journal_title：Nature cell biology

authors： Peter M,Castro A,Lorca T,Le Peuch C,Magnaghi-Jaulin L,Dorée M,Labbé JC

更新日期：2001-01-01 00:00:00

abstract：:For accurate segregation of chromosomes during cell division, microtubule fibres must attach sister kinetochores to opposite poles of the mitotic spindle (bi-orientation). Aurora kinases are linked to oncogenesis and have been implicated in the regulation of chromosome-microtubule attachments. Although loss of Aurora ...

journal_title：Nature cell biology

authors： Lampson MA,Renduchitala K,Khodjakov A,Kapoor TM

更新日期：2004-03-01 00:00:00

abstract：:Science denial is not new but, in the digital age, evidence-based conclusions appear to be increasingly threatened by beliefs based on emotion and isolated personal experience. When confronting a post-truth world, scientists must defend the scientific method and increase public engagement. ...

journal_title：Nature cell biology

authors：

更新日期：2018-11-01 00:00:00

abstract：:Nutrient availability is central for T-cell functions and immune responses. Here we report that CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non-essential amino acid Asn. Increased Asn levels enhance CD8+ T-cell activation and effector functions against tumour cells in vitro and in ...

journal_title：Nature cell biology

authors： Wu J,Li G,Li L,Li D,Dong Z,Jiang P

更新日期：2021-01-01 00:00:00

abstract：:Store-operated Ca(2+) channels (SOCs) are activated in response to Ca(2+) release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca(2+) content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STI...

journal_title：Nature cell biology

authors： Shin DM,Muallem S

更新日期：2008-06-01 00:00:00

abstract：:Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external...

journal_title：Nature cell biology

authors： Celià-Terrassa T,Kang Y

更新日期：2018-08-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved 'self-eating' process. Although the genes essential for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how Atg proteins control autophagosome formation in mammalian cells remains to be elucidated. Here, we demonstrate that Bif-1 (also known as E...

journal_title：Nature cell biology

authors： Takahashi Y,Coppola D,Matsushita N,Cualing HD,Sun M,Sato Y,Liang C,Jung JU,Cheng JQ,Mulé JJ,Pledger WJ,Wang HG

更新日期：2007-10-01 00:00:00

abstract：:FoxG1 is an evolutionarily conserved, winged-helix transcriptional repressor that maintains progenitor cells in the vertebrate forebrain. How the activity of FoxG1 is regulated is not known. Here, we report that in the developing Xenopus and mouse forebrain, FoxG1 is nuclear in progenitor cells but cytoplasmic in diff...

journal_title：Nature cell biology

authors： Regad T,Roth M,Bredenkamp N,Illing N,Papalopulu N

更新日期：2007-05-01 00:00:00

abstract：:The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of new therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been shown to prevent diet-i...

journal_title：Nature cell biology

authors： Moisan A,Lee YK,Zhang JD,Hudak CS,Meyer CA,Prummer M,Zoffmann S,Truong HH,Ebeling M,Kiialainen A,Gérard R,Xia F,Schinzel RT,Amrein KE,Cowan CA

更新日期：2015-01-01 00:00:00

abstract：:YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression ...

journal_title：Nature cell biology

authors： Mo JS,Meng Z,Kim YC,Park HW,Hansen CG,Kim S,Lim DS,Guan KL

更新日期：2015-04-01 00:00:00

abstract：:Cytokinesis requires the spatio-temporal coordination of cell-cycle control and cytoskeletal reorganization. Members of the Rho-family of GTPases are crucial regulators of this process and assembly of the contractile ring depends on local activation of Rho signalling. Here, we show that the armadillo protein p0071, un...

journal_title：Nature cell biology

authors： Wolf A,Keil R,Götzl O,Mun A,Schwarze K,Lederer M,Hüttelmaier S,Hatzfeld M

更新日期：2006-12-01 00:00:00

abstract：:Extracellular signal regulated kinases (ERKs) represent a signalling hub in many physiological responses and have pivotal functions in cell proliferation, differentiation, development and death, as well as in synaptic plasticity. Mitogen-activated protein kinase phosphatases (MKPs) selectively inactivate ERKs by depho...

journal_title：Nature cell biology

authors： Kang TH,Kim KT

更新日期：2006-08-01 00:00:00

abstract：:Obesity occurs when excess energy accumulates in white adipose tissue (WAT), whereas brown adipose tissue (BAT), specialized for energy expenditure through thermogenesis, potently counteracts obesity. Factors that induce brown adipocyte commitment and energy expenditure would be a promising defence against adiposity. ...

journal_title：Nature cell biology

authors： Wang J,Liu R,Wang F,Hong J,Li X,Chen M,Ke Y,Zhang X,Ma Q,Wang R,Shi J,Cui B,Gu W,Zhang Y,Zhang Z,Wang W,Xia X,Liu M,Ning G

更新日期：2013-12-01 00:00:00

abstract：:The metazoan nuclear pore complex (NPC) disassembles during mitosis, and many of its constituents distribute onto spindles and kinetochores, including the Nup107-160 sub-complex. We have found that Nup107-160 interacts with the gamma-tubulin ring complex (gamma-TuRC), an essential and conserved microtubule nucleator, ...

