当前位置： SCI文献检索 > NATURE CELL BIOLOGY期刊下所有文献 > EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.

Abstract：

:The Notch1 gene has an important role in mammalian cell-fate decision and tumorigenesis. Upstream control mechanisms for transcription of this gene are still poorly understood. In a chemical genetics screen for small molecule activators of Notch signalling, we identified epidermal growth factor receptor (EGFR) as a key negative regulator of Notch1 gene expression in primary human keratinocytes, intact epidermis and skin squamous cell carcinomas (SCCs). The underlying mechanism for negative control of the Notch1 gene in human cells, as well as in a mouse model of EGFR-dependent skin carcinogenesis, involves transcriptional suppression of p53 by the EGFR effector c-Jun. Suppression of Notch signalling in cancer cells counteracts the differentiation-inducing effects of EGFR inhibitors while, at the same time, synergizing with these compounds in induction of apoptosis. Thus, our data reveal a key role of EGFR signalling in the negative regulation of Notch1 gene transcription, of potential relevance for combinatory approaches for cancer therapy.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Kolev V,Mandinova A,Guinea-Viniegra J,Hu B,Lefort K,Lambertini C,Neel V,Dummer R,Wagner EF,Dotto GP

doi

10.1038/ncb1750

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

902-11

issue

8

eissn

1465-7392

issn

1476-4679

pii

ncb1750

journal_volume

10

pub_type

杂志文章

相关文献

NATURE CELL BIOLOGY文献大全
  • Cell plasticity in epithelial homeostasis and tumorigenesis.

    abstract：:The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb3611

    authors： Varga J,Greten FR

    更新日期：2017-10-01 00:00:00

  • Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.

    abstract：:The target of rapamycin complex 2 (TORC2) plays a key role in maintaining the homeostasis of plasma membrane (PM) tension. TORC2 activation following increased PM tension involves redistribution of the Slm1 and 2 paralogues from PM invaginations known as eisosomes into membrane compartments containing TORC2. How Slm1/...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-018-0150-z

    authors： Riggi M,Niewola-Staszkowska K,Chiaruttini N,Colom A,Kusmider B,Mercier V,Soleimanpour S,Stahl M,Matile S,Roux A,Loewith R

    更新日期：2018-09-01 00:00:00

  • Genome-scale RNAi profiling of cell division in human tissue culture cells.

    abstract：:Cell division is fundamental for all organisms. Here we report a genome-scale RNA-mediated interference screen in HeLa cells designed to identify human genes that are important for cell division. We have used a library of endoribonuclease-prepared short interfering RNAs for gene silencing and have used DNA content ana...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1659

    authors： Kittler R,Pelletier L,Heninger AK,Slabicki M,Theis M,Miroslaw L,Poser I,Lawo S,Grabner H,Kozak K,Wagner J,Surendranath V,Richter C,Bowen W,Jackson AL,Habermann B,Hyman AA,Buchholz F

    更新日期：2007-12-01 00:00:00

  • A role for CSLD3 during cell-wall synthesis in apical plasma membranes of tip-growing root-hair cells.

    abstract：:In plants, cell shape is defined by the cell wall, and changes in cell shape and size are dictated by modification of existing cell walls and deposition of newly synthesized cell-wall material. In root hairs, expansion occurs by a process called tip growth, which is shared by root hairs, pollen tubes and fungal hyphae...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2294

    authors： Park S,Szumlanski AL,Gu F,Guo F,Nielsen E

    更新日期：2011-07-17 00:00:00

  • The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.

    abstract：:In vertebrates, centromeres lack defined sequences and are thought to be propagated by epigenetic mechanisms involving the incorporation of specialized nucleosomes containing the histone H3 variant centromere protein (CENP)-A. However, the precise mechanisms that target CENP-A to centromeres remain poorly understood. ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1396

    authors： Okada M,Cheeseman IM,Hori T,Okawa K,McLeod IX,Yates JR 3rd,Desai A,Fukagawa T

