Abstract:
:Store-operated Ca(2+) channels (SOCs) are activated in response to Ca(2+) release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca(2+) content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STIM1 in skeletal muscle, and a prominent role of SOCs in muscle development and function.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Shin DM,Muallem Sdoi
10.1038/ncb0608-639subject
Has Abstractpub_date
2008-06-01 00:00:00pages
639-41issue
6eissn
1465-7392issn
1476-4679pii
ncb0608-639journal_volume
10pub_type
新闻abstract::Phosphatase and tensin homologue (Pten) suppresses neoplastic growth by negatively regulating PI(3)K signalling through its phosphatase activity. To gain insight into the actions of non-catalytic Pten domains in normal physiological processes and tumorigenesis, we engineered mice lacking the PDZ-binding domain (PDZ-BD...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3369
更新日期:2016-07-01 00:00:00
abstract::We have identified Rab10 as an ER-specific Rab GTPase that regulates ER structure and dynamics. We show that Rab10 localizes to the ER and to dynamic ER-associated structures that track along microtubules and mark the position of new ER tubule growth. Rab10 depletion or expression of a Rab10 GDP-locked mutant alters E...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2647
更新日期:2013-02-01 00:00:00
abstract::Wiskott-Aldrich syndrome protein (WASP) and N-WASP have emerged as key proteins connecting signalling cascades to actin polymerization. Here we show that the amino-terminal WH1 domain, and not the polyproline-rich region, of N-WASP is responsible for its recruitment to sites of actin polymerization during Cdc42-indepe...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35017080
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abstract::The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of stalled DNA replication forks is a recently identified PARPi-resistance mechanism that promotes genomic stability in BRCA1/2-deficient cancers. D...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3626
更新日期:2017-11-01 00:00:00
abstract::Chromosome loss or gain is associated with a large number of solid cancers, providing genomic plasticity and thus adaptability to cancer cells. Numerical centrosome abnormalities arising from centrosome over-duplication or failed cytokinesis are a recognized cause of aneuploidy. In higher eukaryotic cells, the centros...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1735
更新日期:2008-06-01 00:00:00
abstract::Many classical biologists working in Antarctica have 'gone molecular' to study the physiological basis for life on or below the ice. Investigating the remarkable adaptations of specific cells, organelles and molecules to this extreme environment can provide new perspectives on the processes studied in conventional exp...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb0103-3
更新日期:2003-01-01 00:00:00
abstract::Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyses the trimethylation of histone H3 on Lys 27 (H3K27), which represses gene transcription. EZH2 enhances cancer-cell invasiveness and regulates stem cell differentiation. Here, we demonstrate that EZH2 can ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2139
更新日期:2011-01-01 00:00:00
abstract::To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt - a major kinase that coordinates diverse signalling pathways - phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphoryla...
journal_title:Nature cell biology
pub_type: 评论,新闻
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更新日期:2009-04-01 00:00:00
abstract::KLF4 (GKLF/EZF) encodes a transcription factor that is associated with both tumour suppression and oncogenesis. We describe the identification of KLF4 in a functional genomic screen for genes that bypass RAS(V12)-induced senescence. However, in untransformed cells, KLF4 acts as a potent inhibitor of proliferation. KLF...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1314
更新日期:2005-11-01 00:00:00
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journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2985
更新日期:2014-07-01 00:00:00
abstract::LATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. LATS1 inhibits both the phosphorylation of cofilin by LIMK...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1140
更新日期:2004-07-01 00:00:00
abstract::Dynamic regulation of adhesion complexes is required for cell migration and has therefore emerged as a key issue in the study of cell motility. Recent progress has been made in defining some of the molecular mechanisms by which adhesion disassembly is regulated, including the contributions of adhesion adaptor proteins...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1175
更新日期:2004-10-01 00:00:00
abstract::When co-translationally inserted into endoplasmic reticulum (ER) membranes, newly synthesized proteins encounter the lumenal environment of the ER, which contains chaperone proteins that facilitate the folding reactions necessary for protein oligomerization, maturation and export from the ER. Here we show, using a tem...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35010558
更新日期:2000-05-01 00:00:00
abstract::Transforming growth factor-beta (TGF-beta) induces epithelial-mesenchymal transdifferentiation (EMT) accompanied by cellular differentiation and migration. Despite extensive transcriptomic profiling, the identification of TGF-beta-inducible, EMT-specific genes has met with limited success. Here we identify a post-tran...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2029
更新日期:2010-03-01 00:00:00
