Abstract:
:Wnt/β-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO-LGR4/5-ZNF3/RNF43 is now shown to direct Wnt/β-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanisms that influence organ development and regeneration.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Birchmeier Wdoi
10.1038/ncb3349subject
Has Abstractpub_date
2016-04-27 00:00:00pages
463-5issue
5eissn
1465-7392issn
1476-4679pii
ncb3349journal_volume
18pub_type
评论,杂志文章abstract::Actin and myosin are major components of the cell cytoskeleton, with structural and regulatory functions that affect many essential cellular processes. Although they were traditionally thought to function only in the cytoplasm, it is now well accepted that actin and multiple myosins are found in the nucleus. Increasin...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2364
更新日期:2011-11-02 00:00:00
abstract::Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a fam...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-020-0488-x
更新日期:2020-04-01 00:00:00
abstract::Protein ubiquitination regulates many cellular processes, including protein degradation, signal transduction, DNA repair and cell division. In the classical model, a uniform polyubiquitin chain that is linked through Lys 48 is required for recognition and degradation by the 26S proteasome. Here, we used a reconstitute...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1436
更新日期:2006-07-01 00:00:00
abstract::Clathrin-coated vesicles mediate endocytosis and transport between the trans-Golgi network (TGN) and endosomes in eukaryotic cells. Clathrin adaptors play central roles in coat assembly, interacting with clathrin, cargo and membranes. Two main types of clathrin adaptor act in TGN-endosome traffic: GGA proteins and the...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2427
更新日期:2012-02-19 00:00:00
abstract::Over their lifetime, long-term haematopoietic stem cells (HSC) are exposed to a variety of stress conditions that they must endure. Many stresses, such as infection/inflammation, reactive oxygen species, nutritional deprivation and hypoxia, activate unfolded protein response signalling, which induces either adaptive c...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-019-0285-6
更新日期:2019-03-01 00:00:00
abstract::Cellular senescence is a tumour suppressor programme characterized by a stable cell cycle arrest. Here we report that cellular senescence triggered by a variety of stimuli leads to diminished ribosome biogenesis and the accumulation of both rRNA precursors and ribosomal proteins. These defects were associated with red...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0127-y
更新日期:2018-07-01 00:00:00
abstract::Extracellular signal-regulated kinase (ERK) controls fundamental cellular functions, including cell fate decisions. In PC12, cells shifting ERK activation from transient to sustained induces neuronal differentiation. As ERK associates with both regulators and effectors, we hypothesized that the mechanisms underlying t...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1994
更新日期:2009-12-01 00:00:00
abstract::The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb3611
更新日期:2017-10-01 00:00:00
abstract::Endoplasmic reticulum (ER)-associated protein degradation by the ubiquitin-proteasome system requires the dislocation of substrates from the ER into the cytosol. It has been speculated that a functional ubiquitin proteasome pathway is not only essential for proteolysis, but also for the preceding export step. Here, we...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb746
更新日期:2002-02-01 00:00:00
abstract::The intracellular Ca(2+) concentration ([Ca(2+)](i)) in skeletal muscles must be rapidly regulated during the excitation-contraction-relaxation process. However, the signalling components involved in such rapid Ca(2+) movement are not fully understood. Here we report that mice deficient in the newly identified PtdInsP...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1884
更新日期:2009-06-01 00:00:00
abstract::A number of key regulators of mouse embryonic stem (ES) cell identity, including the transcription factor Nanog, show strong expression fluctuations at the single-cell level. The molecular basis for these fluctuations is unknown. Here we used a genetic complementation strategy to investigate expression changes during ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2603
更新日期:2012-11-01 00:00:00
abstract::The actin filament (F-actin) cytoskeleton associates dynamically with the plasma membrane and is thus ideally positioned to participate in endocytosis. Indeed, a wealth of genetic and biochemical evidence has confirmed that actin interacts with components of the endocytic machinery, although its precise function in en...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1025
更新日期:2003-08-01 00:00:00
abstract::We have identified Rab10 as an ER-specific Rab GTPase that regulates ER structure and dynamics. We show that Rab10 localizes to the ER and to dynamic ER-associated structures that track along microtubules and mark the position of new ER tubule growth. Rab10 depletion or expression of a Rab10 GDP-locked mutant alters E...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2647
更新日期:2013-02-01 00:00:00
abstract::YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3111
更新日期:2015-04-01 00:00:00