journal_title：Nature cell biology

authors： Mishra RK,Chakraborty P,Arnaoutov A,Fontoura BM,Dasso M

更新日期：2010-02-01 00:00:00

abstract：:Cancer-induced immune responses affect tumour progression and therapeutic response. In multiple murine models and clinical datasets, we identified large variations of neutrophils and macrophages that define 'immune subtypes' of triple-negative breast cancer (TNBC), including neutrophil-enriched (NES) and macrophage-en...

journal_title：Nature cell biology

authors： Kim IS,Gao Y,Welte T,Wang H,Liu J,Janghorban M,Sheng K,Niu Y,Goldstein A,Zhao N,Bado I,Lo HC,Toneff MJ,Nguyen T,Bu W,Jiang W,Arnold J,Gu F,He J,Jebakumar D,Walker K,Li Y,Mo Q,Westbrook TF,Zong C,Rao A,

更新日期：2019-09-01 00:00:00

abstract：:Topoisomerase II (Topo II) is required to separate intertwined sister chromatids before chromosome segregation can occur in mitosis. However, it remains to be resolved whether Topo II has any role in checkpoint control. Here we report that when phosphorylated, Ser 1524 of Topo IIalpha acts as a binding site for the BR...

journal_title：Nature cell biology

authors： Luo K,Yuan J,Chen J,Lou Z

更新日期：2009-02-01 00:00:00

abstract：:Although nuclear envelope (NE) assembly is known to require the GTPase Ran, the membrane fusion machinery involved is uncharacterized. NE assembly involves formation of a reticular network on chromatin, fusion of this network into a closed NE and subsequent expansion. Here we show that p97, an AAA-ATPase previously im...

journal_title：Nature cell biology

authors： Hetzer M,Meyer HH,Walther TC,Bilbao-Cortes D,Warren G,Mattaj IW

更新日期：2001-12-01 00:00:00

abstract：:Lingual keratinized epithelial cells, which constitute the filiform papillae of the tongue, have one of the most rapid tissue turnover rates in the mammalian body and are thought to be the source of squamous cell carcinoma of the tongue. However, the mechanism of tissue maintenance and regeneration is largely unknown ...

journal_title：Nature cell biology

authors： Tanaka T,Komai Y,Tokuyama Y,Yanai H,Ohe S,Okazaki K,Ueno H

更新日期：2013-05-01 00:00:00

abstract：:Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic traffic, the potential impact of endocytic traffic on integrin-induced signals is unknown. Here, we demonstr...

journal_title：Nature cell biology

authors： Alanko J,Mai A,Jacquemet G,Schauer K,Kaukonen R,Saari M,Goud B,Ivaska J

更新日期：2015-11-01 00:00:00

abstract：:Glycogen has long been considered to have a function in energy metabolism. However, our recent study indicated that glycogen metabolism, directed by cytosolic phosphoenolpyruvate carboxykinase Pck1, controls the formation and maintenance of CD8+ memory T (Tmem) cells by regulating redox homeostasis1. This unusual meta...

journal_title：Nature cell biology

authors： Zhang H,Tang K,Ma J,Zhou L,Liu J,Zeng L,Zhu L,Xu P,Chen J,Wei K,Liang X,Lv J,Xie J,Liu Y,Wan Y,Huang B

更新日期：2020-01-01 00:00:00

abstract：:The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from other extracellular vesicles in terms of their biogenesis and functions remains ...

journal_title：Nature cell biology

authors： Mathieu M,Martin-Jaular L,Lavieu G,Théry C

更新日期：2019-01-01 00:00:00

abstract：:Collective cell migration is essential for both physiological and pathological processes. Adherens junctions (AJs) maintain the integrity of the migrating cell group and promote cell coordination while allowing cellular rearrangements. Here, we show that AJs undergo a continuous treadmilling along the lateral sides of...

journal_title：Nature cell biology

authors： Peglion F,Llense F,Etienne-Manneville S

更新日期：2014-07-01 00:00:00

abstract：:Work over the past two years has led to a breakthrough in our understanding of the molecular basis of the directionality of the kinesin motor proteins. This breakthrough has come first from the reversal of directionality of the kinesin-related motor Ncd, followed closely by the reversal of kinesin's directionality and...

journal_title：Nature cell biology

authors： Endow SA

更新日期：1999-10-01 00:00:00

abstract：:KLF4 (GKLF/EZF) encodes a transcription factor that is associated with both tumour suppression and oncogenesis. We describe the identification of KLF4 in a functional genomic screen for genes that bypass RAS(V12)-induced senescence. However, in untransformed cells, KLF4 acts as a potent inhibitor of proliferation. KLF...

journal_title：Nature cell biology

authors： Rowland BD,Bernards R,Peeper DS

更新日期：2005-11-01 00:00:00

abstract：:PX domains are found in a variety of proteins that associate with cell membranes, but their molecular function has remained obscure. We show here that the PX domains in p47phox and p40phox subunits of the phagocyte NADPH oxidase bind to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P(2)) and phosphatidylinositol-3...

journal_title：Nature cell biology

authors： Kanai F,Liu H,Field SJ,Akbary H,Matsuo T,Brown GE,Cantley LC,Yaffe MB

更新日期：2001-07-01 00:00:00