Prions remodel gene expression in yeast.

abstract：:Accurate chromosome segregation during cell division in metazoans relies on proper chromosome congression at the equator. Chromosome congression is achieved after bi-orientation to both spindle poles shortly after nuclear envelope breakdown, or by the coordinated action of motor proteins that slide misaligned chromoso...

journal_title：Nature cell biology

authors： Barisic M,Aguiar P,Geley S,Maiato H

更新日期：2014-12-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to b...

journal_title：Nature cell biology

authors： Stemmler MP,Eccles RL,Brabletz S,Brabletz T

更新日期：2019-01-01 00:00:00

abstract：:The heterogeneity of exosomal populations has hindered our understanding of their biogenesis, molecular composition, biodistribution and functions. By employing asymmetric flow field-flow fractionation (AF4), we identified two exosome subpopulations (large exosome vesicles, Exo-L, 90-120 nm; small exosome vesicles, Ex...

journal_title：Nature cell biology

authors： Zhang H,Freitas D,Kim HS,Fabijanic K,Li Z,Chen H,Mark MT,Molina H,Martin AB,Bojmar L,Fang J,Rampersaud S,Hoshino A,Matei I,Kenific CM,Nakajima M,Mutvei AP,Sansone P,Buehring W,Wang H,Jimenez JP,Cohen-Gould L,P

更新日期：2018-03-01 00:00:00

abstract：:Inactivation of the von Hippel-Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel-Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dep...

journal_title：Nature cell biology

authors： Krek W

更新日期：2000-07-01 00:00:00

abstract：:The double fertilization process in angiosperms is based on the delivery of a pair of sperm cells by the pollen tube (the male gametophyte), which elongates towards an embryo sac (the female gametophyte) enclosing an egg and a central cell. Several studies have described the mechanisms of gametophyte interaction, and ...

journal_title：Nature cell biology

authors： Mori T,Kuroiwa H,Higashiyama T,Kuroiwa T

更新日期：2006-01-01 00:00:00

abstract：:Cell division is fundamental for all organisms. Here we report a genome-scale RNA-mediated interference screen in HeLa cells designed to identify human genes that are important for cell division. We have used a library of endoribonuclease-prepared short interfering RNAs for gene silencing and have used DNA content ana...

journal_title：Nature cell biology

authors： Kittler R,Pelletier L,Heninger AK,Slabicki M,Theis M,Miroslaw L,Poser I,Lawo S,Grabner H,Kozak K,Wagner J,Surendranath V,Richter C,Bowen W,Jackson AL,Habermann B,Hyman AA,Buchholz F

更新日期：2007-12-01 00:00:00

abstract：: ...

journal_title：Nature cell biology

authors： Serebrenik YV,Shalem O

更新日期：2018-11-01 00:00:00

abstract：:Endothelial cells and leptin receptor+ (LepR+) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone marrow. After irradiation or chemotherapy, these cells are depleted while adipocytes become abundant. We discovered that bone marrow adipocytes sy...

journal_title：Nature cell biology

authors： Zhou BO,Yu H,Yue R,Zhao Z,Rios JJ,Naveiras O,Morrison SJ

更新日期：2017-08-01 00:00:00

abstract：:Cellular transformation and cancer progression is accompanied by changes in the metabolic landscape. Master co-regulators of metabolism orchestrate the modulation of multiple metabolic pathways through transcriptional programs, and hence constitute a probabilistically parsimonious mechanism for general metabolic rewir...

journal_title：Nature cell biology

authors： Torrano V,Valcarcel-Jimenez L,Cortazar AR,Liu X,Urosevic J,Castillo-Martin M,Fernández-Ruiz S,Morciano G,Caro-Maldonado A,Guiu M,Zúñiga-García P,Graupera M,Bellmunt A,Pandya P,Lorente M,Martín-Martín N,Sutherland JD,San

更新日期：2016-06-01 00:00:00

abstract：:The pericentriolar material (PCM), the microtubule-organizing component of the centrosome, contains a multitude of proteins and is commonly described as an amorphous cloud surrounding the centrioles. However, the days of the PCM as an unstructured matrix are numbered. Using super-resolution microscopy, several reports...

journal_title：Nature cell biology

authors： Lüders J

更新日期：2012-11-01 00:00:00

abstract：:It is now well established that stromal interaction molecule 1 (STIM1) is the calcium sensor of endoplasmic reticulum stores required to activate store-operated calcium entry (SOC) channels at the surface of non-excitable cells. However, little is known about STIM1 in excitable cells, such as striated muscle, where th...