    更新日期：2006-05-01 00:00:00

  • Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.

    abstract：:Robust mechanisms to control cell proliferation have evolved to maintain the integrity of organ architecture. Here, we investigated how two critical proliferative pathways, Myc and E2f, are integrated to control cell cycles in normal and Rb-deficient cells using a murine intestinal model. We show that Myc and E2f1-3 h...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3210

    authors： Liu H,Tang X,Srivastava A,Pécot T,Daniel P,Hemmelgarn B,Reyes S,Fackler N,Bajwa A,Kladney R,Koivisto C,Chen Z,Wang Q,Huang K,Machiraju R,Sáenz-Robles MT,Cantalupo P,Pipas JM,Leone G

    更新日期：2015-08-01 00:00:00

  • Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion.

    abstract：:The formation of axon trajectories requires integration of local adhesive interactions with directional information from attractive and repulsive cues. Here, we show that these two types of information are functionally integrated; activation of the transmembrane receptor Roundabout (Robo) by its ligand, the secreted r...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb858

    authors： Rhee J,Mahfooz NS,Arregui C,Lilien J,Balsamo J,VanBerkum MF

    更新日期：2002-10-01 00:00:00

  • LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

    abstract：:Breast cancer brain metastasis (BCBM) is a devastating disease. Radiation therapy remains the mainstay for treatment of this disease. Unfortunately, its efficacy is limited by the dose that can be safely applied. One promising approach to overcoming this limitation is to sensitize BCBMs to radiation by inhibiting thei...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-020-00586-6

    authors： Chen Y,Jiang T,Zhang H,Gou X,Han C,Wang J,Chen AT,Ma J,Liu J,Chen Z,Jing X,Lei H,Wang Z,Bao Y,Baqri M,Zhu Y,Bindra RS,Hansen JE,Dou J,Huang C,Zhou J

    更新日期：2020-10-01 00:00:00

  • In vivo reprogramming for tissue repair.

    abstract：:Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recen...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb3108

    authors： Heinrich C,Spagnoli FM,Berninger B

    更新日期：2015-03-01 00:00:00

  • Correcting improper chromosome-spindle attachments during cell division.

    abstract：:For accurate segregation of chromosomes during cell division, microtubule fibres must attach sister kinetochores to opposite poles of the mitotic spindle (bi-orientation). Aurora kinases are linked to oncogenesis and have been implicated in the regulation of chromosome-microtubule attachments. Although loss of Aurora ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1102

    authors： Lampson MA,Renduchitala K,Khodjakov A,Kapoor TM

    更新日期：2004-03-01 00:00:00

  • Integrin endosomal signalling suppresses anoikis.

    abstract：:Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic traffic, the potential impact of endocytic traffic on integrin-induced signals is unknown. Here, we demonstr...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3250

    authors： Alanko J,Mai A,Jacquemet G,Schauer K,Kaukonen R,Saari M,Goud B,Ivaska J

    更新日期：2015-11-01 00:00:00

  • A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance.

    abstract：:Proteins essential for vesicle formation by the Coat Protein I (COPI) complex are being identified, but less is known about the role of specific lipids. Brefeldin-A ADP-ribosylated substrate (BARS) functions in the fission step of COPI vesicle formation. Here, we show that BARS induces membrane curvature in cooperatio...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1774

    authors： Yang JS,Gad H,Lee SY,Mironov A,Zhang L,Beznoussenko GV,Valente C,Turacchio G,Bonsra AN,Du G,Baldanzi G,Graziani A,Bourgoin S,Frohman MA,Luini A,Hsu VW

    更新日期：2008-10-01 00:00:00

  • Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity.

    abstract：:A number of key regulators of mouse embryonic stem (ES) cell identity, including the transcription factor Nanog, show strong expression fluctuations at the single-cell level. The molecular basis for these fluctuations is unknown. Here we used a genetic complementation strategy to investigate expression changes during ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2603

    authors： MacArthur BD,Sevilla A,Lenz M,Müller FJ,Schuldt BM,Schuppert AA,Ridden SJ,Stumpf PS,Fidalgo M,Ma'ayan A,Wang J,Lemischka IR

