Abstract：
:The pericentriolar material (PCM), the microtubule-organizing component of the centrosome, contains a multitude of proteins and is commonly described as an amorphous cloud surrounding the centrioles. However, the days of the PCM as an unstructured matrix are numbered. Using super-resolution microscopy, several reports have now revealed remarkable domain organization within the PCM.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Lüders Jdoi
10.1038/ncb2617subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1126-8issue
11eissn
1465-7392issn
1476-4679pii
ncb2617journal_volume
14pub_type
杂志文章abstract：:FoxG1 is an evolutionarily conserved, winged-helix transcriptional repressor that maintains progenitor cells in the vertebrate forebrain. How the activity of FoxG1 is regulated is not known. Here, we report that in the developing Xenopus and mouse forebrain, FoxG1 is nuclear in progenitor cells but cytoplasmic in diff...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1573
更新日期：2007-05-01 00:00:00
abstract：:N-WASP is a major cytoskeletal regulator that stimulates Arp2/3-mediated actin nucleation. Here, we identify a nucleation-independent pathway by which N-WASP regulates the cytoskeleton and junctional integrity at the epithelial zonula adherens. N-WASP is a junctional protein whose depletion decreased junctional F-acti...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2290
更新日期：2011-07-24 00:00:00
abstract：:Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a fam...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-020-0488-x
更新日期：2020-04-01 00:00:00
abstract：:Cellular senescence is a tumour suppressor programme characterized by a stable cell cycle arrest. Here we report that cellular senescence triggered by a variety of stimuli leads to diminished ribosome biogenesis and the accumulation of both rRNA precursors and ribosomal proteins. These defects were associated with red...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-018-0127-y
更新日期：2018-07-01 00:00:00
abstract：:The Notch1 gene has an important role in mammalian cell-fate decision and tumorigenesis. Upstream control mechanisms for transcription of this gene are still poorly understood. In a chemical genetics screen for small molecule activators of Notch signalling, we identified epidermal growth factor receptor (EGFR) as a ke...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1750
更新日期：2008-08-01 00:00:00
abstract：:The tumour vascular microenvironment supports tumorigenesis not only by supplying oxygen and diffusible nutrients but also by secreting soluble factors that promote tumorigenesis. Here we identify a feedforward mechanism in which endothelial cells (ECs), in response to tumour-derived mediators, release angiocrines dri...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2954
更新日期：2014-05-01 00:00:00
abstract：:The GTPase dynamin plays an essential part in endocytosis by catalysing the fission of nascent clathrin-coated vesicles from the plasma membrane. Using preformed phosphatidylinositol-4,5-bisphosphate-containing lipid nanotubes as a membrane template for dynamin self-assembly, we investigate the conformational changes ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/8997
更新日期：1999-05-01 00:00:00
abstract：:It has long-been accepted that normal somatic cells have intrinsic mechanisms that limit their proliferative lifespan. Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential. ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb0202-e25
更新日期：2002-02-01 00:00:00
abstract：:The intracellular Ca(2+) concentration ([Ca(2+)](i)) in skeletal muscles must be rapidly regulated during the excitation-contraction-relaxation process. However, the signalling components involved in such rapid Ca(2+) movement are not fully understood. Here we report that mice deficient in the newly identified PtdInsP...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1884
更新日期：2009-06-01 00:00:00
abstract：:Actin and myosin are major components of the cell cytoskeleton, with structural and regulatory functions that affect many essential cellular processes. Although they were traditionally thought to function only in the cytoplasm, it is now well accepted that actin and multiple myosins are found in the nucleus. Increasin...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb2364
更新日期：2011-11-02 00:00:00
abstract：:The store-operated calcium channel (SOC) located in the plasma membrane (PM) mediates capacitative entry of extracellular calcium after depletion of intracellular calcium stores in the endoplasmic or sarcoplasmic reticulum (ER/SR). An intimate interaction between the PM and the ER/SR is essential for the operation of ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb788
更新日期：2002-05-01 00:00:00
abstract：:Different sites of plasma membrane attachment may underlie functional differences between isoforms of Ras. Here we show that palmitoylation and farnesylation targets H-ras to lipid rafts and caveolae, but that the interaction of H-ras with these membrane subdomains is dynamic. GTP-loading redistributes H-ras from raft...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35070050
更新日期：2001-04-01 00:00:00
abstract：:Lamina-associated polypeptide (LAP) 2alpha is a chromatin-associated protein that binds A-type lamins. Mutations in both LAP2alpha and A-type lamins are linked to human diseases called laminopathies, but the molecular mechanisms are poorly understood. The A-type lamin-LAP2alpha complex interacts with and regulates ret...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1793
更新日期：2008-11-01 00:00:00
abstract：:Phosphorylation networks intimately regulate mechanisms of response to therapies. Mapping the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-throughput system to measure the enzymatic activity of kinases using biological peptide targets as phospho-sens...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-019-0328-z
更新日期：2019-06-01 00:00:00
abstract：:Nutrient availability is central for T-cell functions and immune responses. Here we report that CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non-essential amino acid Asn. Increased Asn levels enhance CD8+ T-cell activation and effector functions against tumour cells in vitro and in ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-020-00615-4
更新日期：2021-01-01 00:00:00
abstract：:The small GTPase ADP-ribosylation factor (ARF) regulates the structure and function of the Golgi complex through mechanisms that are understood only in part, and which include an ability to control the assembly of coat complexes and phospholipase D (PLD). Here we describe a new property of ARF, the ability to recruit ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/12993
更新日期：1999-09-01 00:00:00
abstract：:The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion,...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb3524
更新日期：2017-05-31 00:00:00
abstract：:Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cancers. Here, we generate quadruple TIMP knockout (TIMPless) fibroblasts ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3021
更新日期：2014-09-01 00:00:00
abstract：:Clathrin-coated vesicles (CCVs) are a central component of endocytosis and traffic between the trans-Golgi network (TGN) and endosomes. Although endocytic CCV formation is well characterized, much less is known about CCV formation at internal membranes. Here we describe two epsin amino-terminal homology (ENTH) domain-...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb901
更新日期：2003-01-01 00:00:00
abstract：:Primordial germ cell (PGC) development in the human fetus remains relatively uncharted. A new study suggests that epigenetic reprogramming and sex differentiation in human PGCs occur asynchronously over an extended time period. This finding raises questions and implications for in vitro PGC differentiation. ...
