Abstract：
:Formins have been implicated in the regulation of cytoskeletal structure in animals and fungi. Here we show that the formins Bni1 and Bnr1 of budding yeast stimulate the assembly of actin filaments that function as precursors to tropomyosin-stabilized cables that direct polarized cell growth. With loss of formin function, cables disassemble,whereas increased formin activity causes the hyperaccumulation of cable-like filaments. Unlike the assembly of cortical actin patches, cable assembly requires profilin but not the Arp2/3 complex. Thus formins control a distinct pathway for assembling actin filaments that organize the overall polarity of the cell.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Evangelista M,Pruyne D,Amberg DC,Boone C,Bretscher Adoi
10.1038/ncb770keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
260-9issue
3eissn
1465-7392issn
1476-4679pii
ncb770journal_volume
4pub_type
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