Abstract：
:The accurate spatial and temporal coordination of cell polarization with DNA replication and segregation guarantees the fidelity of genetic transmission. Here we report that in Saccharomyces cerevisiae, a build-up or burst of G1 cyclin-dependent kinase (CDK) activity through activation of the cyclin genes CLN1,2 and PCL1,2 is essential for cell morphogenesis, but not for other events associated with the G1-S-phase transition, including DNA replication. Strains lacking a burst of late-G1 cyclin-CDK activity (LG1C(-)) undergo a catastrophic morphogenesis and halt the nuclear cycle at the morphogenesis checkpoint in G2 phase. Consistent with a role in morphogenesis, the Pho85 G1 cyclins Pcl1 and Pcl2 show a unique pattern of localization to sites of polarized cell growth, and strains lacking PCL1 and PCL2 show genetic interactions with the cell polarity GTPase Cdc42, its regulators and downstream effectors. Our data suggest that inability to assemble a septin ring and localize the GTP exchange factor Cdc24 at the incipient bud site may be the primary morphogenetic defects in LG1C-depleted cells. We conclude that a burst of late G1 cyclin-CDK activity is essential for establishing cell polarity and development of the cleavage apparatus.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Moffat J,Andrews Bdoi
10.1038/ncb1078keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
59-66issue
1eissn
1465-7392issn
1476-4679pii
ncb1078journal_volume
6pub_type
杂志文章abstract：:Mitochondrial function degenerates with ageing and in ageing-related neuromuscular degenerative diseases, causing physiological decline of the cell. Factors that can delay the degenerative process are actively sought after. Here, we show that reduced cytosolic protein synthesis is a robust cellular strategy that suppr...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1769
更新日期：2008-09-01 00:00:00
abstract：:The tumour vascular microenvironment supports tumorigenesis not only by supplying oxygen and diffusible nutrients but also by secreting soluble factors that promote tumorigenesis. Here we identify a feedforward mechanism in which endothelial cells (ECs), in response to tumour-derived mediators, release angiocrines dri...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2954
更新日期：2014-05-01 00:00:00
abstract：:In plants, cell shape is defined by the cell wall, and changes in cell shape and size are dictated by modification of existing cell walls and deposition of newly synthesized cell-wall material. In root hairs, expansion occurs by a process called tip growth, which is shared by root hairs, pollen tubes and fungal hyphae...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2294
更新日期：2011-07-17 00:00:00
abstract：:MicroRNAs (miRNAs) have emerged as novel cancer genes. In particular, the miR-17-92 cluster, containing six individual miRNAs, is highly expressed in haematopoietic cancers and promotes lymphomagenesis in vivo. Clinical use of these findings hinges on isolating the oncogenic activity within the 17-92 cluster and defin...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2037
更新日期：2010-04-01 00:00:00
abstract：:Wiskott-Aldrich syndrome protein (WASP) and N-WASP have emerged as key proteins connecting signalling cascades to actin polymerization. Here we show that the amino-terminal WH1 domain, and not the polyproline-rich region, of N-WASP is responsible for its recruitment to sites of actin polymerization during Cdc42-indepe...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35017080
更新日期：2000-07-01 00:00:00
abstract：:Although myosin II filaments are known to exist in non-muscle cells, their dynamics and organization are incompletely understood. Here, we combined structured illumination microscopy with pharmacological and genetic perturbations, to study the process of actomyosin cytoskeleton self-organization into arcs and stress f...
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doi：10.1038/ncb3466
更新日期：2017-02-01 00:00:00
abstract：: ...
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pub_type： 评论,杂志文章
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更新日期：2018-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
abstract：:Examination of the tumour suppressor adenomatous polyposis coli (APC) has shown that it may be multifunctional. Recent work has demonstrated dynamic interactions of APC with the microtubule cytoskeleton, supporting the idea that APC has an important function in cell migration. ...
journal_title：Nature cell biology
pub_type： 新闻,评审
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更新日期：2000-04-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1663
更新日期：2007-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb1140
更新日期：2004-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb3091
更新日期：2015-02-01 00:00:00
abstract：:In vertebrates, centromeres lack defined sequences and are thought to be propagated by epigenetic mechanisms involving the incorporation of specialized nucleosomes containing the histone H3 variant centromere protein (CENP)-A. However, the precise mechanisms that target CENP-A to centromeres remain poorly understood. ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1396
更新日期：2006-05-01 00:00:00
abstract：:To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt - a major kinase that coordinates diverse signalling pathways - phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphoryla...
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pub_type： 评论,新闻
doi：10.1038/ncb0409-377
更新日期：2009-04-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb788
更新日期：2002-05-01 00:00:00
abstract：:The double fertilization process in angiosperms is based on the delivery of a pair of sperm cells by the pollen tube (the male gametophyte), which elongates towards an embryo sac (the female gametophyte) enclosing an egg and a central cell. Several studies have described the mechanisms of gametophyte interaction, and ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1345
更新日期：2006-01-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35008643
更新日期：2000-04-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35078535
更新日期：2001-06-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1557
更新日期：2007-04-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2647
更新日期：2013-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb3575
更新日期：2017-09-01 00:00:00
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更新日期：2011-11-02 00:00:00
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更新日期：2012-10-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1532
更新日期：2007-02-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1038/35014078
更新日期：2000-06-01 00:00:00
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journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3231
更新日期：2015-10-01 00:00:00
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journal_title：Nature cell biology
pub_type： 评论,新闻
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更新日期：2000-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb1504
更新日期：2006-12-01 00:00:00
