Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.

abstract：:The initial differential treatment of the two X chromosomes during X-chromosome inactivation is controlled by the X-inactivation centre (Xic). This locus determines how many X chromosomes are present in a cell ('counting') and which X chromosome will be inactivated in female cells ('choice'). Critical control sequence...

journal_title：Nature cell biology

authors： Bacher CP,Guggiari M,Brors B,Augui S,Clerc P,Avner P,Eils R,Heard E

更新日期：2006-03-01 00:00:00

abstract：:Protein kinases have central functions in various cellular signal transduction pathways through their substrate phosphorylation. Here we show that a protein kinase, DYRK2, has unexpected role as a scaffold for an E3 ubiquitin ligase complex. DYRK2 associates with an E3 ligase complex containing EDD, DDB1 and VPRBP pro...

journal_title：Nature cell biology

authors： Maddika S,Chen J

更新日期：2009-04-01 00:00:00

abstract：:Mitochondria drive apoptosis by releasing pro-apoptotic proteins that promote caspase activation in the cytosol. The rhomboid protease PARL, an intramembrane cleaving peptidase in the inner membrane, regulates mitophagy and plays an ill-defined role in apoptosis. Here, we employed PARL-based proteomics to define its s...

journal_title：Nature cell biology

authors： Saita S,Nolte H,Fiedler KU,Kashkar H,Venne AS,Zahedi RP,Krüger M,Langer T

更新日期：2017-04-01 00:00:00

abstract：:Here we investigate the role of the control of apoptosis in normal cell division. We show that interference with the expression or function of the apoptosis inhibitor survivin causes caspase-dependent cell death in the G2/M phase of the cell cycle, and a cell-division defect characterized by centrosome dysregulation, ...

journal_title：Nature cell biology

authors： Li F,Ackermann EJ,Bennett CF,Rothermel AL,Plescia J,Tognin S,Villa A,Marchisio PC,Altieri DC

更新日期：1999-12-01 00:00:00

abstract：:Lamina-associated polypeptide (LAP) 2alpha is a chromatin-associated protein that binds A-type lamins. Mutations in both LAP2alpha and A-type lamins are linked to human diseases called laminopathies, but the molecular mechanisms are poorly understood. The A-type lamin-LAP2alpha complex interacts with and regulates ret...

journal_title：Nature cell biology

authors： Naetar N,Korbei B,Kozlov S,Kerenyi MA,Dorner D,Kral R,Gotic I,Fuchs P,Cohen TV,Bittner R,Stewart CL,Foisner R

更新日期：2008-11-01 00:00:00

abstract：:The enteric nervous system (ENS) predominantly originates from vagal neural crest (VNC) cells that emerge from the caudal hindbrain, invade the foregut and populate the gastrointestinal tract. However, the gene regulatory network (GRN) orchestrating the early specification of VNC remains unknown. Using an EdnrB enhanc...

journal_title：Nature cell biology

authors： Ling ITC,Sauka-Spengler T

更新日期：2019-12-01 00:00:00

abstract：:Cohesin confers both intrachromatid and interchromatid cohesion through formation of a tripartite ring within which DNA is thought to be entrapped. Here, I discuss what is known about the four stages of the cohesin ring cycle using the ring model as an intellectual framework. I postulate that cohesin loading onto chro...

journal_title：Nature cell biology

authors： Nasmyth K

更新日期：2011-10-03 00:00:00

abstract：:We describe a genome-wide gain-of-function screen for regulators of NF-kappaB, and identify Rap1 (Trf2IP), as an essential modulator of NF-kappaB-mediated pathways. NF-kappaB is induced by ectopic expression of Rap1, whereas its activity is inhibited by Rap1 depletion. In addition to localizing on telomeres, mammalian...

journal_title：Nature cell biology

authors： Teo H,Ghosh S,Luesch H,Ghosh A,Wong ET,Malik N,Orth A,de Jesus P,Perry AS,Oliver JD,Tran NL,Speiser LJ,Wong M,Saez E,Schultz P,Chanda SK,Verma IM,Tergaonkar V

更新日期：2010-08-01 00:00:00

abstract：:The importance of herpes simplex viruses (HSV) as human pathogens and the emerging prospect of using mutant derivatives of HSV-1 as potential anti-cancer therapeutics have necessitated a thorough investigation into the molecular basis of host-cell permissiveness to HSV. Here we show that NIH-3T3 cells transformed with...

journal_title：Nature cell biology

authors： Farassati F,Yang AD,Lee PW

更新日期：2001-08-01 00:00:00

abstract：:Inactivation of the von Hippel-Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel-Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dep...