abstract::During mammalian development, neuroepithelial cells function as mitotic progenitors, which self-renew and generate neurons. Although spindle orientation is important for such polarized cells to undergo symmetric or asymmetric divisions, its role in mammalian neurogenesis remains unclear. Here we show that control of s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1673
更新日期:2008-01-01 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables their collective invasion. Force transmission is mediated by a heterophilic adhesion involving N-cadherin at the CAF membrane and E-cadherin at the cancer cell membrane. Th...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3478
更新日期:2017-03-01 00:00:00
abstract::Dynamic regulation of adhesion complexes is required for cell migration and has therefore emerged as a key issue in the study of cell motility. Recent progress has been made in defining some of the molecular mechanisms by which adhesion disassembly is regulated, including the contributions of adhesion adaptor proteins...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1175
更新日期:2004-10-01 00:00:00
abstract::MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endo...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/10061
更新日期:1999-06-01 00:00:00
abstract::Cytokinesis requires the spatio-temporal coordination of cell-cycle control and cytoskeletal reorganization. Members of the Rho-family of GTPases are crucial regulators of this process and assembly of the contractile ring depends on local activation of Rho signalling. Here, we show that the armadillo protein p0071, un...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1504
更新日期:2006-12-01 00:00:00
abstract::Mammalian and most fungal infectious proteins (also known as prions) are self-propagating amyloid, a filamentous beta-sheet structure. A prion domain determines the infectious properties of a protein by forming the core of the amyloid. We compare the properties of known prion domains and their interactions with the re...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb1105-1039
更新日期:2005-11-01 00:00:00
abstract::The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory proteins and delivery of functional solutes throughout the cell1,2. Molecular mobility through the ER network enables these functionalities, but diffusion alone is not sufficient to explain...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0192-2
更新日期:2018-10-01 00:00:00
abstract::Proteins containing ubiquitin-binding domains (UBDs) interact with ubiquitinated targets and regulate diverse biological processes, including endocytosis, signal transduction, transcription and DNA repair. Many of the UBD-containing proteins are also themselves monoubiquitinated, but the functional role and the mechan...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1354
更新日期:2006-02-01 00:00:00
abstract::MicroRNAs (miRNAs) have emerged as novel cancer genes. In particular, the miR-17-92 cluster, containing six individual miRNAs, is highly expressed in haematopoietic cancers and promotes lymphomagenesis in vivo. Clinical use of these findings hinges on isolating the oncogenic activity within the 17-92 cluster and defin...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2037
更新日期:2010-04-01 00:00:00
abstract::We describe a genome-wide gain-of-function screen for regulators of NF-kappaB, and identify Rap1 (Trf2IP), as an essential modulator of NF-kappaB-mediated pathways. NF-kappaB is induced by ectopic expression of Rap1, whereas its activity is inhibited by Rap1 depletion. In addition to localizing on telomeres, mammalian...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2080
更新日期:2010-08-01 00:00:00
abstract::The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for force generation coupled to plus-end polymerization and depolymerization. Spc24/Spc25 at one end of the Ndc80 complex binds the kinetochore. The N-terminal ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3323
更新日期:2016-04-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature cell biology
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41556-020-0479-y
更新日期:2020-03-01 00:00:00
abstract::Clathrin-coated vesicles (CCVs) are a central component of endocytosis and traffic between the trans-Golgi network (TGN) and endosomes. Although endocytic CCV formation is well characterized, much less is known about CCV formation at internal membranes. Here we describe two epsin amino-terminal homology (ENTH) domain-...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb901
更新日期:2003-01-01 00:00:00
abstract::Reference datasets should be accessible independently of scientific papers in a citable form, allowing attribution. ...
journal_title:Nature cell biology
pub_type: 社论
doi:10.1038/ncb1109-1273a
更新日期:2009-11-01 00:00:00
abstract::Direct reprogramming by forced expression of transcription factors can convert one cell type into another. Thus, desired cell types can be generated bypassing pluripotency. However, direct reprogramming towards renal cells remains an unmet challenge. Here, we identify renal cell fate-inducing factors on the basis of t...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3437
更新日期:2016-12-01 00:00:00
abstract::Phosphorylation networks intimately regulate mechanisms of response to therapies. Mapping the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-throughput system to measure the enzymatic activity of kinases using biological peptide targets as phospho-sens...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-019-0328-z
更新日期:2019-06-01 00:00:00