    更新日期：2012-11-01 00:00:00

  • The extracellular matrix guides the orientation of the cell division axis.

    abstract：:The cell division axis determines the future positions of daughter cells and is therefore critical for cell fate. The positioning of the division axis has been mostly studied in systems such as embryos or yeasts, in which cell shape is well defined. In these cases, cell shape anisotropy and cell polarity affect spindl...

    journal_title：Nature cell biology

    pub_type： 信件

    doi：10.1038/ncb1307

    authors： Théry M,Racine V,Pépin A,Piel M,Chen Y,Sibarita JB,Bornens M

    更新日期：2005-10-01 00:00:00

  • Non-redundant functions of EMT transcription factors.

    abstract：:Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to b...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/s41556-018-0196-y

    authors： Stemmler MP,Eccles RL,Brabletz S,Brabletz T

    更新日期：2019-01-01 00:00:00

  • A new view of mRNA export: separating the wheat from the chaff.

    abstract：:Current models for the export of messenger RNA share the notion that the highly abundant class of nuclear RNA-binding proteins--the hnRNP proteins--have a key role in exporting RNA. But recent studies have led to a new understanding of several non-hnRNP proteins, including SR proteins and the conserved mRNA export fac...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb0901-e201

    authors： Reed R,Magni K

    更新日期：2001-09-01 00:00:00

  • Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.

    abstract：:Mammalian telomeres consist of non-coding TTAGGG repeats that are bound by the multi-protein complex 'shelterin', thus protecting chromosome ends from DNA repair mechanisms and degradation. Mammalian telomeric chromatin is enriched for the constitutive heterochromatin marks H3K9me3, H4K20me3 and HP1 (refs 2, 3, 4, 5, ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1685

    authors： Schoeftner S,Blasco MA

    更新日期：2008-02-01 00:00:00

  • Linking HSCs to their youth.

    abstract：:Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated t...

    journal_title：Nature cell biology

    pub_type： 评论,新闻

    doi：10.1038/ncb2817

    authors： Pietras EM,Passegué E

    更新日期：2013-08-01 00:00:00

  • The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

    abstract：:Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling cascade, but how ubiqu...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2367

    authors： Meerang M,Ritz D,Paliwal S,Garajova Z,Bosshard M,Mailand N,Janscak P,Hübscher U,Meyer H,Ramadan K

    更新日期：2011-10-23 00:00:00

  • Stable RNA interference rules for silencing.

    abstract：:RNA interference has become an indispensable tool for loss-of-function studies across eukaryotes. By enabling stable and reversible gene silencing, shRNAs provide a means to study long-term phenotypes, perform pool-based forward genetic screens and examine the consequences of temporary target inhibition in vivo. Howev...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb2895

    authors： Fellmann C,Lowe SW

    更新日期：2014-01-01 00:00:00

  • Cell fate decisions are specified by the dynamic ERK interactome.

    abstract：:Extracellular signal-regulated kinase (ERK) controls fundamental cellular functions, including cell fate decisions. In PC12, cells shifting ERK activation from transient to sustained induces neuronal differentiation. As ERK associates with both regulators and effectors, we hypothesized that the mechanisms underlying t...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1994

    authors： von Kriegsheim A,Baiocchi D,Birtwistle M,Sumpton D,Bienvenut W,Morrice N,Yamada K,Lamond A,Kalna G,Orton R,Gilbert D,Kolch W

    更新日期：2009-12-01 00:00:00

  • Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis.

    abstract：:Autophagy is an evolutionarily conserved 'self-eating' process. Although the genes essential for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how Atg proteins control autophagosome formation in mammalian cells remains to be elucidated. Here, we demonstrate that Bif-1 (also known as E...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1634

    authors： Takahashi Y,Coppola D,Matsushita N,Cualing HD,Sun M,Sato Y,Liang C,Jung JU,Cheng JQ,Mulé JJ,Pledger WJ,Wang HG

