Abstract:
:Inactivation of the von Hippel-Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel-Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Krek Wdoi
10.1038/35017129keywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
E121-3issue
7eissn
1465-7392issn
1476-4679journal_volume
2pub_type
评论,新闻abstract::In response to DNA damage, eukaryotic cells use a system of checkpoint controls to delay cell-cycle progression. Checkpoint delays provide time for repair of damaged DNA before its replication in S phase and before segregation of chromatids in M phase. The Cds1 (Chk2) tumour-suppressor protein has been implicated in c...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35036406
更新日期:2000-10-01 00:00:00
abstract::Phosphatase and tensin homologue (Pten) suppresses neoplastic growth by negatively regulating PI(3)K signalling through its phosphatase activity. To gain insight into the actions of non-catalytic Pten domains in normal physiological processes and tumorigenesis, we engineered mice lacking the PDZ-binding domain (PDZ-BD...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3369
更新日期:2016-07-01 00:00:00
abstract::LATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. LATS1 inhibits both the phosphorylation of cofilin by LIMK...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1140
更新日期:2004-07-01 00:00:00
abstract::Store-operated Ca(2+) channels (SOCs) are activated in response to Ca(2+) release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca(2+) content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STI...
journal_title:Nature cell biology
pub_type: 新闻
doi:10.1038/ncb0608-639
更新日期:2008-06-01 00:00:00
abstract::Gastrulation leads to three germ layers--ectoderm, mesoderm and endoderm--that are separated by two basement membranes. In the mouse embryo, the emergent gut endoderm results from the widespread intercalation of cells of two distinct origins: pluripotent epiblast-derived definitive endoderm (DE) and extra-embryonic vi...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3070
更新日期:2014-12-01 00:00:00
abstract::Caenorhabditis elegans chromosomes contain specialized regions called pairing centres, which mediate homologous pairing and synapsis during meiosis. Four related proteins, ZIM-1, 2, 3 and HIM-8, associate with these sites and are required for their essential functions. Here we show that short sequence elements enriche...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1904
更新日期:2009-08-01 00:00:00
abstract::Neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE are members of a family of proteins that use the Arp2/3 complex to stimulate actin assembly in actin-based motile processes. By entering into distinct macromolecular complexes, they act as convergent nodes of different signalling pathways. The role of WAVE in g...
journal_title:Nature cell biology
pub_type: 信件
doi:10.1038/ncb1304
更新日期:2005-10-01 00:00:00
abstract::Phosphorylation networks intimately regulate mechanisms of response to therapies. Mapping the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-throughput system to measure the enzymatic activity of kinases using biological peptide targets as phospho-sens...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-019-0328-z
更新日期:2019-06-01 00:00:00
abstract::Haematopoietic stem cells (HSCs) arise in the developing aorta during embryogenesis. The number of HSC clones born has been estimated through transplantation, but experimental approaches to assess the absolute number of forming HSCs in a native setting have remained challenging. Here, we applied single-cell and clonal...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3444
更新日期:2017-01-01 00:00:00
abstract::The gene LMNA encodes the proteins lamins A and C and is implicated in nine different laminopathies - inherited diseases that are linked to premature ageing. Recent evidence has demonstrated that lamins A and C have essential functions in protecting cells from physical damage, as well as in maintaining the function of...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb1104-1062
更新日期:2004-11-01 00:00:00
abstract::The pericentriolar material (PCM), the microtubule-organizing component of the centrosome, contains a multitude of proteins and is commonly described as an amorphous cloud surrounding the centrioles. However, the days of the PCM as an unstructured matrix are numbered. Using super-resolution microscopy, several reports...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2617
更新日期:2012-11-01 00:00:00
abstract::The heterogeneity of exosomal populations has hindered our understanding of their biogenesis, molecular composition, biodistribution and functions. By employing asymmetric flow field-flow fractionation (AF4), we identified two exosome subpopulations (large exosome vesicles, Exo-L, 90-120 nm; small exosome vesicles, Ex...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0040-4
更新日期:2018-03-01 00:00:00
abstract::Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions. ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3645
更新日期:2017-11-29 00:00:00
abstract::YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3111
更新日期:2015-04-01 00:00:00
abstract::During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes that specify lineage and differentiation status. Among these factors, the transforming growth factor (TGF)-beta family is imp...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb434
更新日期:2007-09-01 00:00:00