journal_title：Nature cell biology

authors： Stiber J,Hawkins A,Zhang ZS,Wang S,Burch J,Graham V,Ward CC,Seth M,Finch E,Malouf N,Williams RS,Eu JP,Rosenberg P

更新日期：2008-06-01 00:00:00

abstract：:Repulsive guidance molecule (RGM) is a recently identified protein implicated in both axonal guidance and neural tube closure. The avoidance of chick RGM in the posterior optic tectum by growing temporal, but not nasal, retinal ganglion cell axons is thought to contribute to visual map formation. In contrast to ephrin...

journal_title：Nature cell biology

authors： Rajagopalan S,Deitinghoff L,Davis D,Conrad S,Skutella T,Chedotal A,Mueller BK,Strittmatter SM

更新日期：2004-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as novel cancer genes. In particular, the miR-17-92 cluster, containing six individual miRNAs, is highly expressed in haematopoietic cancers and promotes lymphomagenesis in vivo. Clinical use of these findings hinges on isolating the oncogenic activity within the 17-92 cluster and defin...

journal_title：Nature cell biology

authors： Mavrakis KJ,Wolfe AL,Oricchio E,Palomero T,de Keersmaecker K,McJunkin K,Zuber J,James T,Khan AA,Leslie CS,Parker JS,Paddison PJ,Tam W,Ferrando A,Wendel HG

更新日期：2010-04-01 00:00:00

abstract：:The promyelocytic leukaemia (PML) tumour-suppressor protein potentiates p53 function by regulating post-translational modifications, such as CBP-dependent acetylation and Chk2-dependent phosphorylation, in the PML-Nuclear Body (NB). PML was recently shown to interact with the p53 ubiquitin-ligase Mdm2 (refs 4-6); howe...

journal_title：Nature cell biology

authors： Bernardi R,Scaglioni PP,Bergmann S,Horn HF,Vousden KH,Pandolfi PP

更新日期：2004-07-01 00:00:00

abstract：:The SNF2h (sucrose non-fermenting protein 2 homologue)-containing chromatin-remodelling complex NoRC silences a fraction of ribosomal RNA genes (rDNA) by establishing a heterochromatic structure at the rDNA promoter. Here we show that the acetyltransferase MOF (males absent on the first) acetylates TIP5, the largest s...

journal_title：Nature cell biology

authors： Zhou Y,Schmitz KM,Mayer C,Yuan X,Akhtar A,Grummt I

更新日期：2009-08-01 00:00:00

abstract：:Clathrin-coated vesicles (CCVs) are a central component of endocytosis and traffic between the trans-Golgi network (TGN) and endosomes. Although endocytic CCV formation is well characterized, much less is known about CCV formation at internal membranes. Here we describe two epsin amino-terminal homology (ENTH) domain-...

journal_title：Nature cell biology

authors： Duncan MC,Costaguta G,Payne GS

更新日期：2003-01-01 00:00:00

abstract：:In the version of this Article originally published, ref. 52 was incorrectly only attributed to its corresponding author, Fre, S., and an older title was used. The correct citation should have been: Lilja, A. M. et al. Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain...

journal_title：Nature cell biology

authors： Wuidart A,Sifrim A,Fioramonti M,Matsumura S,Brisebarre A,Brown D,Centonze A,Dannau A,Dubois C,Van Keymeulen A,Voet T,Blanpain C

更新日期：2018-09-01 00:00:00

abstract：:Junior researchers are encouraged to gain experience abroad, and for senior scientists, sabbaticals remain popular. France has taken the next step in fostering international exchange, by supporting long-term collaborations with foreign laboratories and by creating research units abroad. ...

journal_title：Nature cell biology

authors：

更新日期：2007-06-01 00:00:00

abstract：:Many extracellular signals are transmitted to the interior of the cell by receptors with seven membrane-spanning helices that trigger their effects by means of heterotrimeric guanine-nucleotide-binding regulatory proteins (G proteins). These G-protein-coupled receptors (GPCRs) control various physiological functions i...

journal_title：Nature cell biology

authors： Cvejic S,Zhu Z,Felice SJ,Berman Y,Huang XY

更新日期：2004-06-01 00:00:00

abstract：:Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory element...

journal_title：Nature cell biology

authors： Shapira SN,Seale P

更新日期：2017-08-31 00:00:00

abstract：:Tissue stem cells are the cell of origin for many malignancies. Metabolites regulate the balance between self-renewal and differentiation, but whether endogenous metabolic pathways or nutrient availability predispose stem cells towards transformation remains unknown. Here, we address this question in epidermal stem ce...