abstract::Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal, we have developed cell culture conditions to closely mimic events occurring during pancreatic islet organogenesis and β...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0271-4
更新日期:2019-02-01 00:00:00
abstract::Pyruvate kinase M2 (PKM2) is upregulated in multiple cancer types and contributes to the Warburg effect by unclear mechanisms. Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1. Phosphor...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2629
更新日期:2012-12-01 00:00:00
abstract::The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of new therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been shown to prevent diet-i...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3075
更新日期:2015-01-01 00:00:00
abstract::In mammals, motile cilia cover many organs, such as fallopian tubes, respiratory tracts and brain ventricles. The development and function of these organs critically depend on efficient directional fluid flow ensured by the alignment of ciliary beating. To identify the mechanisms involved in this process, we analysed ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2040
更新日期:2010-04-01 00:00:00
abstract::Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated chloride channel expressed in a wide variety of epithelial cells, mutations of which are responsible for the hallmark defective chloride secretion observed in cystic fibrosis (CF). Although CFTR has been implicated in bicarbonate secretion,...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1047
更新日期:2003-10-01 00:00:00
abstract::FoxG1 is an evolutionarily conserved, winged-helix transcriptional repressor that maintains progenitor cells in the vertebrate forebrain. How the activity of FoxG1 is regulated is not known. Here, we report that in the developing Xenopus and mouse forebrain, FoxG1 is nuclear in progenitor cells but cytoplasmic in diff...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1573
更新日期:2007-05-01 00:00:00
abstract::In the version of this Article originally published, ref. 52 was incorrectly only attributed to its corresponding author, Fre, S., and an older title was used. The correct citation should have been: Lilja, A. M. et al. Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain...
journal_title:Nature cell biology
pub_type: 已发布勘误
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更新日期:2018-09-01 00:00:00
abstract::Guard cells, which form stomata in leaf epidermes, sense a multitude of environmental signals and integrate this information to regulate stomatal movements. Compared with the advanced understanding of light and water stress responses in guard cells, the molecular mechanisms that underlie stomatal CO(2) signalling have...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1387
更新日期:2006-04-01 00:00:00
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journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1025
更新日期:2003-08-01 00:00:00
abstract::Blocking mitotic progression has been proposed as an attractive therapeutic strategy to impair proliferation of tumour cells. However, how cells survive during prolonged mitotic arrest is not well understood. We show here that survival during mitotic arrest is affected by the special energetic requirements of mitotic ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3231
更新日期:2015-10-01 00:00:00
abstract::Assisted reproductive technologies (ART) are exceptional among clinical therapies, as unlike most medical procedures, ART have generational consequences. Further, human embryo research in the US has been sponsored solely by the private sector and, until recent biotechnology forays into human embryonic stem cell (hESC)...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb-nm-fertilityS19
更新日期:2002-10-01 00:00:00
abstract::Here we show that segregation of homologous chromosomes and that of sister chromatids are differentially regulated in Xenopus and possibly in other higher eukaryotes. Upon hormonal stimulation, Xenopus oocytes microinjected with antibodies against the anaphase-promoting complex (APC) activator Fizzy or the APC core su...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35050607
更新日期:2001-01-01 00:00:00
abstract::Organs and cells must adapt to shear stress induced by biological fluids, but how fluid flow contributes to the execution of specific cell programs is poorly understood. Here we show that shear stress favours mitochondrial biogenesis and metabolic reprogramming to ensure energy production and cellular adaptation in ki...
journal_title:Nature cell biology
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
abstract::Hypoxia and acidosis occur in a wide variety of physiological and pathological settings that include muscle stress, tumour development and ischaemic disorders. A central element in the adaptive response to cellular hypoxia is HIF (hypoxia-inducible factor), a transcription factor that activates an array of genes impli...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1144
更新日期:2004-07-01 00:00:00
abstract:: ...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/s41556-018-0246-5
更新日期:2018-12-01 00:00:00
abstract::Somatic cell reprogramming by exogenous factors requires cooperation with transcriptional co-activators and co-repressors to effectively remodel the epigenetic environment. How this interplay is regulated remains poorly understood. Here, we demonstrate that NCoR/SMRT co-repressors bind to pluripotency loci to create a...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0047-x
更新日期:2018-04-01 00:00:00