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Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia.

Abstract：

:In mammals, motile cilia cover many organs, such as fallopian tubes, respiratory tracts and brain ventricles. The development and function of these organs critically depend on efficient directional fluid flow ensured by the alignment of ciliary beating. To identify the mechanisms involved in this process, we analysed motile cilia of mouse brain ventricles, using biophysical and molecular approaches. Our results highlight an original orientation mechanism for ependymal cilia whereby basal bodies first dock apically with random orientations, and then reorient in a common direction through a coupling between hydrodynamic forces and the planar cell polarity (PCP) protein Vangl2, within a limited time-frame. This identifies a direct link between external hydrodynamic cues and intracellular PCP signalling. Our findings extend known PCP mechanisms by integrating hydrodynamic forces as long-range polarity signals, argue for a possible sensory role of ependymal cilia, and will be of interest for the study of fluid flow-mediated morphogenesis.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Guirao B,Meunier A,Mortaud S,Aguilar A,Corsi JM,Strehl L,Hirota Y,Desoeuvre A,Boutin C,Han YG,Mirzadeh Z,Cremer H,Montcouquiol M,Sawamoto K,Spassky N

doi

10.1038/ncb2040

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

341-50

issue

4

eissn

1465-7392

issn

1476-4679

pii

ncb2040

journal_volume

12

pub_type

杂志文章

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