journal_title：Nature cell biology

authors： Krek W

更新日期：2000-07-01 00:00:00

abstract：:Cellular senescence is a tumour suppressor programme characterized by a stable cell cycle arrest. Here we report that cellular senescence triggered by a variety of stimuli leads to diminished ribosome biogenesis and the accumulation of both rRNA precursors and ribosomal proteins. These defects were associated with red...

journal_title：Nature cell biology

authors： Lessard F,Igelmann S,Trahan C,Huot G,Saint-Germain E,Mignacca L,Del Toro N,Lopes-Paciencia S,Le Calvé B,Montero M,Deschênes-Simard X,Bury M,Moiseeva O,Rowell MC,Zorca CE,Zenklusen D,Brakier-Gingras L,Bourdeau V,Oeffin

更新日期：2018-07-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is essential for organogenesis and is triggered during carcinoma progression to an invasive state. Transforming growth factor-beta (TGF-beta) cooperates with signalling pathways, such as Ras and Wnt, to induce EMT, but the molecular mechanisms are not clear. Here, we report that...

journal_title：Nature cell biology

authors： Vincent T,Neve EP,Johnson JR,Kukalev A,Rojo F,Albanell J,Pietras K,Virtanen I,Philipson L,Leopold PL,Crystal RG,de Herreros AG,Moustakas A,Pettersson RF,Fuxe J

更新日期：2009-08-01 00:00:00

abstract：:Most invasive solid tumours display predominantly collective invasion, in which groups of cells invade the peritumoral stroma while maintaining cell-cell contacts. As the concepts and experimental models for functional analysis of collective cancer cell invasion are rapidly developing, we propose a framework for addre...

journal_title：Nature cell biology

authors： Friedl P,Locker J,Sahai E,Segall JE

更新日期：2012-08-01 00:00:00

abstract：:Physiological oxidants that are generated by activated phagocytes comprise the main source of oxidative stress during inflammation. Oxidants such as taurine chloramine (TnCl) and hydrogen peroxide (H(2)O(2)) can damage proteins and induce apoptosis, but the role of specific protein oxidation in this process has not be...

journal_title：Nature cell biology

authors： Klamt F,Zdanov S,Levine RL,Pariser A,Zhang Y,Zhang B,Yu LR,Veenstra TD,Shacter E

更新日期：2009-10-01 00:00:00

abstract：:Store-operated Ca(2+) channels (SOCs) are activated in response to Ca(2+) release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca(2+) content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STI...

journal_title：Nature cell biology

authors： Shin DM,Muallem S

更新日期：2008-06-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cancers. Here, we generate quadruple TIMP knockout (TIMPless) fibroblasts ...

journal_title：Nature cell biology

authors： Shimoda M,Principe S,Jackson HW,Luga V,Fang H,Molyneux SD,Shao YW,Aiken A,Waterhouse PD,Karamboulas C,Hess FM,Ohtsuka T,Okada Y,Ailles L,Ludwig A,Wrana JL,Kislinger T,Khokha R

更新日期：2014-09-01 00:00:00

abstract：:BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to neurodegeneration. The voltage-gated sodium channel (Na(v)1) beta2-subunit (beta2), a type I membrane protein that covalently binds to Na(v)1 alpha-subunits, is a substrate for BACE1 and gamma-secretase...

journal_title：Nature cell biology

authors： Kim DY,Carey BW,Wang H,Ingano LA,Binshtok AM,Wertz MH,Pettingell WH,He P,Lee VM,Woolf CJ,Kovacs DM

更新日期：2007-07-01 00:00:00

abstract：:Metaphase spindles are microtubule-based structures that use a multitude of proteins to modulate their morphology and function. Today, we understand many details of microtubule assembly, the role of microtubule-associated proteins, and the action of molecular motors. Ultimately, the challenge remains to understand how...

journal_title：Nature cell biology

authors： Reber SB,Baumgart J,Widlund PO,Pozniakovsky A,Howard J,Hyman AA,Jülicher F

更新日期：2013-09-01 00:00:00

abstract：:The vertebrate neural crest arises at the border of the neural plate during early stages of nervous system development; however, little is known about the molecular mechanisms underlying neural crest formation. Here we identify a secreted protein, Noelin-1, which has the ability to prolong neural crest production. Noe...

journal_title：Nature cell biology

authors： Barembaum M,Moreno TA,LaBonne C,Sechrist J,Bronner-Fraser M

更新日期：2000-04-01 00:00:00

abstract：:Several subunits of the class III phosphatidylinositol-3-OH kinase (PI(3)K-III) complex are known as tumour suppressors. Here we uncover a function for this complex and its catalytic product phosphatidylinositol-3-phosphate (PtdIns(3)P) in cytokinesis. We show that PtdIns(3)P localizes to the midbody during cytokinesi...