abstract::Most invasive solid tumours display predominantly collective invasion, in which groups of cells invade the peritumoral stroma while maintaining cell-cell contacts. As the concepts and experimental models for functional analysis of collective cancer cell invasion are rapidly developing, we propose a framework for addre...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2548
更新日期:2012-08-01 00:00:00
abstract::The tumour vascular microenvironment supports tumorigenesis not only by supplying oxygen and diffusible nutrients but also by secreting soluble factors that promote tumorigenesis. Here we identify a feedforward mechanism in which endothelial cells (ECs), in response to tumour-derived mediators, release angiocrines dri...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2954
更新日期:2014-05-01 00:00:00
abstract::Mitochondria drive apoptosis by releasing pro-apoptotic proteins that promote caspase activation in the cytosol. The rhomboid protease PARL, an intramembrane cleaving peptidase in the inner membrane, regulates mitophagy and plays an ill-defined role in apoptosis. Here, we employed PARL-based proteomics to define its s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3488
更新日期:2017-04-01 00:00:00
abstract::Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory element...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3591
更新日期:2017-08-31 00:00:00
abstract::The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication stress response protein in two proteomic screens. ETAA1-deficient c...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3415
更新日期:2016-11-01 00:00:00
abstract::Chromophore-assisted laser inactivation (CALI) is a light-mediated technique used to selectively inactivate proteins within cells. Here, we demonstrate that GFP can be used as a CALI reagent to locally inactivate proteins in living cells. We show that focused laser irradiation of EGFP-alpha-actinin expressed in Swiss ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb772
更新日期:2002-04-01 00:00:00
abstract::The store-operated calcium channel (SOC) located in the plasma membrane (PM) mediates capacitative entry of extracellular calcium after depletion of intracellular calcium stores in the endoplasmic or sarcoplasmic reticulum (ER/SR). An intimate interaction between the PM and the ER/SR is essential for the operation of ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb788
更新日期:2002-05-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature cell biology
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41556-020-0479-y
更新日期:2020-03-01 00:00:00
abstract::Humans suffer from high rates of fetal aneuploidy, often arising from the absence of meiotic crossover recombination between homologous chromosomes. Meiotic recombination is initiated by double-strand breaks (DSBs) generated by the SPO11 transesterase. In yeast and worms, at least one buffering mechanism, crossover ho...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2451
更新日期:2012-03-04 00:00:00
abstract::The directional movement of cells in a gradient of external stimulus is termed chemotaxis and is important in many aspects of development and differentiated cell function. Phophoinositide 3-kinases (PI(3)Ks) are thought to have critical roles within the gradient-sensing machinery of a variety of highly motile cells, s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1517
更新日期:2007-01-01 00:00:00
abstract::Junior researchers are encouraged to gain experience abroad, and for senior scientists, sabbaticals remain popular. France has taken the next step in fostering international exchange, by supporting long-term collaborations with foreign laboratories and by creating research units abroad. ...
journal_title:Nature cell biology
pub_type: 社论
doi:10.1038/ncb0607-613
更新日期:2007-06-01 00:00:00
abstract::Individual neurons form specific elaborate dendritic structures that receive presynaptic information. The pattern of dendritic branching is regulated by the microtubule-associated motor protein dynein, which is responsible for the transport of essential endosomes and other organelles into the dendrites. ...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb1008-1131
更新日期:2008-10-01 00:00:00
abstract::Physiological oxidants that are generated by activated phagocytes comprise the main source of oxidative stress during inflammation. Oxidants such as taurine chloramine (TnCl) and hydrogen peroxide (H(2)O(2)) can damage proteins and induce apoptosis, but the role of specific protein oxidation in this process has not be...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1968
更新日期:2009-10-01 00:00:00
abstract::Activation of mitosis-promoting factor (MPF) drives mitotic commitment. In human cells active MPF appears first on centrosomes. We show that local activation of MPF on the equivalent organelle of fission yeast, the spindle pole body (SPB), promotes Polo kinase activity at the SPBs long before global MPF activation dri...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2633
更新日期:2013-01-01 00:00:00
abstract::Mitochondrial function degenerates with ageing and in ageing-related neuromuscular degenerative diseases, causing physiological decline of the cell. Factors that can delay the degenerative process are actively sought after. Here, we show that reduced cytosolic protein synthesis is a robust cellular strategy that suppr...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1769
更新日期:2008-09-01 00:00:00