    更新日期：2007-10-01 00:00:00

  • ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells.

    abstract：:Tumour growth and invasiveness require extracellular matrix (ECM) degradation and are stimulated by the GALA pathway, which induces protein O-glycosylation in the endoplasmic reticulum (ER). ECM degradation requires metalloproteases, but whether other enzymes are required is unclear. Here, we show that GALA induces th...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-020-00590-w

    authors： Ros M,Nguyen AT,Chia J,Le Tran S,Le Guezennec X,McDowall R,Vakhrushev S,Clausen H,Humphries MJ,Saltel F,Bard FA

    更新日期：2020-11-01 00:00:00

  • The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.

    abstract：:Cellular transformation and cancer progression is accompanied by changes in the metabolic landscape. Master co-regulators of metabolism orchestrate the modulation of multiple metabolic pathways through transcriptional programs, and hence constitute a probabilistically parsimonious mechanism for general metabolic rewir...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3357

    authors： Torrano V,Valcarcel-Jimenez L,Cortazar AR,Liu X,Urosevic J,Castillo-Martin M,Fernández-Ruiz S,Morciano G,Caro-Maldonado A,Guiu M,Zúñiga-García P,Graupera M,Bellmunt A,Pandya P,Lorente M,Martín-Martín N,Sutherland JD,San

    更新日期：2016-06-01 00:00:00

  • Enhancing brown fat with NFIA.

    abstract：:Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory element...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3591

    authors： Shapira SN,Seale P

    更新日期：2017-08-31 00:00:00

  • Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly.

    abstract：:Although nuclear envelope (NE) assembly is known to require the GTPase Ran, the membrane fusion machinery involved is uncharacterized. NE assembly involves formation of a reticular network on chromatin, fusion of this network into a closed NE and subsequent expansion. Here we show that p97, an AAA-ATPase previously im...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1201-1086

    authors： Hetzer M,Meyer HH,Walther TC,Bilbao-Cortes D,Warren G,Mattaj IW

    更新日期：2001-12-01 00:00:00

  • FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.

    abstract：:The molecular mechanisms underlying the formation of carriers trafficking from the Golgi complex to the cell surface are still ill-defined; nevertheless, the involvement of a lipid-based machinery is well established. This includes phosphatidylinositol 4-phosphate (PtdIns(4)P), the precursor for phosphatidylinositol 4...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1119

    authors： Godi A,Di Campli A,Konstantakopoulos A,Di Tullio G,Alessi DR,Kular GS,Daniele T,Marra P,Lucocq JM,De Matteis MA

    更新日期：2004-05-01 00:00:00

  • MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling.

    abstract：:ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardio...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1696

    authors： David R,Brenner C,Stieber J,Schwarz F,Brunner S,Vollmer M,Mentele E,Müller-Höcker J,Kitajima S,Lickert H,Rupp R,Franz WM

    更新日期：2008-03-01 00:00:00

  • Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.

    abstract：:During interphase, centrosomes are held together by a proteinaceous linker that connects the proximal ends of the mother and daughter centriole. This linker is disassembled at the onset of mitosis in a process known as centrosome disjunction, thereby facilitating centrosome separation and bipolar spindle formation. Th...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2120

    authors： Mardin BR,Lange C,Baxter JE,Hardy T,Scholz SR,Fry AM,Schiebel E

    更新日期：2010-12-01 00:00:00

  • The expression of Sox17 identifies and regulates haemogenic endothelium.

    abstract：:Although it is well recognized that haematopoietic stem cells (HSCs) develop from a specialized population of endothelial cells known as haemogenic endothelium, the regulatory pathways that control this transition are not well defined. Here we identify Sox17 as a key regulator of haemogenic endothelial development. An...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2724

    authors： Clarke RL,Yzaguirre AD,Yashiro-Ohtani Y,Bondue A,Blanpain C,Pear WS,Speck NA,Keller G

    更新日期：2013-05-01 00:00:00