journal_title：Nature cell biology

authors： Sagona AP,Nezis IP,Pedersen NM,Liestøl K,Poulton J,Rusten TE,Skotheim RI,Raiborg C,Stenmark H

更新日期：2010-04-01 00:00:00

abstract：:Organization of chromatin by epigenetic mechanisms is essential for establishing and maintaining cellular identity in developing and adult organisms. A key question that remains unresolved about this process is how epigenetic marks are transmitted to the next cell generation during cell division. Here we provide a mod...

journal_title：Nature cell biology

authors： Hansen KH,Bracken AP,Pasini D,Dietrich N,Gehani SS,Monrad A,Rappsilber J,Lerdrup M,Helin K

更新日期：2008-11-01 00:00:00

abstract：:Many classical biologists working in Antarctica have 'gone molecular' to study the physiological basis for life on or below the ice. Investigating the remarkable adaptations of specific cells, organelles and molecules to this extreme environment can provide new perspectives on the processes studied in conventional exp...

journal_title：Nature cell biology

authors： Römisch K,Matheson T

更新日期：2003-01-01 00:00:00

abstract：:Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed microtubule seeds or from γ-tubulin recruited to the side of a pre-existing microtubule. Here, we found that microtubules c...

journal_title：Nature cell biology

authors： Basnet N,Nedozralova H,Crevenna AH,Bodakuntla S,Schlichthaerle T,Taschner M,Cardone G,Janke C,Jungmann R,Magiera MM,Biertümpfel C,Mizuno N

更新日期：2018-10-01 00:00:00

abstract：:The formation of branched epithelial networks is fundamental to the development of many organs, such as the lung, the kidney or the vasculature. Little is known about the mechanisms that control cell rearrangements during tubulogenesis and regulate the size of individual tubes. Recent studies indicate that whereas the...

journal_title：Nature cell biology

authors： Jaźwińska A,Ribeiro C,Affolter M

更新日期：2003-10-01 00:00:00

abstract：:The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributo...

journal_title：Nature cell biology

authors： Delaunay S,Frye M

更新日期：2019-05-01 00:00:00

abstract：:Assisted reproductive technologies (ART) are exceptional among clinical therapies, as unlike most medical procedures, ART have generational consequences. Further, human embryo research in the US has been sponsored solely by the private sector and, until recent biotechnology forays into human embryonic stem cell (hESC)...

journal_title：Nature cell biology

authors： Schatten GP

更新日期：2002-10-01 00:00:00

abstract：:The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice. We show that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells. Cel...

journal_title：Nature cell biology

authors： Laberge RM,Sun Y,Orjalo AV,Patil CK,Freund A,Zhou L,Curran SC,Davalos AR,Wilson-Edell KA,Liu S,Limbad C,Demaria M,Li P,Hubbard GB,Ikeno Y,Javors M,Desprez PY,Benz CC,Kapahi P,Nelson PS,Campisi J

更新日期：2015-08-01 00:00:00

abstract：:The intracellular Ca(2+) concentration ([Ca(2+)](i)) in skeletal muscles must be rapidly regulated during the excitation-contraction-relaxation process. However, the signalling components involved in such rapid Ca(2+) movement are not fully understood. Here we report that mice deficient in the newly identified PtdInsP...

journal_title：Nature cell biology

authors： Shen J,Yu WM,Brotto M,Scherman JA,Guo C,Stoddard C,Nosek TM,Valdivia HH,Qu CK

更新日期：2009-06-01 00:00:00

abstract：:Aberrant microRNA (miRNA) expression is a defining feature of human malignancy. Specific miRNAs have been identified as promoters or suppressors of metastatic progression. miRNAs control metastasis through divergent or convergent regulation of metastatic gene pathways. Some miRNA regulatory networks govern cell-autono...

journal_title：Nature cell biology

authors： Pencheva N,Tavazoie SF

更新日期：2013-06-01 00:00:00

abstract：:Lingual keratinized epithelial cells, which constitute the filiform papillae of the tongue, have one of the most rapid tissue turnover rates in the mammalian body and are thought to be the source of squamous cell carcinoma of the tongue. However, the mechanism of tissue maintenance and regeneration is largely unknown ...

journal_title：Nature cell biology

authors： Tanaka T,Komai Y,Tokuyama Y,Yanai H,Ohe S,Okazaki K,Ueno H

更新日期：2013-05-01 00:00:00