Abstract:
:Primordial germ cell (PGC) development in the human fetus remains relatively uncharted. A new study suggests that epigenetic reprogramming and sex differentiation in human PGCs occur asynchronously over an extended time period. This finding raises questions and implications for in vitro PGC differentiation.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Laird DJdoi
10.1038/ncb2665subject
Has Abstractpub_date
2013-01-01 00:00:00pages
13-5issue
1eissn
1465-7392issn
1476-4679pii
ncb2665journal_volume
15pub_type
评论,杂志文章abstract::Work over the past two years has led to a breakthrough in our understanding of the molecular basis of the directionality of the kinesin motor proteins. This breakthrough has come first from the reversal of directionality of the kinesin-related motor Ncd, followed closely by the reversal of kinesin's directionality and...
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journal_title:Nature cell biology
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abstract::The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor metastasis-free survival of patients with breast cancer with localized disease. DTCs persist in distant tissues despite systemic administration of adjuvant chemotherapy. Many assume that this is because the majority of DTCs are quies...
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journal_title:Nature cell biology
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abstract::Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalie...
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journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2080
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abstract::The mitochondrial inner membrane is the central energy-converting membrane of eukaryotic cells. The electrochemical proton gradient generated by the respiratory chain drives the ATP synthase. To maintain this proton-motive force, the inner membrane forms a tight barrier and strictly controls the translocation of ions....
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journal_title:Nature cell biology
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abstract::Accurate chromosome segregation during cell division in metazoans relies on proper chromosome congression at the equator. Chromosome congression is achieved after bi-orientation to both spindle poles shortly after nuclear envelope breakdown, or by the coordinated action of motor proteins that slide misaligned chromoso...
journal_title:Nature cell biology
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pub_type: 信件
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journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1133
更新日期:2004-06-01 00:00:00
abstract::Protein substrates of the proteasome must apparently be unfolded and translocated through a narrow channel to gain access to the proteolytic active sites of the enzyme. Protein folding in vivo is mediated by molecular chaperones. Here, to test for chaperone activity of the proteasome, we assay the reactivation of dena...
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abstract::The cell division axis determines the future positions of daughter cells and is therefore critical for cell fate. The positioning of the division axis has been mostly studied in systems such as embryos or yeasts, in which cell shape is well defined. In these cases, cell shape anisotropy and cell polarity affect spindl...
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abstract::Ciliates and flagellates temporarily swim backwards on collision by generating a mechanoreceptor potential. Although this potential has been shown to be associated with cilia in Paramecium, the molecular entity of the mechanoreceptor has remained unknown. Here we show that Chlamydomonas cells express TRP11, a member o...
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journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1188
更新日期:2004-11-01 00:00:00
abstract::Spatial and temporal coordination of polo-like kinase 1 (Plk1) activity is necessary for mitosis and cytokinesis, and this is achieved through binding to phosphorylated docking proteins with distinct subcellular localizations. Although cyclin-dependent kinase 1 (Cdk1) creates these phosphorylated docking sites in meta...
journal_title:Nature cell biology
pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
abstract::Many classical biologists working in Antarctica have 'gone molecular' to study the physiological basis for life on or below the ice. Investigating the remarkable adaptations of specific cells, organelles and molecules to this extreme environment can provide new perspectives on the processes studied in conventional exp...
journal_title:Nature cell biology
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
abstract::ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardio...
journal_title:Nature cell biology
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更新日期:2008-03-01 00:00:00
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journal_title:Nature cell biology
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
abstract::Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a fam...
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journal_title:Nature cell biology
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更新日期:2015-07-01 00:00:00