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A potential link between obesity and neural stem cell dysfunction.

Abstract：

:Given the important role of the hypothalamus in regulating feeding and metabolism, there has been considerable interest in a possible function for hypothalamic stem cells in modulating body weight in health and disease. Mice given a high-fat diet develop inflammation in the hypothalamus and lose key types of neurons. It now appears that another effect of a high-fat diet is to reduce neural stem cell numbers, as well as their ability to make new neurons--effects that are associated with activation of the IKKβ/NF-κB pathway--thereby exacerbating the primary loss of neurons and resulting in altered feeding behaviour and obesity.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Livesey FJ

doi

10.1038/ncb2599

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

987-9

issue

10

eissn

1465-7392

issn

1476-4679

pii

ncb2599

journal_volume

14

pub_type

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