journal_title：Nature cell biology

authors： Baksh SC,Todorova PK,Gur-Cohen S,Hurwitz B,Ge Y,Novak JSS,Tierney MT,Dela Cruz-Racelis J,Fuchs E,Finley LWS

更新日期：2020-07-01 00:00:00

abstract：:The initial differential treatment of the two X chromosomes during X-chromosome inactivation is controlled by the X-inactivation centre (Xic). This locus determines how many X chromosomes are present in a cell ('counting') and which X chromosome will be inactivated in female cells ('choice'). Critical control sequence...

journal_title：Nature cell biology

authors： Bacher CP,Guggiari M,Brors B,Augui S,Clerc P,Avner P,Eils R,Heard E

更新日期：2006-03-01 00:00:00

abstract：:The enteric nervous system (ENS) predominantly originates from vagal neural crest (VNC) cells that emerge from the caudal hindbrain, invade the foregut and populate the gastrointestinal tract. However, the gene regulatory network (GRN) orchestrating the early specification of VNC remains unknown. Using an EdnrB enhanc...

journal_title：Nature cell biology

authors： Ling ITC,Sauka-Spengler T

更新日期：2019-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature cell biology

authors： Bagci H,Sriskandarajah N,Robert A,Boulais J,Elkholi IE,Tran V,Lin ZY,Thibault MP,Dubé N,Faubert D,Hipfner DR,Gingras AC,Côté JF

更新日期：2020-03-01 00:00:00

abstract：:Formins have been implicated in the regulation of cytoskeletal structure in animals and fungi. Here we show that the formins Bni1 and Bnr1 of budding yeast stimulate the assembly of actin filaments that function as precursors to tropomyosin-stabilized cables that direct polarized cell growth. With loss of formin funct...

journal_title：Nature cell biology

authors： Evangelista M,Pruyne D,Amberg DC,Boone C,Bretscher A

更新日期：2002-03-01 00:00:00

abstract：:The AP-1 transcription factor c-Jun is essential for cellular proliferation in many cell types, but the molecular link between growth factors and c-Jun activation has been enigmatic. In this study we identify a previously uncharacterized RING-domain-containing protein, RACO-1 (RING domain AP-1 co-activator-1), as a c-...

journal_title：Nature cell biology

authors： Davies CC,Chakraborty A,Cipriani F,Haigh K,Haigh JJ,Behrens A

更新日期：2010-10-01 00:00:00

abstract：:Clathrin-coated vesicles mediate endocytosis and transport between the trans-Golgi network (TGN) and endosomes in eukaryotic cells. Clathrin adaptors play central roles in coat assembly, interacting with clathrin, cargo and membranes. Two main types of clathrin adaptor act in TGN-endosome traffic: GGA proteins and the...

journal_title：Nature cell biology

authors： Daboussi L,Costaguta G,Payne GS

更新日期：2012-02-19 00:00:00

abstract：:In the unicellular eukaryote Saccharomyces cerevisiae, Cln3-cyclin-dependent kinase activity enables Start, the irreversible commitment to the cell division cycle. However, the concentration of Cln3 has been paradoxically considered to remain constant during G1, due to the presumed scaling of its production rate with ...

journal_title：Nature cell biology

authors： Litsios A,Huberts DHEW,Terpstra HM,Guerra P,Schmidt A,Buczak K,Papagiannakis A,Rovetta M,Hekelaar J,Hubmann G,Exterkate M,Milias-Argeitis A,Heinemann M

更新日期：2019-11-01 00:00:00

abstract：:Protein degradation in eukaryotes often requires the ubiquitin-selective chaperone p97 for substrate recruitment and ubiquitin-chain assembly. However, the physiological relevance of p97, and its role in developmental processes, remain unclear. Here, we discover an unanticipated function for CDC-48/p97 in myosin assem...

journal_title：Nature cell biology

authors： Janiesch PC,Kim J,Mouysset J,Barikbin R,Lochmüller H,Cassata G,Krause S,Hoppe T

更新日期：2007-04-01 00:00:00

abstract：:The directional movement of cells in a gradient of external stimulus is termed chemotaxis and is important in many aspects of development and differentiated cell function. Phophoinositide 3-kinases (PI(3)Ks) are thought to have critical roles within the gradient-sensing machinery of a variety of highly motile cells, s...

journal_title：Nature cell biology

authors： Ferguson GJ,Milne L,Kulkarni S,Sasaki T,Walker S,Andrews S,Crabbe T,Finan P,Jones G,Jackson S,Camps M,Rommel C,Wymann M,Hirsch E,Hawkins P,Stephens L

更新日期：2007-01-01 00:00:00