Abstract：
:Obesity occurs when excess energy accumulates in white adipose tissue (WAT), whereas brown adipose tissue (BAT), specialized for energy expenditure through thermogenesis, potently counteracts obesity. Factors that induce brown adipocyte commitment and energy expenditure would be a promising defence against adiposity. Here, we show that Lgr4 homozygous mutant (Lgr4(m/m)) mice show reduced adiposity and resist dietary and leptin mutant-induced obesity with improved glucose metabolism. Lgr4(m/m) mice show a striking increase in energy expenditure, and exhibit brown-like adipocytes in WAT depots with higher expression of BAT and beige cell markers. Furthermore, Lgr4 ablation potentiates brown adipocyte differentiation from the stromal vascular fraction of epididymal WAT, partially through retinoblastoma 1 gene (Rb1) reduction. A functional low-frequency human LGR4 variant (A750T) has been associated with body mass index in a Chinese obese-versus-control study. Our results identify an important role for LGR4 in energy balance and body weight control through regulating the white-to-brown fat transition.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Wang J,Liu R,Wang F,Hong J,Li X,Chen M,Ke Y,Zhang X,Ma Q,Wang R,Shi J,Cui B,Gu W,Zhang Y,Zhang Z,Wang W,Xia X,Liu M,Ning Gdoi
10.1038/ncb2867subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1455-63issue
12eissn
1465-7392issn
1476-4679pii
ncb2867journal_volume
15pub_type
杂志文章abstract：:The guanosine tri-phosphatase Ran stimulates assembly of microtubule spindles. However, it is not known what aspects of the microtubule cytoskeleton are subject to regulation by Ran in mitosis. Here we show that Ran-GTP stimulates microtubule assembly by increasing the rescue frequency of microtubules three- to eightf...
journal_title：Nature cell biology
pub_type： 杂志文章
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更新日期：2001-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb1604
更新日期：2007-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb1341
更新日期：2006-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-05-31 00:00:00
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pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb1354
更新日期：2006-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb1098
更新日期：2004-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb1517
更新日期：2007-01-01 00:00:00
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pub_type： 评论,新闻
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更新日期：2010-10-01 00:00:00
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doi：10.1038/ncb1899
更新日期：2009-07-01 00:00:00
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pub_type： 评论,杂志文章
doi：10.1038/ncb0908-1019
更新日期：2008-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb2629
更新日期：2012-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
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pub_type： 杂志文章,已发布勘误
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更新日期：2011-08-14 00:00:00
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更新日期：2002-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-01-01 00:00:00