journal_title：Nature cell biology
pub_type： 评论,杂志文章
doi：10.1038/ncb2665
更新日期：2013-01-01 00:00:00
abstract：:Epigenetic mechanisms participate in the regulation of gene transcription in eukaryotes. Two studies in yeast have revealed an additional mechanism for controlling global gene transcription that is based on an inherited self-perpetuating change in the conformation of two different components of key transcriptional reg...
journal_title：Nature cell biology
pub_type： 评论,杂志文章
doi：10.1038/ncb0309-241
更新日期：2009-03-01 00:00:00
abstract：:Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints. Histone H2AX, p53 binding-protein 1 (53BP1) and Chk2 are targets of ATM-mediated phosphorylation, but little is known about their roles in sig...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb884
更新日期：2002-12-01 00:00:00
abstract：:Plant cell morphogenesis relies on the organization and function of two polymer arrays separated by the plasma membrane: the cortical microtubule cytoskeleton and cellulose microfibrils in the cell wall. Studies using in vivo markers confirmed that one function of the cortical microtubule array is to drive organizatio...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1886
更新日期：2009-07-01 00:00:00
abstract：:Endothelial cells and leptin receptor+ (LepR+) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone marrow. After irradiation or chemotherapy, these cells are depleted while adipocytes become abundant. We discovered that bone marrow adipocytes sy...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3570
更新日期：2017-08-01 00:00:00
abstract：:Mitochondria drive apoptosis by releasing pro-apoptotic proteins that promote caspase activation in the cytosol. The rhomboid protease PARL, an intramembrane cleaving peptidase in the inner membrane, regulates mitophagy and plays an ill-defined role in apoptosis. Here, we employed PARL-based proteomics to define its s...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3488
更新日期：2017-04-01 00:00:00
abstract：:Filament-forming cytoskeletal proteins are essential for the structure and organization of all cells. Bacterial homologues of the major eukaryotic cytoskeletal families have now been discovered, but studies suggest that yet more remain to be identified. We demonstrate that the metabolic enzyme CTP synthase (CtpS) form...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2087
更新日期：2010-08-01 00:00:00
abstract：:mTOR (mammalian target of rapamycin) signalling and macroautophagy (henceforth autophagy) regulate numerous pathological and physiological processes, including cellular responses to altered nutrient levels. However, the mechanisms regulating mTOR and autophagy remain incompletely understood. Lysosomes are dynamic intr...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2204
更新日期：2011-04-01 00:00:00
abstract：:Aberrant microRNA (miRNA) expression is a defining feature of human malignancy. Specific miRNAs have been identified as promoters or suppressors of metastatic progression. miRNAs control metastasis through divergent or convergent regulation of metastatic gene pathways. Some miRNA regulatory networks govern cell-autono...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb2769
更新日期：2013-06-01 00:00:00
abstract：:Science denial is not new but, in the digital age, evidence-based conclusions appear to be increasingly threatened by beliefs based on emotion and isolated personal experience. When confronting a post-truth world, scientists must defend the scientific method and increase public engagement. ...
journal_title：Nature cell biology
pub_type： 社论
doi：10.1038/s41556-018-0231-z
更新日期：2018-11-01 00:00:00
abstract：:Protein ubiquitination regulates many cellular processes, including protein degradation, signal transduction, DNA repair and cell division. In the classical model, a uniform polyubiquitin chain that is linked through Lys 48 is required for recognition and degradation by the 26S proteasome. Here, we used a reconstitute...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1436
更新日期：2006-07-01 00:00:00
